General Information of the Cell Line
Cell Line ID
CL000249
Cell Line Name
OVCAR-3
Synonyms
Ovcar-3
OVCAR 3
OVCAR.3
NIH:OVCAR-3
NIH:Ovcar-3
NIH:OVCAR3
NIH-OVCAR-3
NIHOVCAR3
OVCAR3
Ovcar3
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0465
Tissue Information
Ascites
Disease
High grade ovarian serous adenocarcinoma (NCIt: C105555)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00926, Cyclin-dependent kinase 1
Compound ID Compound Name Compound Formula
CP0567322
4-[(7'-cyclopentyl-6'-oxospiro[cyclopropane-1,5'-pyrrolo[2,3-d]pyrimidine]-2'-yl)amino]benzenesulfonamide
   Show/Hide
C19H21N5O3S
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0573919
US11384083, Example 2
   Show/Hide
C19H27N5O3S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003433
(Arylindolyl)maleimide deriv. 27
   Show/Hide
C21H16N4O2  2
1
GI50 = 4490 nM
   TI
   LI
   LO
   TS
2
LC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0006369
6-[3-[4-[1-(5-cyanopentyl)indol-3-yl]-1-hydroxy-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanenitrile
   Show/Hide
C32H31N5O3  1
1
LC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0007711
(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-N'-propylprop-2-enehydrazide;2,2,2-trifluoroacetic acid
   Show/Hide
C26H31F3N4O3  1
1
GI50 = 135 nM
   TI
   LI
   LO
   TS
CP0015738
(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
   Show/Hide
C24H36N4O6S2  1
1
GI50 = 4.6 nM
   TI
   LI
   LO
   TS
CP0033135
N-[2-[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
   Show/Hide
C27H30F3N7O3S  1
1
GI50 = 970 nM
   TI
   LI
   LO
   TS
CP0047056
5-(2,5-Dihydroxy-benzylamino)-N-dodecyl-2-hydroxy-benzamide
   Show/Hide
C26H38N2O4  1
1
GI50 = 1900 nM
   TI
   LI
   LO
   TS
CP0082019
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
   Show/Hide
C22H21NO2S  1
1
GI50 = 2510 nM
   TI
   LI
   LO
   TS
CP0086475
2-[(4-methoxyphenyl)-diphenylmethyl]sulfanylethanamine
   Show/Hide
C22H23NOS  1
1
GI50 = 150 nM
   TI
   LI
   LO
   TS
CP0112599
US8569511, 2
   Show/Hide
C23H22F2N6O2  1
1
IC50 = 5550 nM
   TI
   LI
   LO
   TS
CP0130031
(4-benzylphenyl)-[1-(2-fluoro-5-hydroxybenzoyl)piperidin-4-yl]methanone
   Show/Hide
C26H24FNO3  1
1
IC50 = 20700 nM
   TI
   LI
   LO
   TS
CP0176598
N-[4-[2-[(2S,3S,5R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide
   Show/Hide
C34H52N4O7S2Si  1
1
GI50 = 2951.21 nM
   TI
   LI
   LO
   TS
CP0267543
5-(2,5-Dihydroxy-benzylamino)-N-hexyl-2-hydroxy-benzamide
   Show/Hide
C20H26N2O4  1
1
GI50 = 4000 nM
   TI
   LI
   LO
   TS
CP0270683
5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-N-(3-phenyl-propyl)-benzamide
   Show/Hide
C23H24N2O4  1
1
GI50 = 6500 nM
   TI
   LI
   LO
   TS
CP0320349
N-benzyl-5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzamide
   Show/Hide
C21H20N2O4  1
1
GI50 = 21000 nM
   TI
   LI
   LO
   TS
CP0337077
4-(2,5-Dihydroxy-benzylamino)-N-(3-phenyl-propyl)-benzamide
   Show/Hide
C23H24N2O3  1
1
GI50 = 3000 nM
   TI
   LI
   LO
   TS
CP0345034
[(2R)-1-(4-tert-butylphenoxy)-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate
   Show/Hide
C29H28N4O7  1
1
LC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0358636
N-[2-(4-chlorophenyl)ethyl]-5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzamide
   Show/Hide
C22H21ClN2O4  1
1
GI50 = 5900 nM
   TI
   LI
   LO
   TS
CP0370065
5-(4-chlorophenyl)-2-(4-methoxyphenyl)-[1,3]thiazolo[3,2-b][1,2,4]triazole
   Show/Hide
C17H12ClN3OS  1
1
LC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0451722
(1S,7R,10S,16E,21R)-7-methyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
   Show/Hide
C20H30N4O6S2  1
1
GI50 = 22 nM
   TI
   LI
   LO
   TS
CP0473514
2-chloro-N-(6-(4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-yl)acetamide
   Show/Hide
C12H8ClF3N4O2  1
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CP0549023
N-[2-[2-[2-methoxy-5-(trifluoromethyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
   Show/Hide
C23H21F6N5O3S  1
1
GI50 > 30000 nM
   TI
   LI
   LO
   TS
CP0863007
7,9-di((Z)-dec-1-enyl)-6,8-dimethyl-1,2,3,4-tetrahydroquinolizinium chloride
