General Information of the Protein
Protein ID
PT02542
Protein Name
Mitogen-activated protein kinase kinase kinase 12
Secondarily
Protein Name
Dual leucine zipper bearing kinase
Leucine-zipper protein kinase
MAPK-upstream kinase
Mixed lineage kinase
Gene Name
MAP3K12
Secondarily
Gene Name
ZPK
Sequence
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
Function
Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway.
    Show/Hide
Uniprot ID
Primary ID:
Q12852

Secondarily ID:
B3KSS9
G3V1Y2
Q86VQ5
Q8WY25
    Show/Hide
Ensembl ID
ENSG00000139625
HGNC ID
HGNC:6851
Subcellular Location
Cytoplasm
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0069320
 Compound Info 
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C23H26F2N6O
  1
1
IC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0280018
 Compound Info 
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)azetidin-3-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C21H22F2N6O
  1
1
IC50 = 57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0310455
 Compound Info 
2-[[6-cyclopropyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H25N5O
  1
1
IC50 = 62 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0557875
 Compound Info 
2-[[6-cyclobutyloxy-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C23H27N5O2
  1
1
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0090025
 Compound Info 
1-[4-[2-(3,3-difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyridin-4-yl]piperidin-1-yl]ethanone
   Show/Hide
C22H24F5N5O
  1
1
IC50 = 69 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069314
 Compound Info 
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-(oxan-4-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C20H21F2N5O
  1
1
IC50 = 70 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0334594
 Compound Info 
2-[[4-(4-cyanooxan-4-yl)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C21H20F2N6O
  1
1
IC50 = 79 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0477226
 Compound Info 
CHEMBL4128619
   Show/Hide
C21H26F3N5O
  1
1
IC50 = 99 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0090028
 Compound Info 
6-piperidin-3-yl-2-pyrrolidin-1-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
   Show/Hide
C19H23F3N6
  1
1
IC50 = 109 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0338914
 Compound Info 
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C18H19F2N5O
  1
1
IC50 = 125 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0016719
 Compound Info 
5-[5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethoxy)pyridin-2-amine
   Show/Hide
C20H24F3N5O2
  2
1
IC50 = 129 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 195 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0338913
 Compound Info 
2-[[6-(azetidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H26N6O
  1
1
IC50 = 141 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0023938
 Compound Info 
CHEMBL3715238
   Show/Hide
C21H24F3N5O
  1
1
IC50 = 144 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0224284
 Compound Info 
CHEMBL3718522
   Show/Hide
C19H19F6N5O
  1
1
IC50 = 180 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0350211
 Compound Info 
2-[[4-(2-cyanopropan-2-yl)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C19H18F2N6
  1
1
IC50 = 193 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0478051
 Compound Info 
5-[1-(cyclopentylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
   Show/Hide
C23H28F3N5O
  1
1
IC50 = 202 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0389292
 Compound Info 
CHEMBL4128889
   Show/Hide
C20H26F3N5O
  1
1
IC50 = 208 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0122103
 Compound Info 
5-[1-(cyclobutylmethyl)-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
   Show/Hide
C22H26F3N5O
  1
1
IC50 = 210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429458
 Compound Info 
2-[[6-ethyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C21H25N5O
  1
1
IC50 = 213 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0116371
 Compound Info 
[3-[2-methyl-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C23H22F3N5O
  1
1
IC50 = 229 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069301
 Compound Info 
2-[[6-(3-methoxyazetidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C23H28N6O2
  1
1
IC50 = 233 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0133222
 Compound Info 
CHEMBL3717481
   Show/Hide
C20H24F3N5O
  1
1
IC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0538682
 Compound Info 
5-[5-[(1S,5R)-3-(2-methoxyethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
   Show/Hide
C20H26F3N5O
  1
1
IC50 = 265 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396483
 Compound Info 
5-[5-[(1S,5R)-3-(oxetan-3-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
   Show/Hide
C21H26F3N5O
  1
1
IC50 = 274 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069316
 Compound Info 
1-[4-[2-(3,3-difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]ethanone
   Show/Hide
C21H23F5N6O
  1
1
IC50 = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0122104
 Compound Info 
CHEMBL3718265
   Show/Hide
C19H22F3N5O
  1
1
IC50 = 302 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0261263
 Compound Info 
3-methyl-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
   Show/Hide
C22H29N5O
  1
1
IC50 = 303 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0477225
 Compound Info 
CHEMBL4125721
   Show/Hide
C21H24F3N5O2
  1
1
IC50 = 304 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0074414
 Compound Info 
CHEMBL3714987
   Show/Hide
C20H25F2N5O2
  1
1
IC50 = 328 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552526
 Compound Info 
5-[1-ethyl-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
   Show/Hide
C19H22F3N5O
  1
1
IC50 = 406 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0116367
 Compound Info 
2-(3,3-difluoropyrrolidin-1-yl)-6-piperidin-3-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
   Show/Hide
C19H21F5N6
  1
1
IC50 = 408 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0090027
 Compound Info 
2-(3,3-difluoropyrrolidin-1-yl)-6-piperidin-4-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
   Show/Hide
C19H21F5N6
  1
1
IC50 = 410 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387150
 Compound Info 
2-(3,3-difluoropyrrolidin-1-yl)-6-(oxan-4-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
   Show/Hide
C19H20F5N5O
  1
1
IC50 = 440 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0345784
 Compound Info 
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)azetidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C20H24N6O
  1
1
IC50 = 459 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0390422
 Compound Info 
5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
   Show/Hide
C22H26F3N5O
  1
1
IC50 = 485 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0310487
 Compound Info 
[3-[6-[(4-cyclopropylpyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C25H27N5O
  1
1
IC50 = 486 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0024698
 Compound Info 
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H28N6O
  1
1
IC50 = 536 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552789
 Compound Info 
3-chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
   Show/Hide
C21H26ClN5O
  1
1
IC50 = 574 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0116207
 Compound Info 
CHEMBL3717769
   Show/Hide
C19H22F5N5
  1
1
IC50 = 611 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0252750
 Compound Info 
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)pyrrolidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C21H26N6O
  1
1
IC50 = 632 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398650
 Compound Info 
[3-[2-methyl-6-[(5-methyl-1,3-thiazol-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C21H23N5OS
  1
1
IC50 = 641 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0313241
 Compound Info 
2-[[1-cyclopentyl-5-(oxolan-3-yl)pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C18H21N5O
  1
1
IC50 = 698 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0345783
 Compound Info 
2-[[1-(3,3-difluorocyclopentyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H26F2N6O
  1
1
IC50 = 721 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069318
 Compound Info 
[3-[2-methyl-6-[(4-methylpyridin-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C23H25N5O
  1
1
IC50 = 767 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0456375
 Compound Info 
CHEMBL4127238
   Show/Hide
C21H26F3N5O2
  1
1
