Protein Information

General Information of the Protein

Protein ID	PT01213
Protein Name	Histone deacetylase 6
Secondarily Protein Name	Tubulin-lysine deacetylase HDAC6
Gene Name	HDAC6
Secondarily Gene Name	KIAA0901 JM21
Sequence	MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHPH Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Epigenetic regulator > Eraser > Histone deacetylase > HDAC class IIb
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10220385). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10220385). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly; via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Show/Hide
Uniprot ID	Primary ID: Q9UBN7 Secondarily ID: O94975 Q6NT75 Q7L3E5 Q96CY0 Show/Hide
Ensembl ID	ENSG00000094631
HGNC ID	HGNC:14064
Subcellular Location	Cytoplasm Cytoplasm Cytoskeleton Nucleus Perikaryon Cell projection Dendrite Cell projection Axon Cell projection Cilium Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasm Cytoskeleton Cilium basal body

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000068 , A-549

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0052435 Compound Info	4-[[(3S)-1-(4-chlorophenyl)-3-methyl-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C18H18ClN3O3	1
1	EC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0243831 Compound Info	N-hydroxy-4-[(3-methyl-2-oxo-1-quinolin-6-ylpyrrolidin-3-yl)amino]benzamide Show/Hide	C21H20N4O3	1
1	EC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0090887 Compound Info	US8716285, 4 Show/Hide	C18H16ClN3O2	1
1	EC50 = 460 nM Bioactivity Info	TI LI LO TS
CP0231393 Compound Info	4-[[1-(4-chlorophenyl)-3-methyl-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C18H18ClN3O3	1
1	EC50 = 530 nM Bioactivity Info	TI LI LO TS
CP0121113 Compound Info	(7S)-N-hydroxy-7-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxamide Show/Hide	C20H19N5O2	1
1	EC50 = 690 nM Bioactivity Info	TI LI LO TS
CP0187630 Compound Info	US8716285, 7 Show/Hide	C15H16N4O2	1
1	EC50 = 730 nM Bioactivity Info	TI LI LO TS
CP0173808 Compound Info	US8716285, 15 Show/Hide	C21H19ClN4O2	1
1	EC50 = 930 nM Bioactivity Info	TI LI LO TS
CP0463407 Compound Info	US8716285, 40 Show/Hide	C17H17FN2O4S	1
1	EC50 = 990 nM Bioactivity Info	TI LI LO TS
CP0003832 Compound Info	N'-hydroxy-N-phenyloctanediamide Show/Hide	C14H20N2O3	2
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1030 nM Bioactivity Info	TI LI LO TS
CP0128613 Compound Info	N-hydroxy-4-[(1-naphthalen-2-yl-2-oxopyrrolidin-3-yl)amino]benzamide Show/Hide	C21H19N3O3	1
1	EC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0118301 Compound Info	US8716285, 24 Show/Hide	C20H19N5O2	1
1	EC50 = 1180 nM Bioactivity Info	TI LI LO TS
CP0359037 Compound Info	US8716285, 10 Show/Hide	C21H20N4O2	1
1	EC50 = 1310 nM Bioactivity Info	TI LI LO TS
CP0052124 Compound Info	4-[[1-(4-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H16ClN3O3	1
1	EC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0091644 Compound Info	(7R)-N-hydroxy-7-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxamide Show/Hide	C20H19N5O2	2
1	EC50 = 1600 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1640 nM Bioactivity Info	TI LI LO TS
CP0118314 Compound Info	US8716285, 42 Show/Hide	C17H17ClN2O4S	1
1	EC50 = 1720 nM Bioactivity Info	TI LI LO TS
CP0257134 Compound Info	4-[[(3R)-1-(4-chlorophenyl)-3-methyl-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C18H18ClN3O3	1
1	EC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0128612 Compound Info	4-[[1-[3-[2-(dimethylamino)ethoxy]phenyl]-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C21H26N4O4	1
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0487991 Compound Info	US8716285, 36 Show/Hide	C21H21N5O2	1
1	EC50 = 2250 nM Bioactivity Info	TI LI LO TS
CP0119162 Compound Info	N-hydroxy-4-[(3-methyl-2-oxo-1-phenylpyrrolidin-3-yl)amino]benzamide Show/Hide	C18H19N3O3	1
1	EC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0231390 Compound Info	4-[[1-(3-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H16ClN3O3	1
1	EC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0052438 Compound Info	4-[[1-(4-cyanophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C18H16N4O3	1
1	EC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0213538 Compound Info	N-hydroxy-2-[[5-(3-nitrophenyl)furan-2-yl]methyl]-3,4-dihydro-1H-isoquinoline-7-carboxamide Show/Hide	C21H19N3O5	1
1	EC50 = 3450 nM Bioactivity Info	TI LI LO TS
CP0128615 Compound Info	4-[[1-(4-chlorophenyl)pyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H18ClN3O2	1
1	EC50 = 4300 nM Bioactivity Info	TI LI LO TS
CP0147132 Compound Info	4-[[1-(3,4-dichlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H15Cl2N3O3	1
1	EC50 = 4300 nM Bioactivity Info	TI LI LO TS
CP0118296 Compound Info	US8716285, 14 Show/Hide	C21H19ClN4O2	1
1	EC50 = 4950 nM Bioactivity Info	TI LI LO TS
CP0541960 Compound Info	US8716285, 5 Show/Hide	C16H17N3O2	1
1	EC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0119161 Compound Info	N-hydroxy-4-[(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzamide Show/Hide	C17H17N3O3	1
1	EC50 = 5900 nM Bioactivity Info	TI LI LO TS
CP0052120 Compound Info	4-[[1-(2-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H16ClN3O3	1
1	EC50 = 6700 nM Bioactivity Info	TI LI LO TS
CP0518707 Compound Info	US8716285, 13 Show/Hide	C21H19ClN4O2	1
1	EC50 = 8700 nM Bioactivity Info	TI LI LO TS
CP0091643 Compound Info	4-[(1-benzyl-2-oxopyrrolidin-3-yl)amino]-N-hydroxybenzamide Show/Hide	C18H19N3O3	1
1	EC50 = 11400 nM Bioactivity Info	TI LI LO TS
CP0243832 Compound Info	US8716285, 53 Show/Hide	C19H18N6O2	1
1	EC50 = 11800 nM Bioactivity Info	TI LI LO TS
CP0178676 Compound Info	N-hydroxy-4-[[1-(4-methylsulfonylphenyl)-2-oxopyrrolidin-3-yl]amino]benzamide Show/Hide	C18H19N3O5S	1
1	EC50 = 11900 nM Bioactivity Info	TI LI LO TS
CP0536146 Compound Info	US8716285, 1 Show/Hide	C17H17FN2O2	1
1	EC50 = 12450 nM Bioactivity Info	TI LI LO TS
CP0247789 Compound Info	4-[[1-(4-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-2-fluoro-N-hydroxybenzamide Show/Hide	C17H15ClFN3O3	1
1	EC50 = 13500 nM Bioactivity Info	TI LI LO TS
CP0188391 Compound Info	N-hydroxy-4-[[2-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]amino]benzamide Show/Hide	C18H16F3N3O3	1
1	EC50 = 16200 nM Bioactivity Info	TI LI LO TS
CP0052437 Compound Info	N-hydroxy-4-[[2-oxo-1-(2-phenylethyl)pyrrolidin-3-yl]amino]benzamide Show/Hide	C19H21N3O3	1
1	EC50 = 16600 nM Bioactivity Info	TI LI LO TS
CP0366400 Compound Info	3-chloro-4-[[1-(4-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H15Cl2N3O3	1
1	EC50 = 17400 nM Bioactivity Info	TI LI LO TS
CP0243833 Compound Info	N-hydroxy-4-[(5-oxo-1-phenylpyrrolidin-3-yl)amino]benzamide Show/Hide	C17H17N3O3	1
1	EC50 = 18100 nM Bioactivity Info	TI LI LO TS
CP0231392 Compound Info	N-hydroxy-4-(methylamino)benzamide Show/Hide	C8H10N2O2	1
1	EC50 = 19200 nM Bioactivity Info	TI LI LO TS
CP0052436 Compound Info	N-hydroxy-4-(2-oxo-1-phenylpyrrolidin-3-yl)oxybenzamide Show/Hide	C17H16N2O4	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0128619 Compound Info	N-hydroxy-4-[methyl-(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzamide Show/Hide	C18H19N3O3	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000072 , A2780

