Brief Information of the Cell Line and Protein
Cell Line ID: CL000045 , A-375
 Cell Line Info 
Synonyms
A 375
A375
A375-MEL
A375-mel
A375mel
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0132
Protein ID: PT01080 , Dual specificity mitogen-activated protein kinase kinase 1
 Protein Info 
Gene Name MAP2K1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q02750
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000045
 Cell Line Info 
 Protein ID: PT01080
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0061810
 Compound Info 
4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1H-indazole-5-carboxamide
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C16H14FIN4O3
  1
1
EC50 = 0.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0116131
 Compound Info 
7-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,2-benzothiazole-6-carboxamide
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C16H13FIN3O3S
  1
1
EC50 = 0.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0301325
 Compound Info 
N-[(2R)-2,3-dihydroxypropoxy]-7-(2-fluoro-4-iodoanilino)-1,2-benzothiazole-6-carboxamide
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C17H15FIN3O4S
  1
1
EC50 = 1.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0270741
 Compound Info 
N-(cyclopropylmethoxy)-4-(2-fluoro-4-iodoanilino)-1H-indazole-5-carboxamide
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C18H16FIN4O2
  1
1
EC50 = 1.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0061813
 Compound Info 
N-ethoxy-4-(2-fluoro-4-iodoanilino)-1H-indazole-5-carboxamide
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C16H14FIN4O2
  1
1
EC50 = 2.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0139330
 Compound Info 
N-[(2R)-2,3-dihydroxypropoxy]-4-(2-fluoro-4-iodoanilino)-1H-indazole-5-carboxamide
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C17H16FIN4O4
  1
1
EC50 = 3.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0339840
 Compound Info 
4-(4-bromo-2-fluoroanilino)-N-(2-hydroxyethoxy)-1H-indazole-5-carboxamide
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C16H14BrFN4O3
  1
1
EC50 = 6.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0319000
 Compound Info 
7-fluoro-3-(2-fluoro-4-iodoanilino)-N-[(2S)-2-hydroxypropoxy]furo[3,2-c]pyridine-2-carboxamide
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C17H14F2IN3O4
  1
1
EC50 = 7.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0318998
 Compound Info 
N-[(2R)-2,3-dihydroxypropoxy]-3-(2-fluoro-4-iodoanilino)furo[3,2-c]pyridine-2-carboxamide
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C17H15FIN3O5
  1
1
EC50 = 34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS