General Information of the Protein
Protein ID
PT02512
Protein Name
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Gene Name
PDE10A
Sequence
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPATSKSTSEKPTRKVDD
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Organism
Rattus norvegicus, Rat
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 10
>
Phosphodiesterase 10A
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
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Uniprot ID
Primary ID:
Q9QYJ6

Secondarily ID:
Q6S9E6
Q6S9E7
Q6S9E8
Q6S9E9
Q9QYJ5
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Ensembl ID
ENSG00000112541
Subcellular Location
Cytoplasm
Cytosol
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0046376
 Compound Info 
PF-2545920
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C25H20N4O
  2
1
IC50 = 0.5012 nM
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2
IC50 = 0.6457 nM
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CP0880529
 Compound Info 
2-[4-[1-(2-[18F]-fluoroethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]-phenoxymethyl]-quinoline
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C26H21FN4O
  1
1
IC50 = 0.5012 nM
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CP0168595
 Compound Info 
2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-3,5-dimethylpyridine
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C24H23FN4O
  1
1
IC50 = 1.585 nM
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CP0399327
 Compound Info 
2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-6-methylpyridine
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C23H21FN4O
  1
1
IC50 = 2.512 nM
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CP0105098
 Compound Info 
2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-5-methoxypyridine
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C23H21FN4O2
  1
1
IC50 = 3.162 nM
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CP0452191
 Compound Info 
2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-6-methoxypyridine
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C23H21FN4O2
  1
1
IC50 = 3.162 nM
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CP0419876
 Compound Info 
2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-3-methoxypyridine
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C23H21FN4O2
  1
1
IC50 = 3.981 nM
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CP0500207
 Compound Info 
2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-3,4,5-trimethylpyridine
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C25H25FN4O
  1
1
IC50 = 3.981 nM
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CP0390230
 Compound Info 
7-methoxy-4-pyridin-3-yl-6-(2-quinolin-2-ylethoxy)quinazoline
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C25H20N4O2
  1
1
IC50 = 5 nM
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CP0400548
 Compound Info 
3-methoxy-2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]pyridine
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C23H19F3N4O2
  1
1
IC50 = 5.012 nM
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CP0466842
 Compound Info 
5-methoxy-2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]pyridine
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C23H19F3N4O2
  1
1
IC50 = 5.012 nM
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CP0046541
 Compound Info 
7-methoxy-6-[3-(1-methylbenzimidazol-2-yl)propoxy]-4-(3-phenylpiperidin-1-yl)quinazoline
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C31H33N5O2
  1
1
IC50 = 10 nM
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CP0399328
 Compound Info 
2-bromo-6-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine
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C22H18BrFN4O
  1
1
IC50 = 10 nM
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CP0419877
 Compound Info 
5-bromo-2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine
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C22H18BrFN4O
  1
1
IC50 = 10 nM
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CP0503248
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-quinolin-2-ylethoxy)quinazoline
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C31H30N4O2
  1
1
IC50 = 12 nM
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CP0520746
 Compound Info 
7-methoxy-3-methyl-6-(2-quinolin-2-ylethoxy)quinazolin-4-one
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C21H19N3O3
  1
1
IC50 = 12 nM
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CP0391027
 Compound Info 
2-[[4-[1-(3-fluoropropyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-3-methoxypyridine
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C24H23FN4O2
  1
1
IC50 = 12.59 nM
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CP0529500
 Compound Info 
7-methoxy-N,N-dimethyl-6-(2-quinolin-2-ylethoxy)quinazolin-4-amine
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C22H22N4O2
  1
1
IC50 = 14 nM
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CP0500206
 Compound Info 
3-fluoro-2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine
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C22H18F2N4O
  1
1
IC50 = 15.85 nM
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CP0506049
 Compound Info 
2-[[4-[1-(3-fluoropropyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-5-methoxypyridine
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C24H23FN4O2
  1
1
IC50 = 15.85 nM
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CP0233769
 Compound Info 
6-methoxy-7-(2-quinolin-2-ylethoxy)quinazoline
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C20H17N3O2
  1
1
IC50 = 17 nM
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CP0481488
 Compound Info 
1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]pyrrolidin-3-ol
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C21H20ClN5O
  1
1
IC50 = 19 nM
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CP0482193
 Compound Info 
1-(2,6-dichlorophenyl)-N-ethyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C19H15Cl2N5O
  1
1
IC50 = 19 nM
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CP0565855
 Compound Info 
1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C23H25ClN6O
  1
1
IC50 = 19 nM
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CP0452189
 Compound Info 
2-[[4-[1-(3-fluoropropyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-6-methylpyridine
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C24H23FN4O
  1
1
IC50 = 19.95 nM
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CP0490371
 Compound Info 
2-ethoxy-6-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine
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C24H23FN4O2
  1
1
IC50 = 19.95 nM
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CP0414049
 Compound Info 
N-ethyl-4-methyl-1-pyridin-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C18H16N6O
  1
1
IC50 = 21 nM
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CP0425611
 Compound Info 
1-(2-chlorophenyl)-4-methyl-N-(pyridin-2-ylmethyl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C23H17ClN6O
  1
1
IC50 = 21 nM
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CP0453340
 Compound Info 
1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]piperidin-3-ol
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C22H22ClN5O
  1
1
IC50 = 21 nM
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CP0400550
 Compound Info 
6-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine-2-carbonitrile
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C23H18FN5O
  1
1
IC50 = 31.62 nM
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CP0400551
 Compound Info 
3-bromo-2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-6-methoxypyridine
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C23H20BrFN4O2
  1
1
IC50 = 31.62 nM
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CP0440262
 Compound Info 
2-cyclopropyl-6-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine
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C25H23FN4O
  1
1
IC50 = 31.62 nM
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CP0452190
 Compound Info 
5-cyclopropyl-2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine
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C25H23FN4O
  1
1
IC50 = 31.62 nM
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CP0414199
 Compound Info 
4-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C21H20ClN5O
  1
1
IC50 = 35 nM
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CP0435545
 Compound Info 
ethyl 1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylate
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C19H15ClN4O2
  1
1
IC50 = 35 nM
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CP0477195
 Compound Info 
N-ethyl-1-(2-methoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C19H18N6O2
  1
1
IC50 = 35 nM
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CP0385742
 Compound Info 
1-(2-chlorophenyl)-8-[(4-methoxypiperidin-1-yl)methyl]-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline
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C23H24ClN5O
  1
1
IC50 = 39 nM
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CP0385743
 Compound Info 
1-(2-chlorophenyl)-4-methyl-N-(2-morpholin-4-ylethyl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C23H23ClN6O2
  1
1
IC50 = 39 nM
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CP0425609
 Compound Info 
N-ethyl-4-methyl-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C18H16N6O
  1
1
IC50 = 39 nM
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CP0435544
 Compound Info 
N-ethyl-4-methyl-1-pyridin-3-yl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C18H16N6O
  1
1
IC50 = 39 nM
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CP0481487
 Compound Info 
1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]piperidin-4-ol
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C22H22ClN5O
  1
1
IC50 = 39 nM
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CP0482195
 Compound Info 
1-(2-chlorophenyl)-4-methyl-N-(2-pyrrolidin-1-ylethyl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C23H23ClN6O
  1
1
IC50 = 39 nM
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CP0480454
 Compound Info 
4-[2-methyl-3-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C16H17F3N6O
  1
1
IC50 = 46.77 nM
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CP0425610