Cell Line Info

Cell Line ID: CL000023 , BTI-Tn-5B1-4

Cell Line Info

Cell Line ID: CL000742 , FreeStyle 293-F

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000131 , HEK293-F

Cell Line Info

Cell Line ID: CL000314 , HEK293T/17

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000162 , HeLa S3

Cell Line Info

Cell Line ID: CL000083 , MCF-7

Cell Line Info

Cell Line ID: CL000020 , Neuro-2a

Cell Line Info

Cell Line ID: CL000186 , RPMI-8226

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0070180 Compound Info	tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate Show/Hide	C22H30N4O6	3
1	IC50 = 0.326 nM
2	IC50 = 27 nM
3	IC50 = 40 nM
CP0005479 Compound Info	CHEBI:46024 Show/Hide	C17H22N2O3	47
1	IC50 = 0.4 nM
2	IC50 = 0.419 nM
3	IC50 = 0.42 nM
4	IC50 = 0.8 nM
5	IC50 = 1 nM
6	IC50 = 1.07 nM
7	IC50 = 1.1 nM
8	IC50 = 1.4 nM
9	IC50 = 1.5 nM
10	IC50 = 1.56 nM
11	IC50 = 1.6 nM
12	IC50 = 1.94 nM
13	IC50 = 2 nM
14	IC50 = 2.09 nM
15	IC50 = 2.3 nM
16	IC50 = 2.31 nM
17	IC50 = 2.6 nM
18	IC50 = 3.13 nM
19	IC50 = 3.49 nM
20	IC50 = 3.55 nM
21	IC50 = 4.53 nM
22	IC50 = 5 nM
23	IC50 = 6 nM
24	IC50 = 8.2 nM
25	IC50 = 8.6 nM
26	IC50 = 8.922 nM
27	IC50 = 9 nM
28	IC50 = 9.3 nM
29	IC50 = 11.1 nM
30	IC50 = 13 nM
31	IC50 = 15 nM
32	IC50 = 16.8 nM
33	IC50 = 20 nM
34	IC50 = 38 nM
35	IC50 = 51 nM
36	IC50 = 53 nM
37	IC50 = 56 nM
38	IC50 = 65 nM
39	IC50 = 81 nM
40	IC50 = 91 nM
41	IC50 = 600 nM
42	IC50 = 1210 nM
43	IC50 = 3600 nM
44	Ki = 0.13 nM
45	Ki = 0.99 nM
46	Ki = 1 nM
47	Ki = 3.02 nM
CP0029628 Compound Info	4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide Show/Hide	C17H17ClN2O2	3
1	IC50 = 0.5 nM
2	IC50 = 2 nM
3	IC50 = 2.3 nM
CP0361287 Compound Info	1-[[4-(hydroxycarbamoyl)phenyl]methyl]-3,4-dihydro-2H-quinoline-6-carboxamide Show/Hide	C18H19N3O3	1
1	IC50 = 0.7 nM
CP0127873 Compound Info	3-fluoro-N-hydroxy-4-[(2-methylbenzimidazol-1-yl)methyl]benzamide Show/Hide	C16H14FN3O2	2
1	IC50 = 0.8 nM
2	IC50 = 3 nM
CP0011675 Compound Info	N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9-yl)methyl]benzamide Show/Hide	C20H21N3O2	1
1	IC50 = 1.4 nM
CP0003832 Compound Info	N'-hydroxy-N-phenyloctanediamide Show/Hide	C14H20N2O3	125
1	IC50 = 1.4 nM
2	IC50 = 2 nM
3	IC50 = 2.71 nM
4	IC50 = 3.9 nM
5	IC50 = 4.87 nM
6	IC50 = 5 nM
7	IC50 = 6.7 nM
8	IC50 = 6.9 nM
9	IC50 = 7.25 nM
10	IC50 = 7.7 nM
11	IC50 = 7.76 nM
12	IC50 = 8.8 nM
13	IC50 = 9 nM
14	IC50 = 9.1 nM
15	IC50 = 9.2 nM
16	IC50 = 9.3 nM
17	IC50 = 9.4 nM
18	IC50 = 10 nM
19	IC50 = 10.8 nM
20	IC50 = 11 nM
21	IC50 = 12 nM
22	IC50 = 13 nM
23	IC50 = 14 nM
24	IC50 = 14.5 nM
25	IC50 = 15 nM
26	IC50 = 15.1 nM
27	IC50 = 16.3 nM
28	IC50 = 17 nM
29	IC50 = 17.2 nM
30	IC50 = 17.4 nM
31	IC50 = 18 nM
32	IC50 = 18.5 nM
33	IC50 = 19 nM
34	IC50 = 19.4 nM
35	IC50 = 19.8 nM
36	IC50 = 20 nM
37	IC50 = 20.2 nM
38	IC50 = 21 nM
39	IC50 = 21.6 nM
40	IC50 = 23 nM
41	IC50 = 24 nM
42	IC50 = 24.25 nM
43	IC50 = 24.4 nM
44	IC50 = 25 nM
45	IC50 = 25.6 nM
46	IC50 = 26 nM
47	IC50 = 26.9 nM
48	IC50 = 27 nM
49	IC50 = 28 nM
50	IC50 = 28.6 nM
51	IC50 = 28.9 nM
52	IC50 = 29 nM
53	IC50 = 29.7 nM
54	IC50 = 30 nM
55	IC50 = 31 nM
56	IC50 = 32 nM
57	IC50 = 33 nM
58	IC50 = 33.1 nM
59	IC50 = 34 nM
60	IC50 = 35 nM
61	IC50 = 36 nM
62	IC50 = 38 nM
63	IC50 = 38.9 nM
64	IC50 = 39 nM
65	IC50 = 39.9 nM
66	IC50 = 40 nM
67	IC50 = 41.9 nM
68	IC50 = 42 nM
69	IC50 = 43 nM
70	IC50 = 47 nM
71	IC50 = 49 nM
72	IC50 = 50 nM
73	IC50 = 51 nM
74	IC50 = 52 nM
75	IC50 = 53 nM
76	IC50 = 54 nM
77	IC50 = 57.3 nM
78	IC50 = 60 nM
79	IC50 = 63 nM
80	IC50 = 65 nM
81	IC50 = 70 nM
82	IC50 = 70.83 nM
83	IC50 = 71 nM
84	IC50 = 72.34 nM
85	IC50 = 74 nM
86	IC50 = 75.9 nM
87	IC50 = 78.3 nM
