N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-3-tert-butylbenzamide

N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide

N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-3-(trifluoromethyl)benzamide

N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-3-[(2S)-2,4-dimethylpiperazin-1-yl]-5-(trifluoromethyl)benzamide

N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-3-chlorobenzamide

N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]benzamide

N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-4-(trifluoromethyl)pyridine-2-carboxamide

N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-6-(trifluoromethyl)pyridine-2-carboxamide

DABRAFENIB

US10568884, Cpd 5

N5-(3-(9H-Purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride

pyridylpurine aminoisoquinoline, 1

US10568884, Cpd 9

N-(5-chloro-3-(4-(2-(2-cyanoethylamino)pyrimidin-4-yl)-1-isopropyl-1H-pyrazol-3-yl)-2-fluorophenyl)methanesulfonamide

methyl(2S)-1-(4-(3-(5-chloro-3-(cyclopropanesulfonamido)-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

methyl(2S)-1-(4-(3-(2-fluoro-3-(propylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

Methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate

US10568884, Cpd 10

US10568884, Cpd 11

(R)-3-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethylamino)cyclohex-2-enone

US10568884, Cpd 15

US10568884, Cpd 12

(R)-3-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethylamino)cyclopent-2-enone

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1H-pyrazole-4-sulfonamide

US10568884, Cpd 13

methyl(2S)-1-(4-(3-(2,5-dichloro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

3-(dimethylamino)-N-[4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]benzamide

(S)-1-(3-tert-butylisoxazol-5-yl)-3-(2-fluoro-5-(7-(methylamino)-2-oxo-1-(tetrahydrofuran-3-yl)-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)urea

US9216981, 4

US10568884, Cpd 20

Methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(oxan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate

N-(4-chloro-3-methylphenyl)-4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide

(R)-4-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethylamino)-5,6-dihydropyridin-2(1H)-one

US10568884, Cpd 7

(R)-N-(1-(4-(8-Methoxy-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethyl)acetamide

US9216981, 30

4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide

2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclopentanesulfonamide

US8497274, 32

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-fluorobenzenesulfonamide

methyl(2S)-1-(4-(3-(2-chloro-3-(ethylsulfonamido)-4,5-difluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

US10568884, Cpd 34

US10568884, Cpd 26

4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide

3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-fluorobenzenesulfonamide

PLX-4032

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-methylpropane-1-sulfonamide

rac-(3-(5-aminopyridin-3-yl)-5-(2-fluoro-6-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone

US10568884, Cpd 2

rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(isoindolin-5-yl)thiophen-2-yl)methanone

4-methyl-N-(3-propan-2-ylphenyl)-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide

(R)-N-(1-(4-(8-Chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)acetamide

rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-7-yl)thiophen-2-yl)methanone

rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-6-yl)thiophen-2-yl)methanone

1-(3-tert- butyl-1- phenyl-1H- pyrazol-5- yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea

aminoquinazoline, 19

1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-((S)-2-hydroxy-3,3-dimethylbutyl)urea

US9593100, Compound 24

US9216981, 5

rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-7-yl)thiophen-2-yl)methanone

5-amino-4-(3-chloro-5-hydroxyphenyl)-2-(cyclopropylamino)thieno[2,3-d]pyrimidine-6-carboxamide

(R)-N-(1-(4-(7-Methoxy-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethyl)acetamide

(R)-1-(2-Hydroxyethyl)-N-((R)-1-(4-(6-(pyridin-4-yl)-quinazolin-2 ylamino)phenyl)ethyl)piperidine-2-carboxamide

(R)-N-(1-(4-(8-Methyl-6-(pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)acetamide

aminoisoquinoline, 15

aminoquinazoline, 20

4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide

1-(3,3-Dimethylbutyl)-3-[2-fluoro-4-methyl-5-(2-methylaminopyrido[2,3-d]pyrimidin-6-yl)phenyl]urea

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]butane-2-sulfonamide

methyl(2S)-1-(4-(3-(2-fluoro-3-(3,3,3-trifluoropropylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

US9216981, 35

aminoisoquinoline, 16

N-(3-cyanophenyl)-4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide

rac-(3-(5-aminopyridin-3-yl)-5-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone

1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]oxolane-3-sulfonamide

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1,3-thiazole-2-sulfonamide

US10568884, Cpd 32

1-cyclopropyl-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]methanesulfonamide

US10568884, Cpd 4

aminoisoquinoline, 12b

rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-6-yl)thiophen-2-yl)methanone

(R)-N-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethyl)acetamide

3-(1-methylpyrazol-4-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;hydrochloride

aminoisoquinoline, 13

1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- 6-(3- morpholino- propoxy) quinazolin-4- yloxy)phenyl) urea

rac-(5-(4-(aminomethyl)phenyl)thiophen-2-yl)(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone

3-(1H-imidazol-5-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide

rac-(3-(5-(hydroxymethyl)pyridin-3-yl)-5-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone

N-(5-chloro-6-methylpyridin-3-yl)-5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylbenzamide

1-(3,3-dimethylbutyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2,2,2-trifluoroethanesulfonamide

US9216981, 11

rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(3-(pyrrolidin-1-ylmethyl)phenyl)thiophen-2-yl)methanone

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclobutanesulfonamide

aminoisoquinoline, 14

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyrrolidine-1-sulfonamide

3-Methoxy-N-methyl-N-(4-(6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)propanamide

(R)-N-((R)-1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)piperidine-2-carboxamide

(R)-1-methyl-N-((R)-1-(4-(6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethyl)piperidine-2-carboxamide

3-((methylamino)methyl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide dihydrochloride

US9216981, 1

methyl(2S)-1-(4-(1-isopropyl-3-(2,4,5-trifluoro-3-(methylsulfonamido)phenyl)-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

