General Information of the Cell Line
Cell Line ID
CL000123
Cell Line Name
GIST430
Synonyms
GIST-430
GIST 430
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_7040
Disease
Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00888, Mast/stem cell growth factor receptor Kit
 Protein Info 
Compound ID Compound Name Compound Formula
CP0436766
 Compound Info 
3-[2-(2-aminopyrimidin-5-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C27H27F3N6O
  1
1
GI50 = 51 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002211
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
   Show/Hide
C22H27FN4O2
  1
1
GI50 = 98 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035428
 Compound Info 
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
   Show/Hide
C29H27F3N6O
  1
1
GI50 = 149 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0184069
 Compound Info 
3-[2-(6-amino-5-methylpyridin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C29H30F3N5O
  1
1
GI50 = 307 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0351447
 Compound Info 
3-[2-(2-aminopyrimidin-5-yl)ethynyl]-2-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C27H27F3N6O
  1
1
GI50 = 308 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0270974
 Compound Info 
4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(pyridin-3-ylethynyl)benzamide
   Show/Hide
C28H27F3N4O
  1
1
GI50 = 333 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0191185
 Compound Info 
3-[2-(6-aminopyridin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C28H28F3N5O
  1
1
GI50 = 404 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0461776
 Compound Info 
3-[2-(6-aminopyridazin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C27H27F3N6O
  1
1
GI50 = 459 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0303422
 Compound Info 
3-[2-[2-(2-methoxyethylamino)pyrimidin-5-yl]ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C30H33F3N6O2
  1
1
GI50 = 481 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0448634
 Compound Info 
3-[2-(3-methoxypyridin-2-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C29H29F3N4O2
  1
1
GI50 = 564 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0161700
 Compound Info 
4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-(2-pyridin-2-ylethynyl)benzamide
   Show/Hide
C28H27F3N4O
  1
1
GI50 = 697 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0351448
 Compound Info 
3-(2-imidazo[1,2-a]pyridin-7-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C30H28F3N5O
  1
1
GI50 = 723 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0538822
 Compound Info 
3-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-[3-fluoro-4-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-methylbenzamide
   Show/Hide
C26H27FN6O
  1
1
GI50 = 920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0184068
 Compound Info 
3-[2-(1-aminoisoquinolin-4-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C32H30F3N5O
  1
1
GI50 = 926 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0002778
 Compound Info 
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
   Show/Hide
C29H31N7O
  1
1
GI50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0161699
 Compound Info 
N-[3-fluoro-4-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-methyl-3-(2-pyridin-3-ylethynyl)benzamide
   Show/Hide
C27H27FN4O
  1
1
GI50 = 1639 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0538824
 Compound Info 
4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(5-phenylmethoxypyridin-2-yl)ethynyl]benzamide
   Show/Hide
C35H33F3N4O2
  1
1
GI50 = 2005 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0436767
 Compound Info 
3-[2-(2-aminopyrimidin-5-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]benzamide
   Show/Hide
C26H28N6O
  1
1
GI50 = 2063 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0043225
 Compound Info 
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
   Show/Hide
C21H15ClF4N4O3
  1
1
GI50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0448635
 Compound Info 
3-iodo-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C21H23F3IN3O
  1
1
GI50 = 3905 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0531605
 Compound Info 
4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-3-(2-pyridin-3-ylethynyl)benzamide
   Show/Hide
C27H28N4O
  1
1
GI50 = 4032 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0191187
 Compound Info 
4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-([1,2,4]triazolo[4,3-a]pyridin-7-yl)ethynyl]benzamide
   Show/Hide
C29H27F3N6O
  1
1
GI50 = 4145 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0351449
 Compound Info 
2-ethyl-3-iodo-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
   Show/Hide
C22H25F3IN3O
  1
1
GI50 = 15858 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0002211
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
   Show/Hide
 C22H27FN4O2  1
1
GI50 = 2000 nM
   TI
   LI
   LO
   TS
CP0043225
 Compound Info 
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
   Show/Hide
 C21H15ClF4N4O3  1
1
GI50 > 2000 nM
   TI
   LI
   LO
   TS
CP0135795
 Compound Info 
1-(5-ethyl-1,2-oxazol-3-yl)-3-[4-[2-[[6-(4-ethylpiperazin-1-yl)pyrimidin-4-yl]amino]-1,3-thiazol-5-yl]phenyl]urea
   Show/Hide
 C25H29N9O2S  1
1
GI50 = 1 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line