 Compound Info 
[1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]piperidin-3-yl]methanol
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C23H24ClN5O
  1
1
IC50 = 47 nM
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CP0481490
 Compound Info 
N-ethyl-4-methyl-1-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C19H18N6O
  1
1
IC50 = 47 nM
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CP0482192
 Compound Info 
N-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]ethanamine
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C19H18ClN5
  1
1
IC50 = 47 nM
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CP0385740
 Compound Info 
N-ethyl-4-methyl-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C19H17N5O
  1
1
IC50 = 50 nM
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CP0440871
 Compound Info 
N-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]-1-phenylmethanamine
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C24H20ClN5
  1
1
IC50 = 50 nM
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CP0447959
 Compound Info 
N-ethyl-1-(5-methoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C19H18N6O2
  1
1
IC50 = 50 nM
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CP0433377
 Compound Info 
N-benzyl-1-(2-chlorophenyl)-N,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C25H20ClN5O
  1
1
IC50 = 51 nM
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CP0482191
 Compound Info 
1-(2-chlorophenyl)-4-methyl-N-(oxan-4-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-8-amine
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C21H20ClN5O
  1
1
IC50 = 51 nM
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CP0482330
 Compound Info 
N-ethyl-1-(2-methoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C20H19N5O2
  1
1
IC50 = 51 nM
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CP0381821
 Compound Info 
1-(2-chlorophenyl)-4-methyl-N-(2-phenylethyl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C25H20ClN5O
  1
1
IC50 = 52 nM
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CP0450414
 Compound Info 
N-ethyl-1-(2-fluorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C19H16FN5O
  1
1
IC50 = 52 nM
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CP0481489
 Compound Info 
4-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]amino]cyclohexan-1-ol
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C22H22ClN5O
  1
1
IC50 = 52 nM
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CP0411633
 Compound Info 
4-[2-cyclopropyl-3-[1-(2-methoxyethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H24N6O2
  1
1
IC50 = 53.7 nM
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CP0542605
 Compound Info 
(1-methylsulfonylindol-5-yl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C20H20N6O3S
  1
1
IC50 = 54 nM
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CP0526575
 Compound Info 
4-[3-[1-[(2S)-2-methoxypropyl]pyrazol-4-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C18H24N6O2
  1
1
IC50 = 60.26 nM
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CP0480453
 Compound Info 
4-[3-[1-(cyclopropylmethyl)pyrazol-4-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C18H22N6O
  1
1
IC50 = 64.57 nM
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CP0411635
 Compound Info 
4-[3-[1-(2-methoxy-2-methylpropyl)pyrazol-4-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H26N6O2
  1
1
IC50 = 66.07 nM
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CP0425613
 Compound Info 
N-benzyl-1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C24H18ClN5O
  1
1
IC50 = 74 nM
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CP0450415
 Compound Info 
1-(2-chlorophenyl)-N-ethyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C19H16ClN5O
  1
1
IC50 = 74 nM
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CP0450478
 Compound Info 
1-(2-chlorophenyl)-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-[1,2,4]triazolo[4,3-a]quinoxaline
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C22H23ClN6
  1
1
IC50 = 74 nM
 Bioactivity Info 
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CP0490370
 Compound Info 
6-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]pyridine-3-carbonitrile
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C23H18FN5O
  1
1
IC50 = 79.43 nM
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CP0382733
 Compound Info 
3-[1-(2-methoxyethyl)pyrazol-4-yl]-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carbonitrile
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C17H19N7O2
  1
1
IC50 = 85.11 nM
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CP0481902
 Compound Info 
4-[2-cyclopropyl-3-[6-(2-methoxyethyl)pyridin-3-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C21H25N5O2
  1
1
IC50 = 97.72 nM
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CP0400549
 Compound Info 
2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-5-(trifluoromethyl)pyridine
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C23H18F4N4O
  1
1
IC50 = 100 nM
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CP0517900
 Compound Info 
2-[[4-[1-(2-fluoroethyl)-4-pyridin-4-ylpyrazol-3-yl]phenoxy]methyl]-6-(trifluoromethyl)pyridine
