General Information of the Cell Line
Cell Line ID
CL000320
Cell Line Name
NCI-H3122
Synonyms
H3122
H-3122
NCIH3122
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_5160
Tissue Information
Pleural effusion
Disease
Lung adenocarcinoma (NCIt: C3512)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01203, ALK tyrosine kinase receptor
Compound ID Compound Name Compound Formula
CP0073076
(2R)-2-[5-[6-amino-5-[(1R)-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol
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C22H23FN6O3S
 3
1
IC50 = 1.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 21 nM
   TI
   LI
   LO
   TS
3
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0054448
6,6-dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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C30H33N3O2
 1
1
IC50 = 17.9 nM
   TI
   LI
   LO
   TS
CP0066933
1256580-46-7
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C30H34N4O2
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0199533
9-ethyl-6,6-dimethyl-8-[1-(oxan-4-ylmethyl)-3,6-dihydro-2H-pyridin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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C32H35N3O2
 1
1
IC50 = 49 nM
   TI
   LI
   LO
   TS
CP0059911
2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methylbenzamide
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C30H38ClN7O3
 1
1
IC50 = 85 nM
   TI
   LI
   LO
   TS
CP0031719
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
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C21H22Cl2FN5O
 4
1
IC50 = 108 nM
   TI
   LI
   LO
   TS
2
IC50 = 261 nM
   TI
   LI
   LO
   TS
3
IC50 = 623 nM
   TI
   LI
   LO
   TS
4
IC50 = 838 nM
   TI
   LI
   LO
   TS
CP0095494
9-ethyl-6,6-dimethyl-8-[1-(oxane-4-carbonyl)-3,6-dihydro-2H-pyridin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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C32H33N3O3
 1
1
IC50 = 126 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0141542
3-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]-N-[2-[2-(prop-2-enoylamino)ethoxy]ethyl]propanamide
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C38H52ClN7O6S  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0523269
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-(pyridin-3-ylmethyl)carbamodithioate
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C28H26FN7O2S2  1
1
IC50 = 33400 nM
   TI
   LI
   LO
   TS
CP0689377
SPEBRUTINIB
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C22H22FN5O3  1
1
IC50 = 32500 nM
   TI
   LI
   LO
   TS
CP0871866
N-(5-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide
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C29H36ClN7O4S  1
1
GI50 < 0.3 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Pleural effusion)
Cell Line Name Organism Disease
U-937 Homo sapiens (Human) Adult acute monocytic leukemia
SU-DHL-1 Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
SR Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
MC116 Homo sapiens (Human) B-cell non-Hodgkin lymphoma
K-562 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/A02 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/Adr Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/R7 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/DOX Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
MDA-MB-231 Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-415 Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-468 Homo sapiens (Human) Breast adenocarcinoma
SK-BR-3 Homo sapiens (Human) Breast adenocarcinoma
AU565 Homo sapiens (Human) Breast adenocarcinoma
CAL-51 Homo sapiens (Human) Breast carcinoma
CAL-120 Homo sapiens (Human) Breast carcinoma
DG-75 Homo sapiens (Human) Burkitt lymphoma
SUP-T1 Homo sapiens (Human) Childhood T lymphoblastic lymphoma
Pfeiffer Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
WSU-DLCL2 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
Karpas-422 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
DoHH2 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
KATO III Homo sapiens (Human) Down syndrome
GIST-T1 Homo sapiens (Human) Gastrointestinal stromal tumor
GIST-5R Homo sapiens (Human) Gastrointestinal stromal tumor
MZ-CRC-1 Homo sapiens (Human) Hereditary thyroid gland medullary carcinoma
L-428 Homo sapiens (Human) Hodgkin lymphoma
KM-H2 Homo sapiens (Human) Hodgkin lymphoma
T-47D Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/2a Homo sapiens (Human) Invasive breast carcinoma of no special type
T-47 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 MX100 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/VP Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-2a Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D:A18 Homo sapiens (Human) Invasive breast carcinoma of no special type
MVLN Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF/MX Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/Topo Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD2 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7aro Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M6 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-10 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M24 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7piGST Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-Y1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/ADM Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7:WS8 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-FLV1000 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-neo/Her2 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 cl.24 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/DX1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-LC3 Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D-KBluc Homo sapiens (Human) Invasive breast carcinoma of no special type
Calu-6 Homo sapiens (Human) Lung adenocarcinoma
Calu-3 Homo sapiens (Human) Lung adenocarcinoma
HCC78 Homo sapiens (Human) Lung adenocarcinoma
NCI-H3255 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2122 Homo sapiens (Human) Lung adenocarcinoma
COR-L105 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1437 Homo sapiens (Human) Lung adenocarcinoma
HCC4006 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1792 Homo sapiens (Human) Lung adenocarcinoma
DFCI032 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1355 Homo sapiens (Human) Lung adenocarcinoma
NCI-H460 Homo sapiens (Human) Lung large cell carcinoma
U-1810 Homo sapiens (Human) Lung large cell carcinoma
COR-L23/R Homo sapiens (Human) Lung large cell carcinoma
H460/MX20 Homo sapiens (Human) Lung large cell carcinoma
H460R Homo sapiens (Human) Lung large cell carcinoma
H69AR Homo sapiens (Human) Lung small cell carcinoma
NCI-H69 Homo sapiens (Human) Lung small cell carcinoma
GLC-4/ADR Homo sapiens (Human) Lung small cell carcinoma
STC 1 Homo sapiens (Human) Lung small cell carcinoma
RERF-LC-A1 Homo sapiens (Human) Lung squamous cell carcinoma
Calu-1 Homo sapiens (Human) Lung squamous cell carcinoma
HCC95 Homo sapiens (Human) Lung squamous cell carcinoma
RERF-LC-AI Tet-off Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1650 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H1666 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H929 Homo sapiens (Human) Plasma cell myeloma
KMS-11 Homo sapiens (Human) Plasma cell myeloma
UTMC-2 Homo sapiens (Human) Plasma cell myeloma
KMS-12-PE Homo sapiens (Human) Plasma cell myeloma
NCI-H226 Homo sapiens (Human) Pleural epithelioid mesothelioma
Karpas-1106P Homo sapiens (Human) Primary mediastinal (thymic) large B-cell lymphoma