General Information of the Protein
Protein ID
PT01327
Protein Name
Sterol O-acyltransferase 1
Secondarily
Protein Name
Acyl-coenzyme A:cholesterol acyltransferase 1
Cholesterol acyltransferase 1
Gene Name
SOAT1
Secondarily
Gene Name
ACACT
ACACT1
ACAT
ACAT1
SOAT
STAT
Sequence
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:9020103, PubMed:32433614, PubMed:32433613, PubMed:32944968). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614).
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Uniprot ID
Primary ID:
P35610

Secondarily ID:
A6NC40
A8K3P4
A9Z1V7
B4DU95
Q5T0X4
Q8N1E4
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Ensembl ID
ENSG00000057252
HGNC ID
HGNC:11177
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000582 , AC29
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0844807
 Compound Info 
(R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl 3-methylbutanoate
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C21H24O6
  1
1
IC50 = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000023 , BTI-Tn-5B1-4
 Cell Line Info 
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Cell Line ID: CL000063 , Hep-G2
 Cell Line Info 
Cell Line ID: CL000188 , J774A1
 Cell Line Info 
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Cell Line ID: CL000040 , THP-1
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0034055
 Compound Info 
(Z)-Octadec-9-enoic acid phenylamide
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C24H39NO
  2
1 IC50 = 140 nM
2 IC50 = 170 nM
CP0275514
 Compound Info 
1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl]-3,5-dimethyl-1H-pyrazole
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C25H28N4OS
  1
1 IC50 = 300 nM
CP0688800
 Compound Info 
2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)-ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)-pyridin-3-yl)acetamide hydrochloride
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C23H31ClN6OS3
  1
1 IC50 = 450 nM
CP0761592
 Compound Info 
Pyripyropene A
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C31H35NO10
  2
1 IC50 = 640 nM
2 IC50 > 80000 nM
CP0186602
 Compound Info 
[(1S,2S,5S,6R,7R,9S,10S,18R)-5-acetyloxy-6-(acetyloxymethyl)-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-9-yl] 4-cyanobenzoate
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C37H38N2O10
  1
1 IC50 = 4160 nM
CP0257977
 Compound Info 
2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide
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C23H39NO4
  1
1 IC50 = 4200 nM
CP0088062
 Compound Info 
2-[7-(2,2-dimethylpropanoylamino)-4,6-dimethyl-1-octyl-2,3-dihydroindol-5-yl]acetic acid
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C25H40N2O3
  1
1 IC50 = 4900 nM
CP0285941
 Compound Info 
1-(3,4-Dimethoxy-phenyl)-2-[4-((2S,3R,4R,5S)-5-{4-[2-(3,4-dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-3-methoxy-phenyl}-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenoxy]-propan-1-ol
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C42H52O11
  1
1 IC50 = 8000 nM
CP0088064
 Compound Info 
2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)acetylsulfamate
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C29H43NO4S
  1
1 IC50 = 23500 nM
CP0129375
 Compound Info 
N-(2-phenylphenyl)octanamide
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C20H25NO
  1
1 IC50 = 61000 nM
CP0229844
 Compound Info 
N-(2-phenylphenyl)nonanamide
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C21H27NO
  1
1 IC50 = 65000 nM
CP0193230
 Compound Info 
2-(4-{(2S,3R,4R,5S)-5-[4-(2-Benzo[1,3]dioxol-5-yl-2-hydroxy-1-methyl-ethoxy)-3-methoxy-phenyl]-3,4-dimethyl-tetrahydro-furan-2-yl}-2-methoxy-phenoxy)-1-(3,4-dimethoxy-phenyl)-propan-1-ol
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C41H48O11
  1
1 IC50 = 82000 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT06252 Sterol O-acyltransferase 1 Chlorocebus aethiops, Green monkey, Cercopithecus aethiops
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT03513 Sterol O-acyltransferase 1 Mus musculus, Mouse
 Protein Info