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C23H18F4N4O
  1
1
IC50 = 100 nM
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CP0535017
 Compound Info 
[3-(2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C21H25N5OS
  1
1
IC50 = 100 nM
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CP0535019
 Compound Info 
1-[5-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carbonyl]indol-1-yl]ethanone
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C21H20N6O2
  1
1
IC50 = 100 nM
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CP0549711
 Compound Info 
4-[2-methyl-3-[1-(pyridin-4-ylmethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C20H21N7O
  1
1
IC50 = 102.33 nM
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CP0511167
 Compound Info 
4-[2-methyl-3-[2-(2-methylpropyl)-1,3-thiazol-5-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C18H23N5OS
  1
1
IC50 = 104.71 nM
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CP0398225
 Compound Info 
4-[[1-(2-chloro-5-methoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C22H22ClN5O2
  1
1
IC50 = 106 nM
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CP0498444
 Compound Info 
(1-methylsulfonylindol-5-yl)-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C20H20N6O3S
  1
1
IC50 = 107 nM
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CP0435370
 Compound Info 
4-[3-[1-(2-fluoroethyl)pyrazol-4-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C16H19FN6O
  1
1
IC50 = 112.2 nM
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CP0556577
 Compound Info 
4-[2-methyl-3-(1-propan-2-ylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C17H22N6O
  1
1
IC50 = 112.2 nM
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CP0409221
 Compound Info 
N-ethyl-4-methyl-1-(4-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
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C19H18N6O
  1
1
IC50 = 113 nM
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CP0538446
 Compound Info 
1-[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]-N,N-dimethylmethanamine
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C19H18ClN5
  1
1
IC50 = 113 nM
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CP0386831
 Compound Info 
4-[3-[6-(ethoxymethyl)pyridin-3-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H23N5O2
  1
1
IC50 = 117.49 nM
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CP0508481
 Compound Info 
5-(2-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazin-3-yl)-N-propan-2-ylpyridin-2-amine
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C19H24N6O
  1
1
IC50 = 125.89 nM
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CP0379404
 Compound Info 
4-[2-methyl-3-(6-propan-2-ylpyridin-3-yl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H23N5O
  1
1
IC50 = 134.9 nM
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CP0522983
 Compound Info 
4-[3-[6-(2-ethoxyethyl)pyridin-3-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C20H25N5O2
  1
1
IC50 = 134.9 nM
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CP0410122
 Compound Info 
4-[3-[1-[(2-chlorophenyl)methyl]pyrazol-4-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C21H21ClN6O
  1
1
IC50 = 138.04 nM
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CP0056799
 Compound Info 
4-[3-[1-(2-methoxyethyl)pyrazol-4-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C17H22N6O2
  1
1
IC50 = 141.25 nM
 Bioactivity Info 
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CP0414691
 Compound Info 
4-[3-[6-(2-methoxy-2-methylpropyl)pyridin-3-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C21H27N5O2
  1
1
IC50 = 141.25 nM
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CP0391671
 Compound Info 
4-[2-methyl-3-[1-(2-methylpropyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C18H24N6O
  1
1
IC50 = 144.54 nM
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CP0352707
 Compound Info 
6,7-dimethoxy-4-(3-phenylpiperidin-1-yl)quinazoline
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C21H23N3O2
  1
1
IC50 = 146 nM
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CP0474693
 Compound Info 
4-[2-ethyl-3-[1-(2-methoxyethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C18H24N6O2
  1
1
IC50 = 154.88 nM
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CP0379800
 Compound Info 
4-[3-[6-(3-methoxypropyl)pyridin-3-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C20H25N5O2
  1
1
IC50 = 154.88 nM
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CP0048656
 Compound Info 
4-[3-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H22N4O4
  1
1
IC50 = 158.49 nM
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CP0379804
 Compound Info 
4-[2-methyl-3-[6-(2-propan-2-yloxyethyl)pyridin-3-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C21H27N5O2
  1
1
IC50 = 169.82 nM
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CP0428851
 Compound Info 
4-[3-[6-(2-methoxyethyl)pyridin-3-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H23N5O2
  1
1
IC50 = 181.97 nM
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CP0488686
 Compound Info 
4-[2-methyl-3-[6-(2-methylpropyl)pyridin-3-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C20H25N5O
  1
