Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-[2-(2-aminopyrimidin-5-yl)ethynyl]-2-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
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 PubChem ID
CID: 137641923
Canonical SMILES
CN1CCN(Cc2ccc(NC(=O)c3cccc(C#Cc4cnc(N)nc4)c3C)cc2C(F)(F)F)CC1
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Compound Formula C27H27F3N6O
Compound Structure
Protein Name
 Protein Info 
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000123 GIST430
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 308 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.2 nM