US10568884, Cpd 6

1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

3-((dimethylamino)methyl)-N-{(2R)-[7-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide dihydrochloride

N-(4-{1-[(2-Methoxyethyl)amino]ethyl}phenyl)-6-pyridin-4-ylquinazolin-2-amine

1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- 6-(2- morpholino- ethoxy) quinazolin-4- yloxy)phenyl) urea

aminoisoquinoline, 12a

6-[2-[3-(dimethylsulfamoylamino)-2,6-difluoroanilino]pyridin-3-yl]-7H-purine

rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl)methanone

N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-3-(1H-pyrazol-4-yl)-5-(trifluoromethyl)benzamide;hydrochloride

rac-(5-(2-(aminomethyl)phenyl)thiophen-2-yl)(3-(5-aminopyridin-3-yl)-5-(2-fluoro-6-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone

3-(ethylaminomethyl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride

3-(2-aminopropan-2-yl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide dihydrochloride

N-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethyl)-acetamide

1-(5-tert- butylisoxazol- 3-yl)-3-{3- [7-methoxy- 6-(2- methoxyethoxy) quinolazin-4- yloxy]phenyl} urea hydrochloride

rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(isoindolin-5-yl)thiophen-2-yl)methanone

3-Methoxy-N-((1R)-1-{4-[(6-pyridin-4-ylquinazolin-2-yl)-amino]phenyl}ethyl)propanamide

Benzo[d]imidazo[2,1-b]thiazol-2-yl-[5-(2-hydroxy-phenyl)-3-pyridin-3-yl-4,5-dihydro-pyrazol-1-yl]-methanone

1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimethoxy- quinalozin- 4-yloxy)phenyl) urea

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(1-phenyl-3-(1,1,1-trifluoro-2-methylpropan-2-yl)-1H-pyrazol-5-yl)urea

rac-N-(5-(5-(2-hydroxyphenyl)-1-(5-(pyridin-2-yl)thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)pyridin-3-yl)acetamide

N-Methyl-N-{4-[(6-pyridin-4-ylquinazolin-2-yl)amino]-phenyl}acetamide

(R)-5-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethylamino)-1,2-dihydropyridin-3(6H)-one

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2,2-dimethylpropane-1-sulfonamide

rac-(5-(2-(aminomethyl)phenyl)thiophen-2-yl)(3-(5-aminopyridin-3-yl)-5-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone

N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]piperidine-1-sulfonamide

3-(1-aminocyclobutyl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride

US10568884, Cpd 30

3-Methoxy-N-(1-{4-[(6-pyridin-4-ylquinazolin-2-yl)amino]-phenyl}ethyl)propanamide

(R)-N-((R)-1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)pyrrolidine-2-carboxamide

3-(2-methylpyrazol-3-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;hydrochloride

US10568884, Cpd 29

US10245267, Example 1156

methyl(2S)-1-(4-(3-(3-chloro-2-(methylsulfonamido)pyridin-4-yl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone

1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7- methoxy- quinazolin- 4-yloxy)phenyl) urea

rac-(5-(4-(aminomethyl)phenyl)thiophen-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone

1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]urea

CEP-32496

1-(3,3-Dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea

1-(3-(6,7- dimethoxy- quinazolin- 4- ylthio)phenyl)- 3- (3-(2- fluoropropan-2- yl)isoxazol-5-yl) urea

rac-(5-(2-(aminomethyl)phenyl)thiophen-2-yl)(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone

1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-hydroxy- 7- methoxy- quinazolin- 4- yloxy)phenyl) urea

6-[2-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluoroanilino]pyridin-3-yl]-7H-purine

rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl)methanone

N-(2-Methoxyethyl)-4-{[6-(4-methylpyridin-3-yl)quinazolin-2-yl]amino}benzamide

1-[5-(1,3- difluoro-2- methylpropan- 2- yl)isoxazol- 3-yl]-3- [3- (6,7- dimethoxy- quinazolin- 4- ylthio)phenyl] urea

US10568884, Cpd 19

1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- 7-(3- morpholino- propoxy) quinazolin-4- yloxy)phenyl) urea

1-(3-tert-butylisoxazol-5-yl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)urea

N-[3-[2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]phenyl]-3-(trifluoromethyl)benzamide

1-(5-tert- Butylisoxazol- 3-yl)-3-{3- [6-methoxy- 7-(2- methoxy- quinazolin- 4-yloxy]phenyl} urea hydrochloride

1-(3-tert-Butylisoxazol-5-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea

5-amino-4-(3-chloro-5-hydroxyphenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]thieno[2,3-d]pyrimidine-6-carboxamide

1-[5-(1,3- difluoro-2- methylpropan-2- yl)isoxazol- 3-yl]-3-[3- (6,7- dimethoxy- quinazolin- 4- yloxy)phenyl] urea

rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(3-(pyrrolidin-1-ylmethyl)phenyl)thiophen-2-yl)methanone

1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-hydroxy- 6- methoxy- quinazolin- 4- yloxy)phenyl) urea

1-(3,3-Dimethylbutyl)-3-(2-fluoro-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea

5-amino-2-(cyclopropylamino)-4-(2-fluoro-3-hydroxyphenyl)thieno[2,3-d]pyrimidine-6-carboxamide

1-(5-tert- butylisoxazol- 3-yl)-3-(5-(6,7- dimethoxy- quinazolin- 4-yloxy)-2- fluorophenyl) urea

1-(5-tert- butylisoxazol- 3-yl)- 3-(5- (6,7- dimethoxy- quinazolin- 4- yloxy)-2,4- difluorophenyl) urea

1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimethoxy- quinazolin- 4-ylthio)phenyl) urea