1
IC50 = 181.97 nM
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CP0379802
 Compound Info 
4-[3-(6-ethylpyridin-3-yl)-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C18H21N5O
  1
1
IC50 = 190.55 nM
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CP0414692
 Compound Info 
2-[5-(2-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazin-3-yl)pyridin-2-yl]ethanol
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C18H21N5O2
  1
1
IC50 = 194.98 nM
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CP0488687
 Compound Info 
4-[3-[2-(2-methoxyethyl)pyridin-4-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H23N5O2
  1
1
IC50 = 194.98 nM
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CP0508483
 Compound Info 
4-[3-[6-(2-methoxyethoxy)pyridin-3-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H23N5O3
  1
1
IC50 = 199.53 nM
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CP0398570
 Compound Info 
4-[2-methyl-3-(6-pyrrolidin-1-ylpyridin-3-yl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C20H24N6O
  1
1
IC50 = 218.78 nM
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CP0498445
 Compound Info 
[3-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C20H23N5OS
  1
1
IC50 = 229 nM
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CP0411634
 Compound Info 
4-[2-methyl-3-[1-(quinolin-2-ylmethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C24H23N7O
  1
1
IC50 = 234.42 nM
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CP0549710
 Compound Info 
4-[3-(1-ethylpyrazol-4-yl)-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C16H20N6O
  1
1
IC50 = 234.42 nM
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CP0499785
 Compound Info 
4-[3-[6-[(3S)-3-methoxypyrrolidin-1-yl]pyridin-3-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C21H26N6O2
  1
1
IC50 = 234.42 nM
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CP0411783
 Compound Info 
4-[2-methyl-3-(6-propan-2-yloxypyridin-3-yl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H23N5O2
  1
1
IC50 = 245.47 nM
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CP0296762
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-2-ylethoxy)quinazoline
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C27H28N4O2
  1
1
IC50 = 247 nM
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CP0549709
 Compound Info 
4-[2-methoxy-3-[1-(2-methoxyethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C17H22N6O3
  1
1
IC50 = 257.04 nM
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CP0523066
 Compound Info 
4-[3-[5-(2-methoxyethyl)pyridin-2-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H23N5O2
  1
1
IC50 = 257.04 nM
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CP0419391
 Compound Info 
4-[[1-(2-chloro-5-ethoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C23H24ClN5O2
  1
1
IC50 = 266 nM
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CP0573430
 Compound Info 
4-[[1-(5-methoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C21H22N6O2
  1
1
IC50 = 271 nM
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CP0488685
 Compound Info 
4-[2-methoxy-3-[6-(2-methoxyethyl)pyridin-3-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H23N5O3
  1
1
IC50 = 275.42 nM
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CP0516962
 Compound Info 
4-[2-methyl-3-(6-piperazin-1-ylpyridin-3-yl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C20H25N7O
  1
1
IC50 = 275.42 nM
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CP0386714
 Compound Info 
4-[3-[6-(2-methoxyethyl)pyridin-3-yl]-2-(trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H20F3N5O2
  1
1
IC50 = 281.84 nM
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CP0532944
 Compound Info 
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C19H21N5OS
  1
1
IC50 = 288 nM
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CP0511166
 Compound Info 
4-[2-methyl-3-[2-(2-methylpropyl)-1,3-oxazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C18H23N5O2
  1
1
IC50 = 302 nM
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CP0490041
 Compound Info 
4-[3-[1-(2-methoxyethyl)pyrazol-4-yl]-2-(trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C17H19F3N6O2
  1
1
IC50 = 309.03 nM
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CP0516963
 Compound Info 
4-[2-methyl-3-(6-methylpyridin-3-yl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C17H19N5O
  1
1
IC50 = 309.03 nM
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CP0482864
 Compound Info 
4-[[1-(2-chloro-5-propoxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C24H26ClN5O2
  1
1
IC50 = 322 nM
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CP0433369
 Compound Info 
ethyl 4-methyl-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylate
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C19H16N4O2
  1
1
IC50 = 325 nM
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CP0419237
 Compound Info 
4-[3-(6-cyclopropylpyridin-3-yl)-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C19H21N5O
  1
1
IC50 = 338.84 nM
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CP0463133
 Compound Info 
4-[3-[6-(2-methoxyethyl)pyridin-3-yl]-2-propan-2-ylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C21H27N5O2
  1
1
IC50 = 338.84 nM
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CP0523084
 Compound Info 
3-[6-(2-methoxyethyl)pyridin-3-yl]-2-methyl-8-pyridin-3-ylimidazo[1,2-a]pyrazine
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C20H19N5O
  1
1
IC50 = 338.84 nM
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CP0490043
 Compound Info 
3-[1-(2-methoxyethyl)pyrazol-4-yl]-2-methyl-8-pyridin-4-ylimidazo[1,2-a]pyrazine
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C18H18N6O
  1
1
IC50 = 346.74 nM
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CP0480570
 Compound Info 
3-[6-(2-methoxyethyl)pyridin-3-yl]-2-methyl-8-pyridin-4-ylimidazo[1,2-a]pyrazine
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C20H19N5O
  1
1
IC50 = 346.74 nM
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CP0398569
 Compound Info 
4-[3-[6-(2-methoxyethyl)pyridin-3-yl]-2,6-dimethylimidazo[1,2-a]pyrazin-8-yl]morpholine
   Show/Hide
C20H25N5O2
  1
1
IC50 = 407.38 nM
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CP0499784
 Compound Info 
3-[6-(2-methoxyethyl)pyridin-3-yl]-2-methyl-8-pyrrolidin-1-ylimidazo[1,2-a]pyrazine
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C19H23N5O
  1
1
IC50 = 407.38 nM
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CP0550584
 Compound Info 
1-benzofuran-5-yl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C19H17N5O2
  1
1
IC50 = 447 nM
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CP0147040
 Compound Info 
US11419874, Example 28
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C15H10ClN5
  1
1
IC50 = 480 nM
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CP0490042
 Compound Info 
3-[1-(2-methoxyethyl)pyrazol-4-yl]-2-methyl-8-pyrrolidin-1-ylimidazo[1,2-a]pyrazine
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C17H22N6O
  1
1
IC50 = 501.19 nM
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CP0484238
 Compound Info 
[3-[5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C21H22F3N5OS
  1
1
IC50 = 550 nM
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CP0486657
 Compound Info 
[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
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C20H23N5O4
  1
1
IC50 = 551 nM
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CP0474694
 Compound Info 
3-[1-(2-methoxyethyl)pyrazol-4-yl]-2-methyl-8-pyridin-3-ylimidazo[1,2-a]pyrazine
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C18H18N6O
  1
1
IC50 = 562.34 nM
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CP0553270
 Compound Info 
4-[3-[1-(2-methoxyethyl)pyrrol-3-yl]-2-methylimidazo[1,2-a]pyrazin-8-yl]morpholine
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C18H23N5O2
  1
1
IC50 = 562.34 nM
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CP0540142
 Compound Info 
(3,4-dimethoxyphenyl)-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C19H21N5O3
  1
1
IC50 = 589 nM
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CP0571414
 Compound Info 
4-[3-[6-(2-methoxyethyl)pyridin-3-yl]-2-methyl-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl]morpholine
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C20H22F3N5O2
  1
1
IC50 = 602.56 nM
 Bioactivity Info 
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CP0542603
 Compound Info 
[3-(5-propan-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C22H27N5OS
  1
1
IC50 = 603 nM
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CP0535023
 Compound Info 
5-(difluoromethyl)-7-[1-[(3,4-dimethoxyphenyl)methyl]piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine
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C20H23F2N5O2
  1
1
IC50 = 661 nM
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CP0542604
 Compound Info 
[3-[5-(difluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C21H22F2N4OS
  1
1
IC50 = 724 nM
 Bioactivity Info 
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CP0532947
 Compound Info 
7-[1-(4,5,6,7-tetrahydro-1-benzothiophene-2-carbonyl)piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine-5-carbonitrile
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C20H20N6OS
  1
1
IC50 = 759 nM
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CP0376865
 Compound Info 
2-(2-isoquinolin-7-yloxyethyl)quinoline
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C20H16N2O
  1
1
IC50 = 809 nM
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CP0553921
 Compound Info 
(4-methoxyphenyl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C18H19N5O2
  1
1
IC50 = 871 nM
 Bioactivity Info 
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CP0535021
 Compound Info 
[3-[5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C20H21F2N5OS
  1
1
IC50 = 912 nM
 Bioactivity Info 
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CP0060511
 Compound Info 
4-[3-[1-(2-methoxyethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]morpholine
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C16H20N6O2
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0152286
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-propoxyquinazoline
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C23H27N3O2
  1
1
IC50 = 1040 nM
 Bioactivity Info 
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CP0529994