   Show/Hide
C31H52ClN  1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0863011
N,N,N-trimethyl-3-(octadec-1-en-2-ylsulfonyl)propan-1-aminium chloride
   Show/Hide
C24H50ClNO2S  1
1
IC50 = 4440 nM
   TI
   LI
   LO
   TS
CP0863685
8-((E)-dec-1-enyl)-6-((Z)-dec-1-enyl)-5,7-dimethyl-2,3-dihydro-1H-indolizinium chloride
   Show/Hide
C30H50ClN  1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0870770
Aanibamine
   Show/Hide
C30H50ClN  1
1
IC50 = 860 nM
   TI
   LI
   LO
   TS
CP0882086
6-Dec-1-(Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium chloride
   Show/Hide
C20H32ClN  2
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
2
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0882087
6,8-di((E)-dec-1-enyl)-5,7-dimethyl-2,3-dihydro-1H-indolizinium chloride
   Show/Hide
C30H50ClN  2
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
2
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0882142
6,8-Didecyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium chloride
   Show/Hide
C30H54ClN  1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0897293
1-(7-Benzyl-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride
   Show/Hide
C24H25ClN4O  1
1
GI50 = 285 nM
   TI
   LI
   LO
   TS
CP0906523
7-Benzyl-N-(4-methoxyphenyl)-N,2,5-trimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride
   Show/Hide
C23H25ClN4O  1
1
GI50 = 35.2 nM
   TI
   LI
   LO
   TS
CP0908282
7,9-di((E)-dec-1-enyl)-6,8-dimethyl-1,2,3,4-tetrahydroquinolizinium chloride
   Show/Hide
C31H52ClN  1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0915766
1,3-di((E)-dec-1-enyl)-2,4-dimethyl-7,8,9,10-tetrahydro-6H-pyrido[1,2-a]azepinium chloride
   Show/Hide
C32H54ClN  2
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
2
IC50 = 3600 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Ascites)
Cell Line Name Organism Disease
PEO1 Homo sapiens (Human) BRCA2-associated hereditary breast and ovarian cancer syndrome
MAST Homo sapiens (Human) Breast carcinoma
Ramos Homo sapiens (Human) Burkitt lymphoma
CA46 Homo sapiens (Human) Burkitt lymphoma
CellSensor STAT6-bla RA-1 Homo sapiens (Human) Burkitt lymphoma
NCI-H716 Homo sapiens (Human) Cecum adenocarcinoma
COLO 205 Homo sapiens (Human) Colon adenocarcinoma
COLO 201 Homo sapiens (Human) Colon adenocarcinoma
DiFi Homo sapiens (Human) Colorectal carcinoma
U-2932 Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
DB Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
HEC-50B Homo sapiens (Human) Endometrial adenocarcinoma
SNU-5 Homo sapiens (Human) Gastric adenocarcinoma
SNU-16 Homo sapiens (Human) Gastric adenocarcinoma
SNU-620 Homo sapiens (Human) Gastric adenocarcinoma
SNU-638 Homo sapiens (Human) Gastric adenocarcinoma
SNU-668 Homo sapiens (Human) Gastric signet ring cell adenocarcinoma
OVCAR-5 Homo sapiens (Human) High grade ovarian serous adenocarcinoma
COV318 Homo sapiens (Human) High grade ovarian serous adenocarcinoma
ZR-75-1 Homo sapiens (Human) Invasive breast carcinoma of no special type
SK-HEP-1 Homo sapiens (Human) Liver and intrahepatic bile duct epithelial neoplasm
OV-90 Homo sapiens (Human) Ovarian adenocarcinoma
LK2 Homo sapiens (Human) Ovarian carcinoma
RMG-I Homo sapiens (Human) Ovarian clear cell adenocarcinoma
PA-1 Homo sapiens (Human) Ovarian mixed germ cell tumor
SK-OV-3 Homo sapiens (Human) Ovarian serous cystadenocarcinoma
SKOV3/TR Homo sapiens (Human) Ovarian serous cystadenocarcinoma
AsPC-1 Homo sapiens (Human) Pancreatic ductal adenocarcinoma
HEC Homo sapiens (Human) Peritoneal malignant mesothelioma
Ehrlich-Lettre ascites strain E Mus musculus (Mouse) Malignant neoplasms of the mouse mammary gland
RAW 264.7 Mus musculus (Mouse) Mouse leukemia
L1210 Mus musculus (Mouse) Mouse leukemia
L1210/R81 Mus musculus (Mouse) Mouse leukemia
RAW-Lucia ISG Mus musculus (Mouse) Mouse leukemia
RAW-Lucia ISG-KO-STING Mus musculus (Mouse) Mouse leukemia
RAW 264 Mus musculus (Mouse) Mouse leukemia
J774 Mus musculus (Mouse) Mouse reticulum cell sarcoma
J774A1 Mus musculus (Mouse) Mouse reticulum cell sarcoma
HTC Rattus norvegicus (Rat) Rat hepatocellular carcinoma