Brief Information of the Cell Line and Protein
Cell Line ID: CL000049 , C6
Synonyms
C-6
C 6
RGC-6
RGC6
RGc6
Category Cancer cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_0194
Protein ID: PT01194 , Histamine H3 receptor
Gene Name HRH3
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q9Y5N1
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000049  Protein ID: PT01194
 
Compound ID Compound Name Compound Formula
CP0409792
(3-Fluoro-phenyl)-{2-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-methanone
   Show/Hide
C22H22FNO2
 1
1
Ki = 0.1 nM
   TI
   LI
   LO
   TS
CP0136874
(2R)-N,3-dimethyl-2-(methylamino)-N-[(1R,2S,5S,6S,9R,12S,13R,16S)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-16-yl]butanamide
   Show/Hide
C29H49N3O
 1
1
Ki = 0.21 nM
   TI
   LI
   LO
   TS
CP0427752
4'-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile
   Show/Hide
C21H24N2O
 1
1
Ki = 0.22 nM
   TI
   LI
   LO
   TS
CP0193419
6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methylnicotinamide
   Show/Hide
C21H25N3O2
 1
1
Ki = 0.26 nM
   TI
   LI
   LO
   TS
CP0289268
N-methyl-N'-phenyl-N'-[4-(2-pyrrolidin-1-ylethoxy)phenyl]propane-1,3-diamine
   Show/Hide
C22H31N3O
 1
1
Ki = 0.28 nM
   TI
   LI
   LO
   TS
CP0135044
(4'-(3-((2R,5R)-2,5-dimethylpyrrolidin-1-yl)propoxy)biphenyl-4-yl)(morpholino)methanone
   Show/Hide
C26H34N2O3
 1
1
Ki = 0.42 nM
   TI
   LI
   LO
   TS
CP0194592
(R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile
   Show/Hide
C22H22N2O
 1
1
Ki = 0.45 nM
   TI
   LI
   LO
   TS
CP0056575
1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine
   Show/Hide
C20H32N2O
 1
1
Ki = 0.63 nM
   TI
   LI
   LO
   TS
CP0354240
N-methyl-4-phenyl-4-[4-(2-pyrrolidin-1-ylethoxy)phenyl]butan-1-amine
   Show/Hide
C23H32N2O
 1
1
Ki = 0.89 nM
   TI
   LI
   LO
   TS
CP0296352
N-methyl-3-phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]propan-1-amine
   Show/Hide
C22H30N2O
 1
1
Ki = 1.4 nM
   TI
   LI
   LO
   TS
CP0401512
1-(4-(4-(piperidin-1-ylmethyl)phenyl)but-3-ynyl)piperidine
   Show/Hide
C21H30N2
 1
1
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CP0069162
N-methyl-N'-phenyl-N'-[4-(2-pyrrolidin-1-ylethoxy)phenyl]ethane-1,2-diamine
   Show/Hide
C21H29N3O
 1
1
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CP0493188
4-{methyl[(1R,2S,5S,6S,9R,12S,13R,16S)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-16-yl]amino}benzonitrile
   Show/Hide
C30H41N3
 1
1
Ki = 1.66 nM
   TI
   LI
   LO
   TS
CP0473959
2-[4-[4-[(3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]phenyl]phenyl]pyridazin-3-one
   Show/Hide
C23H24N4O
 1
1
Ki = 1.9 nM
   TI
   LI
   LO
   TS
CP0119048
1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine
   Show/Hide
C17H26ClNO
 1
1
Ki = 2.7 nM
   TI
   LI
   LO
   TS
CP0479001
1-(3-(3-phenylpropoxy)propyl)piperidine
   Show/Hide
C17H27NO
 1
1
Ki = 3.1 nM
   TI
   LI
   LO
   TS
CP0077617
(1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-16-amine
   Show/Hide
C24H40N2
 1
1
Ki = 5.37 nM
   TI
   LI
   LO
   TS
