General Information of the Protein
Protein ID
PT01727
Protein Name
3',5'-cyclic-AMP phosphodiesterase 4C
Secondarily
Protein Name
DPDE1
PDE21
cAMP-specific phosphodiesterase 4C
Gene Name
PDE4C
Secondarily
Gene Name
DPDE1
Sequence
MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 4
>
Phosphodiesterase 4C
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
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Uniprot ID
Primary ID:
Q08493

Secondarily ID:
B3KTC4
Q9UN44
Q9UN45
Q9UN46
Q9UPJ6
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Ensembl ID
ENSG00000105650
HGNC ID
HGNC:8782
Subcellular Location
Cell projection
Cilium
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0015304
 Compound Info 
2-cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one
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C30H38N6O4
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0037308
 Compound Info 
(R,S)-Rolipram
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C16H21NO3
  7
1 IC50 = 118 nM
2 IC50 = 640 nM
3 IC50 = 1258 nM
4 IC50 = 2630 nM
5 IC50 = 3410 nM
6 IC50 = 3690 nM
7 IC50 = 59000 nM
CP0069130
 Compound Info 
(Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3-yl)-2-methyl-propan-1-one
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C14H18N2O
  1
1 IC50 = 239 nM
Clinical Information about the Protein
Target 1 ( Phosphodiesterase 4C (PDE4C) )
Target Type Patented-recorded Target