Brief Information of the Compound and Protein
Compound Name
N-[(2R)-7-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide
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PubChem ID
CID: 51354887
SID: 121273865
Canonical SMILES
CN(C)Cc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2C1
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Compound Formula C30H31F3N4O3
Compound Structure
Protein Name
RAF proto-oncogene serine/threonine-protein kinase
Protein Classification
Enzyme
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Kinase
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Protein Kinase
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TKL protein kinase group
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TKL protein kinase RAF family
Uniprot ID
P04049
Gene Name
RAF1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS