Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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 PubChem ID
CID: 51354885
SID: 121273863
Canonical SMILES
NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(c1)C(F)(F)F
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Compound Formula C28H27F3N4O3
Compound Structure
Protein Name
 Protein Info 
RAF proto-oncogene serine/threonine-protein kinase
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P04049
Gene Name
RAF1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.2 nM