Brief Information of the Compound and Protein
Compound Name
2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-(oxan-4-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile
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PubChem ID
CID: 90067507
Canonical SMILES
FC1(F)CCN(C1)c1cc(cc(Nc2cc(ccn2)C#N)n1)C1CCOCC1
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Compound Formula C20H21F2N5O
Compound Structure
Protein Name
Mitogen-activated protein kinase kinase kinase 12
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
Uniprot ID
Q12852
Gene Name
MAP3K12
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.9 nM