88	IC50 = 78.98 nM
89	IC50 = 82 nM
90	IC50 = 85 nM
91	IC50 = 85.5 nM
92	IC50 = 88 nM
93	IC50 = 90 nM
94	IC50 = 91 nM
95	IC50 = 96 nM
96	IC50 = 98 nM
97	IC50 = 100 nM
98	IC50 = 109 nM
99	IC50 = 110 nM
100	IC50 = 110.6 nM
101	IC50 = 118 nM
102	IC50 = 144 nM
103	IC50 = 160 nM
104	IC50 = 169.5 nM
105	IC50 = 195 nM
106	IC50 = 196 nM
107	IC50 = 200 nM
108	IC50 = 202.11 nM
109	IC50 = 210 nM
110	IC50 = 226 nM
111	IC50 = 250 nM
112	IC50 = 340 nM
113	IC50 = 350 nM
114	IC50 = 400 nM
115	IC50 = 800 nM
116	IC50 = 5600 nM
117	Kd = 300 nM
118	Ki = 1 nM
119	Ki = 1.6 nM
120	Ki = 18 nM
121	Ki = 20 nM
122	Ki = 21 nM
123	Ki = 22 nM
124	Ki = 29 nM
125	Ki = 126 nM
CP0057110 Compound Info	4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide Show/Hide	C19H23N3O3	4
1	IC50 = 1.6 nM
2	IC50 = 5 nM
3	IC50 = 5.2 nM
4	IC50 = 20 nM
CP0141462 Compound Info	US10858323, Compound 1 Show/Hide	C14H14N4O2	2
1	IC50 = 1.7 nM
2	IC50 = 2 nM
CP0007846 Compound Info	N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide Show/Hide	C20H21N3O2	25
1	IC50 = 1.9 nM
2	IC50 = 2 nM
3	IC50 = 3.5 nM
4	IC50 = 4 nM
5	IC50 = 4.4 nM
6	IC50 = 9.4 nM
7	IC50 = 11.14 nM
8	IC50 = 13.7 nM
9	IC50 = 14 nM
10	IC50 = 15 nM
11	IC50 = 18 nM
12	IC50 = 20 nM
13	IC50 = 25.76 nM
14	IC50 = 26.35 nM
15	IC50 = 27 nM
16	IC50 = 27.4 nM
17	IC50 = 28.28 nM
18	IC50 = 28.71 nM
19	IC50 = 28.88 nM
20	IC50 = 31 nM
21	IC50 = 78.74 nM
22	IC50 = 854 nM
23	IC50 < 300 nM
24	Ki = 3.3 nM
25	Ki = 4 nM
CP0571176 Compound Info	4-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide Show/Hide	C17H18N2O2	1
1	IC50 = 2.3 nM
CP0003580 Compound Info	Faridak Show/Hide	C21H23N3O2	12
1	IC50 = 2.5 nM
2	IC50 = 4 nM
3	IC50 = 5.6 nM
4	IC50 = 10.5 nM
5	IC50 < 15 nM
6	IC50 = 15 nM
7	IC50 = 123.8 nM
8	IC50 = 130 nM
9	IC50 < 300 nM
10	Ki = 0.7 nM
11	Ki = 1.5 nM
12	Ki = 54 nM
CP0363242 Compound Info	US8609678, 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [89] Show/Hide	C24H26ClN5O3	3
1	IC50 = 2.6 nM
2	IC50 = 3 nM
3	IC50 = 2200 nM
CP0325385 Compound Info	4-[[[4-(dimethylamino)benzoyl]-[2-(4-methylanilino)-2-oxoethyl]amino]methyl]-N-hydroxybenzamide Show/Hide	C26H28N4O4	1
1	IC50 = 3 nM
CP0024637 Compound Info	N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide Show/Hide	C41H43N3O7S	8
1	IC50 = 4 nM
2	IC50 = 8.5 nM
3	IC50 = 13 nM
4	IC50 = 15 nM
5	IC50 = 1600 nM
6	Ki = 0.9 nM
7	Ki = 16 nM
8	Ki = 142 nM
CP0007484 Compound Info	N-hydroxy-4-[(14-methyl-13,15-dioxo-9,12,14-triazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3,5,7-tetraen-9-yl)methyl]benzamide Show/Hide	C22H20N4O4	1
1	IC50 = 4 nM
CP0013501 Compound Info	N-hydroxy-6-(6-morpholin-4-yl-1,3-dioxobenzo[de]isoquinolin-2-yl)hexanamide Show/Hide	C22H25N3O5	1
1	IC50 = 4 nM
CP0007526 Compound Info	US9249087, 8 Show/Hide	C18H18N2O2	1
1	IC50 = 4.08 nM
CP0004475 Compound Info	RICOLINOSTAT Show/Hide	C24H27N5O3	12
1	IC50 = 4.7 nM
2	IC50 = 5 nM
3	IC50 = 6.8 nM
4	IC50 = 7 nM
5	IC50 = 9 nM
6	IC50 = 17 nM
7	IC50 = 17.9 nM
8	IC50 = 20 nM
9	IC50 = 27 nM
10	IC50 = 29 nM
11	IC50 = 2600 nM
12	Ki = 1 nM
CP0352415 Compound Info	4-[[2,4-dioxo-3-(2-phenylethyl)quinazolin-1-yl]methyl]-N-hydroxybenzamide Show/Hide	C24H21N3O4	1
1	IC50 = 4.7 nM
CP0545559 Compound Info	4-[8-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]octanoylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide Show/Hide	C37H46N6O10	1
1	IC50 = 4.86 nM
CP0044706 Compound Info	(2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide Show/Hide	C22H25N3O3	2
1	IC50 = 5.93 nM
2	Ki = 9.5 nM
CP0531237 Compound Info	4-[[1-[[4-(diethylaminomethyl)phenyl]methyl]-2-oxo-4-phenylquinolin-3-yl]oxymethyl]-N-hydroxybenzamide Show/Hide	C35H35N3O4	1
