N-[4-[[5,5-dimethyl-2,4-dioxo-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidin-1-yl]methyl]pyridin-2-yl]acetamide

1-((1r,4r)-4-morpholinocyclohexyl)-3-(2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

2-phenyl-N-(3-(5-(2-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)acetamide

6,6-dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

1-((1r,4r)-4-morpholinocyclohexyl)-3-(2-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridine

3-(2-benzyl-1-methyl-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-(2-(2-chlorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine

3-[2-(2-methyl-benzyl)-1H-benzoimidazol-5-yl]-1-(4-morpholin-4-yl-cyclhexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

N-[3-[5-[2-[3-[2-(dimethylamino)ethyl]anilino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide

3-(2-(2-fluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

N-[3-[5-[2-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide

3-(2-(3-fluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-(2-benzyl-1H-1,3-benzodiazol-6-yl)-1-[4-(morpholin-4-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-[2-(4-methyl-benzyl)-1H-benzoimidazol-5-yl]-1-(4-morpholin-4-yl-cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

3-(2-(2-bromobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

3-(2-(2,6-difluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

N-[3-[5-[2-[(2-methyl-3,4-dihydro-1H-isoquinolin-6-yl)amino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide

3-(2-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

2,6-difluoro-N-(3-(5-(2-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide

5-bromo-4-N-(5-ethyl-1H-pyrazol-3-yl)-2-N-[(3-pyridin-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine

3-(2-(3-chlorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-(2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

N-[3-[5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide

3-(2-(3,5-difluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

3-(2-(2,3-difluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-((1r,4r)-4-morpholinocyclohexyl)-3-(2-phenyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-[2-(3-methyl-benzyl)-1H-benzoimidazol-5-yl]-1-(4-morpholin-4-yl-cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methyl)-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

N-[3-[5-[2-[4-[2-(dimethylamino)ethyl]anilino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2,6-difluorobenzamide

N-[3-[5-[2-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2,6-difluorobenzamide

5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

N-[3-[5-[2-(3-morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamide

(R)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

1-((1r,4r)-4-morpholinocyclohexyl)-3-(2-phenethyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

5-bromo-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-4-N-(5-propyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

5-bromo-4-N-(5-propan-2-yl-1H-pyrazol-3-yl)-2-N-(pyridin-3-ylmethyl)pyrimidine-2,4-diamine

(S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

phenyl N-[3-[5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]carbamate

1-((2-(isopropylamino)pyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

3-(2-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

1-((2-ethylpyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

2-cyclopentyl-N-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)acetamide

1-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)-3-phenylurea

3-(2-(4-chlorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-(2-(3,4-difluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylthio)phenyl)imidazolidin-1-yl)methyl)-N-methylpicolinamide

tert-butyl N-[4-[[5,5-dimethyl-2,4-dioxo-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidin-1-yl]methyl]pyridin-2-yl]carbamate

3-(2-(4-fluorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-((2-chloropyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

1-((2-(benzylamino)pyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

5,5-dimethyl-1-((2-(phenylamino)pyridin-4-yl)methyl)-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

1-((2-(4-methoxybenzylamino)pyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

2-cyclohexyl-N-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)acetamide

1-((2-(cyclohexylamino)pyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

2,6-difluoro-N-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide

1-((1r,4r)-4-morpholinocyclohexyl)-3-(2-(naphthalen-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one

N-[3-[5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]benzamide

5-bromo-4-N-(5-propyl-1H-pyrazol-3-yl)-2-N-(pyridin-3-ylmethyl)pyrimidine-2,4-diamine

(S)-5-methyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

1-((2-ethoxypyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

3-(2-(2,3-dichlorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-((1r,4r)-4-morpholinocyclohexyl)-3-(2-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluoromethylsulfinyl)phenyl)imidazolidine-2,4-dione

1-((2-fluoropyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylthio)phenyl)imidazolidin-1-yl)methyl)picolinamide

5-bromo-4-N-(5-ethyl-1H-pyrazol-3-yl)-2-N-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

3-(2-((2-methylthiazol-4-yl)methyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

2,6-difluoro-N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide

5-bromo-2-N-[2-(furan-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

5-bromo-4-N-(5-methyl-1H-pyrazol-3-yl)-2-N-prop-2-enylpyrimidine-2,4-diamine

3-(2-benzyl-7-methyl-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-((2-(dimethylamino)pyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

