Brief Information of the Cell Line and Protein
Cell Line ID: CL000012 , Sf21
Synonyms
SF21
Sf-21
SF-21
IPLB-SF-21-AE
IPLB-Sf21-AE
IPLB-SF21-AE
IPLB-SF 21AE
IPLB-Sf21AE
IPLB-SF21AE
IPLB-SF-21
IPLB-Sf-21
IPLB-SF 21
IPLB-Sf21
IPLB-SF21
Category Spontaneously immortalized cell line
Organism
Spodoptera frugiperda (Fall armyworm)
Cellosaurus ID
CVCL_0518
Protein ID: PT03525 , Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Gene Name PIK3CA
Organism Mus musculus, Mouse
Protein Classification Enzyme
Uniprot ID P42337
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000012  Protein ID: PT03525
 
Compound ID Compound Name Compound Formula
CP0071675
2-(difluoromethyl)-3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-7-methoxybenzimidazol-5-amine
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C20H24F2N8O3
 1
1
IC50 = 0.22 nM
   TI
   LI
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   TS
CP0071769
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazol-4-ol
   Show/Hide
C19H21F2N7O3
 1
1
IC50 = 0.9 nM
   TI
   LI
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   TS
CP0399989
2-(difluoromethyl)-1-(4,6-dimorpholin-4-ylpyrimidin-2-yl)benzimidazol-4-ol
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C20H22F2N6O3
 1
1
IC50 = 1.5 nM
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CP0388767
2-(difluoromethyl)-3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-7-methoxy-N-methylbenzimidazol-5-amine
   Show/Hide
C21H26F2N8O3
 1
1
IC50 = 2 nM
   TI
   LI
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   TS
CP0440261
4-[4-[2-(difluoromethyl)-4-ethoxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
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C21H25F2N7O3
 1
1
IC50 = 2.7 nM
   TI
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   TS
CP0452381
4-[4-[2-(difluoromethyl)-4-methoxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C20H23F2N7O3
 1
1
IC50 = 2.7 nM
   TI
   LI
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   TS
CP0395727
4-[4-[2-(difluoromethyl)-4-methoxybenzimidazol-1-yl]-6-morpholin-4-ylpyrimidin-2-yl]morpholine
   Show/Hide
C21H24F2N6O3
 1
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
CP0399986
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazol-4-amine
   Show/Hide
C19H22F2N8O2
 1
1
IC50 = 4.8 nM
   TI
   LI
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   TS
CP0475130
4-[2-[2-(difluoromethyl)-4-methoxybenzimidazol-1-yl]-6-morpholin-4-ylpyrimidin-4-yl]morpholine
   Show/Hide
C21H24F2N6O3
 1
1
IC50 = 5.1 nM
   TI
   LI
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   TS
CP0461571
2-(difluoromethyl)-3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-7-methoxy-N,N-dimethylbenzimidazol-5-amine
   Show/Hide
C22H28F2N8O3
 1
1
IC50 = 8 nM
   TI
   LI
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CP0007933
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1H-benzimidazole
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C19H21F2N7O2
 1
1
IC50 = 8.6 nM
   TI
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   TS
CP0395726
methyl 2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazole-4-carboxylate
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C21H23F2N7O4
 1
1
IC50 = 9.3 nM
   TI
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   TS
CP0400071
4-[4-[2-(difluoromethyl)-4-propoxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
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C22H27F2N7O3
 1
1
IC50 = 16 nM
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   LI
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   TS
CP0075331
4-[4-[4-(difluoromethoxy)-2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C20H21F4N7O3
 1
1
IC50 = 26 nM
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   TS
CP0395725
[2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazol-4-yl]methanol
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C20H23F2N7O3
 1
1
IC50 = 27 nM
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CP0399984
4-[4-[4-butoxy-2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
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C23H29F2N7O3
 1
1
IC50 = 28 nM
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   TS
CP0475132
4-[2-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-ylpyrimidin-4-yl]morpholine
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C20H22F2N6O2
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0482934
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-methoxybenzimidazol-5-ol
   Show/Hide
C20H23F2N7O4
 1
1
IC50 = 32 nM
   TI
   LI
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   TS
CP0401183
4-[4-[2-(fluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
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C19H22FN7O2
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0071674
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-5-methoxybenzimidazol-4-ol
   Show/Hide
C20H23F2N7O4
 1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CP0388766
4-[4-[2-(difluoromethyl)-4,6-dimethoxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C21H25F2N7O4
 1
1
IC50 = 58 nM
   TI
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   LO
   TS
CP0391223
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazole-4-carbonitrile
   Show/Hide
C20H20F2N8O2
 1
1
IC50 = 61 nM
   TI
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   TS
CP0388768
4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-ylpyrimidin-2-yl]morpholine
   Show/Hide
C20H22F2N6O2
 1
1
IC50 = 88 nM
   TI
   LI
   LO
   TS
CP0386175
4-[4-(2-methylbenzimidazol-1-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C19H23N7O2
 1
1
IC50 = 143 nM
   TI
   LI
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   TS
CP0475125
4-[4-[2-(methylsulfanylmethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C20H25N7O2S
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0388763
