General Information of the Protein
Protein ID
PT00577
Protein Name
Histamine receptor H3
Gene Name
HRH3
Sequence
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
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Organism
Macaca mulatta, Rhesus macaque
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q865E1
Subcellular Location
Cell membrane
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0540768
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclohexanecarboxamide
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C23H35N3O
  1
1
Ki = 0.39 nM
 Bioactivity Info 
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CP0070912
 Compound Info 
3,5-dimethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,2-oxazole-4-carboxamide
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C22H30N4O2
  1
1
Ki = 0.4 nM
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CP0492985
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclopentanecarboxamide
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C22H33N3O
  1
1
Ki = 0.5 nM
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CP0476801
 Compound Info 
2,2,3,3-tetramethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]cyclopropane-1-carboxamide
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C24H37N3O
  1
1
Ki = 0.55 nM
 Bioactivity Info 
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CP0500998
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]bicyclo[2.2.1]heptane-2-carboxamide
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C24H35N3O
  1
1
Ki = 0.55 nM
 Bioactivity Info 
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CP0476800
 Compound Info 
2-cyclopentyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]acetamide
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C23H35N3O
  1
1
Ki = 0.85 nM
 Bioactivity Info 
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CP0107784
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]oxane-4-carboxamide
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C22H33N3O2
  1
1
Ki = 0.97 nM
 Bioactivity Info 
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CP0462174
 Compound Info 
3-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,2-oxazole-5-carboxamide
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C21H28N4O2
  1
1
Ki = 1.1 nM
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CP0484202
 Compound Info 
6-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]pyridine-2-carboxamide
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C23H30N4O
  1
1
Ki = 1.4 nM
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CP0436027
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]furan-3-carboxamide
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C21H27N3O2
  1
1
Ki = 1.8 nM
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CP0406979
 Compound Info 
1-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-3-(thiophen-2-ylmethyl)urea
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C21H28N4OS
  1
1
Ki = 1.9 nM
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CP0087368
 Compound Info 
5-fluoro-2-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]benzamide
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C24H30FN3O
  1
1
Ki = 2.5 nM
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CP0509429
 Compound Info 
3,4-difluoro-N-[2-methyl-6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-yl]benzenesulfonamide
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C21H26F2N4O2S
  1
1
Ki = 2.5 nM
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CP0525020
 Compound Info 
N-[2-methyl-6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-yl]benzamide
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C22H28N4O
  1
1
Ki = 3 nM
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CP0475033
 Compound Info 
2-cyclopentyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]acetamide
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C22H33N3O
  1
1
Ki = 3.1 nM
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CP0380162
 Compound Info 
1-(2,4-difluorophenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]urea
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C21H25F2N3O2
  1
1
Ki = 3.4 nM
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CP0406982
 Compound Info 
1-(3,5-dichlorophenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]urea
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C21H25Cl2N3O2
  1
1
Ki = 3.4 nM
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CP0553880
 Compound Info 
N-[2-methyl-4-[(3R)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]oxane-4-carboxamide
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C22H33N3O2
  1
1
Ki = 3.9 nM
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CP0484201
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]furan-2-carboxamide
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C21H27N3O2
  1
1
Ki = 3.9 nM
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CP0489114
 Compound Info 
1-cyclohexyl-3-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C22H34N4O
  1
1
Ki = 4.1 nM
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CP0540854
 Compound Info 
N-[2-methyl-6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-yl]naphthalene-1-carboxamide
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C26H30N4O
  1
1
Ki = 4.2 nM
 Bioactivity Info 
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CP0380999
 Compound Info 
1-cyclohexyl-3-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H36N4O
  1
1
Ki = 4.6 nM
 Bioactivity Info 
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CP0537690
 Compound Info 
2-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,3-oxazole-4-carboxamide
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C21H28N4O2
  1
1
Ki = 4.6 nM
 Bioactivity Info 
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CP0484124
 Compound Info 
5-methyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1H-pyrazole-3-carboxamide
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C21H29N5O
  1
1
Ki = 4.7 nM
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CP0517271
 Compound Info 
N-[2-methyl-6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-yl]-2-phenylacetamide
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C23H30N4O
  1
1
Ki = 4.9 nM
 Bioactivity Info 
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CP0567287
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperidine-1-carboxamide
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C21H32N4O
  1
1
Ki = 6 nM
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CP0948376
 Compound Info 
N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)tetrahydro-2H-pyran-4-carboxamide
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C22H33N3O2
  1
1
Ki = 6.8 nM
 Bioactivity Info 
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CP0374981
 Compound Info 
1-[(3,5-dichlorophenyl)methyl]-3-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H28Cl2N4O
  1
1
Ki = 7.1 nM
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CP0553879
 Compound Info 
N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]oxolane-2-carboxamide
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C21H31N3O2
  1
1
Ki = 7.33 nM
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CP0438205
 Compound Info 
N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]oxolane-2-carboxamide
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C21H31N3O2
  1
1
Ki = 7.34 nM
 Bioactivity Info 
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CP0375427
 Compound Info 
1-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-3-(thiophen-2-ylmethyl)urea
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C22H30N4OS
  1
1
Ki = 8.4 nM
 Bioactivity Info 
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CP0848190
 Compound Info 
2-cyclopentyl-N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)acetamide
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C23H35N3O
  1
1
Ki = 8.4 nM
 Bioactivity Info 
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CP0432603
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]oxolane-2-carboxamide
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C20H29N3O2
  1
1
Ki = 8.7 nM
 Bioactivity Info 
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CP0856213
 Compound Info 
