General Information of the Cell Line
Cell Line ID
CL000353
Cell Line Name
K562/Adr
Synonyms
K562/adr
K-562adr
K562adr
K562/ADM
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_3827
Tissue Information
Pleural effusion
Disease
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01546, ATP-dependent translocase ABCB1
Compound ID Compound Name Compound Formula
CP0484493
(2Z,5Z)-3-[3-(diethylamino)propyl]-2-(5-fluoro-2-oxo-1H-indol-3-ylidene)-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C28H32FN3O5S
 1
1
Ki = 120 nM
   TI
   LI
   LO
   TS
CP0486480
(2E,5Z)-3-[3-(diethylamino)propyl]-2-(5-fluoro-2-oxo-1H-indol-3-ylidene)-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C28H32FN3O5S
 1
1
Ki = 120 nM
   TI
   LI
   LO
   TS
CP0486481
(2Z,5Z)-2-(5-chloro-2-oxo-1H-indol-3-ylidene)-3-[3-(diethylamino)propyl]-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C28H32ClN3O5S
 1
1
Ki = 220 nM
   TI
   LI
   LO
   TS
CP0538149
(2E,5Z)-2-(5-chloro-2-oxo-1H-indol-3-ylidene)-3-[3-(diethylamino)propyl]-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C28H32ClN3O5S
 1
1
Ki = 220 nM
   TI
   LI
   LO
   TS
CP0486479
(2Z,5Z)-3-[3-(diethylamino)propyl]-2-(5-methyl-2-oxo-1H-indol-3-ylidene)-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C29H35N3O5S
 1
1
Ki = 320 nM
   TI
   LI
   LO
   TS
CP0538147
(2E,5Z)-3-[3-(diethylamino)propyl]-2-(5-methyl-2-oxo-1H-indol-3-ylidene)-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C29H35N3O5S
 1
1
Ki = 320 nM
   TI
   LI
   LO
   TS
CP0484494
(2E,5Z)-3-[3-(diethylamino)propyl]-2-(6-fluoro-2-oxo-1H-indol-3-ylidene)-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C28H32FN3O5S
 1
1
Ki = 470 nM
   TI
   LI
   LO
   TS
CP0538148
(2Z,5Z)-3-[3-(diethylamino)propyl]-2-(6-fluoro-2-oxo-1H-indol-3-ylidene)-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C28H32FN3O5S
 1
1
Ki = 470 nM
   TI
   LI
   LO
   TS
CP0453284
(2E,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[3-(diethylamino)propyl]-2-(2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C26H27N3O4S
 1
1
Ki = 480 nM
   TI
   LI
   LO
   TS
CP0528887
(2Z,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[3-(diethylamino)propyl]-2-(2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C26H27N3O4S
 1
1
Ki = 480 nM
   TI
   LI
   LO
   TS
CP0528885
(2E,5Z)-3-[3-(diethylamino)propyl]-2-(2-oxo-1H-indol-3-ylidene)-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C28H33N3O5S
 1
1
Ki = 730 nM
   TI
   LI
   LO
   TS
CP0528886
(2Z,5Z)-3-[3-(diethylamino)propyl]-2-(2-oxo-1H-indol-3-ylidene)-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C28H33N3O5S
 1
1
Ki = 730 nM
   TI
   LI
   LO
   TS
CP0486482
(2Z,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[3-(diethylamino)propyl]-2-(5-methyl-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C27H29N3O4S
 1
1
Ki = 940 nM
   TI
   LI
   LO
   TS
CP0540207
(2E,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[3-(diethylamino)propyl]-2-(5-methyl-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C27H29N3O4S
 1
1
Ki = 940 nM
   TI
   LI
   LO
   TS
CP0453282
(2Z,5Z)-3-[3-(diethylamino)propyl]-5-[(2,4-difluorophenyl)methylidene]-2-(6-fluoro-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
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C25H24F3N3O2S
 1
1
Ki = 1010 nM
   TI
   LI
   LO
   TS
CP0528884
(2E,5Z)-3-[3-(diethylamino)propyl]-5-[(2,4-difluorophenyl)methylidene]-2-(6-fluoro-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C25H24F3N3O2S
 1
1
Ki = 1010 nM
   TI
   LI
   LO
   TS
CP0380093
(2Z,5Z)-3-[2-(dimethylamino)ethyl]-2-(5-fluoro-2-oxo-1H-indol-3-ylidene)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C22H20FN3O3S
 1
1
Ki = 1340 nM
   TI
   LI
   LO
   TS
CP0484495
(2E,5Z)-3-[2-(dimethylamino)ethyl]-2-(5-fluoro-2-oxo-1H-indol-3-ylidene)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C22H20FN3O3S
 1
1
Ki = 1340 nM
   TI
   LI
   LO
   TS
CP0484492
(2Z,5Z)-3-[3-(diethylamino)propyl]-5-[(2-hydroxyphenyl)methylidene]-2-(5-methyl-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C26H29N3O3S
 1
1
Ki = 1710 nM
   TI
   LI
   LO
   TS
CP0486478
(2E,5Z)-3-[3-(diethylamino)propyl]-5-[(2-hydroxyphenyl)methylidene]-2-(5-methyl-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C26H29N3O3S
 1
1
Ki = 1710 nM
   TI
   LI
   LO
   TS
CP0380094
