Protein Information

General Information of the Protein

Protein ID	PT00999
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Secondarily Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
Gene Name	PIK3CD
Sequence	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Transferase
Function	Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. Show/Hide
Uniprot ID	Primary ID: O00329 Secondarily ID: A6NCG0 G1FFP1 O15445 Q5SR49 Show/Hide
Ensembl ID	ENSG00000171608
HGNC ID	HGNC:8977
Subcellular Location	Cytoplasm

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000144 , 3T3 MEFs WT

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0003061 Compound Info	9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C21H24N4O2	1
1	IC50 = 252 nM Bioactivity Info	TI LI LO TS
CP0111428 Compound Info	2-[(1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one Show/Hide	C17H19N5O2	1
1	IC50 = 2655 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000023 , BTI-Tn-5B1-4

Cell Line Info

Cell Line ID: CL000690 , CCRF-SB

Cell Line Info

Cell Line ID: CL000182 , JeKo-1

Cell Line Info

Cell Line ID: CL000180 , Karpas-422

Cell Line Info

Cell Line ID: CL000752 , PBMC iPSC #1

Cell Line Info

Cell Line ID: CL000174 , Raji

Cell Line Info

Cell Line ID: CL000003 , Ramos

Cell Line Info

Cell Line ID: CL000019 , Rat1

Cell Line Info

Cell Line ID: CL000531 , Ri-1

Cell Line Info

Cell Line ID: CL000012 , Sf21

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000999 , SU-DHL-5

Cell Line Info

Cell Line ID: CL000040 , THP-1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0010760 Compound Info	5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one Show/Hide	C22H18FN7O	22
1	EC50 = 8 nM
2	IC50 = 1.2 nM
3	IC50 = 1.6 nM
4	IC50 = 2 nM
5	IC50 = 2.1 nM
6	IC50 = 2.5 nM
7	IC50 = 2.7 nM
8	IC50 = 3 nM
9	IC50 = 3.1 nM
10	IC50 = 3.2 nM
11	IC50 = 4.3 nM
12	IC50 = 4.7 nM
13	IC50 = 5.9 nM
14	IC50 = 6 nM
15	IC50 = 7 nM
16	IC50 = 9 nM
17	IC50 = 10 nM
18	IC50 = 19 nM
19	IC50 = 24 nM
20	IC50 = 25 nM
21	IC50 = 31 nM
22	IC50 = 831 nM
CP0007933 Compound Info	2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1H-benzimidazole Show/Hide	C19H21F2N7O2	8
1	EC50 = 10 nM
2	IC50 = 3 nM
3	IC50 = 3.9 nM
4	IC50 = 4.6 nM
5	IC50 = 5 nM
6	IC50 = 6 nM
7	IC50 = 38 nM
8	IC50 = 49 nM
CP0144172 Compound Info	N-[5-[4-[5-[[(2S,6R)-2,6-dimethylmorpholin-4-yl]methyl]-1,3-oxazol-2-yl]-1H-indazol-6-yl]-2-methoxypyridin-3-yl]methanesulfonamide Show/Hide	C24H28N6O5S	3
1	IC50 = 0.33 nM
2	IC50 = 3.981 nM
3	Ki = 0.07943 nM
CP0026318 Compound Info	5-chloro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)ethyl]quinazolin-4-one Show/Hide	C21H16ClN7O	2
1	IC50 = 0.8 nM
2	IC50 = 0.9 nM
CP0022456 Compound Info	4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]-2-fluorobenzamide Show/Hide	C23H20FN7O	1
1	IC50 = 0.8 nM
CP0238997 Compound Info	2-[1-[[5-(2-ethylbenzimidazol-1-yl)-7-morpholin-4-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C27H35N7O2S	1
1	IC50 = 1 nM
CP0219705 Compound Info	2-amino-4-[[(1S)-1-[7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenylquinolizin-2-yl]ethyl]amino]-6-methylpyrimidine-5-carbonitrile Show/Hide	C29H22F2N6O	1
1	IC50 = 1 nM
CP0013383 Compound Info	(3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1H-indol-2-one Show/Hide	C27H22N6O	1
1	IC50 = 1 nM
CP0060921 Compound Info	US10065963, 32c Show/Hide	C20H22ClFN6O2	2
1	IC50 < 1 nM
2	IC50 = 1.1 nM