N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)cyclohexanecarboxamide
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C23H35N3O
  1
1
Ki = 9 nM
 Bioactivity Info 
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CP0501000
 Compound Info 
N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropanecarboxamide
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C20H29N3O
  1
1
Ki = 9.6 nM
 Bioactivity Info 
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CP0422519
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropanecarboxamide
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C19H27N3O
  1
1
Ki = 9.7 nM
 Bioactivity Info 
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CP0489113
 Compound Info 
4-methyl-N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C22H35N5O
  1
1
Ki = 10.5 nM
 Bioactivity Info 
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CP0500862
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-4-phenylpiperazine-1-carboxamide
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C26H35N5O
  1
1
Ki = 10.6 nM
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CP0395415
 Compound Info 
2-cyclopentyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]acetamide
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C23H35N3O
  1
1
Ki = 10.7 nM
 Bioactivity Info 
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CP0525051
 Compound Info 
1,5-dimethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]pyrazole-3-carboxamide
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C22H31N5O
  1
1
Ki = 10.8 nM
 Bioactivity Info 
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CP0456099
 Compound Info 
1-cyclohexyl-3-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H36N4O
  1
1
Ki = 11.2 nM
 Bioactivity Info 
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CP0403914
 Compound Info 
4-methyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C22H35N5O
  1
1
Ki = 12.7 nM
 Bioactivity Info 
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CP0440508
 Compound Info 
1-acetyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-2-carboxamide
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C22H32N4O2
  1
1
Ki = 14.1 nM
 Bioactivity Info 
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CP0541595
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)phenyl]cyclopropanecarboxamide
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C20H26F3N3O
  1
1
Ki = 14.7 nM
 Bioactivity Info 
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CP0406981
 Compound Info 
1-[4-[2-(diethylamino)ethoxy]phenyl]-3-[4-(2-methylpropoxy)phenyl]thiourea
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C23H33N3O2S
  1
1
Ki = 15.7 nM
 Bioactivity Info 
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CP0395398
 Compound Info 
N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]bicyclo[2.2.1]heptane-2-carboxamide
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C23H33N3O
  1
1
Ki = 15.7 nM
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CP0514211
 Compound Info 
N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]oxane-4-carboxamide
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C22H33N3O2
  1
1
Ki = 17 nM
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CP0541615
 Compound Info 
N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]oxolane-2-carboxamide
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C21H31N3O2
  1
1
Ki = 17 nM
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CP0379883
 Compound Info 
N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropanecarboxamide
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C20H29N3O
  1
1
Ki = 17.7 nM
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CP0380117
 Compound Info 
1-(3,5-dichloro-4-methylphenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]urea
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C22H27Cl2N3O2
  1
1
Ki = 18.2 nM
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CP0248952
 Compound Info 
1-(3,5-dichlorophenyl)-3-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C22H26Cl2N4O
  1
1
Ki = 19.1 nM
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CP0956798
 Compound Info 
N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide
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C24H35N3O
  1
1
Ki = 19.9 nM
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CP0085869
 Compound Info 
1-(3,5-dichlorophenyl)-3-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H28Cl2N4O
  1
1
Ki = 22.2 nM
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CP0456100
 Compound Info 
4-acetyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C23H35N5O2
  1
1
Ki = 23 nM
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CP0380997
 Compound Info 
4-methyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C21H33N5O
  1
1
Ki = 25.7 nM
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CP0456097
 Compound Info 
1-[(3,5-dichlorophenyl)methyl]-3-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C24H30Cl2N4O
  1
1
Ki = 28.8 nM
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CP0406980
 Compound Info 
4-acetyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]piperazine-1-carboxamide
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C22H33N5O2
  1
1
Ki = 34.1 nM
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CP0456098
 Compound Info 
3-[acetyl(methyl)amino]-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-1-carboxamide
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C23H35N5O2
  1
1
Ki = 35.5 nM
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CP0905229
 Compound Info 
2,2,3,3-tetramethyl-N-(2-methyl-4-(2-methyl-1,3'-bipyrrolidin-1'-yl)phenyl)cyclopropanecarboxamide
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C24H37N3O
  1
1
Ki = 37.3 nM
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CP0456096
 Compound Info 
1-(3,5-dichlorophenyl)-3-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea
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C23H28Cl2N4O
  1
1
Ki = 43 nM
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CP0539731
 Compound Info 
1-acetyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-2-carboxamide
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C23H34N4O2
  1
1
Ki = 44.9 nM
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CP0380163
 Compound Info 
1-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-3-(4-phenoxyphenyl)urea
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C28H32N4O2
  1
1
Ki = 46.8 nM
 Bioactivity Info 
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CP0476802
 Compound Info 
1-acetyl-N-[2-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-2-carboxamide
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C23H34N4O2
  1
1
Ki = 57.7 nM
 Bioactivity Info 
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CP0500999
 Compound Info 
2,2,3,3-tetramethyl-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropane-1-carboxamide
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C24H37N3O
  1
1
Ki = 65.5 nM
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CP0374980
 Compound Info 
3-[acetyl(methyl)amino]-N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]pyrrolidine-1-carboxamide
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C24H37N5O2
  1
1
Ki = 89.7 nM
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CP0524039
 Compound Info 
1-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]-3-(4-phenoxyphenyl)urea
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C29H34N4O2
  1
1
Ki = 115.2 nM
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CP0478833
 Compound Info 
N-[3-methyl-4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]bicyclo[2.2.1]heptane-2-carboxamide
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C24H35N3O
  1
1
Ki = 130.3 nM
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CP0407021
 Compound Info 
2,2,3,3-tetramethyl-N-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]cyclopropane-1-carboxamide
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C23H35N3O
  1
1
Ki = 143.8 nM
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Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01194 Histamine H3 receptor Homo sapiens, Human
 Protein Info 
PT03573 Histamine H3 receptor Cavia porcellus, Guinea pig
 Protein Info