(2Z,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-2-(5-chloro-2-oxo-1H-indol-3-ylidene)-3-[3-(diethylamino)propyl]-1,3-thiazolidin-4-one
   Show/Hide
C26H26ClN3O4S
 1
1
Ki = 1780 nM
   TI
   LI
   LO
   TS
CP0528889
(2E,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-2-(5-chloro-2-oxo-1H-indol-3-ylidene)-3-[3-(diethylamino)propyl]-1,3-thiazolidin-4-one
   Show/Hide
C26H26ClN3O4S
 1
1
Ki = 1780 nM
   TI
   LI
   LO
   TS
CP0374599
(2Z,5Z)-3-[2-(dimethylamino)ethyl]-2-(6-fluoro-2-oxo-1H-indol-3-ylidene)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C22H20FN3O3S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0395965
(2E,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[2-(dimethylamino)ethyl]-2-(2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C23H21N3O4S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0395966
(2Z,5Z)-2-(5-chloro-2-oxo-1H-indol-3-ylidene)-3-[3-(diethylamino)propyl]-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C25H26ClN3O3S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0395967
(2Z,5Z)-3-[2-(dimethylamino)ethyl]-5-[(4-hydroxyphenyl)methylidene]-2-(5-methyl-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C23H23N3O3S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0453283
(2E,5Z)-3-[2-(dimethylamino)ethyl]-2-(6-fluoro-2-oxo-1H-indol-3-ylidene)-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C22H20FN3O3S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0471972
(2E,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[3-(diethylamino)propyl]-2-(6-fluoro-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C26H26FN3O4S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0528888
(2Z,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[3-(diethylamino)propyl]-2-(6-fluoro-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C26H26FN3O4S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0528890
(2E,5Z)-3-[2-(dimethylamino)ethyl]-5-[(4-hydroxyphenyl)methylidene]-2-(5-methyl-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C23H23N3O3S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0538150
(2E,5Z)-2-(5-chloro-2-oxo-1H-indol-3-ylidene)-3-[3-(diethylamino)propyl]-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
   Show/Hide
C25H26ClN3O3S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0538151
(2Z,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[3-(diethylamino)propyl]-2-(5-fluoro-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C26H26FN3O4S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0538152
(2E,5Z)-3-[3-(diethylamino)propyl]-5-[(3,4-difluorophenyl)methylidene]-2-(5-fluoro-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C25H24F3N3O2S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0538153
(2Z,5Z)-3-[3-(diethylamino)propyl]-5-[(3,4-difluorophenyl)methylidene]-2-(5-fluoro-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C25H24F3N3O2S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0539345
(2E,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[3-(diethylamino)propyl]-2-(5-fluoro-2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C26H26FN3O4S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0540205
(2Z,5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-[2-(dimethylamino)ethyl]-2-(2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C23H21N3O4S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0540206
(2Z,5Z)-3-[2-(dimethylamino)ethyl]-5-[(4-hydroxyphenyl)methylidene]-2-(2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C22H21N3O3S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
CP0540605
(2E,5Z)-3-[2-(dimethylamino)ethyl]-5-[(4-hydroxyphenyl)methylidene]-2-(2-oxo-1H-indol-3-ylidene)-1,3-thiazolidin-4-one
   Show/Hide
C22H21N3O3S
 1
1
Ki > 2230 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Pleural effusion)
Cell Line Name Organism Disease
U-937 Homo sapiens (Human) Adult acute monocytic leukemia
SU-DHL-1 Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
SR Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
MC116 Homo sapiens (Human) B-cell non-Hodgkin lymphoma
K-562 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/A02 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/R7 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/DOX Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
