2-tert-butyl-N-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-1,3-thiazole-5-carboxamide

3-tert-butyl-N-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]pyrrolidine-1-carboxamide

2-tert-butyl-N-[[2-methyl-4-[2-(pyridin-4-ylamino)pyrimidin-4-yl]phenyl]methyl]-1,3-thiazole-5-carboxamide

N-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-(2-methylpropyl)azetidine-1-carboxamide

US10894048, Ref. Ex Comp. 1

IBRUTINIB

1-(2-fluoro-6-pyrrolidin-1-ylphenyl)-3-[3-[(2R)-1-(2-hydroxyethyl)-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl]urea

N-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxyazetidine-1-carboxamide

2-[4-(2-fluorophenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

2-tert-butyl-N-[[2-methyl-4-[2-[(3-methyl-1,2-oxazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-1,3-thiazole-5-carboxamide

N-[[4-(2-anilinopyrimidin-4-yl)-2-methylphenyl]methyl]-2-tert-butyl-1,3-thiazole-5-carboxamide

N-[3-[2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]-6,7-dioxo-5-propan-2-ylpteridin-8-yl]phenyl]prop-2-enamide

3-amino-5-[4-[[4-(4-chlorophenyl)pyridin-2-yl]carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

2-(4-(2-fluorophenoxy)phenyl)-7-(1-propioloylpyrrolidin-3-yl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide

3-tert-butyl-N-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]cyclopentane-1-carboxamide

5-tert-butyl-N-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-1,3,4-thiadiazole-2-carboxamide

2-tert-butyl-N-[[2-methyl-4-[2-[(1-methylpyrazol-3-yl)amino]pyrimidin-4-yl]phenyl]methyl]-1,3-thiazole-5-carboxamide

US9447106, 27b (peak 2)

N-[3-[2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6,7-dioxo-5-propan-2-ylpteridin-8-yl]phenyl]prop-2-enamide

3-amino-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]-5-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazole-4-carboxamide

2-(4-phenoxyphenyl)-7-(1-propioloylpyrrolidin-3-yl)-1Himidazo[1,2-b]pyrazole-3-carboxamide

2-tert-butyl-N-[[2-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]-1,3-thiazole-5-carboxamide

2-(4-phenoxyphenyl)-7-(1-prop-2-ynoylazetidin-3-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[3-[[2-(4-morpholin-4-ylanilino)-5-pyridin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide

3-amino-5-[4-[(4-bromopyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

2-[4-(4-fluorophenoxy)phenyl]-7-(1-prop-2-ynoylazetidin-3-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

CHEMBL4878090

4-tert-butyl-N-[[2-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide

3-amino-5-[4-[[4-(4-fluorophenyl)pyridin-2-yl]carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-5-[4-[(4-phenylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

N-[3-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6,7-dioxo-5H-pteridin-8-yl]phenyl]prop-2-enamide

2-[4-(4-methoxyphenoxy)phenyl]-7-(1-prop-2-ynoylazetidin-3-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[[4-(2-aminopyrimidin-4-yl)-2-methylphenyl]methyl]-2-tert-butyl-1,3-thiazole-5-carboxamide

3-amino-5-[4-[(4-iodopyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

2-[4-(4-methylphenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

2-[4-(2,4-difluorophenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

CHEMBL4856592

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazole-4-carboxamide

2-[4-(4-bromophenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

2-(4-(2-methoxyphenoxy)phenyl)-7-(1-propioloylpyrrolidin-3-yl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide

2-(4-phenoxyphenyl)-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[3-[3-[(2-chloro-6-fluorophenyl)methylamino]-1H-1,2,4-triazol-5-yl]phenyl]prop-2-enamide

N-[3-[[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-[6-(methylamino)pyrazin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide

(R)-1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-(pyrrolidin-1-yl)phenyl)urea

N-[[4-(6-aminopyrimidin-4-yl)-2-methylphenyl]methyl]-2-tert-butyl-1,3-thiazole-5-carboxamide

3-amino-5-[4-[(4-methoxypyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

2-tert-butyl-N-[[2-methyl-4-[2-[(1-methyltriazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-1,3-thiazole-5-carboxamide

3-amino-5-[4-[(4-ethylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-ynoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-5-[4-[[4-(4-cyanophenyl)pyridin-2-yl]carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-iodopyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

3-amino-5-[4-[(4-chloropyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-5-[4-[(4-ethylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

