Brief Information of the Cell Line and Protein
Cell Line ID: CL000077 , Ba/F3
Synonyms
BA/F3
BaF3
BAF3
Baf3
Category Factor-dependent cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0161
Protein ID: PT01203 , ALK tyrosine kinase receptor
Gene Name ALK
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q9UM73
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000077  Protein ID: PT01203
 
Compound ID Compound Name Compound Formula
CP0871866
N-(5-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide
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C29H36ClN7O4S
 4
1
GI50 = 1 nM
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2
GI50 = 6.9 nM
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3
GI50 = 29 nM
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4
GI50 = 460 nM
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CP0031719
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
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C21H22Cl2FN5O
 6
1
GI50 = 150 nM
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2
GI50 = 320 nM
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3
GI50 = 430 nM
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4
GI50 = 590 nM
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5
IC50 = 150.8 nM
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6
IC50 = 260 nM
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CP0019908
BDBM50242742
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C30H40ClN7O3S
 2
1
IC50 = 3.7 nM
   TI
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2
IC50 = 4 nM
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CP0195200
2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]ethanol
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C30H40ClN5O4S
 1
1
IC50 = 8.1 nM
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CP0225633
5-chloro-2-N-(4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C27H34ClN5O3S
 1
1
IC50 = 10.6 nM
   TI
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CP0100657
5-chloro-2-N-[5-methyl-4-(1-methylpiperidin-4-yl)-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C29H38ClN5O3S
 1
1
IC50 = 11.5 nM
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CP0116539
5-methyl-2-N-[5-methyl-4-(1-methylpiperidin-4-yl)-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C30H41N5O3S
 1
1
IC50 = 14.6 nM
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CP0375645
2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]acetamide
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C30H39ClN6O4S
 1
1
IC50 = 16.5 nM
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CP0056941
5-chloro-2-N-(2-cyclobutyloxy-5-methyl-4-piperidin-4-ylphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C29H36ClN5O3S
 1
1
IC50 = 17.3 nM
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CP0149293
5-chloro-2-N-[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C32H44ClN7O3S
 1
1
IC50 = 24.8 nM
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CP0375646
2-[[5-chloro-2-[5-methyl-4-(1-methylpiperidin-4-yl)-2-propan-2-yloxyanilino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
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C28H37ClN6O3S
 1
1
IC50 = 25 nM
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CP0271938
1-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]-2-(dimethylamino)ethanone
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C32H43ClN6O4S
 1
1
IC50 = 25.8 nM
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CP0013877
CERITINIB
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C28H36ClN5O3S
 1
1
IC50 = 26 nM
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CP0433493
2-N-[4-(1-ethylpiperidin-4-yl)-5-methyl-2-propan-2-yloxyphenyl]-5-methyl-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C31H43N5O3S
 1
1
IC50 = 29.4 nM
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   TS
CP0403909
5-chloro-2-N-[5-methyl-2-propan-2-yloxy-4-(1-propan-2-ylpiperidin-4-yl)phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C31H42ClN5O3S
 1
1
IC50 = 29.9 nM
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CP0375885
5-chloro-2-N-[4-(1-ethylpiperidin-4-yl)-5-methyl-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C30H40ClN5O3S
 1
1
IC50 = 32.1 nM
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CP0195203
5-chloro-2-N-(2-piperidin-4-yl-4-propan-2-yloxypyrimidin-5-yl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C25H32ClN7O3S
 1
1
IC50 = 36.4 nM
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CP0524058
5-chloro-4-N-(2-cyclobutylsulfonylphenyl)-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)pyrimidine-2,4-diamine
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C29H36ClN5O3S
 1
1
IC50 = 38.1 nM
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CP0396302
5-methyl-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C29H39N5O3S
 1
1
IC50 = 40.6 nM
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CP0482379
5-chloro-2-N-[4-[1-(2-methoxyethyl)piperidin-4-yl]-5-methyl-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C31H42ClN5O4S
 1
1
IC50 = 43.5 nM
   TI
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   TS
CP0433492
2-N-[4-[1-(2-methoxyethyl)piperidin-4-yl]-5-methyl-2-propan-2-yloxyphenyl]-5-methyl-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C32H45N5O4S
 1
1
IC50 = 44 nM
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CP0396301
4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-2-one
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C28H34ClN5O4S
 1
1
IC50 = 48.3 nM
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CP0463943
2-[4-[2-methyl-4-[[5-methyl-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-5-propan-2-yloxyphenyl]piperidin-1-yl]ethanol
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C31H43N5O4S
 1
1
IC50 = 63.6 nM
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CP0407620
2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]acetic acid
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C30H38ClN5O5S
 1
1
IC50 = 88.9 nM
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CP0529547
4,7-bis[4-(4-methylpiperazin-1-yl)phenyl]pyrazino[1,2-a]benzimidazole
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C32H35N7
 1
1
IC50 = 200 nM
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CP0442082
5-chloro-2-N-[5-methyl-4-[1-(1-methylpiperidin-4-yl)piperidin-4-yl]-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C34H47ClN6O3S
 1
1
IC50 = 258.4 nM
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CP0375640
5-chloro-2-N-[4-[1-(2,2-difluoroethyl)piperidin-4-yl]-5-methyl-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine
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C30H38ClF2N5O3S
 1
1
IC50 = 305.7 nM
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CP0508593
7-(4-methoxyphenyl)-4-[(E)-2-phenylethenyl]pyrazino[1,2-a]benzimidazole
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C25H19N3O
 1
1
IC50 = 780 nM
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CP0385508
2-[4-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid
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C27H28FN7O2
 2
1
IC50 = 1200 nM
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2
IC50 = 2200 nM
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CP0484609
7-bromo-4-chloropyrazino[1,2-a]benzimidazole
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C10H5BrClN3
 1
1
IC50 = 2200 nM
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CP0385511
1-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
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C26H27FN6O
 2
1
IC50 = 3000 nM
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2
IC50 = 3900 nM
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CP0661487
3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea monophosphate
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C26H34Cl2N7O7P
 1
1
IC50 = 3078 nM
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CP0388864
4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C20H15N5
 2
1
IC50 = 3100 nM
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2
IC50 = 4800 nM
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CP0482380
5-chloro-2-N-[5-methyl-4-(1-methylpiperidin-4-yl)-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyridine-2,4-diamine
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C30H39ClN4O3S
 1
1
IC50 = 4240 nM
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CP0395047
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-pyridin-2-ylimidazo[1,2-b]pyridazine
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C21H18FN5
 1
1
IC50 = 6300 nM
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CP0484608
8-bromo-3-(4-methoxyphenyl)pyrimido[1,6-a]benzimidazole
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C17H12BrN3O
 1
1
IC50 = 9000 nM
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