4-[4-morpholin-4-yl-6-[2-(trifluoromethyl)benzimidazol-1-yl]-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C19H20F3N7O2
 1
1
IC50 = 202 nM
   TI
   LI
   LO
   TS
CP0388764
4-[4-(2-methylsulfonylbenzimidazol-1-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C19H23N7O4S
 1
1
IC50 = 203 nM
   TI
   LI
   LO
   TS
CP0388765
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-N-methylbenzimidazol-4-amine
   Show/Hide
C20H24F2N8O2
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0496114
4-[4-(benzimidazol-1-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C18H21N7O2
 1
1
IC50 = 265 nM
   TI
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   TS
CP0475131
[2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazol-4-yl] methanesulfonate
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C20H23F2N7O5S
 1
1
IC50 = 294 nM
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CP0401184
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-N-methylbenzimidazole-4-carboxamide
   Show/Hide
C21H24F2N8O3
 1
1
IC50 = 296 nM
   TI
   LI
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   TS
CP0496383
4-[4-[2-(difluoromethyl)-4,5-dimethoxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C21H25F2N7O4
 1
1
IC50 = 335 nM
   TI
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   TS
CP0475128
4-[4-[2-(difluoromethyl)-4-propan-2-yloxybenzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C22H27F2N7O3
 1
1
IC50 = 364 nM
   TI
   LI
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   TS
CP0437676
4-[4-[2-(methylsulfonylmethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C20H25N7O4S
 1
1
IC50 = 480 nM
   TI
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CP0002420
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
   Show/Hide
C19H17NO3
 1
1
IC50 = 500 nM
   TI
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CP0401185
7-(difluoromethyl)-6-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-[1,3]dioxolo[4,5-e]benzimidazole
   Show/Hide
C20H21F2N7O4
 1
1
IC50 = 550 nM
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   TS
CP0388707
4-[4-[2-(methylsulfinylmethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C20H25N7O3S
 1
1
IC50 = 590 nM
   TI
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   TS
CP0433684
6-methoxy-3-(5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl)quinolin-2(1H)-one
   Show/Hide
C19H15N3O4
 1
1
IC50 = 900 nM
   TI
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CP0452365
4-[4-[2-(difluoromethyl)-7-methoxyimidazo[4,5-c]pyridin-3-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C19H22F2N8O3
 1
1
IC50 = 1290 nM
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CP0482685
2-[5-[(3-methoxyphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methylphenol
   Show/Hide
C17H16N2O3S
 1
1
IC50 = 1970 nM
   TI
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CP0475126
4-[4-(2-methylsulfanylbenzimidazol-1-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
   Show/Hide
C19H23N7O2S
 1
1
IC50 = 2900 nM
   TI
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CP0375548
3-(benzo[d]thiazol-2-yl)-7-hydroxy-2H-chromen-2-one
   Show/Hide
C16H9NO3S
 1
1
IC50 = 3000 nM
   TI
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CP0462132
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-N,N-dimethylbenzimidazol-4-amine
   Show/Hide
C21H26F2N8O2
 1
1
IC50 = 5400 nM
   TI
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   TS
CP0397910
2-[5-[(3-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methoxyphenol
   Show/Hide
C16H13ClN2O3S
 1
1
IC50 = 15370 nM
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CP0400147
5-methoxy-2-[5-[(3-nitrophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]phenol
   Show/Hide
C16H13N3O5S
 1
1
IC50 = 17940 nM
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CP0400330
3-(6-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)-N-phenylpropanamide
   Show/Hide
C16H13ClN2O3
 1
1
IC50 = 19000 nM
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CP0397911
2-[5-[(4-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methoxyphenol
   Show/Hide
C16H13FN2O3S
 1
1
IC50 = 31210 nM
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CP0430768
2-[5-[(2-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methoxyphenol
   Show/Hide
C16H13FN2O3S
 1
1
IC50 = 33920 nM
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CP0373900
1,7-dimethyl-1H-pyrazolo[3,4-b]quinolin-3-yl 2-phenoxyacetate
   Show/Hide
C20H17N3O3
 1
1
IC50 = 38000 nM
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CP0389730
5-methyl-2-[5-[(4-nitrophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]phenol
   Show/Hide
C16H13N3O4S
 1
1
IC50 = 54930 nM
   TI
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CP0397167
3-(2-methoxy-6-phenylpyridin-3-yl)-5-(pyridin-4-yl)-1,2,4-oxadiazole
   Show/Hide
C19H14N4O2
 1
1
IC50 = 78000 nM
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CP0296638
methyl 5-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylmethyl]furan-2-carboxylate
   Show/Hide
C15H14N2O3S2
 1
1
IC50 > 100000 nM
   TI
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   TS
CP0373901
3-(5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl)-6-methylquinolin-2(1H)-one
   Show/Hide
C19H15N3O3
 1
1
IC50 > 100000 nM
   TI
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   TS
CP0395723
[1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazol-2-yl]methanol
   Show/Hide
C19H23N7O3
 1
1
IC50 > 1000 nM
   TI
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   TS
CP0475129
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazole-4-carboxamide
   Show/Hide
C20H22F2N8O3
 1
1
IC50 > 1000 nM
   TI
   LI
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   TS
CP0496115
2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-N,N-dimethylbenzimidazole-4-carboxamide
   Show/Hide
C22H26F2N8O3
 1
1
IC50 > 1000 nM
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