Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one
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 PubChem ID
CID: 44259
SID: 22395183
Canonical SMILES
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
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Compound Formula C28H26N4O3
Compound Structure
Protein Name
 Protein Info 
Insulin-like growth factor 1 receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase InsR family
Uniprot ID
P08069
Gene Name
IGF1R
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  4
1
IC50 = 1325 nM
   TI
   LI
   LO
   TS
2
IC50 = 1533 nM
   TI
   LI
   LO
   TS
3
IC50 = 1646 nM
   TI
   LI
   LO
   TS
4
IC50 = 1701 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 27.5 nM
2 IC50 = 35.03 nM
3 IC50 = 43.3 nM
4 IC50 = 47.4 nM
5 IC50 = 85.33 nM
6 IC50 = 160 nM
7 IC50 = 190 nM
8 IC50 = 200 nM
9 IC50 = 200.7 nM
10 Kd = 210 nM