 Compound Info 
cyclopropyl-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C14H17N5O
  1
1
IC50 = 1047 nM
 Bioactivity Info 
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CP0491961
 Compound Info 
[3-(7-methylimidazo[1,2-a]pyrimidin-5-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C21H24N4OS
  1
1
IC50 = 1096 nM
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CP0484243
 Compound Info 
[3-(5-methoxy-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C20H23N5O2S
  1
1
IC50 = 1148 nM
 Bioactivity Info 
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CP0484309
 Compound Info 
(3-methoxyphenyl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C18H19N5O2
  1
1
IC50 = 1148 nM
 Bioactivity Info 
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CP0542607
 Compound Info 
2,3-dihydro-1,4-benzodioxin-6-yl-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C19H19N5O3
  1
1
IC50 = 1148 nM
 Bioactivity Info 
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CP0540143
 Compound Info 
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)azepan-1-yl]methanone
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C20H23N5OS
  1
1
IC50 = 1288 nM
 Bioactivity Info 
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CP0508762
 Compound Info 
4-[[1-(5-butoxy-2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C25H28ClN5O2
  1
1
IC50 = 1622 nM
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CP0503247
 Compound Info 
7-methoxy-6-(2-phenylethoxy)-4-(3-phenylpiperidin-1-yl)quinazoline
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C28H29N3O2
  1
1
IC50 = 1665 nM
 Bioactivity Info 
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CP0521463
 Compound Info 
4-[[1-(2-chloro-5-propan-2-yloxyphenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C24H26ClN5O2
  1
1
IC50 = 1862 nM
 Bioactivity Info 
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CP0389574
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-3-ylethoxy)quinazoline
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C27H28N4O2
  1
1
IC50 = 2338 nM
 Bioactivity Info 
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CP0488089
 Compound Info 
3-[2-chloro-5-(2,2,2-trifluoroethoxymethyl)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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C18H13ClF3N5O
  1
1
IC50 = 2450 nM
 Bioactivity Info 
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CP0553977
 Compound Info 
[4-methyl-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C19H22N6OS
  1
1
IC50 = 2455 nM
 Bioactivity Info 
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CP0484310
 Compound Info 
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[(2S)-2-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)morpholin-4-yl]methanone
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C18H19N5O2S
  1
1
IC50 = 2630 nM
 Bioactivity Info 
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CP0425612
 Compound Info 
ethyl 4-methyl-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylate
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C19H16N4O2
  1
1
IC50 = 2690 nM
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CP0535020
 Compound Info 
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[3-[5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]methanone
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C20H20F3N5OS
  1
1
IC50 = 2692 nM
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CP0532945
 Compound Info 
[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-[4-(trifluoromethyl)phenyl]methanone
   Show/Hide
C18H16F3N5O
  1
1
IC50 = 3020 nM
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CP0484308
 Compound Info 
2-(3,4-dimethoxyphenyl)-1-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]ethanone
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C20H23N5O3
  1
1
IC50 = 3162 nM
 Bioactivity Info 
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CP0484314
 Compound Info 
(1-methylsulfonylindol-5-yl)-[(3R)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C20H20N6O3S
  1
1
IC50 = 3548 nM
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CP0414237
 Compound Info 
3-(5-butoxypyridin-3-yl)-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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C18H18N6O
  1
1
IC50 = 3800 nM
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CP0448309
 Compound Info 
3-[2-chloro-5-(propoxymethyl)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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C19H18ClN5O
  1
1
IC50 = 3890 nM
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CP0535016
 Compound Info 
phenyl-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C17H17N5O
  1
1
IC50 = 4571 nM
 Bioactivity Info 
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CP0090153
 Compound Info 
4-[[1-(5-butoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C24H28N6O2
  1
1
IC50 = 4823 nM
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CP0498448
 Compound Info 
(2-methoxyphenyl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C18H19N5O2
  1
1
IC50 = 5129 nM
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CP0486899
 Compound Info 
