General Information of the Protein
Protein ID
PT05330
Protein Name
Multidrug and toxin extrusion protein 2
Secondarily
Protein Name
Kidney-specific H(+)/organic cation antiporter
Solute carrier family 47 member 2
Gene Name
SLC47A2
Secondarily
Gene Name
MATE2
Sequence
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWLKGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITLTTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILATRH
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC47 family of multidrug and toxin extrusion transporters
Function
Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney.
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Uniprot ID
Primary ID:
Q86VL8

Secondarily ID:
A0JBX9
A0P8Z7
Q63HJ9
Q8IV44
Q96NA1
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HGNC ID
HGNC:26439
Subcellular Location
Cell membrane
Apical cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000088 , Flp-In-293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0000082
 Compound Info 
CAS_68647
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C18H19N3O
  1
1
IC50 = 6900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035927
 Compound Info 
(Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine,cyanide
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C10H16N6S
  1
1
IC50 = 39000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069487
 Compound Info 
2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol
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C24H40N8O4
  1
1
IC50 = 74000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0001598
 Compound Info 
1,2,3,4-tetrahydro-9-acridinamine
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C13H14N2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036757
 Compound Info 
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
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C19H24N2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0049757
 Compound Info 
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
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C21H29N3O
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0066121
 Compound Info 
N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine
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C18H23NO
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Multidrug and toxin extrusion protein 2 (MATE2) )
Target Type Literature-reported Target