General Information of the Cell Line
Cell Line ID
CL000100
Cell Line Name
U-937
Synonyms
U937
U 937
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0007
Tissue Information
Pleural effusion
Disease
Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01538, 3',5'-cyclic-AMP phosphodiesterase 4D
Compound ID Compound Name Compound Formula
CP0037308
(R,S)-Rolipram
   Show/Hide
C16H21NO3
 1
1
IC50 = 1690 nM
   TI
   LI
   LO
   TS
CP0075844
6-cyclopentyloxy-7-methoxy-N-(2-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C29H30N2O4
 1
1
IC50 = 5780 nM
   TI
   LI
   LO
   TS
CP0153850
6-cyclopentyloxy-7-methoxy-1-phenyl-N-[2-(trifluoromethoxy)phenyl]-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C29H27F3N2O4
 1
1
IC50 = 6660 nM
   TI
   LI
   LO
   TS
CP0479250
6-cyclopentyloxy-7-methoxy-1-phenyl-N-pyridin-2-yl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C27H27N3O3
 1
1
IC50 = 10130 nM
   TI
   LI
   LO
   TS
CP0243354
methyl 2-[(6-cyclopentyloxy-7-methoxy-1-phenyl-3,4-dihydroisoquinoline-3-carbonyl)amino]acetate
   Show/Hide
C25H28N2O5
 1
1
IC50 = 11180 nM
   TI
   LI
   LO
   TS
CP0459229
N-(2-chlorophenyl)-6-cyclopentyloxy-7-methoxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C28H27ClN2O3
 1
1
IC50 = 11250 nM
   TI
   LI
   LO
   TS
CP0075843
6-cyclopentyloxy-N-(2-fluorophenyl)-7-methoxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C28H27FN2O3
 1
1
IC50 = 13780 nM
   TI
   LI
   LO
   TS
CP0153867
6-cyclopentyloxy-7-methoxy-1-phenyl-N-(1,3,4-thiadiazol-2-yl)-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C24H24N4O3S
 1
1
IC50 = 15820 nM
   TI
   LI
   LO
   TS
CP0204479
6-cyclopentyloxy-N-(2,6-difluorophenyl)-7-methoxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C28H26F2N2O3
 1
1
IC50 = 26160 nM
   TI
   LI
   LO
   TS
CP0455611
6-cyclopentyloxy-7-methoxy-N,1-diphenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C28H28N2O3
 1
1
IC50 = 29660 nM
   TI
   LI
   LO
   TS
CP0243355
6-cyclopentyloxy-7-methoxy-N-(4-methoxyphenyl)-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C29H30N2O4
 1
1
IC50 = 32780 nM
   TI
   LI
   LO
   TS
CP0354719
N-(3-chlorophenyl)-6-cyclopentyloxy-7-methoxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C28H27ClN2O3
 1
1
IC50 = 36680 nM
   TI
   LI
   LO
   TS
CP0204478
6-cyclopentyloxy-7-methoxy-N-(3-nitrophenyl)-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C28H27N3O5
 1
1
IC50 = 37420 nM
   TI
   LI
   LO
   TS
CP0157080
6-cyclopentyloxy-7-methoxy-N-(4-methylphenyl)-1-phenyl-3,4-dihydroisoquinoline-3-carboxamide
   Show/Hide
C29H30N2O3
 1
1
IC50 = 38560 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003832
N'-hydroxy-N-phenyloctanediamide
   Show/Hide
C14H20N2O3  3
1
CC50 = 1050 nM
   TI
   LI
   LO
   TS
2
EC50 = 880 nM
   TI
   LI
   LO
   TS
3
IC50 = 4330 nM
   TI
   LI
   LO
   TS
CP0007430
IBRUTINIB
   Show/Hide
C25H24N6O2  1
1
GI50 = 8500 nM
   TI
   LI
   LO
   TS
CP0010193
AG-013736
   Show/Hide
C22H18N4OS  1
1
GI50 = 1980 nM
   TI
   LI
   LO
   TS
CP0016677
N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
   Show/Hide
C35H30N4O4  1
1
GI50 = 1400 nM
   TI
   LI
   LO
   TS
CP0017324
N-[5-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]-3-methylphenyl]-1H-pyrazol-3-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide
   Show/Hide
C31H38N8O3  1
1
GI50 = 5500 nM
   TI
   LI
   LO
   TS
CP0018477
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
   Show/Hide
C21H16ClF3N4O3  2
1
GI50 = 3400 nM
   TI
   LI
   LO
   TS
2
IC50 > 3000 nM
   TI
   LI
   LO
   TS
CP0019439
8-[3-(1-benzofuran-2-yl)-5-chloropyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
   Show/Hide
C21H20ClN3O2  1
1
GI50 = 1360 nM
   TI
   LI
   LO
   TS
CP0037780
(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
   Show/Hide
C16H24N2O4  1
1
IC50 > 500000 nM
   TI
   LI
   LO
   TS
CP0045655
2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione
   Show/Hide
C14H14O4S2  1
1
IC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0071972
US8933079, 149
   Show/Hide
C23H26N4O4  1
1
IC50 = 506000 nM
   TI
   LI
   LO
   TS
CP0142855
N-[6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine;hydrochloride
   Show/Hide
C19H24ClN7S  1
1
GI50 = 2905 nM
   TI
   LI
   LO
   TS
CP0164465
2,3-bis(methylsulfanyl)naphthalene-1,4-dione
   Show/Hide
C12H10O2S2  1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0228522
4-[[4-[2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]methyl]-N-hydroxybenzamide
   Show/Hide
C28H26FN5O4  1
1
IC50 = 20530 nM
   TI
   LI
   LO
   TS
CP0298640
(Z)-1-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-3-phenyl-urea
   Show/Hide
C20H16N4O2  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0360699
2-[4-[[4-[2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]methyl]phenyl]-N-hydroxyacetamide
   Show/Hide
C29H28FN5O4  1
1
IC50 = 30960 nM
   TI
   LI
   LO
   TS
CP0383413
N-[2-methyl-5-(2-oxo-9-pyrazol-1-ylbenzo[h][1,6]naphthyridin-1-yl)phenyl]prop-2-enamide
   Show/Hide
C25H19N5O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0383415
N-[2-methyl-5-(2-oxo-9-pyrazol-1-ylbenzo[h][1,6]naphthyridin-1-yl)phenyl]propanamide
   Show/Hide
C25H21N5O2  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0393151
(2S)-N-hydroxy-4-methyl-2-[[1-[(2-phenylmethoxyphenyl)methyl]triazol-4-yl]methylcarbamoylamino]pentanamide
   Show/Hide
C24H30N6O4  1
1
IC50 = 68400 nM
   TI
   LI
   LO
   TS
CP0408351
2-N-(5-aminopentyl)-9-cyclopentyl-6-N-[4-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine
   Show/Hide
C26H38N8O  1
1
GI50 = 3629 nM
   TI
   LI
   LO
   TS
CP0434043
(2S)-N-hydroxy-2-[(2-methoxyphenyl)carbamoylamino]-4-methylpentanamide
   Show/Hide
C14H21N3O4  1
1
IC50 > 1000000 nM
   TI
   LI
   LO
   TS
CP0441015
N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]propanamide
   Show/Hide
C30H31F3N6OS  1
1
GI50 = 780 nM
   TI
   LI
   LO
   TS
CP0467527
4-tert-butyl-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
   Show/Hide
C35H38N4O4  1
1
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CP0467528
4-(dimethylamino)-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide
   Show/Hide
C36H38N6O5  1
1
GI50 = 2600 nM
   TI
   LI
   LO
   TS
CP0515615
(2S)-2-[(2-chlorophenyl)carbamoylamino]-N-hydroxy-4-methylpentanamide
   Show/Hide
C13H18ClN3O3  1
1
IC50 > 1000000 nM
   TI
   LI
   LO
   TS
CP0531239
N-hydroxy-4-[(2-oxo-4-phenyl-1H-quinolin-3-yl)oxymethyl]benzamide
   Show/Hide
C23H18N2O4  1
1
IC50 = 27900 nM
   TI
   LI
   LO
   TS
CP0637739
(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-oxononyl)-1-methylazetidine-3-carboxamide
   Show/Hide
C27H35N5O3  1
1
CC50 = 240 nM
   TI
   LI
   LO
   TS
CP0641297
N-(5-ethyl-3-isoxazolyl)-N'-[4-(2-[6-(4-ethylpiperazino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea
   Show/Hide
C26H31N9O2S  1
1
GI50 = 1100 nM
   TI
   LI
   LO
   TS
CP0859370
6-(2-(2,6-bis(phenylamino)-9H-purin-9-yl)acetamido)-N-hydroxyhexanamide
   Show/Hide
C25H28N8O3  1
1
IC50 = 4070 nM
   TI
   LI
   LO
   TS
CP0859380
7-(2-(2,6-bis(phenylamino)-9H-purin-9-yl)acetamido)-N-hydroxyheptanamide
   Show/Hide
C26H30N8O3  1
1
IC50 = 3910 nM
   TI
   LI
   LO
   TS
CP0903793
N-hydroxy-6-(2-(6-morpholino-2-(phenylamino)-9H-purin-9-yl)acetamido)hexanamide
   Show/Hide
C23H30N8O4  1
1
IC50 = 6500 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Pleural effusion)
Cell Line Name Organism Disease
SU-DHL-1 Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
SR Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
MC116 Homo sapiens (Human) B-cell non-Hodgkin lymphoma
K-562 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/A02 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/Adr Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/R7 Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
K562/DOX Homo sapiens (Human) Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
MDA-MB-231 Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-415 Homo sapiens (Human) Breast adenocarcinoma
MDA-MB-468 Homo sapiens (Human) Breast adenocarcinoma
SK-BR-3 Homo sapiens (Human) Breast adenocarcinoma
AU565 Homo sapiens (Human) Breast adenocarcinoma
CAL-51 Homo sapiens (Human) Breast carcinoma
CAL-120 Homo sapiens (Human) Breast carcinoma
DG-75 Homo sapiens (Human) Burkitt lymphoma
SUP-T1 Homo sapiens (Human) Childhood T lymphoblastic lymphoma
Pfeiffer Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
WSU-DLCL2 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
Karpas-422 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
DoHH2 Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
KATO III Homo sapiens (Human) Down syndrome
GIST-T1 Homo sapiens (Human) Gastrointestinal stromal tumor
GIST-5R Homo sapiens (Human) Gastrointestinal stromal tumor
MZ-CRC-1 Homo sapiens (Human) Hereditary thyroid gland medullary carcinoma
L-428 Homo sapiens (Human) Hodgkin lymphoma
KM-H2 Homo sapiens (Human) Hodgkin lymphoma
T-47D Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/2a Homo sapiens (Human) Invasive breast carcinoma of no special type
T-47 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 MX100 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/VP Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-2a Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D:A18 Homo sapiens (Human) Invasive breast carcinoma of no special type
MVLN Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF/MX Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/Topo Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD2 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7aro Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M6 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-10 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/MRP1-M24 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/NOD1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7piGST Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-Y1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7/ADM Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7:WS8 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7-FLV1000 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-neo/Her2 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7 cl.24 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-7/DX1 Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF7-LC3 Homo sapiens (Human) Invasive breast carcinoma of no special type
T47D-KBluc Homo sapiens (Human) Invasive breast carcinoma of no special type
Calu-6 Homo sapiens (Human) Lung adenocarcinoma
Calu-3 Homo sapiens (Human) Lung adenocarcinoma
HCC78 Homo sapiens (Human) Lung adenocarcinoma
NCI-H3122 Homo sapiens (Human) Lung adenocarcinoma
NCI-H3255 Homo sapiens (Human) Lung adenocarcinoma
NCI-H2122 Homo sapiens (Human) Lung adenocarcinoma
COR-L105 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1437 Homo sapiens (Human) Lung adenocarcinoma
HCC4006 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1792 Homo sapiens (Human) Lung adenocarcinoma
DFCI032 Homo sapiens (Human) Lung adenocarcinoma
NCI-H1355 Homo sapiens (Human) Lung adenocarcinoma
NCI-H460 Homo sapiens (Human) Lung large cell carcinoma
U-1810 Homo sapiens (Human) Lung large cell carcinoma
COR-L23/R Homo sapiens (Human) Lung large cell carcinoma
H460/MX20 Homo sapiens (Human) Lung large cell carcinoma
H460R Homo sapiens (Human) Lung large cell carcinoma
H69AR Homo sapiens (Human) Lung small cell carcinoma
NCI-H69 Homo sapiens (Human) Lung small cell carcinoma
GLC-4/ADR Homo sapiens (Human) Lung small cell carcinoma
STC 1 Homo sapiens (Human) Lung small cell carcinoma
RERF-LC-A1 Homo sapiens (Human) Lung squamous cell carcinoma
Calu-1 Homo sapiens (Human) Lung squamous cell carcinoma
HCC95 Homo sapiens (Human) Lung squamous cell carcinoma
RERF-LC-AI Tet-off Homo sapiens (Human) Lung squamous cell carcinoma
NCI-H1650 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H1666 Homo sapiens (Human) Minimally invasive lung adenocarcinoma
NCI-H929 Homo sapiens (Human) Plasma cell myeloma
KMS-11 Homo sapiens (Human) Plasma cell myeloma
UTMC-2 Homo sapiens (Human) Plasma cell myeloma
KMS-12-PE Homo sapiens (Human) Plasma cell myeloma
NCI-H226 Homo sapiens (Human) Pleural epithelioid mesothelioma
Karpas-1106P Homo sapiens (Human) Primary mediastinal (thymic) large B-cell lymphoma