General Information of the Protein
Protein ID
PT03513
Protein Name
Sterol O-acyltransferase 1
Secondarily
Protein Name
Acyl-coenzyme A:cholesterol acyltransferase 1
Cholesterol acyltransferase 1
Gene Name
SOAT1
Secondarily
Gene Name
Acact
Sequence
MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVGCHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLDELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWAMFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPPASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRDNYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Transferase
Function
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions.
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Uniprot ID
Primary ID:
Q61263

Secondarily ID:
Q5XK32
Q64180
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Ensembl ID
ENSG00000057252
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000876 , IC-21
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0088064
 Compound Info 
2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)acetylsulfamate
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C29H43NO4S
  2
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 760 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000158 , J774
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01327 Sterol O-acyltransferase 1 Homo sapiens, Human
 Protein Info 
PT06252 Sterol O-acyltransferase 1 Chlorocebus aethiops, Green monkey, Cercopithecus aethiops
 Protein Info