1	IC50 = 6.9 nM
CP0127607 Compound Info	US8614223, 101 Show/Hide	C17H19FN4O2	2
1	IC50 = 7 nM
2	IC50 = 7.5 nM
CP0202226 Compound Info	4-[(1,1-dioxo-2,3-dihydrothieno[3,2-b]indol-4-yl)methyl]-N-hydroxybenzamide Show/Hide	C18H16N2O4S	2
1	IC50 = 8 nM
2	IC50 = 8.2 nM
CP0003676 Compound Info	N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide Show/Hide	C23H24N8O4S	3
1	IC50 = 8 nM
2	IC50 = 27 nM
3	IC50 = 674 nM
CP0226157 Compound Info	N-hydroxy-2-[4-[methyl-(2-methylquinazolin-4-yl)amino]phenoxy]acetamide Show/Hide	C18H18N4O3	1
1	IC50 = 8.6 nM
CP0119682 Compound Info	US9249087, 2 Show/Hide	C16H14N2O2	1
1	IC50 = 9.75 nM
CP0038690 Compound Info	(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide Show/Hide	C15H14N2O4S	6
1	IC50 = 9.85 nM
2	IC50 = 27 nM
3	IC50 = 82 nM
4	IC50 = 6432 nM
5	Ki = 1.6 nM
6	Ki = 10 nM
CP0351412 Compound Info	US9249087, 43 Show/Hide	C11H11N3O2	1
1	IC50 = 10.9 nM
CP0354530 Compound Info	N-[2-(cyclohexylamino)-2-oxoethyl]-N-[[4-(hydroxycarbamoyl)phenyl]methyl]-3,5-dimethylbenzamide Show/Hide	C25H31N3O4	1
1	IC50 = 11 nM
CP0082014 Compound Info	N-[5-(5,6-dichloroindol-1-yl)pentyl]-2-sulfanylacetamide Show/Hide	C15H18Cl2N2OS	1
1	IC50 = 11.4 nM
CP0531238 Compound Info	4-[[1-[[4-(diethylaminomethyl)phenyl]methyl]-2-oxo-4-pyridin-3-ylquinolin-3-yl]oxymethyl]-N-hydroxybenzamide Show/Hide	C34H34N4O4	1
1	IC50 = 11.5 nM
CP0243832 Compound Info	US8716285, 53 Show/Hide	C19H18N6O2	1
1	IC50 = 12 nM
CP0431646 Compound Info	5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-1,2-oxazole-3-carboxamide Show/Hide	C13H11Cl2N3O4	1
1	IC50 = 12 nM
CP0129460 Compound Info	US9249087, 19 Show/Hide	C20H23N3O2	1
1	IC50 = 12.5 nM
CP0108813 Compound Info	N-hydroxy-2-[4-[methyl(quinazolin-4-yl)amino]phenoxy]acetamide Show/Hide	C17H16N4O3	1
1	IC50 = 14 nM
CP0144627 Compound Info	4-[[[2-(benzylamino)-2-oxoethyl]-[4-(dimethylamino)benzoyl]amino]methyl]-N-hydroxybenzamide Show/Hide	C26H28N4O4	1
1	IC50 = 14 nM
CP0052435 Compound Info	4-[[(3S)-1-(4-chlorophenyl)-3-methyl-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C18H18ClN3O3	1
1	IC50 = 17 nM
CP0066396 Compound Info	N-hydroxy-4-[2-methoxy-5-[methyl-(2-methylquinazolin-4-yl)amino]phenoxy]butanamide Show/Hide	C21H24N4O4	1
1	IC50 = 17 nM
CP0075789 Compound Info	N-hydroxy-2-[4-[methyl-(2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino]phenoxy]acetamide Show/Hide	C17H20N4O3	1
1	IC50 = 17 nM
CP0243831 Compound Info	N-hydroxy-4-[(3-methyl-2-oxo-1-quinolin-6-ylpyrrolidin-3-yl)amino]benzamide Show/Hide	C21H20N4O3	1
1	IC50 = 18 nM
CP0054577 Compound Info	N-[[4-(hydroxycarbamoyl)phenyl]methyl]-1-methylpyrrole-2-carboxamide Show/Hide	C14H15N3O3	1
1	IC50 = 19 nM
CP0324814 Compound Info	US8748451, 5 Show/Hide	C20H16N2O2	1
1	IC50 = 19 nM
CP0821110 Compound Info	6-(Cyclohexylcarbonyl)-N-hydroxy-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide Show/Hide	C15H20N2O3S	1
1	IC50 = 20 nM
CP0242450 Compound Info	US9216962, CFH401 Show/Hide	C18H16N4O3S2	1
1	IC50 = 20 nM
CP0053451 Compound Info	6-(2-Mercapto-acetylamino)-hexanoic acid quinolin-8-ylamide Show/Hide	C17H21N3O2S	2
1	IC50 = 20 nM
2	IC50 = 21 nM
CP0231393 Compound Info	4-[[1-(4-chlorophenyl)-3-methyl-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C18H18ClN3O3	1
1	IC50 = 21 nM
CP0738929 Compound Info	N-Hydroxy-5-(1-methyl-1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide Show/Hide	C14H15N3O3S	1
1	IC50 = 24 nM
CP0417643 Compound Info	4-tert-butyl-N-[4-(hydroxycarbamoyl)phenyl]benzamide Show/Hide	C18H20N2O3	1
1	IC50 = 24 nM
CP0127868 Compound Info	N-hydroxy-4-[[2-hydroxyethyl-(2-phenylacetyl)amino]methyl]benzamide Show/Hide	C18H20N2O4	2
