General Information of the Protein
Protein ID
PT01782
Protein Name
Monoglyceride lipase
Secondarily
Protein Name
HU-K5
Lysophospholipase homolog
Lysophospholipase-like
Monoacylglycerol lipase
Gene Name
MGLL
Sequence
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
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Uniprot ID
Primary ID:
Q99685

Secondarily ID:
B3KRC2
B7Z9D1
Q6IBG9
Q96AA5
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Ensembl ID
ENSG00000074416
HGNC ID
HGNC:17038
Subcellular Location
Cytoplasm
Cytosol
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0038808
 Compound Info 
BDBM50300355
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C27H24N2O9
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380789
 Compound Info 
5-[[4-(3-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
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C17H17N5O2
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380509
 Compound Info 
5-[[4-[3-(hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
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C18H19N5O2
  1
1
IC50 = 27 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380779
 Compound Info 
N-methyl-N-(naphthalen-2-ylmethyl)-5-[(4-phenylphenyl)methyl]tetrazole-2-carboxamide
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C27H23N5O
  1
1
IC50 = 84.5 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0380780
 Compound Info 
5-[[4-(2-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
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C17H17N5O2
  1
1
IC50 = 98.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380778
 Compound Info 
N,N-dimethyl-5-[[4-(2-methylphenyl)phenyl]methyl]tetrazole-2-carboxamide
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C18H19N5O
  1
1
IC50 = 121.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399472
 Compound Info 
5-[[4-(3-carbamoylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
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C18H18N6O2
  1
1
IC50 = 137.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0375145
 Compound Info 
N,N-dimethyl-5-[[4-(3-methylphenyl)phenyl]methyl]tetrazole-2-carboxamide
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C18H19N5O
  1
1
IC50 = 139.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407813
 Compound Info 
5-[[4-(3-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
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C17H17N5O2
  1
1
IC50 = 170.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0381258
 Compound Info 
5-[[4-(4-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
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C17H17N5O2
  1
1
IC50 = 209.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380781
 Compound Info 
N-methyl-N-(4-phenylbutyl)-5-[(4-phenylphenyl)methyl]tetrazole-2-carboxamide
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C26H27N5O
  1
1
IC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399471
 Compound Info 
N,N-dimethyl-5-[[4-(4-methylphenyl)phenyl]methyl]tetrazole-2-carboxamide
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C18H19N5O
  1
1
IC50 = 334.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380782
 Compound Info 
[5-[(4-phenylphenyl)methyl]tetrazol-2-yl]-piperidin-1-ylmethanone
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C20H21N5O
  1
1
IC50 = 346.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433847
 Compound Info 
5-[[4-[4-(hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
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C18H19N5O2
  1
1
IC50 = 372.2 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0433848
 Compound Info 
methyl 3-[4-[[2-(dimethylcarbamoyl)tetrazol-5-yl]methyl]phenyl]benzoate
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C19H19N5O3
  1
1
IC50 = 498.5 nM
 Bioactivity Info 
   TI
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   LO
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CP0433845
 Compound Info 
5-[[4-[3-(hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
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C18H19N5O2
  1
1
IC50 = 520.2 nM
 Bioactivity Info 
   TI
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CP0380514
 Compound Info 
N-cyclohexyl-N-methyl-5-[(4-phenylphenyl)methyl]tetrazole-2-carboxamide
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C22H25N5O
  1
1
IC50 = 601.5 nM
 Bioactivity Info 
   TI
   LI
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CP0433849
 Compound Info 
5-[[4-(3-acetylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-2-carboxamide
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C19H19N5O2
  1
1
IC50 = 807.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0376029
 Compound Info 
N,N-dimethyl-5-[[4-(4-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide
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C18H19N5O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380511
 Compound Info 
5-[[4-(2-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
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C17H17N5O2
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380515
 Compound Info 
5-[[4-(3-carbamoylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
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C18H18N6O2
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380516
 Compound Info 
N-methyl-N-(4-phenylbutyl)-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
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C26H27N5O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380776
 Compound Info 
5-[[4-(4-hydroxyphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
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C17H17N5O2
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380777
 Compound Info 
methyl 3-[4-[[1-(dimethylcarbamoyl)tetrazol-5-yl]methyl]phenyl]benzoate
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C19H19N5O3
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0380790
 Compound Info 
N,N-dimethyl-5-[[4-(3-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide
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C18H19N5O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0381259
 Compound Info 
N-cyclohexyl-N-methyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
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C22H25N5O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399470
 Compound Info 
5-[[4-(3-acetylphenyl)phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
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C19H19N5O2
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399475
 Compound Info 
[5-[(4-phenylphenyl)methyl]tetrazol-1-yl]-piperidin-1-ylmethanone
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C20H21N5O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407562
 Compound Info 
5-[[4-[4-(hydroxymethyl)phenyl]phenyl]methyl]-N,N-dimethyltetrazole-1-carboxamide
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C18H19N5O2
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0456753
 Compound Info 
N,N-dimethyl-5-[[4-(2-methylphenyl)phenyl]methyl]tetrazole-1-carboxamide
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C18H19N5O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0484150
 Compound Info 
N-methyl-N-(naphthalen-2-ylmethyl)-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
   Show/Hide
C27H23N5O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
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Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Cell Line ID: CL000100 , U-937
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0127332
 Compound Info 
US9133148, 1a
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C24H21F6NO7
  1
1 IC50 = 3 nM
CP0445556
 Compound Info 
4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
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C24H23N3O5
  2
1 IC50 = 4 nM
2 IC50 = 204.5 nM
CP0038808
 Compound Info 
BDBM50300355
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C27H24N2O9
  9
1 IC50 = 5.6 nM
2 IC50 = 6 nM
3 IC50 = 10 nM
4 IC50 = 37 nM
5 IC50 = 48 nM
6 IC50 = 49.3 nM
7 IC50 = 520 nM
8 IC50 = 1100 nM
9 IC50 = 1700 nM
CP0229968
 Compound Info 
[1-(2,4-difluoro-5-hydroxybenzoyl)piperidin-4-yl]-(4-phenylsulfanylphenyl)methanone
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C25H21F2NO3S
  2
1 IC50 = 18 nM
2 Ki = 11 nM
CP0137965
 Compound Info 
[1-(2-fluoro-5-hydroxybenzoyl)piperidin-4-yl]-(4-phenylsulfanylphenyl)methanone
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C25H22FNO3S
  2
1 IC50 = 30 nM
2 Ki = 27 nM
CP0350802
 Compound Info 
(4-benzylphenyl)-[1-(2,4-difluoro-5-hydroxybenzoyl)piperidin-4-yl]methanone
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C26H23F2NO3
  2
1 IC50 = 36 nM
2 Ki = 30 nM
CP0130031
 Compound Info 
(4-benzylphenyl)-[1-(2-fluoro-5-hydroxybenzoyl)piperidin-4-yl]methanone
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C26H24FNO3
  2
1 IC50 = 49 nM
2 Ki = 37 nM
Clinical Information about the Protein
Target 1 ( Monoglyceride lipase (MAGL) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Neuropathic pain [ICD-11: 8E43.0]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 ABX-1431
 Drug Info 
Phase 1
Neuropathic pain