N-[4-[[5,5-dimethyl-2,4-dioxo-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidin-1-yl]methyl]pyridin-2-yl]methanesulfonamide

1-(quinolin-4-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

4-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine

5-bromo-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-4-N-[5-(2-phenylethyl)-1H-pyrazol-3-yl]pyrimidine-2,4-diamine

5-bromo-4-N-(5-methyl-1H-pyrazol-3-yl)-2-N-(2-pyridin-3-ylethyl)pyrimidine-2,4-diamine

5-bromo-4-N-(5-methyl-1H-pyrazol-3-yl)-2-N-[3-(5-methyl-1H-pyrazol-4-yl)propyl]pyrimidine-2,4-diamine

5-chloro-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

5-[[[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]methyl]-1,2-oxazole-3-carboxamide

5-bromo-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

5,5-dimethyl-1-((2-morpholinopyridin-4-yl)methyl)-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylthio)phenyl)imidazolidin-1-yl)methyl)picolinonitrile

4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylthio)phenyl)imidazolidin-1-yl)methyl)picolinic acid

5,5-dimethyl-1-((2-(piperidin-1-yl)pyridin-4-yl)methyl)-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

5,5-dimethyl-1-((2-(piperazin-1-yl)pyridin-4-yl)methyl)-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

5,5-dimethyl-1-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)methyl)-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione

[5-[[[5-bromo-4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]methyl]-1,2-oxazol-3-yl]-pyrrolidin-1-ylmethanone

5-bromo-2-N-[(3-tert-butyl-1,2-oxazol-5-yl)methyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

2-N-[(3-cyclopropyl-1,2-oxazol-5-yl)methyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

N-[3-[5-(2-amino-3H-benzimidazol-5-yl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-chlorobenzamide

2-chloro-N-(3-(5-(pyridin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide

2-chloro-N-(3-(5-(2-(phenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide

N-[3-[5-(2-anilinopyrimidin-4-yl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]benzamide

4-(6-(3-nitrophenyl)imidazo[2,1-b]thiazol-5-yl)-N-phenylpyrimidin-2-amine

4-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2-N-[(5-methyl-1,2-oxazol-3-yl)methyl]pyrimidine-2,4-diamine

2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

5-bromo-4-N-(5-methyl-1H-pyrazol-3-yl)-2-N-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

2-N-[(3-cyclopropyl-1,2-oxazol-5-yl)methyl]-4-N-[5-(3-methoxypropyl)-1H-pyrazol-3-yl]pyrimidine-2,4-diamine

5-bromo-2-N-[(5-methylpyrazin-2-yl)methyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-4-N-[5-(2-phenylethyl)-1H-pyrazol-3-yl]pyrimidine-2,4-diamine

5-bromo-2-N-[2-(3-methyl-1,2-oxazol-5-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

5-bromo-4-N-[5-(3-methoxypropyl)-1H-pyrazol-3-yl]-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine

4-N-[5-(3-methoxypropyl)-1H-pyrazol-3-yl]-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine

[3-[[2-[(3-methyl-1,2-oxazol-5-yl)methylamino]pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]methanol

5-bromo-4-N-(5-methyl-1H-pyrazol-3-yl)-2-N-[(3-methylpyridin-2-yl)methyl]pyrimidine-2,4-diamine

4-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2-N-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine

(S)-5-methyl-1-(pyridin-3-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

(S)-5-methyl-3-(4-(methylsulfonyl)phenyl)-1-(quinolin-4-ylmethyl)imidazolidine-2,4-dione

(S)-5-methyl-1-(piperidin-4-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

(S)-5-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

(S)-1-((1H-imidazol-4-yl)methyl)-5-methyl-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

(S)-4-((5-methyl-2,4-dioxo-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidin-1-yl)methyl)pyridine 1-oxide

(S)-4-((5-methyl-2,4-dioxo-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidin-1-yl)methyl)quinoline 1-oxide

(S)-1-benzyl-5-methyl-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

(S)-1-(isoquinolin-4-ylmethyl)-5-methyl-3-(4-(trifluoromethylsulfonyl)phenyl)imidazolidine-2,4-dione

5-[[[4-[[5-(3-methoxypropyl)-1H-pyrazol-3-yl]amino]pyrimidin-2-yl]amino]methyl]-1,2-oxazole-3-carboxamide

[3-[4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl]azetidin-1-yl]-[4-[[(2S)-2,3-dihydroxypropoxy]methyl]pyridin-2-yl]methanone