2-(4-(4-methoxyphenoxy)phenyl)-7-(1-propioloylpyrrolidin-3-yl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[3-[2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-6,7-dioxo-5-propan-2-ylpteridin-8-yl]phenyl]prop-2-enamide

3-amino-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]-5-[4-(pyridin-2-ylcarbamoyl)phenyl]imidazole-4-carboxamide

2-[4-(2-methoxyphenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

2-[4-(3-fluorophenoxy)phenyl]-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[[4-(4-fluorophenyl)pyridin-2-yl]carbamoyl]phenyl]imidazole-4-carboxamide

2-[4-(2-fluorophenoxy)phenyl]-7-(1-prop-2-enoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[[4-(4-chlorophenyl)pyridin-2-yl]carbamoyl]phenyl]imidazole-4-carboxamide

4-tert-butyl-N-[[2-ethyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-phenylpyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

3-amino-5-[4-[(4-cyanopyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

N-[3-[5-ethyl-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6,7-dioxopteridin-8-yl]phenyl]prop-2-enamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-ethylpyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

3-amino-5-[4-[(4-methylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-5-[4-[(5-methylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]-5-[4-(1,3-thiazol-2-ylcarbamoyl)phenyl]imidazole-4-carboxamide

3-amino-5-[4-[(4-ethylpyridin-2-yl)carbamoyl]phenyl]-2-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazole-4-carboxamide

2-(4-phenoxyphenyl)-7-(1-prop-2-enoylazetidin-3-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-chloropyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-(pyrrolidin-1-yl)phenyl)urea

2-methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide

N-[3-[2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxyanilino]-6,7-dioxo-5-propan-2-ylpteridin-8-yl]phenyl]prop-2-enamide

N-[3-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6,7-dioxo-5-propylpteridin-8-yl]phenyl]prop-2-enamide

3-amino-5-[4-[(4-propan-2-ylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-5-[4-[(4-bromopyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[[4-(4-cyanophenyl)pyridin-2-yl]carbamoyl]phenyl]imidazole-4-carboxamide

ACP-196

1-[(3R)-3-[[2-[4-(4-ethylpiperazin-1-yl)anilino]-5-[6-(methylamino)pyrazin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidin-1-yl]prop-2-en-1-one

7-(1-but-2-ynoylpiperidin-4-yl)-2-[4-(2-fluorophenoxy)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-5-[4-[(5-chloropyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

N-[3-[2-[4-[2-(dimethylamino)ethoxy]-2-methoxyanilino]-6,7-dioxo-5-propan-2-ylpteridin-8-yl]phenyl]prop-2-enamide

2-tert-butyl-N-[[2-methyl-4-[2-(pyridin-2-ylamino)pyrimidin-4-yl]phenyl]methyl]-1,3-thiazole-5-carboxamide

CHEMBL4856208

1-[(3R)-3-[[5-[6-(methylamino)pyrazin-2-yl]-2-(4-morpholin-4-ylanilino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidin-1-yl]prop-2-en-1-one

1-[4-[[5-[2-(methylamino)pyridin-4-yl]-2-(4-morpholin-4-ylanilino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidin-1-yl]prop-2-en-1-one

3-amino-5-[4-[(4-ethylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpyrrolidin-2-yl]imidazole-4-carboxamide

2-tert-butyl-N-[[2-methyl-4-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)amino]pyrimidin-4-yl]phenyl]methyl]-1,3-thiazole-5-carboxamide

7-[1-[(E)-4-(dimethylamino)but-2-enoyl]piperidin-4-yl]-2-(4-phenoxyphenyl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[2-(3-aminoanilino)pyrimidin-5-yl]-2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide

3-amino-5-[4-[(5-fluoro-4-methylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-cyanopyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

N-[3-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6,7-dioxo-5-propan-2-ylpteridin-8-yl]phenyl]prop-2-enamide

CHEMBL4863078

2-[4-(2,4-difluorophenoxy)phenyl]-7-(1-prop-2-enoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[4-methyl-3-[[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]carbamoyl]phenyl]isoquinoline-6-carboxamide

N-[4-methyl-3-[[2-[3-[(1-prop-2-enoylpiperidin-4-yl)amino]anilino]pyrimidin-5-yl]carbamoyl]phenyl]isoquinoline-6-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-methylpyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

2-[4-(3-fluorophenoxy)phenyl]-7-(1-prop-2-enoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

2-[4-(2-methoxyphenoxy)phenyl]-7-(1-prop-2-enoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

7-(1-but-2-ynoylpiperidin-4-yl)-2-[4-(2-methoxyphenoxy)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[3-[[2-[3-[[1-(2-fluoroacetyl)piperidin-4-yl]amino]anilino]pyrimidin-5-yl]carbamoyl]-4-methylphenyl]isoquinoline-6-carboxamide

N-[3-[[2-(3-aminoanilino)pyrimidin-5-yl]carbamoyl]-4-methylphenyl]-6-methoxynaphthalene-2-carboxamide

7-(1-but-2-ynoylpiperidin-4-yl)-2-[4-(2,4-difluorophenoxy)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[3-[[2-(3-aminoanilino)pyrimidin-5-yl]carbamoyl]-4-methylphenyl]naphthalene-2-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(4-methoxypyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

2-(4-phenoxyphenyl)-7-[4-(prop-2-ynoylamino)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

2-[4-(4-bromophenoxy)phenyl]-7-(1-prop-2-enoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-5-[4-[(4-ethylpyridin-2-yl)carbamoyl]phenyl]-2-(2-prop-2-enoyl-2-azaspiro[3.3]heptan-6-yl)imidazole-4-carboxamide

5-(1,3-benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amine

4-tert-butyl-N-[[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-(trifluoromethyl)phenyl]methyl]benzamide

4-(4-phenoxyphenyl)-11-prop-2-enoyl-3,6,7,11-tetrazatricyclo[6.4.0.02,6]dodeca-1(8),2,4-triene-5-carboxamide

7-(1-but-2-ynoylpiperidin-4-yl)-2-[4-(4-methylphenoxy)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-cyclopentylphenyl)urea

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-(pyridin-2-ylcarbamoyl)phenyl]imidazole-4-carboxamide

2-(4-(4-fluorophenoxy)phenyl)-7-(1-propioloylpyrrolidin-3-yl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide

7-[1-[(E)-pent-2-enoyl]piperidin-4-yl]-2-(4-phenoxyphenyl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-chlorophenyl)urea

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(5-fluoro-4-methylpyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

2-[4-(4-methylphenoxy)phenyl]-7-(1-prop-2-enoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-2-[(2S)-1-but-2-ynoylpiperidin-2-yl]-5-[4-[(5-methylpyridin-2-yl)carbamoyl]phenyl]imidazole-4-carboxamide

7-(1-acryloylpyrrolidin-3-yl)-2-(4-phenoxyphenyl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-tert-butylphenyl)urea

4-tert-butyl-N-[[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide

N-[3-[[2-(3-aminoanilino)pyrimidin-5-yl]carbamoyl]-4-methylphenyl]-6-bromonaphthalene-2-carboxamide

7-(1-acryloylpyrrolidin-3-yl)-2-(4-(2-fluorophenoxy)phenyl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide

2-[4-(4-methoxyphenoxy)phenyl]-7-(1-prop-2-enoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[(2-chloro-6-fluorophenyl)methyl]-5-(3,4-dimethoxyphenyl)-1H-1,2,4-triazol-3-amine

7-(1-but-2-ynoylazetidin-3-yl)-2-[4-(4-methoxyphenoxy)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

2-[4-(4-bromophenoxy)phenyl]-7-(1-but-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

7-(1-but-2-ynoylpiperidin-4-yl)-2-[4-(4-methoxyphenoxy)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-2-[(1-prop-2-enoylpiperidin-4-yl)methyl]-5-[4-(pyridin-2-ylcarbamoyl)phenyl]imidazole-4-carboxamide

3-amino-2-[(2S)-1-prop-2-enoylpyrrolidin-2-yl]-5-[4-(pyridin-2-ylcarbamoyl)phenyl]imidazole-4-carboxamide

7-(1-but-2-ynoylazetidin-3-yl)-2-(4-phenoxyphenyl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-cyclopropylphenyl)urea

N-[3-[[2-[3-[[1-[(E)-4-(dimethylamino)but-2-enoyl]piperidin-4-yl]amino]anilino]pyrimidin-5-yl]carbamoyl]-4-methylphenyl]isoquinoline-6-carboxamide

3-amino-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]-5-[4-(pyridazin-3-ylcarbamoyl)phenyl]imidazole-4-carboxamide

N-[3-[[2-(3-aminoanilino)pyrimidin-5-yl]carbamoyl]-4-methylphenyl]-6-hydroxynaphthalene-2-carboxamide

1-amino-2-(4-phenoxyphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)imidazo[1,2-b]pyrazole-3-carboxamide

2-(4-phenoxyphenyl)-7-[3-(prop-2-enoylamino)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-5-[4-[(4-ethylpyridin-2-yl)carbamoyl]phenyl]-2-[(2S)-1-prop-2-enoylazepan-2-yl]imidazole-4-carboxamide

N-[2-(3-aminoanilino)pyrimidin-5-yl]-2-methyl-5-[(3-pyridin-3-ylbenzoyl)amino]benzamide

N-[3-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5-methyl-6,7-dioxopteridin-8-yl]phenyl]prop-2-enamide

N-[2-(3-aminoanilino)pyrimidin-5-yl]-2-methyl-5-[(4-phenylbenzoyl)amino]benzamide

1-[(3R)-3-[[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-[6-(methylamino)pyrazin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidin-1-yl]prop-2-en-1-one

N-[(2-chloro-6-fluorophenyl)methyl]-5-[3-(methylamino)phenyl]-1H-1,2,4-triazol-3-amine

1-[(2R)-2-[[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-[6-(methylamino)pyrazin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]pyrrolidin-1-yl]prop-2-en-1-one

N-[3-[[2-(3-aminoanilino)pyrimidin-5-yl]carbamoyl]-4-methylphenyl]anthracene-2-carboxamide

5-(3-amino-4-methoxyphenyl)-N-[(2-chloro-6-fluorophenyl)methyl]-1H-1,2,4-triazol-3-amine

5-[[2-(1-adamantyl)acetyl]amino]-N-[2-(3-aminoanilino)pyrimidin-5-yl]-2-methylbenzamide

7-(1-(but-2-ynoyl)pyrrolidin-3-yl)-2-(4-phenoxyphenyl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[2-(3-aminoanilino)pyrimidin-5-yl]-5-[[3-(furan-2-yl)benzoyl]amino]-2-methylbenzamide

N-[4-methyl-3-[[2-[3-[3-(prop-2-enoylamino)propanoylamino]anilino]pyrimidin-5-yl]carbamoyl]phenyl]isoquinoline-6-carboxamide

(S)-1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-phenylurea

N-[3-[[2-(3-aminoanilino)pyrimidin-5-yl]carbamoyl]-4-methylphenyl]isoquinoline-6-carboxamide

11-[(E)-4-(dimethylamino)but-2-enoyl]-4-(4-phenoxyphenyl)-3,6,7,11-tetrazatricyclo[6.4.0.02,6]dodeca-1(8),2,4-triene-5-carboxamide

N-[3-[[2-(3-aminoanilino)pyrimidin-5-yl]carbamoyl]-4-methylphenyl]quinoline-6-carboxamide

7-(1-but-2-ynoylpiperidin-4-yl)-2-[4-(4-fluorophenoxy)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

1-[(2S)-2-[[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-[6-(methylamino)pyrazin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]pyrrolidin-1-yl]prop-2-en-1-one

benzyl N-[3-[[2-(3-aminoanilino)pyrimidin-5-yl]carbamoyl]-4-methylphenyl]carbamate

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-(trifluoromethyl)phenyl)urea

2-[4-(4-fluorophenoxy)phenyl]-7-(1-prop-2-enoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-fluorophenyl)urea

7-(1-but-2-ynoylazetidin-3-yl)-2-[4-(4-fluorophenoxy)phenyl]-5H-imidazo[1,2-b]pyrazole-3-carboxamide

N-[2-(3-aminoanilino)pyrimidin-5-yl]-5-[[3-(6-fluoropyridin-3-yl)benzoyl]amino]-2-methylbenzamide

5-(3-aminophenyl)-N-[(2-chloro-6-fluorophenyl)methyl]-1H-1,2,4-triazol-3-amine

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenyl)-3-(2-(piperidin-1-yl)phenyl)urea

7-(1-(but-2-ynoyl)pyrrolidin-3-yl)-2-(4-(4-methoxyphenoxy)phenyl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide

3-amino-5-[4-(phenylcarbamoyl)phenyl]-2-[(2S)-1-prop-2-enoylpiperidin-2-yl]imidazole-4-carboxamide

7-(1-(but-2-ynoyl)pyrrolidin-3-yl)-2-(4-(2-fluorophenoxy)phenyl)-1H-imidazo[1,2-b]pyrazole-3-carboxamide