IC50 = 829 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0555734
 Compound Info 
CHEMBL3715469
   Show/Hide
C20H27N5O2
  1
1
IC50 = 873 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0116369
 Compound Info 
2-[[6-(1-benzoylpiperidin-3-yl)-2-methylpyrimidin-4-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C23H22N6O
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0557876
 Compound Info 
[3-[6-[(4-methoxypyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C23H25N5O2
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210720
 Compound Info 
CHEMBL3717627
   Show/Hide
C20H25F2N5O
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0429459
 Compound Info 
[3-[2-methyl-6-[(4-propan-2-ylpyridin-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C25H29N5O
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0538684
 Compound Info 
CHEMBL4127922
   Show/Hide
C18H20F3N5O2
  1
1
IC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0206891
 Compound Info 
2-[[1-(cyclobutylmethyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H28N6O
  1
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0089908
 Compound Info 
2-[[6-methyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C20H23N5O
  1
1
IC50 = 1600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0088423
 Compound Info 
3-chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine
   Show/Hide
C19H26ClN5O
  1
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0550383
 Compound Info 
CHEMBL4126530
   Show/Hide
C18H20F3N5O
  1
1
IC50 = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0088424
 Compound Info 
5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
   Show/Hide
C20H26F3N5O
  1
1
IC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0332421
 Compound Info 
3-fluoro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
   Show/Hide
C21H26FN5O
  1
1
IC50 = 2800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0318746
 Compound Info 
2-[[4-cyclopropyl-5-[1-(oxetan-3-yl)piperidin-4-yl]-1,3-thiazol-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C20H23N5OS
  1
1
IC50 = 8600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0023938
 Compound Info 
CHEMBL3715238
   Show/Hide
C21H24F3N5O
  1
1 Ki = 0.17 nM
CP0557875
 Compound Info 
2-[[6-cyclobutyloxy-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C23H27N5O2
  1
1 Ki = 0.2 nM
CP0069320
 Compound Info 
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C23H26F2N6O
  1
1 Ki < 0.5 nM
CP0280018
 Compound Info 
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)azetidin-3-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C21H22F2N6O
  1
1 Ki = 0.7 nM
CP0069314
 Compound Info 
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-(oxan-4-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C20H21F2N5O
  1
1 Ki = 0.9 nM
CP0090025
 Compound Info 
1-[4-[2-(3,3-difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyridin-4-yl]piperidin-1-yl]ethanone
   Show/Hide
C22H24F5N5O
  1
1 Ki = 1 nM
CP0310455
 Compound Info 
2-[[6-cyclopropyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H25N5O
  1
1 Ki = 1 nM
CP0116207
 Compound Info 
CHEMBL3717769
   Show/Hide
C19H22F5N5
  1
1 Ki = 1 nM
CP0224284
 Compound Info 
CHEMBL3718522
   Show/Hide
C19H19F6N5O
  1
1 Ki = 1.6 nM
CP0016719
 Compound Info 
CHEMBL3719135
   Show/Hide
C20H24F3N5O2
  1
1 Ki = 1.9 nM
CP0090027
 Compound Info 
2-(3,3-difluoropyrrolidin-1-yl)-6-piperidin-4-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
   Show/Hide
C19H21F5N6
  1
1 Ki = 2 nM
CP0390422
 Compound Info 
5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
   Show/Hide
C22H26F3N5O
  1
1 Ki = 2.3 nM
CP0133222
 Compound Info 
CHEMBL3717481
   Show/Hide
C20H24F3N5O
  1
1 Ki = 2.7 nM
CP0261263
 Compound Info 
3-methyl-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
   Show/Hide
C22H29N5O
  1
1 Ki = 3.7 nM
CP0429459
 Compound Info 
[3-[2-methyl-6-[(4-propan-2-ylpyridin-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C25H29N5O
  1
1 Ki = 4 nM
CP0334594
 Compound Info 
2-[[4-(4-cyanooxan-4-yl)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C21H20F2N6O
  1
1 Ki = 5 nM
CP0338914
 Compound Info 
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C18H19F2N5O
  1
1 Ki = 5 nM
CP0122104
 Compound Info 
CHEMBL3718265
   Show/Hide
C19H22F3N5O