CP0068001 Compound Info	US8653092, 67 Show/Hide	C21H25F3N6O2	3
1	IC50 = 1.5 nM
2	IC50 = 11 nM
3	IC50 = 23 nM
CP0513993 Compound Info	1-[[2-(5-fluoro-1H-indol-4-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]-N,N-dimethylpiperidin-4-amine Show/Hide	C26H31FN6OS	1
1	IC50 = 1.8 nM
CP0110718 Compound Info	2-[1-[[2-(2-ethylbenzimidazol-1-yl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C28H38N8O2	2
1	IC50 = 2 nM
2	Ki = 2 nM
CP0148454 Compound Info	2-[1-[[9-methyl-6-morpholin-4-yl-2-(2-propan-2-ylbenzimidazol-1-yl)purin-8-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C29H40N8O2	2
1	IC50 = 2 nM
2	Ki = 2 nM
CP0238995 Compound Info	2-[1-[[2-[2-(1-methoxyethyl)benzimidazol-1-yl]-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C29H40N8O3	1
1	IC50 = 2 nM
CP0001658 Compound Info	4-[(2S)-2-(4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)pyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C23H18N8O	1
1	IC50 = 2 nM
CP0551744 Compound Info	cyclobutyl-[(3S)-3-[[6-(5,6-dimethoxypyridin-3-yl)thieno[2,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]methanone Show/Hide	C22H25N5O3S	1
1	IC50 = 2.2 nM
CP0239062 Compound Info	4-[6-[[2,2-dimethyl-4-(oxetan-3-yl)piperazin-1-yl]methyl]-2-(2-ethylbenzimidazol-1-yl)thieno[3,2-d]pyrimidin-4-yl]morpholine Show/Hide	C29H37N7O2S	1
1	IC50 = 2.3 nM
CP0315883 Compound Info	N,N-dimethyl-1-[[2-(2-methyl-1-benzothiophen-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperidin-4-amine Show/Hide	C27H33N5OS2	1
1	IC50 = 2.4 nM
CP0053343 Compound Info	4-amino-6-[[(1S)-1-(6-fluoro-3,4-dipyridin-2-ylquinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile Show/Hide	C26H19FN8	1
1	IC50 = 2.4 nM
CP0097841 Compound Info	US9227977, Compound (I) Show/Hide	C36H31F4N7O5	1
1	IC50 = 2.5 nM
CP0005428 Compound Info	Duvelisib Show/Hide	C22H17ClN6O	2
1	IC50 = 2.5 nM
2	IC50 = 27 nM
CP0339241 Compound Info	N,N-dimethyl-1-[[2-(2-methylbenzimidazol-1-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperidin-4-amine Show/Hide	C26H33N7OS	1
1	IC50 = 2.7 nM
CP0007893 Compound Info	4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine Show/Hide	C23H27N7O3S2	10
1	IC50 = 3 nM
2	IC50 = 4 nM
3	IC50 = 7 nM
4	IC50 = 9 nM
5	IC50 = 12.59 nM
6	IC50 = 15.7 nM
7	IC50 = 50.12 nM
8	IC50 = 75 nM
9	Kd = 3.3 nM
10	Kd = 5 nM
CP0086188 Compound Info	2-[1-[[2-(2-cyclopropylbenzimidazol-1-yl)-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C29H38N8O2	1
1	IC50 = 3 nM
CP0339254 Compound Info	2-[1-[[2-(2-ethylbenzimidazol-1-yl)-6-morpholin-4-yl-7H-purin-8-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C27H36N8O2	1
1	IC50 = 3 nM
CP0176936 Compound Info	2,4-diamino-6-[[(1S)-1-[7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenylquinolizin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile Show/Hide	C28H21F2N7O	1
1	IC50 = 3.3 nM
CP0543235 Compound Info	cyclobutyl-[(3S)-3-[6-(5,6-dimethoxypyridin-3-yl)thieno[2,3-d]pyrimidin-4-yl]oxypyrrolidin-1-yl]methanone Show/Hide	C22H24N4O4S	1
1	IC50 = 3.3 nM
CP0330198 Compound Info	US8653092, 68 Show/Hide	C24H29F3N6O3	2
1	IC50 = 4 nM
2	IC50 = 7 nM
CP0239063 Compound Info	4-[2-(2-ethylbenzimidazol-1-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine Show/Hide	C25H31N7O3S2	2
1	IC50 = 4.1 nM
2	IC50 = 4.3 nM
CP0169311 Compound Info	2-[1-[[2-(2-ethylbenzimidazol-1-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C28H36N6O2S	3
1	IC50 = 5 nM
2	IC50 = 5.3 nM
3	Ki = 5.5 nM
CP0193312 Compound Info	2-[1-[[2-[2-(1-hydroxyethyl)benzimidazol-1-yl]-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C28H38N8O3	1
1	IC50 = 5 nM
CP0333253 Compound Info	3-[[4-methyl-5-(4-pyrazol-1-ylphenyl)-1,3-thiazol-2-yl]carbamoylamino]-N-(3-methyl-2H-pyrrol-5-yl)propanamide Show/Hide	C22H23N7O2S	1
1	IC50 = 5 nM
CP0140106 Compound Info	2-methoxy-5-[4-[(3S)-1-propanoylpyrrolidin-3-yl]oxyquinazolin-6-yl]pyridine-3-carbonitrile Show/Hide	C22H21N5O3	1
1	IC50 = 5 nM
CP0574226 Compound Info	1-[(3S)-3-[[6-(5,6-dimethoxypyridin-3-yl)thieno[2,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one Show/Hide	C20H23N5O3S	1
1	IC50 = 5.7 nM
CP0339253 Compound Info	2-[1-[[2-[2-(dimethylamino)benzimidazol-1-yl]-9-methyl-6-morpholin-4-ylpurin-8-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C28H39N9O2	1
1	IC50 = 6 nM
CP0111104 Compound Info	(2S)-2-amino-N-[5-[6-chloro-5-[(3-methylphenyl)sulfonylamino]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]-3-methylbutanamide Show/Hide	C21H24ClN5O3S2	1
1	IC50 = 6 nM
CP0140244 Compound Info	5-[4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl]-2-methoxypyridine-3-carbonitrile Show/Hide	C28H24N6O3	2
1	IC50 = 7 nM
2	IC50 = 9 nM
CP0081378 Compound Info	8-[(2R)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholin-4-ylchromen-4-one Show/Hide	C28H29F2N3O5	1
1	IC50 = 8.6 nM
CP0237222 Compound Info	1-[(3S)-3-[6-(6-methoxypyridin-3-yl)quinazolin-4-yl]oxypyrrolidin-1-yl]propan-1-one Show/Hide	C21H22N4O3	1
1	IC50 = 9 nM
CP0345063 Compound Info	1-[4-[3-[6-(3,4-dimethoxyphenyl)quinazolin-4-yl]benzoyl]piperazin-1-yl]ethanone Show/Hide	C29H28N4O4	2
1	IC50 = 9 nM
2	IC50 = 14 nM
CP0169312 Compound Info	1-[(2-indol-1-yl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl)methyl]-N,N-dimethylpiperidin-4-amine Show/Hide	C26H32N6OS	1
1	IC50 = 10 nM
CP0192746 Compound Info	2-[1-[[5-(2-ethylbenzimidazol-1-yl)-7-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidin-2-yl]methyl]piperidin-4-yl]propan-2-ol Show/Hide	C27H35N7O2S	1
1	IC50 = 10 nM
CP0085980 Compound Info	tert-butyl (3S)-3-[6-(3,4-dimethoxyphenyl)quinazolin-4-yl]oxypyrrolidine-1-carboxylate Show/Hide	C25H29N3O5	1
1	IC50 = 10 nM
CP0046475 Compound Info	8-[(8-fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C25H26FN3O5	2
1	IC50 = 11 nM
2	IC50 = 15 nM
CP0214687 Compound Info	1-[(3S)-3-[6-(6-methoxypyridin-3-yl)quinolin-4-yl]oxypyrrolidin-1-yl]propan-1-one Show/Hide	C22H23N3O3	1
1	IC50 = 11 nM
CP0513992 Compound Info	N,N-dimethyl-1-[[2-(3-methylphenyl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperidin-4-amine Show/Hide	C25H33N5OS	1
1	IC50 = 12 nM
CP0068002 Compound Info	US8653092, 61 Show/Hide	C24H28F3N5O4	2
1	IC50 = 12 nM
2	IC50 = 28 nM
CP0097722 Compound Info	US9227977, Compound A Show/Hide	C39H39ClN8O5	1
1	IC50 = 12 nM
CP0225071 Compound Info	2-[(1S)-1-[4-amino-3-(3-fluoro-4-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoroquinazolin-4-one Show/Hide	C26H23F2N7O2	1
1	IC50 = 14 nM
CP0569111 Compound Info	5-chloro-3-(3-fluorophenyl)-2-[(2S,5S)-5-methyl-1-(7H-purin-6-yl)pyrrolidin-2-yl]quinazolin-4-one Show/Hide	C24H19ClFN7O	1
1	IC50 = 14 nM
CP0043078 Compound Info	US8653092, 1 Show/Hide	C24H31N5O4	2
1	IC50 = 15 nM
2	IC50 = 76 nM
CP0140107 Compound Info	1-[(3R)-3-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]oxypyrrolidin-1-yl]propan-1-one Show/Hide	C23H25N3O4	1
1	IC50 = 15 nM
CP0186992 Compound Info	1-[(2-indazol-1-yl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl)methyl]-N,N-dimethylpiperidin-4-amine Show/Hide	C25H31N7OS	1
1	IC50 = 16 nM
CP0419316 Compound Info	1-[(3S)-3-[6-(3,4-dimethoxyphenyl)quinazolin-4-yl]oxypyrrolidin-1-yl]ethanone Show/Hide	C22H23N3O4	1
1	IC50 = 16 nM
CP0303600 Compound Info	US8653092, 83 Show/Hide	C24H32N6O3	2
1	IC50 = 17 nM
2	IC50 = 30 nM
CP0027760 Compound Info	3-amino-6-[4-chloro-3-[(2,3-difluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide Show/Hide	C18H14ClF2N5O3S	1
1	IC50 = 18 nM
CP0067930 Compound Info	US8653092, 81 Show/Hide	C21H28N6O2	1
1	IC50 = 20 nM
CP0131435 Compound Info	1-[4-[3-[6-(6-methoxypyridin-3-yl)quinazolin-4-yl]benzoyl]piperazin-1-yl]ethanone Show/Hide	C27H25N5O3	2
1	IC50 = 20 nM
2	IC50 = 29 nM
CP0140243 Compound Info	1-[(3S)-3-[[6-(6-methoxypyridin-3-yl)-1,5-naphthyridin-4-yl]oxy]pyrrolidin-1-yl]propan-1-one Show/Hide	C21H22N4O3	1
1	IC50 = 22 nM
CP0239064 Compound Info	1-[[2-(benzimidazol-1-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]-N,N-dimethylpiperidin-4-amine Show/Hide	C25H31N7OS	1
1	IC50 = 23 nM
CP0006058 Compound Info	2-amino-N-[(1S)-1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C30H24N8O2	1
1	IC50 = 23 nM
CP0066459 Compound Info	US8653092, 63 Show/Hide	C21H24F3N5O3	3
1	IC50 = 23 nM
2	IC50 = 27 nM
3	IC50 = 51 nM
CP0193269 Compound Info	1-[(2-imidazo[1,2-a]pyridin-5-yl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl)methyl]-N,N-dimethylpiperidin-4-amine Show/Hide	C25H31N7OS	1
1	IC50 = 27 nM
CP0247119 Compound Info	N,N-dimethyl-1-[[2-(3-methylisoquinolin-4-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperidin-4-amine Show/Hide	C28H34N6OS	1
1	IC50 = 29 nM
CP0020253 Compound Info	3-amino-6-[4-chloro-3-[(3-fluoro-2-methylphenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide Show/Hide	C19H17ClFN5O3S	1
1	IC50 = 34 nM
CP0239066 Compound Info	4-[6-[[4-(dimethylamino)piperidin-1-yl]methyl]-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]-1,3-dihydroindol-2-one Show/Hide	C26H32N6O2S	1
1	IC50 = 41 nM
CP0067931 Compound Info	1-[4-[3-[6-(6-methoxypyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]benzoyl]piperazin-1-yl]ethanone Show/Hide	C26H28N6O3	1
1	IC50 = 65 nM
CP0249954 Compound Info	1-[4-[3-[6-(6-methoxypyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]phenoxy]piperidin-1-yl]ethanone Show/Hide	C26H29N5O3	1
1	IC50 = 83 nM
CP0114236 Compound Info	N-[1-[8-chloro-5-(3-fluorophenyl)imidazo[1,5-a]pyridin-6-yl]ethyl]-7H-purin-6-amine Show/Hide	C20H15ClFN7	1
1	IC50 < 100 nM
CP0186648 Compound Info	2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)-N-phenylacetamide Show/Hide	C16H18N4O3	1
1	IC50 = 118 nM
CP0010682 Compound Info	2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one Show/Hide	C22H19N7O	4
1	IC50 = 130 nM
2	IC50 = 160 nM
3	IC50 = 500 nM
4	Ki = 20 nM
CP0241717 Compound Info	1-[(3S)-3-[[6-(6-methoxypyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]propan-1-one Show/Hide	C20H25N5O3	1
1	IC50 = 132 nM
CP0019793 Compound Info	N-[5-[2-[(1S)-1-cyclopropylethyl]-7-(methylsulfamoyl)-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide Show/Hide	C20H24N4O4S2	1
1	IC50 = 158.49 nM
CP0231955 Compound Info	1-[(3S)-3-[6-(6-methoxypyridin-3-yl)cinnolin-4-yl]oxypyrrolidin-1-yl]propan-1-one Show/Hide	C21H22N4O3	1
1	IC50 = 188 nM
CP0002420 Compound Info	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one Show/Hide	C19H17NO3	10
1	IC50 = 220 nM
2	IC50 = 570 nM
3	IC50 = 950 nM
4	IC50 = 1050 nM
5	IC50 = 1330 nM
6	IC50 = 1360 nM
7	IC50 = 1362 nM
8	IC50 = 1600 nM
9	IC50 = 3223 nM
10	IC50 = 14900 nM
CP0066777 Compound Info	(2S,3R)-3-methyl-1-N-[12-(1,1,1-trifluoro-2-methylpropan-2-yl)-8-oxa-3-thia-5,11-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,9,11-pentaen-4-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C20H22F3N5O3S	1
1	IC50 = 220 nM
CP0050326 Compound Info	2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-ylamino)acetonitrile Show/Hide	C18H14N8O	1
1	IC50 = 240 nM
CP0084873 Compound Info	8-(1-anilinoethyl)-6-methyl-2-morpholin-4-ylchromen-4-one Show/Hide	C22H24N2O3	1
1	IC50 = 260 nM
CP0008405 Compound Info	(2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H22F3N5O2S	2
1	IC50 = 290 nM
2	IC50 = 1150 nM
CP0116057 Compound Info	(2S)-1-N-[5-(2-tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]azetidine-1,2-dicarboxamide Show/Hide	C17H22N6O2S	1
1	IC50 = 290 nM
CP0017013 Compound Info	N-[5-[2-[(1S)-1-cyclopropylethyl]-7-methylsulfonyl-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide Show/Hide	C20H23N3O4S2	1
1	IC50 = 316.23 nM
CP0107865 Compound Info	(2S)-1-N-[5-(2-tert-butylpyridin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H25N5O2S	1
1	IC50 = 330 nM
CP0107860 Compound Info	(2S)-1-N-[5-[2-(diethylamino)pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H25N7O2S	1
1	IC50 = 340 nM
CP0109038 Compound Info	(2S)-1-N-[5-(2-tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H24N6O2S	3
1	IC50 = 350 nM
2	IC50 = 380 nM
3	IC50 = 530 nM
CP0674930 Compound Info	(2S)-N1-[4-methyl-5-[2-[2,2,2-trideuterio-1,1-bis(trideuteriomethyl)ethyl]pyrimidin-4-yl]thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H24N6O2S	1
1	IC50 = 360 nM
CP0078092 Compound Info	(2S,3R)-3-methyl-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C20H24F3N5O2S	1
1	IC50 = 390 nM
CP0051959 Compound Info	(2S)-1-N-[4-chloro-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H19ClF3N5O2S	1
1	IC50 = 430 nM
CP0107863 Compound Info	N-[5-(2-tert-butylpyridin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1-carboxamide Show/Hide	C18H24N4OS	1
1	IC50 = 590 nM
CP0057012 Compound Info	(2S)-1-N-[5-(2-cyclobutylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H22N6O2S	1
1	IC50 = 690 nM
CP0102055 Compound Info	(2S)-1-N-[4-methyl-5-[2-(1-methylcyclopropyl)pyrimidin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H22N6O2S	1
1	IC50 = 810 nM
CP0688695 Compound Info	7-methyl-9-(2-methylbenzylamino)-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one Show/Hide	C21H24N4O2	1
1	IC50 = 870 nM
CP0102057 Compound Info	(2S)-1-N-[4-methyl-5-(2-propan-2-ylpyrimidin-4-yl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C17H22N6O2S	1
1	IC50 = 960 nM
CP0157490 Compound Info	(2S)-1-N-[5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H20F3N5O2S	1
1	IC50 = 1100 nM
CP0107861 Compound Info	(2S)-1-N-[5-[2-(1-cyanocyclopropyl)pyridin-4-yl]-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H20N6O2S	1
1	IC50 = 2000 nM
CP0051973 Compound Info	(2S)-1-N-[5-(2-tert-butylpyridin-4-yl)-4-methyl-1,3-thiazol-2-yl]-2-N-methylpyrrolidine-1,2-dicarboxamide Show/Hide	C20H27N5O2S	1
1	IC50 = 4200 nM
CP0239025 Compound Info	N-[1-[2-(3,5-difluorophenyl)-8-methylimidazo[1,2-a]pyridin-3-yl]ethyl]-7H-purin-6-amine Show/Hide	C21H17F2N7	1
1	IC50 < 200 nM
CP0047685 Compound Info	(2S)-1-N-[4-methyl-5-(4-pyrazol-1-ylphenyl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H20N6O2S	1
1	Ki = 220 nM

Clinical Information about the Protein

Target 1 ( PI3-kinase delta (PIK3CD) )

Target Type	Successful Target
Disease	11 Target-related Diseases				11
1	Chronic lymphocytic leukaemia [ICD-11: 2A82.0]
2	Small lymphocytic lymphoma [ICD-11: 2A82.0]
3	Breast cancer [ICD-11: 2C60-2C65]
4	Asthma [ICD-11: CA23]
5	Stomach cancer [ICD-11: 2B72]
6	Follicular lymphoma [ICD-11: 2A80]
7	Lymphoma [ICD-11: 2A80-2A86]
8	Myeloid leukaemia [ICD-11: 2B33.1]
9	Haematological malignancy [ICD-11: 2B33.Y]
10	Colorectal cancer [ICD-11: 2B91.Z]
11	Rheumatoid arthritis [ICD-11: FA20]
Approved Drug(s)	4 Approved Drugs				4
1	Idelalisib	Drug Info	Approved	Chronic lymphocytic leukaemia
2	IPI-145	Drug Info	Approved	Small lymphocytic lymphoma
3	Leniolisib	Drug Info	Approved	Stomach cancer
4	Umbralisib	Drug Info	Approved	Follicular lymphoma
Clinical Trial Drug(s)	10 Clinical Trial Drugs				10
1	Buparlisib	Drug Info	Phase 3	Breast cancer
2	AZD8154	Drug Info	Phase 2	Asthma
3	Parsaclisib	Drug Info	Phase 2	Follicular lymphoma
4	INCB40093	Drug Info	Phase 1/2	Lymphoma
5	AMG 319	Drug Info	Phase 1	Myeloid leukaemia
6	GS-9820	Drug Info	Phase 1	Lymphoma
7	GS-9901	Drug Info	Phase 1	Haematological malignancy
8	GSK2292767	Drug Info	Phase 1	Asthma
9	PA-799	Drug Info	Phase 1/2	Colorectal cancer
10	RP6530	Drug Info	Phase 2	Chronic lymphocytic leukaemia
Discontinued Drug(s)	1 Discontinued Drug				1
1	Wortmannin	Drug Info	Terminated	Haematological malignancy
Investigative Drug(s)	1 Investigative Drug				1
1	ETP-46321	Drug Info	Investigative	Rheumatoid arthritis

Target 2 ( HUMAN PI3-kinase delta (PIK3CD) )

Target Type	Unknown Type Target
Disease	1 Target-related Disease				1
1	Follicular lymphoma [ICD-11: 2A80]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	Duvelisib	Drug Info	Approved	Follicular lymphoma

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han