| Compound ID |
Compound Name |
Compound Formula |
|
CP0423457
|
N-[4-[(E)-2-[4-(4-methylpiperazin-1-yl)-6-[(5-propan-2-yl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]ethenyl]phenyl]prop-2-enamide
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|
C26H32N8O
|
1
|
| 1 |
GI50 = 6.4 nM
|
|
|
|
CP0441015
|
N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]propanamide
Show/Hide
|
C30H31F3N6OS
|
1
|
| 1 |
GI50 = 75 nM
|
|
|
|
CP0479968
|
1-[4-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]phenyl]piperidin-1-yl]prop-2-en-1-one
Show/Hide
|
C27H34N8O
|
1
|
| 1 |
GI50 = 438 nM
|
|
|
|
CP0219702
|
US9266883, 23
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|
C19H19N5O4
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0262125
|
US9266883, 26
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|
C22H24N6O3
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0231012
|
US9266883, 33
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|
C19H19N5O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0388620
|
methyl N-[4-[7-amino-3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxypyrazolo[1,5-a]pyrimidin-6-yl]phenyl]carbamate
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|
C28H32N6O5
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0482293
|
3-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-1-(6-formylpyridin-2-yl)-1-methylurea
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|
C17H18N6O3
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0189486
|
US9266883, 234
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|
C18H17N5O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0078209
|
US9266883, 13
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|
C17H15N5O3
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0231015
|
3-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-1-(6-formylpyridin-2-yl)-1-(2-methoxyethyl)urea
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|
C19H22N6O4
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0444841
|
US9266883, 3
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|
C16H13N5O2
|
1
|
| 1 |
IC50 = 108 nM
|
|
|
|
CP0069664
|
US9266883, 8
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|
C15H12N6O2
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0346996
|
US9266883, 31
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|
C21H21N5O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0149294
|
(1S,2S,3R,4R)-3-[[5-cyano-2-[4-[4-(dimethylamino)piperidin-1-yl]-2-(2-methylpropoxy)anilino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
Show/Hide
|
C30H40N8O2
|
1
|
| 1 |
IC50 = 162 nM
|
|
|
|
CP0262124
|
US9266883, 25
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|
C20H20N6O3
|
1
|
| 1 |
IC50 = 224 nM
|
|
|
|
CP0387357
|
US9266883, 14
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|
C15H11F3N4O3
|
1
|
| 1 |
IC50 = 531 nM
|
|
|
|
CP0069663
|
US9266883, 38
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|
C20H22N6O3
|
1
|
| 1 |
IC50 = 588 nM
|
|
|
|
CP0346997
|
US9266883, 202
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|
C20H21N5O4
|
1
|
| 1 |
IC50 = 741 nM
|
|
|
|
CP0149459
|
N-(5-cyano-4-propan-2-yloxypyridin-2-yl)-6-formylpyrrolo[2,3-b]pyridine-1-carboxamide
Show/Hide
|
C18H15N5O3
|
1
|
| 1 |
IC50 = 750 nM
|
|
|
|
CP0231011
|
US9266883, 4
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|
C15H13ClN4O2
|
1
|
| 1 |
IC50 = 916 nM
|
|
|
|
CP0418567
|
3-[4-amino-7-[3-(hydroxymethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
Show/Hide
|
C17H18N4O2
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0061016
|
3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenol
Show/Hide
|
C17H18N4O
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0078208
|
2-formyl-N-[5-(trifluoromethyl)pyridin-2-yl]quinoline-8-carboxamide
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|
C17H10F3N3O2
|
1
|
| 1 |
IC50 = 2755 nM
|
|
|
|
CP0149458
|
N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide
Show/Hide
|
C23H25N5O4
|
1
|
| 1 |
IC50 = 2800 nM
|
|
|
|
CP0385511
|
1-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
Show/Hide
|
C26H27FN6O
|
1
|
| 1 |
IC50 = 4400 nM
|
|
|
|
CP0388615
|
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-(1,3-thiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C23H26N6O3S
|
1
|
| 1 |
IC50 = 4400 nM
|
|
|
|
CP0385508
|
2-[4-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid
Show/Hide
|
C27H28FN7O2
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0388864
|
4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
Show/Hide
|
C20H15N5
|
1
|
| 1 |
IC50 = 5900 nM
|
|
|
|
CP0395047
|
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-pyridin-2-ylimidazo[1,2-b]pyridazine
Show/Hide
|
C21H18FN5
|
1
|
| 1 |
IC50 = 9200 nM
|
|
|
|
CP0388616
|
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
Show/Hide
|
C26H29N5O3
|
1
|
| 1 |
IC50 > 11000 nM
|
|
|
|
CP0138866
|
1-[4-[3-[4-amino-5-(2-fluoro-5-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
Show/Hide
|
C22H25FN6O2
|
1
|
| 1 |
IC50 > 11000 nM
|
|
|
|
CP0231013
|
US9266883, 11
Show/Hide
|
C15H15N5O3
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
|
CP0231014
|
US9266883, 201
Show/Hide
|
C17H15N5O2
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
|
CP0487228
|
7-formyl-N-(5-methyl-1H-pyrazol-3-yl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide
Show/Hide
|
C14H15N5O2
|
1
|
| 1 |
IC50 > 3000 nM
|
|
|