  1
1 Ki = 5.6 nM
CP0090028
 Compound Info 
6-piperidin-3-yl-2-pyrrolidin-1-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
   Show/Hide
C19H23F3N6
  1
1 Ki = 7 nM
CP0116367
 Compound Info 
2-(3,3-difluoropyrrolidin-1-yl)-6-piperidin-3-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
   Show/Hide
C19H21F5N6
  1
1 Ki = 7 nM
CP0555734
 Compound Info 
CHEMBL3715469
   Show/Hide
C20H27N5O2
  1
1 Ki = 7.4 nM
CP0069301
 Compound Info 
2-[[6-(3-methoxyazetidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C23H28N6O2
  1
1 Ki = 8 nM
CP0338913
 Compound Info 
2-[[6-(azetidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H26N6O
  1
1 Ki = 8 nM
CP0074414
 Compound Info 
CHEMBL3714987
   Show/Hide
C20H25F2N5O2
  1
1 Ki = 8 nM
CP0122103
 Compound Info 
CHEMBL3714822
   Show/Hide
C22H26F3N5O
  1
1 Ki = 8.1 nM
CP0538682
 Compound Info 
CHEMBL3716231
   Show/Hide
C20H26F3N5O
  1
1 Ki = 9.4 nM
CP0350211
 Compound Info 
2-[[4-(2-cyanopropan-2-yl)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C19H18F2N6
  1
1 Ki = 14 nM
CP0552789
 Compound Info 
3-chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
   Show/Hide
C21H26ClN5O
  1
1 Ki = 15 nM
CP0310487
 Compound Info 
[3-[6-[(4-cyclopropylpyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C25H27N5O
  1
1 Ki = 18 nM
CP0429458
 Compound Info 
2-[[6-ethyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C21H25N5O
  1
1 Ki = 18 nM
CP0116371
 Compound Info 
[3-[2-methyl-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C23H22F3N5O
  1
1 Ki = 24 nM
CP0252750
 Compound Info 
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)pyrrolidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C21H26N6O
  1
1 Ki = 25 nM
CP0069316
 Compound Info 
1-[4-[2-(3,3-difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]ethanone
   Show/Hide
C21H23F5N6O
  1
1 Ki = 33 nM
CP0398650
 Compound Info 
[3-[2-methyl-6-[(5-methyl-1,3-thiazol-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C21H23N5OS
  1
1 Ki = 35 nM
CP0210720
 Compound Info 
CHEMBL3717627
   Show/Hide
C20H25F2N5O
  1
1 Ki = 35 nM
CP0387150
 Compound Info 
2-(3,3-difluoropyrrolidin-1-yl)-6-(oxan-4-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine
   Show/Hide
C19H20F5N5O
  1
1 Ki = 41 nM
CP0024698
 Compound Info 
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H28N6O
  1
1 Ki = 42 nM
CP0345783
 Compound Info 
2-[[1-(3,3-difluorocyclopentyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H26F2N6O
  1
1 Ki = 48 nM
CP0345784
 Compound Info 
2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)azetidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C20H24N6O
  1
1 Ki = 48 nM
CP0313241
 Compound Info 
2-[[1-cyclopentyl-5-(oxolan-3-yl)pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C18H21N5O
  1
1 Ki = 54 nM
CP0557876
 Compound Info 
[3-[6-[(4-methoxypyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C23H25N5O2
  1
1 Ki = 57 nM
CP0069318
 Compound Info 
[3-[2-methyl-6-[(4-methylpyridin-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone
   Show/Hide
C23H25N5O
  1
1 Ki = 85 nM
CP0116369
 Compound Info 
2-[[6-(1-benzoylpiperidin-3-yl)-2-methylpyrimidin-4-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C23H22N6O
  1
1 Ki = 90 nM
CP0089908
 Compound Info 
2-[[6-methyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C20H23N5O
  1
1 Ki = 93 nM
CP0332421
 Compound Info 
3-fluoro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine
   Show/Hide
C21H26FN5O
  1
1 Ki = 96 nM
CP0206891
 Compound Info 
2-[[1-(cyclobutylmethyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C22H28N6O
  1
1 Ki = 133 nM
CP0304367
 Compound Info 
3-methoxy-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine
   Show/Hide
C20H29N5O2
  1
1 Ki = 140 nM
CP0088424
 Compound Info 
5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine
   Show/Hide
C20H26F3N5O
  1
1 Ki = 150 nM
CP0318746
 Compound Info 
2-[[4-cyclopropyl-5-[1-(oxetan-3-yl)piperidin-4-yl]-1,3-thiazol-2-yl]amino]pyridine-4-carbonitrile
   Show/Hide
C20H23N5OS
  1
1 Ki = 569 nM
CP0088423
 Compound Info 
3-chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine
   Show/Hide
C19H26ClN5O
  1
1 Ki = 1000 nM
CP0332420
 Compound Info 
3-methyl-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine
   Show/Hide
C20H29N5O
  1
1 Ki > 1000 nM