1	IC50 = 25 nM
2	IC50 = 376 nM
CP0013041 Compound Info	HPOB Show/Hide	C17H18N2O4	4
1	IC50 = 25 nM
2	IC50 = 56 nM
3	IC50 = 58 nM
4	IC50 = 85 nM
CP0896038 Compound Info	N-Hydroxy-6-(1-methyl-1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide Show/Hide	C14H15N3O3S	1
1	IC50 = 28 nM
CP0004955 Compound Info	(5R,8S,11S)-5-methyl-8-propan-2-yl-11-[(E)-4-sulfanylbut-1-enyl]-10-oxa-3,17-dithia-7,14,19,20-tetrazatricyclo[14.2.1.12,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione Show/Hide	C21H28N4O4S3	2
1	IC50 = 28.11 nM
2	IC50 = 121 nM
CP0117239 Compound Info	N-hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-7-carboxamide Show/Hide	C14H16N4O3	1
1	IC50 = 33 nM
CP0237014 Compound Info	2-(4,5-dichloro-1-methylpyrrole-2-carbonyl)-N-hydroxy-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-7-carboxamide Show/Hide	C14H14Cl2N4O3	1
1	IC50 = 33 nM
CP0004988 Compound Info	pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate Show/Hide	C21H20N4O3	7
1	IC50 = 34 nM
2	IC50 = 3930 nM
3	IC50 = 13000 nM
4	IC50 > 10000 nM
5	IC50 > 30000 nM
6	IC50 > 50000 nM
7	IC50 > 100000 nM
CP0650041 Compound Info	N-hydroxy-6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide Show/Hide	C13H18N2O3S	1
1	IC50 = 35 nM
CP0056288 Compound Info	N-hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamide Show/Hide	C16H17N3O3	1
1	IC50 = 36 nM
CP0864100 Compound Info	5-(Cyclohexanecarbonyl)-N-hydroxy-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-2-carboxamide Show/Hide	C15H20N2O3S	1
1	IC50 = 36 nM
CP0211234 Compound Info	N-hydroxy-2-(1-methylpyrrole-2-carbonyl)-1,3-dihydroisoindole-5-carboxamide Show/Hide	C15H15N3O3	1
1	IC50 = 40 nM
CP0121113 Compound Info	(7S)-N-hydroxy-7-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxamide Show/Hide	C20H19N5O2	1
1	IC50 = 40 nM
CP0952932 Compound Info	4-[[(3S,4S)-3-(1-cyclopentyl-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-methyl-pyrrolidin-1-yl]methyl]benzenecarbohydroxamic acid Show/Hide	C23H28N6O3	1
1	IC50 = 40 nM
CP0056287 Compound Info	N-hydroxy-2-(4-methoxybenzoyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-7-carboxamide Show/Hide	C16H17N3O4	1
1	IC50 = 43 nM
CP0822100 Compound Info	N-hydroxy-5-pivaloyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide Show/Hide	C13H18N2O3S	1
1	IC50 = 47 nM
CP0091644 Compound Info	(7R)-N-hydroxy-7-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxamide Show/Hide	C20H19N5O2	2
1	IC50 = 48 nM
2	IC50 = 50 nM
CP0687903 Compound Info	2-(cyclohexanecarbonyl)-N-hydroxy-1,2,3,4-tetrahydroisoquinoline-6-carboxamide Show/Hide	C17H22N2O3	1
1	IC50 = 50 nM
CP0213538 Compound Info	N-hydroxy-2-[[5-(3-nitrophenyl)furan-2-yl]methyl]-3,4-dihydro-1H-isoquinoline-7-carboxamide Show/Hide	C21H19N3O5	1
1	IC50 = 50 nM
CP0336446 Compound Info	2-(2,2-dimethylpropanoyl)-N-hydroxy-3,4-dihydro-1H-isoquinoline-6-carboxamide Show/Hide	C15H20N2O3	1
1	IC50 = 52 nM
CP0788729 Compound Info	2-(cycloheptanecarbonyl)-N-hydroxy-1,2,3,4-tetrahydroisoquinoline-6-carboxamide Show/Hide	C18H24N2O3	1
1	IC50 = 54 nM
CP0085762 Compound Info	3-N-hydroxy-1-N-phenylbenzene-1,3-dicarboxamide Show/Hide	C14H12N2O3	1
1	IC50 = 57 nM
CP0742181 Compound Info	3-(biphenylcarbonyl)-N-hydroxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-carboxamide Show/Hide	C24H22N2O3	1
1	IC50 = 59 nM
CP0731869 Compound Info	N-Hydroxy-2-((4-(trifluoromethyl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide Show/Hide	C17H15F3N2O4S	1
1	IC50 = 60 nM
CP0147132 Compound Info	4-[[1-(3,4-dichlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H15Cl2N3O3	1
1	IC50 = 63 nM
CP0197800 Compound Info	3-[5-(Trifluoroacetyl)thiophen-2-yl]benzoic Acid Show/Hide	C13H7F3O3S	1
