General Information of the Protein
Protein ID
PT01728
Protein Name
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
Secondarily
Protein Name
HCP1
TM22
cAMP-specific phosphodiesterase 7A
Gene Name
PDE7A
Sequence
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 7
>
Phosphodiesterase 7A
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:8389765, PubMed:9195912, PubMed:19350606). May have a role in muscle signal transduction (PubMed:9195912).
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Uniprot ID
Primary ID:
Q13946

Secondarily ID:
A0AVH6
A8K436
A8K9G5
O15380
Q96T72
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Ensembl ID
ENSG00000205268
HGNC ID
HGNC:8791
Subcellular Location
Cytoplasm
Cytosol
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0545787
 Compound Info 
2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-pyridin-2-yl]-4-pyridin-3-yl-2H-phthalazin-1-one; hydrochloride
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C34H30N4O5
  1
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000116 , MOLT-4
 Cell Line Info 
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0083426
 Compound Info 
N,N,2-trimethyl-5-nitrobenzenesulfonamide
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C9H12N2O4S
  3
1 IC50 = 90 nM
2 IC50 = 2100 nM
3 IC50 = 2320 nM
CP0223616
 Compound Info 
N-[4-(5-cyclohexylimino-4-methyl-1,3,4-thiadiazol-2-yl)phenyl]acetamide
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C17H22N4OS
  1
1 IC50 = 140 nM
CP0059743
 Compound Info 
1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
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C10H14N4O2
  1
1 IC50 = 85600 nM
Clinical Information about the Protein
Target 1 ( Phosphodiesterase 7A (PDE7A) )
Target Type Discontinued Target