| Compound ID |
Compound Name |
Compound Formula |
|
CP0672877
|
1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea
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|
C23H29FN6O
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0462126
|
3-[(methylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide
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|
C28H27F3N4O3
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0051156
|
3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide
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|
C29H29F3N4O3
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0051154
|
3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide
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|
C29H29F3N4O3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0395958
|
N-[(2R)-7-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide
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|
C30H31F3N4O3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0516601
|
(2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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|
C29H29F3N4O3
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0454420
|
(2S)-N-[3-[(Isopropylamino)methyl]-5-(trifluoromethyl)-phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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|
C30H31F3N4O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0289301
|
(2S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-({2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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|
C28H27F3N4O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0289302
|
(2S)-7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-N-[3-[(dimethylamino)methyl]-5-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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|
C30H31F3N4O3
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0051623
|
N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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|
C28H27F3N4O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0310249
|
(2S)-7-{[2-(acetylamino)pyridin-4-yl]oxy}-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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|
C26H25F3N4O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0095082
|
DABRAFENIB
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|
C23H20F3N5O2S2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0103363
|
7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-N-[3-[(isopropylamino)methyl]-5-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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|
C31H33F3N4O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0162287
|
(2R)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-({2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide
Show/Hide
|
C28H27F3N4O3
|
1
|
| 1 |
IC50 = 780 nM
|
|
|
|
CP0524812
|
N-[(2S)-7-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide
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|
C30H31F3N4O3
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0103387
|
4-{[7-({[3-(Aminomethyl)-5-(trifluoromethyl)phenyl]amino}carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-N-methylpyridine-2-carboxamide
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|
C26H25F3N4O3
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0297198
|
4-[[7-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]-N-methylpyridine-2-carboxamide
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|
C25H21ClF3N3O3
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0234965
|
4-{[7-({[4-(Aminomethyl)-3-(trifluoromethyl)phenyl]amino}carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-Nmethylpyridine-2-carboxamide
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|
C26H25F3N4O3
|
1
|
| 1 |
IC50 = 5000 nM
|
|
|
|
CP0006321
|
PLX-4032
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|
C23H18ClF2N3O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0225022
|
4-[3-(3-{[4-Chloro-3-(trifluoromethyl)phenyl]amino}-3-oxopropyl)phenoxy]-N-methylpyridine-2-carboxamide
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|
C23H19ClF3N3O3
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
|
CP0234964
|
4-[4-(3-{[4-Chloro-3-(trifluoromethyl)phenyl]amino}-3-oxopropyl)phenoxy]-N-methylpyridine-2-carboxamide
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|
C23H19ClF3N3O3
|
1
|
| 1 |
IC50 > 25000 nM
|
|
|