3-(5-butoxy-2-chlorophenyl)-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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C19H18ClN5O
  1
1
IC50 = 5500 nM
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CP0484239
 Compound Info 
7-[(3S)-1-[(2-chloro-6-methylpyridin-4-yl)methyl]piperidin-3-yl]-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
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C18H19ClF2N6
  1
1
IC50 = 5623 nM
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CP0389452
 Compound Info 
3-[2-chloro-5-(propan-2-yloxymethyl)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
   Show/Hide
C19H18ClN5O
  1
1
IC50 = 6030 nM
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CP0482863
 Compound Info 
4-[[4-methyl-1-(5-propoxypyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C23H26N6O2
  1
1
IC50 = 6131 nM
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CP0484312
 Compound Info 
4-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carbonyl]benzonitrile
   Show/Hide
C18H16N6O
  1
1
IC50 = 6918 nM
 Bioactivity Info 
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CP0532946
 Compound Info 
7-[1-(1-benzofuran-5-ylmethyl)piperidin-3-yl]-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
   Show/Hide
C20H19F2N5O
  1
1
IC50 = 7586 nM
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CP0547066
 Compound Info 
4-[[1-[5-(2-methoxyethoxy)pyridin-3-yl]-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C23H26N6O3
  1
1
IC50 = 7762 nM
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CP0527831
 Compound Info 
cyclohexyl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C17H23N5O
  1
1
IC50 = 7762 nM
 Bioactivity Info 
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CP0484316
 Compound Info 
5-(difluoromethyl)-7-[(3S)-1-[(2,6-dimethylpyridin-4-yl)methyl]piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine
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C19H22F2N6
  1
1
IC50 = 8318 nM
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CP0448292
 Compound Info 
3-[2-chloro-5-(trifluoromethoxy)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
   Show/Hide
C16H9ClF3N5O
  1
1
IC50 = 8910 nM
 Bioactivity Info 
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CP0488088
 Compound Info 
3-[2-chloro-5-(2-methoxyethoxy)phenyl]-7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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C18H16ClN5O2
  1
1
IC50 = 9120 nM
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CP0482862
 Compound Info 
4-[[4-methyl-1-(5-propan-2-yloxypyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
   Show/Hide
C23H26N6O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0428749
 Compound Info 
4-[4-chloro-3-(7-methyl-2,4,5,8,12-pentazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-3-yl)phenyl]morpholine
   Show/Hide
C19H17ClN6O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0529995
 Compound Info 
4,5,6,7-tetrahydro-1-benzothiophen-2-yl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]methanone
   Show/Hide
C18H20N6OS
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0910630
 Compound Info 
(RS)-[3-(1H-Pyrrolo[2,3-b]pyridin-4-yl)-1-piperidyl]-(4,5,6,7-tetrahydrobenzothiophen-2-yl)methanone
   Show/Hide
C21H23N3OS
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0484242
 Compound Info 
1-[4-(4,5,6,7-tetrahydro-1-benzothiophene-2-carbonyl)-2-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanone
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C20H22N6O2S
  1
1
IC50 > 3020 nM
 Bioactivity Info 
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CP0376864
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(pyridin-3-ylmethoxy)quinazoline
   Show/Hide
C26H26N4O2
  1
1
IC50 > 3200 nM
 Bioactivity Info 
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CP0431292
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(quinolin-2-ylmethoxy)quinazoline
   Show/Hide
C30H28N4O2
  1
1
IC50 > 3200 nM
 Bioactivity Info 
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CP0498870
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(2-pyridin-4-ylethoxy)quinazoline
   Show/Hide
C27H28N4O2
  1
1
IC50 > 3200 nM
 Bioactivity Info 
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CP0499347
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(pyridin-2-ylmethoxy)quinazoline
   Show/Hide
C26H26N4O2
  1
1
IC50 > 3200 nM
 Bioactivity Info 
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CP0520756
 Compound Info 
7-methoxy-4-(3-phenylpiperidin-1-yl)-6-(pyridin-4-ylmethoxy)quinazoline
   Show/Hide
C26H26N4O2
  1
1
IC50 > 3200 nM
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Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0046376
 Compound Info 
PF-2545920
   Show/Hide
C25H20N4O
  3
1 IC50 = 0.18 nM
2 IC50 = 0.5 nM
3 Ki = 0.17 nM
CP0083432
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline
   Show/Hide
C20H21NO4
  1
1 IC50 = 36 nM
CP0025586
 Compound Info 
4-[3-[6-(2-methoxyethyl)pyridin-3-yl]-2-methylimidazo[1,2-b]pyridazin-8-yl]morpholine
   Show/Hide
C19H23N5O2
  1
1 Ki ~ 19 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01875 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Homo sapiens, Human
 Protein Info