1	IC50 = 70 nM
CP0053450 Compound Info	6-(3-adamantan-1-yl-ureido)hexanoic acid hydroxyamide Show/Hide	C17H29N3O3	1
1	IC50 = 73 nM
CP0114237 Compound Info	N-hydroxy-5-(1-methylindole-2-carbonyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-2-carboxamide Show/Hide	C17H17N5O3	1
1	IC50 = 76 nM
CP0494407 Compound Info	N-hydroxy-2-(1-methylindole-5-carbonyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-7-carboxamide Show/Hide	C18H18N4O3	1
1	IC50 = 85 nM
CP0057690 Compound Info	N-hydroxy-7-(4-phenylbenzoyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C20H18N4O3	1
1	IC50 = 87 nM
CP0338016 Compound Info	2-(2,2-dimethylpropanoyl)-N-hydroxy-1,3-dihydroisoindole-5-carboxamide Show/Hide	C14H18N2O3	1
1	IC50 = 89 nM
CP0231390 Compound Info	4-[[1-(3-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H16ClN3O3	1
1	IC50 = 90 nM
CP0165687 Compound Info	3-[4-(acridin-9-ylamino)phenyl]-N-hydroxypropanamide Show/Hide	C22H19N3O2	1
1	IC50 = 99.3 nM
CP0562239 Compound Info	2-(cyclohexanecarbonyl)-N-hydroxy-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-7-carboxamide Show/Hide	C15H21N3O3	1
1	IC50 = 100 nM
CP0052438 Compound Info	4-[[1-(4-cyanophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C18H16N4O3	1
1	IC50 = 100 nM
CP0012463 Compound Info	BENZHYDROXAMIC ACID Show/Hide	C7H7NO2	1
1	IC50 = 115 nM
CP0684285 Compound Info	3-(cycloheptanecarbonyl)-N-hydroxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-carboxamide Show/Hide	C19H26N2O3	1
1	IC50 = 120 nM
CP0687901 Compound Info	N-hydroxy-3-pivaloyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-carboxamide Show/Hide	C16H22N2O3	1
1	IC50 = 120 nM
CP0698423 Compound Info	2-(biphenylcarbonyl)-N-hydroxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine-7-carboxamide Show/Hide	C24H22N2O3	1
1	IC50 = 120 nM
CP0742180 Compound Info	N-hydroxy-3-(1-methyl-1H-pyrrole-2-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-carboxamide Show/Hide	C17H19N3O3	1
1	IC50 = 130 nM
CP0178676 Compound Info	N-hydroxy-4-[[1-(4-methylsulfonylphenyl)-2-oxopyrrolidin-3-yl]amino]benzamide Show/Hide	C18H19N3O5S	1
1	IC50 = 140 nM
CP0052124 Compound Info	4-[[1-(4-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H16ClN3O3	1
1	IC50 = 160 nM
CP0637650 Compound Info	(E)-3-(3-Bromo-4-hydroxyphenyl)-N-(3-(hydroxyamino)-3-oxopropyl)-2-(hydroxyimino)propanamide Show/Hide	C12H14BrN3O5	1
1	IC50 = 190 nM
CP0005567 Compound Info	N-hydroxy-4-[2-[(E)-2-phenylethenyl]-1,3-thiazol-4-yl]butanamide Show/Hide	C15H16N2O2S	1
1	IC50 = 199.3 nM
CP0085832 Compound Info	(1R,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone Show/Hide	C24H36N4O6S2	3
1	IC50 = 226 nM
2	IC50 = 790 nM
3	IC50 = 1400 nM
CP0036471 Compound Info	2,2,2-Trifluoro-1-(5-{3-[(methylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl}thiophen-2-yl)ethanone Show/Hide	C10H7F3N2O4S2	2
1	IC50 = 230 nM
2	IC50 = 320 nM
CP0087151 Compound Info	2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl}thiophen-2-yl)ethanone Show/Hide	C12H11F3N2O4S2	1
1	IC50 = 240 nM
CP0052437 Compound Info	N-hydroxy-4-[[2-oxo-1-(2-phenylethyl)pyrrolidin-3-yl]amino]benzamide Show/Hide	C19H21N3O3	1
1	IC50 = 240 nM
CP0188391 Compound Info	N-hydroxy-4-[[2-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]amino]benzamide Show/Hide	C18H16F3N3O3	1
1	IC50 = 250 nM
CP0053521 Compound Info	5-methyl-3-phenyl-N-[5-[(2-sulfanylacetyl)amino]pentyl]-1,2-oxazole-4-carboxamide Show/Hide	C18H23N3O3S	1
1	IC50 = 260 nM
CP0410605 Compound Info	N-hydroxy-2-(1-methylpyrrole-2-carbonyl)-1,3,4,5-tetrahydro-2-benzazepine-7-carboxamide Show/Hide	C17H19N3O3	1
1	IC50 = 260 nM