CP0069161
4-(3-(Methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol
   Show/Hide
C26H32N2O2
 1
1
Ki = 7.4 nM
   TI
   LI
   LO
   TS
CP0382611
(R)-4-(6-(2-(2-methylpiperidin-1-yl)ethyl)naphthalen-2-yl)benzonitrile
   Show/Hide
C25H26N2
 1
1
Ki = 8.71 nM
   TI
   LI
   LO
   TS
CP0436852
Conessine analogue, 12c
   Show/Hide
C30H42N2O
 1
1
Ki = 12.3 nM
   TI
   LI
   LO
   TS
CP0427216
(3aR,6aR)-1-(4'-Bromo-biphenyl-4-yl)-5-methyl-octahydropyrrolo[3,4-b]pyrrole
   Show/Hide
C19H21BrN2
 1
1
Ki = 12.3 nM
   TI
   LI
   LO
   TS
CP0472186
2,2,2-trichloroethyl N-methyl-N-[(1R,2S,5S,6S,9R,12S,13R,16S)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-16-yl]carbamate
   Show/Hide
C26H39Cl3N2O2
 1
1
Ki = 19.7 nM
   TI
   LI
   LO
   TS
CP0497470
(3aR,6aR)-1-(4-Benzyl-phenyl)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole
   Show/Hide
C20H24N2
 1
1
Ki = 26.3 nM
   TI
   LI
   LO
   TS
CP0489686
Conessine analogue, 12j
   Show/Hide
C25H43N3O2S
 1
1
Ki = 30.9 nM
   TI
   LI
   LO
   TS
CP0093148
4-[3-(methylamino)azetidin-1-yl]spiro[6,7-dihydro-5H-quinazoline-8,1'-cyclopentane]-2-amine
   Show/Hide
C16H25N5
 1
1
Ki = 63.1 nM
   TI
   LI
   LO
   TS
CP0099745
4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole
   Show/Hide
C16H18N2O2
 1
1
Ki = 63.1 nM
   TI
   LI
   LO
   TS
CP0044460
N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide
   Show/Hide
C15H24N4S
 1
1
Ki = 72.44 nM
   TI
   LI
   LO
   TS
CP0498545
3aR,6aR)-1-(4-Bromo-phenyl)-5-methyl-octahydro-pyrrolo[3,4-b]pyrrole
   Show/Hide
C13H17BrN2
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0093147
4-[(3R)-3-(methylamino)pyrrolidin-1-yl]spiro[6,7-dihydro-5H-quinazoline-8,1'-cyclopentane]-2-amine
   Show/Hide
C17H27N5
 1
1
Ki = 104.71 nM
   TI
   LI
   LO
   TS
CP0095456
4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-8-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-amine
   Show/Hide
C20H27N5
 1
1
Ki = 223.87 nM
   TI
   LI
   LO
   TS
CP0373379
4-[(3R)-3-aminopyrrolidin-1-yl]spiro[6,7-dihydro-5H-quinazoline-8,1'-cyclopentane]-2-amine
   Show/Hide
C16H25N5
 1
1
Ki = 295.12 nM
   TI
   LI
   LO
   TS
CP0443503
(1R,2S,5S,9R,12S,13R,16S)-16-(dimethylamino)-7,13-dimethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-6-one
   Show/Hide
C23H36N2O
 1
1
Ki = 543 nM
   TI
   LI
   LO
   TS
CP0229853
2,4-diamino-5,6-disubstituted pyrimidine, 14
   Show/Hide
C19H25N5
 1
1
Ki = 2238.72 nM
   TI
   LI
   LO
   TS
CP0844933
(4bS,6aS,9aR)-2-Methoxy-8-methyl-5,6,6a,7,8,9,10,11-octahydro-4bH-benzo[4,5]indeno[1,7a-c]pyrrole
   Show/Hide
C17H23NO
 1
1
Ki < 1000 nM
   TI
   LI
   LO
   TS
CP0880169
(4bR,6aS,9aR)-2-Methoxy-8-methyl-5,6,6a,7,8,9,10,11-octahydro-4bH-benz[4,5]indeno[1,7a-c]pyrrole
   Show/Hide
C17H23NO
 1
1
Ki < 1000 nM
   TI
   LI
   LO
   TS
CP0008168
CAS_136434-34-9
   Show/Hide
C18H19NOS
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
CP0055808
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
   Show/Hide
C18H22N2
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS