General Information of the Compound
Compound ID
CP0130031
Compound Name
(4-benzylphenyl)-[1-(2-fluoro-5-hydroxybenzoyl)piperidin-4-yl]methanone
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Formula
C26H24FNO3
Molecular Weight
417.48
Canonical SMILES
Oc1ccc(F)c(c1)C(=O)N1CCC(CC1)C(=O)c1ccc(Cc2ccccc2)cc1
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InChI
InChI=1S/C26H24FNO3/c27-24-11-10-22(29)17-23(24)26(31)28-14-12-21(13-15-28)25(30)20-8-6-19(7-9-20)16-18-4-2-1-3-5-18/h1-11,17,21,29H,12-16H2
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InChIKey
WXGIEJRIHVXHRR-UHFFFAOYSA-N
Physicochemical Property
logP
4.8572
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
57.61
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4798508
Table of Molecular Bioactivities Related to the Compound
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 17000 nM
   TI
   LI
   LO
   TS
CL000084 SK-OV-3 Homo sapiens (Human)  1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CL000249 OVCAR-3 Homo sapiens (Human)  1
1
IC50 = 20700 nM
   TI
   LI
   LO
   TS