MDA-MB-231 Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-415 Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-468 Homo sapiens (Human) Breast adenocarcinoma
SK-BR-3 Homo sapiens (Human) Breast adenocarcinoma
AU565 Homo sapiens (Human) Breast adenocarcinoma
CAL-51 Homo sapiens (Human) Breast carcinoma
CAL-120 Homo sapiens (Human) Breast carcinoma
DG-75 Homo sapiens (Human) Burkitt lymphoma
SUP-T1 Homo sapiens (Human) Childhood T lymphoblastic lymphoma
Pfeiffer Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
WSU-DLCL2 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
Karpas-422 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
DoHH2 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
KATO III Homo sapiens (Human) Down syndrome
GIST-T1 Homo sapiens (Human) Gastrointestinal stromal tumor
GIST-5R Homo sapiens (Human) Gastrointestinal stromal tumor
MZ-CRC-1 Homo sapiens (Human) Hereditary thyroid gland medullary carcinoma
L-428 Homo sapiens (Human) Hodgkin lymphoma
KM-H2 Homo sapiens (Human) Hodgkin lymphoma
T-47D Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/2a Homo sapiens (Human) Invasive breast carcinoma of no special type
T-47 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 MX100 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/VP Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-2a Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D:A18 Homo sapiens (Human) Invasive breast carcinoma of no special type
MVLN Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF/MX Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/Topo Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD2 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7aro Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M6 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-10 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M24 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7piGST Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-Y1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/ADM Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7:WS8 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-FLV1000 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-neo/Her2 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 cl.24 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/DX1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-LC3 Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D-KBluc Homo sapiens (Human) Invasive breast carcinoma of no special type
Calu-6 Homo sapiens (Human) Lung adenocarcinoma
Calu-3 Homo sapiens (Human) Lung adenocarcinoma
HCC78 Homo sapiens (Human) Lung adenocarcinoma
NCI-H3122 Homo sapiens (Human) Lung adenocarcinoma
NCI-H3255 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2122 Homo sapiens (Human) Lung adenocarcinoma
COR-L105 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1437 Homo sapiens (Human) Lung adenocarcinoma
HCC4006 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1792 Homo sapiens (Human) Lung adenocarcinoma
DFCI032 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1355 Homo sapiens (Human) Lung adenocarcinoma
NCI-H460 Homo sapiens (Human) Lung large cell carcinoma
U-1810 Homo sapiens (Human) Lung large cell carcinoma
COR-L23/R Homo sapiens (Human) Lung large cell carcinoma
H460/MX20 Homo sapiens (Human) Lung large cell carcinoma
H460R Homo sapiens (Human) Lung large cell carcinoma
H69AR Homo sapiens (Human) Lung small cell carcinoma
NCI-H69 Homo sapiens (Human) Lung small cell carcinoma
GLC-4/ADR Homo sapiens (Human) Lung small cell carcinoma
STC 1 Homo sapiens (Human) Lung small cell carcinoma
RERF-LC-A1 Homo sapiens (Human) Lung squamous cell carcinoma
Calu-1 Homo sapiens (Human) Lung squamous cell carcinoma
HCC95 Homo sapiens (Human) Lung squamous cell carcinoma
RERF-LC-AI Tet-off Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1650 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H1666 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H929 Homo sapiens (Human) Plasma cell myeloma
KMS-11 Homo sapiens (Human) Plasma cell myeloma
UTMC-2 Homo sapiens (Human) Plasma cell myeloma
KMS-12-PE Homo sapiens (Human) Plasma cell myeloma
NCI-H226 Homo sapiens (Human) Pleural epithelioid mesothelioma
Karpas-1106P Homo sapiens (Human) Primary mediastinal (thymic) large B-cell lymphoma