General Information of the Cell Line
Cell Line ID
CL000427
Cell Line Name
SUP-M2
Synonyms
Sup-M2
SUPM2
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2209
Tissue Information
Cerebrospinal fluid
Disease
Anaplastic large cell lymphoma, ALK-positive (NCIt: C37193)
ALK-positive anaplastic large cell lymphoma (ORDO: Orphanet_300895)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01203, ALK tyrosine kinase receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0659262
 Compound Info 
(1S,2S,3R,4R)-3-{6-Chloro-2-[2-methoxy-4-(4-morpholin-4-yl-piperidin-1-yl)-phenyl]-3H-imidazo[4,5-b]pyridin-7-ylamino}-bicyclo[2.2.1]hept-5-ene-2-carboxylicacidamide
   Show/Hide
C30H36ClN7O3
  1
1
IC50 = 4 nM
 Bioactivity Info 
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CP0704533
 Compound Info 
(1S,2S,3R,4R)-3-{6-Chloro-2-[2-methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-3Himidazo[4,5-b]pyridin-7-ylamino}-bicyclo[2.2.1]hept-5-ene-2-carboxylic
   Show/Hide
C26H30ClN7O2
  1
1
IC50 = 8 nM
 Bioactivity Info 
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CP0842622
 Compound Info 
(1S,2S,3R,4R)-3-{6-Chloro-2-[2-methoxy-4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-3H-imidazo[4,5-b]pyridin-7-ylamino}-bicyclo[2.2.1]hept-5-ene-2-carboxylicacidamide
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C27H32ClN7O2
  1
1
IC50 = 8 nM
 Bioactivity Info 
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CP0078581
 Compound Info 
N-[6-chloro-19-methoxy-17-(4-methylpiperazin-1-yl)-2,4,8,22-tetrazatetracyclo[14.3.1.13,7.19,13]docosa-1(19),3,5,7(22),9,11,13(21),16(20),17-nonaen-10-yl]-N-methylmethanesulfonamide
   Show/Hide
C26H32ClN7O3S
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0762036
 Compound Info 
(1S,2S,3R,4R)-3-(6-Chloro-2-{2-methoxy-4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-3H-imidazo[4,5-b]pyridin-7-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylicacidamide
   Show/Hide
C31H39ClN8O2
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0071455
 Compound Info 
2-[4-[2-[[5-chloro-4-(2-pyrazol-1-ylanilino)pyrimidin-2-yl]amino]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl]piperazin-1-yl]ethanol
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C31H37ClN8O2
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0089290
 Compound Info 
(1S,2S,3R,4R)-3-[[5-chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
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C28H35ClN6O3
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0059911
 Compound Info 
2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C30H38ClN7O3
  1
1
IC50 = 22 nM
 Bioactivity Info 
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CP0110196
 Compound Info 
6-chloro-19-methoxy-17-(4-methylpiperazin-1-yl)-10-propan-2-ylsulfonyl-2,4,8,22-tetrazatetracyclo[14.3.1.13,7.19,13]docosa-1(19),3,5,7(22),9,11,13(21),16(20),17-nonaene
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C27H33ClN6O3S
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0769733
 Compound Info 
(1S,2S,3R,4R)-3-{6-Chloro-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-3H-imidazo[4,5-b]pyridin-7-ylamino}-bicyclo[2.2.1]hept-5-ene-2-carboxylicacidamide
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C25H28ClN7O
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0046482
 Compound Info 
(1S,2S,3R,4R)-3-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
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C30H40ClN7O3
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0555827
 Compound Info 
N-[2-[[5-chloro-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]phenyl]-N-methylmethanesulfonamide
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C30H40ClN7O4S
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0659259
 Compound Info 
(1S,2S,3R,4R)-3-{6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-3H-imidazo[4,5-b]pyridin-7-ylamino}-bicyclo[2.2.1]hept-5-ene-2-carboxylicacidamide
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C25H28BrN7O
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0769350
 Compound Info 
(1S,2S,3R,4R)-3-[6-Chloro-2-(2-methoxy-4-morpholin-4-yl-phenyl)-3H-imidazo[4,5-b]pyridin-7-ylamino]-bicyclo[2.2.1]hept-5-ene-2-carboxylicacidamide
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C25H27ClN6O3
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0091557
 Compound Info 
2-[[5-chloro-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide
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C30H40ClN7O4S
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0191549
 Compound Info 
2-[[5-chloro-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C30H38ClN7O3
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0398360
 Compound Info 
N-[2-[[5-chloro-2-[[1-methoxy-6-(4-methylpiperazin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]phenyl]-N-methylmethanesulfonamide
   Show/Hide
C29H38ClN7O3S
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0091556
 Compound Info 
(1S,2S,3R,4R)-3-[[5-chloro-2-[[(6R)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
   Show/Hide
C30H40ClN7O3
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0294241
 Compound Info 
2-[[5-chloro-2-[[(6R)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C30H38ClN7O3
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0555839
 Compound Info 
2-[4-[2-[[5-chloro-4-[2-(1-methylimidazol-2-yl)anilino]pyrimidin-2-yl]amino]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl]piperazin-1-yl]ethanol
   Show/Hide
C32H39ClN8O2
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0842621
 Compound Info 
(1S,2S,3R,4R)-3-[6-Chloro-2-(2-methoxy-4-morpholin-4-ylmethyl-phenyl)-3Himidazo[4,5-b]pyridin-7-ylamino]-bicyclo[2.2.1]hept-5-ene-2-carboxylicacidamide
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C26H29ClN6O3
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0226176
 Compound Info 
2-[4-[2-[[5-chloro-4-[2-(1,1-dioxo-1,2-thiazolidin-2-yl)anilino]pyrimidin-2-yl]amino]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl]piperazin-1-yl]ethanol
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C31H40ClN7O4S
  1
1
IC50 = 60 nM
 Bioactivity Info 
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CP0285873
 Compound Info 
6-chloro-17-(4-methylpiperazin-1-yl)-10-propan-2-ylsulfonyl-2,4,8,22-tetrazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3,5,7(22),9,11,13(21),16,18-nonaene
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C26H31ClN6O2S
  1
1
IC50 = 70 nM
 Bioactivity Info 
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CP0170188
 Compound Info 
5-chloro-4-N-(2-methoxyphenyl)-2-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrimidine-2,4-diamine
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C22H25ClN6O
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0103868
 Compound Info 
N-[6-chloro-19-methoxy-17-(4-methylpiperazin-1-yl)-2,4,8,22-tetrazatetracyclo[14.3.1.13,7.19,13]docosa-1(19),2,5,7,9,11,13(21),14,16(20),17-decaen-10-yl]-N-methylmethanesulfonamide
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C26H30ClN7O3S
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0110195
 Compound Info 
N-[6-chloro-17-(4-methylpiperazin-1-yl)-2,4,8,22-tetrazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3,5,7(22),9,11,13(21),16,18-nonaen-10-yl]-N-methylmethanesulfonamide
   Show/Hide
C25H30ClN7O2S
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0103867
 Compound Info 
6-chloro-10-methoxy-17-(4-methylpiperazin-1-yl)-2,4,8,22-tetrazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3,5,7(22),9,11,13(21),16,18-nonaene
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C24H27ClN6O
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0275596
 Compound Info 
5-chloro-N2-(8-methoxy-3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-N4-(2-methoxy-4-morpholinophenyl)pyrimidine-2,4-diamine
   Show/Hide
C29H37ClN6O4
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0704531
 Compound Info 
(1S,2S,3R,4R)-3-[6-Chloro-2-(2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine-7-ylamino]-bicyclo[2.2.1]hept-5-ene-2-carboxylicacidamide
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C21H20ClN5O2
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0530939
 Compound Info 
(1S,2S,3R,4R)-3-[[5-chloro-2-[[(6S)-1-methoxy-6-(4-methylpiperazin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
   Show/Hide
C29H38ClN7O2
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0530940
 Compound Info 
(1S,2S,3R,4R)-3-[[5-chloro-2-[[(6R)-1-methoxy-6-(4-methylpiperazin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
   Show/Hide
C29H38ClN7O2
  1
1
IC50 = 200 nM
 Bioactivity Info 
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CP0078539
 Compound Info 
6-chloro-19-methoxy-17-(4-methylpiperazin-1-yl)-2,4,8,22-tetrazatetracyclo[14.3.1.13,7.19,13]docosa-1(19),3,5,7(22),9,11,13(21),16(20),17-nonaene
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C24H27ClN6O
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0283340
 Compound Info 
6-chloro-N-methyl-17-(4-methylpiperazin-1-yl)-2,4,8,22-tetrazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3,5,7(22),9,11,13(21),16,18-nonaene-10-carboxamide
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C25H28ClN7O
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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Protein family and CMB statistics Related to the Cell Line