2-methyl-1-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

cis/trans-3-methyl-1-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

1-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)cycloheptanecarbonitrile

2-ethyl-2-[[4-(methylamino)-6-(1,2,4-triazol-1-yl)-1,3,5-triazin-2-yl]amino]butanenitrile

2,2-dicyclopropyl-2-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)acetonitrile

1-(4-(3-methyl-1H-1,2,4-triazol-1-yl)-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

rac-2-ethyl-2-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)pentanenitrile

1-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)cyclopentanecarbonitrile

cis/trans-4-methyl-1-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

2-cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one

rac-2-methyl-2-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)butanenitrile

N2-(3-ethylpent-1-yn-3-yl)-N4-methyl-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazine-2,4-diamine

1-(4-(methylamino)-6-(1H-pyrazol-1-yl)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-(methylamino)-6-(methylthio)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-(1-cyanocyclohexylamino)-6-(methylamino)-1,3,5-triazin-2-yl)-1H-1,2,4-triazole-3-carbonitrile

2-(4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-ylamino)-2-propylpentanenitrile

1-(4-(1H-imidazol-1-yl)-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-(1H-benzo[d]imidazol-1-yl)-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-(dimethylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-cyclopropyl-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-methoxy-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

4-(1-cyanocyclohexylamino)-6-(methylamino)-1,3,5-triazine-2-carbonitrile

1-(4-(methylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-chloro-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-chloro-6-(methylamino)-1,3,5-triazin-2-ylamino)cycloheptanecarbonitrile

1-(4-chloro-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclopentanecarbonitrile

1-(4-(methylamino)-6-(phenylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-(4-(cyclopentylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

2-(4-chloro-6-(methylamino)-1,3,5-triazin-2-ylamino)-2-propylpentanenitrile

(1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid

1-[(2-chloro-6-fluorophenyl)methyl]-N-(4-methylsulfonylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

2-(4-chloro-6-(methylamino)-1,3,5-triazin-2-ylamino)-2-ethylbutanenitrile

N-(4-carbamoylphenyl)-1-[(2-chloro-6-fluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

(R,S)-Rolipram

6-chloro-N2-cyclohexyl-N4-methyl-1,3,5-triazine-2,4-diamine

1-(4-chloro-6-(cyclopropylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

6-chloro-N2-(1-ethynylcyclohexyl)-N4-methyl-1,3,5-triazine-2,4-diamine

1-(4,6-bis(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-[(2-chloro-6-fluorophenyl)methyl]-N-[4-(methylcarbamoyl)phenyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

6-chloro-N2-methyl-N4-(3-methylpentan-3-yl)-1,3,5-triazine-2,4-diamine

2-(4-chloro-6-(methylamino)-1,3,5-triazin-2-ylamino)-2-methylpropanenitrile

N-(4-acetylphenyl)-1-[(2-chloro-6-fluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-(4-chloro-6-(methoxyamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

N-(4-carbamoylphenyl)-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

N-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-(4-chloro-6-(ethylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

N2-tert-butyl-6-chloro-N4-methyl-1,3,5-triazine-2,4-diamine

1-[(2-chloro-6-fluorophenyl)methyl]-4,6-dioxo-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-5H-1,5-naphthyridine-3-carboxamide

N-(4-acetamidophenyl)-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

N-(4-acetamidophenyl)-1-[(2-chloro-6-fluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4-oxo-1,5-naphthyridine-3-carboxamide

1-[(2-chloro-6-fluorophenyl)methyl]-4,6-dioxo-N-(4-sulfamoylphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2-chloro-6-fluorophenyl)methyl]-N-[4-(dimethylamino)phenyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-N-[4-(pyridin-4-ylmethylcarbamoyl)phenyl]-5H-1,5-naphthyridine-3-carboxamide

N-[4-(diethylamino)phenyl]-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-N-(4-sulfamoylphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-[4-(dimethylamino)phenyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

N-(4-aminophenyl)-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-[4-(methylcarbamoyl)phenyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-((4-amino-6-chloro-1,3,5-triazin-2-yl)(methyl)amino)cyclohexanecarbonitrile

N-[4-(difluoromethoxy)phenyl]-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

N-(3-carbamoylphenyl)-1-[(2-chloro-6-fluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-(4-chloro-6-(dimethylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-[(2,6-dichlorophenyl)methyl]-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-[4-(methylamino)phenyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-(4-amino-6-chloro-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-[(2,6-difluorophenyl)methyl]-N-[4-(morpholine-4-carbonyl)phenyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-N-phenyl-5H-1,5-naphthyridine-3-carboxamide

1-[(2-chloro-6-fluorophenyl)methyl]-N-(3-methylsulfonylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

4-[[1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carbonyl]amino]benzoic acid

N-(4-morpholin-4-ylphenyl)-4,6-dioxo-1-[(2,3,5,6-tetrafluorophenyl)methyl]-5H-1,5-naphthyridine-3-carboxamide

1-[(2-chloro-6-fluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2-chloro-6-fluorophenyl)methyl]-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2-chloro-6-fluorophenyl)methyl]-N-(3-chloro-4-methoxyphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-(4-methylsulfonylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

N-(3-cyanophenyl)-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

2-[4-[[1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carbonyl]amino]phenyl]acetic acid

1-[(2,6-difluorophenyl)methyl]-N-(4-hydroxyphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-N-[4-(trifluoromethoxy)phenyl]-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-(3,5-dimethoxyphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2-methylphenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2-chlorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(3,5-difluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-N-[4-(trifluoromethyl)phenyl]-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-N-(4-piperidin-1-ylphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-(4-methylsulfanylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-(4-fluorophenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(4-fluorophenyl)methyl]-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

N-(4-morpholin-4-ylphenyl)-4,6-dioxo-1-[[2-(trifluoromethyl)phenyl]methyl]-5H-1,5-naphthyridine-3-carboxamide

1-benzyl-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

N-(4-cyanophenyl)-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2-chlorophenyl)methyl]-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

N-(4-acetylphenyl)-1-[(2,6-difluorophenyl)methyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-dichlorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

N-(4-morpholin-4-ylphenyl)-4,6-dioxo-1-[[4-(trifluoromethoxy)phenyl]methyl]-5H-1,5-naphthyridine-3-carboxamide

1-[(2-chloro-4-fluorophenyl)methyl]-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2,4-difluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-benzyl-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2-bromophenyl)methyl]-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-N-(4-methoxyphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2-fluorophenyl)methyl]-4,6-dioxo-N-(3,4,5-trimethoxyphenyl)-5H-1,5-naphthyridine-3-carboxamide

1-(4-amino-6-(methylamino)-1,3,5-triazin-2-ylamino)cyclohexanecarbonitrile

1-[(2-chloro-6-fluorophenyl)methyl]-N-[4-(diethylamino)phenyl]-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(4-fluorophenyl)methyl]-N-(4-morpholin-4-ylphenyl)-4,6-dioxo-5H-1,5-naphthyridine-3-carboxamide

1-[(2,6-difluorophenyl)methyl]-6-methoxy-N-(4-morpholin-4-ylphenyl)-4-oxo-1,5-naphthyridine-3-carboxamide