General Information of the Protein
Protein ID
PT01482
Protein Name
Induced myeloid leukemia cell differentiation protein Mcl-1
Secondarily
Protein Name
Bcl-2-like protein 3
Bcl-2-related protein EAT/mcl1
mcl1/EAT
Gene Name
MCL1
Secondarily
Gene Name
BCL2L3
Sequence
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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Organism
Homo sapiens, Human
Protein Classification
Other cytosolic protein
Function
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
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Uniprot ID
Primary ID:
Q07820

Secondarily ID:
B2R6B2
D3DV03
D3DV04
Q9HD91
Q9NRQ3
Q9NRQ4
Q9UHR7
Q9UHR8
Q9UHR9
Q9UNJ1
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Ensembl ID
ENSG00000143384
HGNC ID
HGNC:6943
Subcellular Location
Membrane
Cytoplasm
Mitochondrion
Nucleus
Nucleoplasm
Clinical Information about the Protein
Target 1 ( Mcl-1 messenger RNA (MCL-1 mRNA) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Chronic myelogenous leukaemia [ICD-11: 2A20.0]
Approved Drug(s) 1 Approved Drug  1
1 Imatinib
 Drug Info 
Approved
Chronic myelogenous leukaemia
Target 2 ( Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) )
Target Type Clinical trial Target
Disease 7 Target-related Diseases  7
1 Multiple myeloma [ICD-11: 2A83]
2 Refractory hematologic malignancy [ICD-11: 2A85.5]
3 Haematological malignancy [ICD-11: 2B33.Y]
4 Acute myeloid leukaemia [ICD-11: 2A60]
5 Trematode infection [ICD-11: 1F8Y]
6 Asthma [ICD-11: CA23]
7 Rheumatoid arthritis [ICD-11: FA20]
Clinical Trial Drug(s) 4 Clinical Trial Drugs  4
1 AMG 176
 Drug Info 
Phase 1
Multiple myeloma
2 AMG 397
 Drug Info 
Phase 1
Refractory hematologic malignancy
3 AZD5991
 Drug Info 
Phase 1
Haematological malignancy
4 MIK665
 Drug Info 
Phase 1
Acute myeloid leukaemia
Discontinued Drug(s) 2 Discontinued Drugs  2
1 BITHIONOL
 Drug Info 
Withdrawn from market
Trematode infection
2 Sch-45752
 Drug Info 
Terminated
Asthma
Investigative Drug(s) 1 Investigative Drug  1
1 ROSMARINIC ACID
 Drug Info 
Investigative
Rheumatoid arthritis