CP0257134 Compound Info	4-[[(3R)-1-(4-chlorophenyl)-3-methyl-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C18H18ClN3O3	1
1	IC50 = 260 nM
CP0253335 Compound Info	US9216962, CFH403-1 Show/Hide	C18H18N4O3S2	1
1	IC50 = 295 nM
CP0196231 Compound Info	N-hydroxy-2-pyridin-3-yl-1,3-thiazole-4-carboxamide Show/Hide	C9H7N3O2S	1
1	IC50 = 300 nM
CP0057862 Compound Info	3-hydroxy-1-[[4-(2-methylphenyl)phenyl]methyl]pyridine-2-thione Show/Hide	C19H17NOS	1
1	IC50 = 306 nM
CP0013905 Compound Info	[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate Show/Hide	C24H27N3O4	2
1	IC50 = 312 nM
2	Ki = 4.2 nM
CP0864082 Compound Info	2-(cycloheptanecarbonyl)-N-hydroxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine-7-carboxamide Show/Hide	C19H26N2O3	1
1	IC50 = 340 nM
CP0056286 Compound Info	N-hydroxy-5-(1-methylpyrrole-2-carbonyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-2-carboxamide Show/Hide	C13H15N5O3	1
1	IC50 = 350 nM
CP0634945 Compound Info	(E)-3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)-N-(2-mercaptoethyl)propanamide Show/Hide	C11H13BrN2O3S	1
1	IC50 = 360 nM
CP0052120 Compound Info	4-[[1-(2-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H16ClN3O3	1
1	IC50 = 360 nM
CP0119161 Compound Info	N-hydroxy-4-[(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzamide Show/Hide	C17H17N3O3	1
1	IC50 = 380 nM
CP0544056 Compound Info	N-hydroxy-4-[[(2,3,4,5,6-pentafluorophenyl)sulfonylamino]methyl]benzamide Show/Hide	C14H9F5N2O4S	1
1	IC50 = 389 nM
CP0119162 Compound Info	N-hydroxy-4-[(3-methyl-2-oxo-1-phenylpyrrolidin-3-yl)amino]benzamide Show/Hide	C18H19N3O3	1
1	IC50 = 460 nM
CP0687899 Compound Info	N-Hydroxy-2-pivaloyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine-7-carboxamide Show/Hide	C16H22N2O3	1
1	IC50 = 490 nM
CP0091643 Compound Info	4-[(1-benzyl-2-oxopyrrolidin-3-yl)amino]-N-hydroxybenzamide Show/Hide	C18H19N3O3	1
1	IC50 = 510 nM
CP0547346 Compound Info	4-[[5-[8-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]octanoylamino]-2-methylbenzimidazol-1-yl]methyl]-3-fluoro-N-hydroxybenzamide Show/Hide	C39H40FN7O9	1
1	IC50 = 647 nM
CP0009029 Compound Info	(6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H-indol-3-ylmethyl)-12-(6-oxo-octyl)-decahydro-4a,7,10,13-tetraaza-benzocyclododecene-5,8,11,14-tetraone Show/Hide	C34H49N5O6	4
1	IC50 = 665.1 nM
2	IC50 = 9600 nM
3	IC50 > 10000 nM
4	Ki = 123.4 nM
CP0085031 Compound Info	5-cyclopropyl-N-[5-(hydroxyamino)-5-oxopentyl]-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide Show/Hide	C15H18N4O3S2	2
1	IC50 = 785 nM
2	IC50 = 790 nM
CP0128615 Compound Info	4-[[1-(4-chlorophenyl)pyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H18ClN3O2	1
1	IC50 = 860 nM
CP0366400 Compound Info	3-chloro-4-[[1-(4-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]-N-hydroxybenzamide Show/Hide	C17H15Cl2N3O3	1
1	IC50 = 1070 nM
CP0209171 Compound Info	N-[5-(hydroxyamino)-5-oxopentyl]-5-(2-methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide Show/Hide	C16H22N4O3S2	2
1	IC50 = 1217 nM
2	IC50 = 1230 nM
CP0636555 Compound Info	(E)-4-(3-(3-Bromo-4-hydroxyphenyl)-2-(hydroxyimino)-propanamido)-N-hydroxybutanamide Show/Hide	C13H16BrN3O5	1
1	IC50 = 1700 nM
CP0231392 Compound Info	N-hydroxy-4-(methylamino)benzamide Show/Hide	C8H10N2O2	1
1	IC50 = 1770 nM
CP0021455 Compound Info	(1R,2R,3R)-2-[4-(5-fluoropyrimidin-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C20H16FN3O2	1
1	IC50 = 1900 nM
CP0126631 Compound Info	N,N'-dihydroxyoctanediamide Show/Hide	C8H16N2O4	2
1	IC50 = 2030 nM
2	Ki = 14.5 nM
CP0243833 Compound Info	N-hydroxy-4-[(5-oxo-1-phenylpyrrolidin-3-yl)amino]benzamide Show/Hide	C17H17N3O3	1
1	IC50 = 2260 nM
CP0634946 Compound Info	psammaplin A Show/Hide	C22H24Br2N4O6S2	1
1	IC50 = 2800 nM
CP0014148 Compound Info	N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide Show/Hide	C17H16N2O3	5
1	IC50 = 2900 nM
2	IC50 = 3100 nM
3	IC50 = 4570 nM
4	IC50 = 9300 nM
5	IC50 = 20000 nM
CP0047253 Compound Info	N-hydroxy-4-methoxy-3-phenylmethoxybenzamide Show/Hide	C15H15NO4	1
1	IC50 = 2900 nM
CP0065816 Compound Info	tert-butyl [(2-methylpropan-2-yl)oxycarbonyl-[8-[(2-methylpropan-2-yl)oxycarbonyl-[(2-methylpropan-2-yl)oxycarbonyloxy]amino]-8-oxooctanoyl]amino] carbonate Show/Hide	C28H48N2O12	1
1	IC50 = 3390 nM
CP0068281 Compound Info	N-(2-aminophenyl)pyrazine-2-carboxamide Show/Hide	C11H10N4O	1
1	IC50 = 3415 nM
CP0124688 Compound Info	N-hydroxy-9H-fluorene-9-carboxamide Show/Hide	C14H11NO2	1
1	IC50 = 4900 nM
CP0052436 Compound Info	N-hydroxy-4-(2-oxo-1-phenylpyrrolidin-3-yl)oxybenzamide Show/Hide	C17H16N2O4	1
1	IC50 = 5740 nM
CP0015005 Compound Info	S-[(E)-4-[(4Z,7S,10S)-4-ethylidene-2,5,8,12-tetraoxo-7-propan-2-yl-9-oxa-16-thia-3,6,13,18-tetrazabicyclo[13.2.1]octadeca-1(17),15(18)-dien-10-yl]but-3-enyl] octanethioate Show/Hide	C29H42N4O6S2	1
1	IC50 = 6950 nM
CP0396397 Compound Info	6-[[4-(benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]-N-hydroxyhexanamide Show/Hide	C14H17N3O7S	1
1	IC50 = 7400 nM
CP0066173 Compound Info	N-hydroxy-2,2-diphenylacetamide Show/Hide	C14H13NO2	1
1	IC50 = 11000 nM
CP0643784 Compound Info	Azumamide E Show/Hide	C27H38N4O6	2
1	IC50 = 12000 nM
2	Ki > 5000 nM
CP0128619 Compound Info	N-hydroxy-4-[methyl-(2-oxo-1-phenylpyrrolidin-3-yl)amino]benzamide Show/Hide	C18H19N3O3	1
1	IC50 = 48800 nM
CP0507132 Compound Info	US9056843, 156 Show/Hide	C21H21F3N4O2	1
1	IC50 > 600 nM
CP0016939 Compound Info	N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide Show/Hide	C23H20N6O	3
1	IC50 > 10000 nM
2	IC50 > 20000 nM
3	IC50 > 30000 nM
CP0008165 Compound Info	N'-(2-aminophenyl)-N-[3-(1-phenyltriazol-4-yl)phenyl]octanediamide Show/Hide	C28H30N6O2	1
1	IC50 > 30000 nM
CP0151685 Compound Info	N-(2-aminophenyl)-4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]anilino]methyl]benzamide Show/Hide	C30H27N7O	1
1	IC50 >= 32000 nM
CP0362720 Compound Info	N-hydroxy-4-[[5-(5-methylthiophen-2-yl)-2-phenyl-1,2,4-triazol-3-yl]methylamino]benzamide Show/Hide	C21H19N5O2S	1
1	Kd = 7.1 nM
CP0233992 Compound Info	3-(3-methyl-4-oxoquinazolin-2-yl)propanoic acid Show/Hide	C12H12N2O3	1
1	Kd = 1500 nM
CP0008777 Compound Info	JNJ-26481585 Show/Hide	C21H26N6O2	2
1	Ki = 16.9 nM
2	Ki = 350 nM
CP0008445 Compound Info	3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide Show/Hide	C21H23N3O5	2
1	Ki = 17 nM
2	Ki = 20 nM
CP0542777 Compound Info	4-[[cyclopropyl-(2,3,4,5-tetrafluorophenyl)sulfonylamino]methyl]-N-hydroxybenzamide Show/Hide	C17H14F4N2O4S	1
1	Ki = 17.3 nM
CP0013235 Compound Info	(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide Show/Hide	C20H32Cl2N4O2	1
1	Ki = 247 nM
CP0642652 Compound Info	Azumamide C Show/Hide	C27H38N4O7	1
1	Ki = 2000 nM

Clinical Information about the Protein

Target 1 ( Histone deacetylase 6 (HDAC6) )

Target Type	Clinical trial Target
Disease	2 Target-related Diseases				2
1	Multiple myeloma [ICD-11: 2A83]
2	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	Citarinostat	Drug Info	Phase 1	Multiple myeloma
Investigative Drug(s)	2 Investigative Drugs				2
1	ST-2987	Drug Info	Investigative	Solid tumour/cancer
2	Tubacin	Drug Info	Investigative	Multiple myeloma

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT03064	Histone deacetylase 6	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han