Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methylbenzamide
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 PubChem ID
CID: 71721648
Canonical SMILES
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3C[C@H](CCCc3c2OC)N2CCN(CCO)CC2)ncc1Cl
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Compound Formula C30H38ClN7O3
Compound Structure
Protein Name
 Protein Info 
ALK tyrosine kinase receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q9UM73
Gene Name
ALK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000469 NCI-H2228
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 175 nM
   TI
   LI
   LO
   TS
CL000320 NCI-H3122
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 85 nM
   TI
   LI
   LO
   TS
CL000427 SUP-M2
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS