Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R,S)-Rolipram
    Show/Hide
 PubChem ID
CID: 5092
SID: 12013590
Canonical SMILES
COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
    Show/Hide
Compound Formula C16H21NO3
Compound Structure
Protein Name
 Protein Info 
3',5'-cyclic-AMP phosphodiesterase 4D
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 4
>
Phosphodiesterase 4D
Uniprot ID
Q08499
Gene Name
PDE4D
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  3
1
IC50 = 92 nM
   TI
   LI
   LO
   TS
2
IC50 = 110 nM
   TI
   LI
   LO
   TS
3
IC50 = 1050 nM
   TI
   LI
   LO
   TS
CL000100 U-937
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1690 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.80618 nM
2 IC50 = 31.6 nM
3 IC50 = 33 nM
4 IC50 = 50 nM
5 IC50 = 60 nM
6 IC50 = 79 nM
7 IC50 = 80 nM
8 IC50 = 82 nM
9 IC50 = 82.5 nM
10 IC50 = 130 nM
11 IC50 = 140 nM
12 IC50 = 160 nM
13 IC50 = 200 nM
14 IC50 = 240 nM
15 IC50 = 320 nM
16 IC50 = 403 nM
17 IC50 = 550 nM
18 IC50 = 590 nM
19 IC50 = 610 nM
20 IC50 = 621 nM
21 IC50 = 622 nM
22 IC50 = 880 nM
23 IC50 = 1000 nM
24 IC50 = 4310 nM
25 Ki = 58.9 nM