General Information of the Cell Line
Cell Line ID
CL000180
Cell Line Name
Karpas-422
Synonyms
KARPAS-422
Karpas 422
KARPAS 422
Karpas422
KARPAS422
K422
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1325
Tissue Information
Pleural effusion
Disease
Diffuse large B-cell lymphoma germinal center B-cell type (NCIt: C36080)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT04856, B-cell lymphoma 6 protein
 Protein Info 
Compound ID Compound Name Compound Formula
CP0545513
 Compound Info 
(2S)-10-[[5-chloro-2-[(3R,5S)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
   Show/Hide
C26H29ClF2N6O3
  1
1
EC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543843
 Compound Info 
(2S)-10-[[5-chloro-2-[(3S,5R)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
   Show/Hide
C26H29ClF2N6O3
  1
1
EC50 > 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT03003, Histone-lysine N-methyltransferase EZH2
 Protein Info 
Protein ID: PT00999, PIK3CD
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0008108
 Compound Info 
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol
   Show/Hide
 C17H18N4O4  1
1
IC50 = 85 nM
   TI
   LI
   LO
   TS
CP0231582
 Compound Info 
Cpi-1205
   Show/Hide
 C27H33F3N4O3  1
1
GI50 = 436 nM
   TI
   LI
   LO
   TS
CP0256275
 Compound Info 
5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
   Show/Hide
 C22H21Cl2N3O3  1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0331609
 Compound Info 
(12S,14S,17E)-23-benzyl-7-chloro-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
   Show/Hide
 C31H31ClN6O4  1
1
GI50 = 25118.86 nM
   TI
   LI
   LO
   TS
CP0393891
 Compound Info 
(12S,14S,17E)-12-(hydroxymethyl)-23-[(3-methoxyphenyl)methyl]-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaene-7-carbonitrile
   Show/Hide
 C33H33N7O5  1
1
GI50 = 5011.87 nM
   TI
   LI
   LO
   TS
CP0412952
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-[(3-methoxyphenyl)methyl]-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
   Show/Hide
 C32H33ClN6O5  1
1
GI50 = 25118.86 nM
   TI
   LI
   LO
   TS
CP0446898
 Compound Info 
(12S,14S,17E)-7-chloro-23-(cyclopropylmethyl)-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
   Show/Hide
 C28H31ClN6O4  1
1
GI50 > 31622.78 nM
   TI
   LI
   LO
   TS
CP0468096
 Compound Info 
8-(2-fluorophenyl)-5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile
   Show/Hide
 C18H12FN5O  1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0469977
 Compound Info 
(12S,14S)-12-(hydroxymethyl)-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,21(29),22(27)-heptaen-24-one
   Show/Hide
 C24H28N6O4  1
1
GI50 = 12589.25 nM
   TI
   LI
   LO
   TS
CP0472404
 Compound Info 
(14S)-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,21(29),22(27)-heptaene-7-carbonitrile
   Show/Hide
 C24H25N7O3  1
1
GI50 = 7943.28 nM
   TI
   LI
   LO
   TS
CP0508447
 Compound Info 
2-[(12S,14S,17E)-7-chloro-23-[(3,3-difluorocyclobutyl)methyl]-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-12-yl]acetic acid
   Show/Hide
 C30H31ClF2N6O5  1
1
GI50 = 19952.62 nM
   TI
   LI
   LO
   TS
CP0519940
 Compound Info 
(12S,14S)-12-(hydroxymethyl)-24-oxo-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,21(29),22(27)-heptaene-7-carbonitrile
   Show/Hide
 C25H27N7O4  1
1
GI50 = 19952.62 nM
   TI
   LI
   LO
   TS
CP0521736
 Compound Info 
(12S,14S,17E)-7-chloro-12-(hydroxymethyl)-23-methyl-15,20-dioxa-2,4,5,9,11,23-hexazahexacyclo[19.7.1.13,10.111,14.04,8.022,27]hentriaconta-1(28),3(31),5,7,9,17,21(29),22(27)-octaen-24-one
   Show/Hide
 C25H27ClN6O4  1
1
GI50 = 5011.87 nM
   TI
   LI
   LO
   TS
CP0567383
 Compound Info 
5-bromo-8-chloro-2-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-7-(3,5-dimethyltriazol-4-yl)-3,4-dihydroisoquinolin-1-one
   Show/Hide
 C21H21BrClN5O2  1
1
IC50 = 36 nM
   TI
   LI
   LO
   TS
CP0863013
 Compound Info 
1-((R)-1-((1r,4R)-4-(3-(trifluoromethoxy)azetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
   Show/Hide
 C30H37F3N4O3S  1
1
GI50 = 32 nM
   TI
   LI
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   TS
CP0863014
 Compound Info 
1-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-indole-3-carboxamide
   Show/Hide
 C32H42N4O3S  1
1
GI50 = 13 nM
   TI
   LI
   LO
   TS
CP0922322
 Compound Info 
1-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-5-fluoro-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
   Show/Hide
 C31H40FN5O3S  1
1
GI50 = 24 nM
   TI
   LI
   LO
   TS
CP0941409
 Compound Info 
2-methyl-N-[(6-methyl-4-methylsulfanyl-2-oxo-1H-pyridin-3-yl)methyl]-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidyl]ethyl]indole-3-carboxamide
   Show/Hide
 C27H33F3N4O2S  1
1
GI50 = 53 nM
   TI
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   LO
   TS
CP0943512
 Compound Info 
1-((R)-1-((1r,4R)-4-(3-cyclopropoxyazetidin-1-yl)cyclohexyl)ethyl)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
   Show/Hide
 C31H41N5O3S  1
1
GI50 = 12 nM
   TI
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Pleural effusion)
Cell Line Name Organism Disease
U-937
 Cell Line Info 
Homo sapiens (Human) Adult acute monocytic leukemia
SU-DHL-1
 Cell Line Info 
Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
SR
 Cell Line Info 
Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
MC116
 Cell Line Info 
Homo sapiens (Human) B-cell non-Hodgkin lymphoma
K-562
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/A02
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/Adr
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/R7
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/DOX
 Cell Line Info 
Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
MDA-MB-231
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-415
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-468
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
SK-BR-3
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
AU565
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
CAL-51
 Cell Line Info 
Homo sapiens (Human) Breast carcinoma
CAL-120
 Cell Line Info 
Homo sapiens (Human) Breast carcinoma
DG-75
 Cell Line Info 
Homo sapiens (Human) Burkitt lymphoma
SUP-T1
 Cell Line Info 
Homo sapiens (Human) Childhood T lymphoblastic lymphoma
Pfeiffer
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
WSU-DLCL2
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
DoHH2
 Cell Line Info 
Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
KATO III
 Cell Line Info 
Homo sapiens (Human) Down syndrome
GIST-T1
 Cell Line Info 
Homo sapiens (Human) Gastrointestinal stromal tumor
GIST-5R
 Cell Line Info 
Homo sapiens (Human) Gastrointestinal stromal tumor
MZ-CRC-1
 Cell Line Info 
Homo sapiens (Human) Hereditary thyroid gland medullary carcinoma
L-428
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
KM-H2
 Cell Line Info 
Homo sapiens (Human) Hodgkin lymphoma
T-47D
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/2a
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
T-47
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 MX100
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/VP
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-2a
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D:A18
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MVLN
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF/MX
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/Topo
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD2
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7aro
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M6
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-10
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M24
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD1
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7piGST
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-Y1
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/ADM
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7:WS8
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-FLV1000
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-neo/Her2
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 cl.24
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/DX1
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-LC3
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D-KBluc
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
Calu-6
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
Calu-3
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC78
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H3122
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H3255
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H2122
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
COR-L105
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1437
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
HCC4006
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1792
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
DFCI032
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H1355
 Cell Line Info 
Homo sapiens (Human) Lung adenocarcinoma
NCI-H460
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
U-1810
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
COR-L23/R
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
H460/MX20
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
H460R
 Cell Line Info 
Homo sapiens (Human) Lung large cell carcinoma
H69AR
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
NCI-H69
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
GLC-4/ADR
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
STC 1
 Cell Line Info 
Homo sapiens (Human) Lung small cell carcinoma
RERF-LC-A1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
Calu-1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
HCC95
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
RERF-LC-AI Tet-off
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1650
 Cell Line Info 
Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H1666
 Cell Line Info 
Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H929
 Cell Line Info 
Homo sapiens (Human) Plasma cell myeloma
KMS-11
 Cell Line Info 
Homo sapiens (Human) Plasma cell myeloma
UTMC-2
 Cell Line Info 
Homo sapiens (Human) Plasma cell myeloma
KMS-12-PE
 Cell Line Info 
Homo sapiens (Human) Plasma cell myeloma
NCI-H226
 Cell Line Info 
Homo sapiens (Human) Pleural epithelioid mesothelioma
Karpas-1106P
 Cell Line Info 
Homo sapiens (Human) Primary mediastinal (thymic) large B-cell lymphoma