| Compound ID |
Compound Name |
Compound Formula |
|
CP0075213
|
2-[3-[5-bromo-2-[4-[(3S)-3,4-dimethylpiperazin-1-yl]-3-methoxyanilino]pyrimidin-4-yl]phenyl]acetonitrile
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|
C25H27BrN6O
|
1
|
| 1 |
EC50 = 1040 nM
|
|
|
|
CP0842155
|
(R/S)-2-(3-(5-bromo-2-(4-(3,4-dimethylpiperazin-1-yl)-3-methoxyphenylamino)pyrimidin-4-yl)phenyl)acetonitrile
Show/Hide
|
C25H27BrN6O
|
1
|
| 1 |
EC50 = 1060 nM
|
|
|
|
CP0257999
|
2-[3-[5-chloro-2-[4-(3,4-dimethylpiperazin-1-yl)-3-methoxyanilino]pyrimidin-4-yl]phenyl]acetonitrile
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|
C25H27ClN6O
|
1
|
| 1 |
EC50 = 1390 nM
|
|
|
|
CP0318706
|
2-[3-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]-5-fluorophenyl]acetonitrile
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|
C24H24ClFN6O
|
1
|
| 1 |
EC50 = 1510 nM
|
|
|
|
CP0241043
|
2-[3-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]-2-methylpropanenitrile
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|
C26H29ClN6O
|
1
|
| 1 |
EC50 = 2350 nM
|
|
|
|
CP0075212
|
2-[3-[5-bromo-2-[4-[(3R)-3,4-dimethylpiperazin-1-yl]-3-methoxyanilino]pyrimidin-4-yl]phenyl]acetonitrile
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|
C25H27BrN6O
|
1
|
| 1 |
EC50 = 3590 nM
|
|
|
|
CP0287070
|
2-[3-[5-chloro-2-[3-ethoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile
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|
C25H27ClN6O
|
1
|
| 1 |
EC50 = 3780 nM
|
|
|
|
CP0223817
|
3-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]-N-(cyanomethyl)benzamide
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|
C25H26ClN7O2
|
1
|
| 1 |
EC50 = 3790 nM
|
|
|
|
CP0075218
|
2-[3-chloro-5-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile
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|
C24H24Cl2N6O
|
1
|
| 1 |
EC50 = 4720 nM
|
|
|
|
CP0018775
|
2-[3-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile
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|
C24H25ClN6O
|
1
|
| 1 |
EC50 = 4730 nM
|
|
|
|
CP0042893
|
ethyl 3-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]benzoate
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|
C25H28ClN5O3
|
1
|
| 1 |
EC50 = 6640 nM
|
|
|
|
CP0075215
|
2-[3-[5-chloro-2-[3-hydroxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile
Show/Hide
|
C23H23ClN6O
|
1
|
| 1 |
EC50 = 7990 nM
|
|
|
|
CP0223815
|
2-[3-[5-chloro-2-[3-(2-methoxyethoxy)-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile
Show/Hide
|
C26H29ClN6O2
|
1
|
| 1 |
EC50 = 9140 nM
|
|
|
|
CP0075214
|
ethyl 5-[[5-chloro-4-[3-(cyanomethyl)phenyl]pyrimidin-2-yl]amino]-2-(4-methylpiperazin-1-yl)benzoate
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|
C26H27ClN6O2
|
1
|
| 1 |
EC50 = 10900 nM
|
|
|
|
CP0258399
|
3-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]-5-methoxybenzonitrile
Show/Hide
|
C24H25ClN6O2
|
1
|
| 1 |
EC50 = 12400 nM
|
|
|
|
CP0176111
|
5-[[5-chloro-4-[3-(cyanomethyl)phenyl]pyrimidin-2-yl]amino]-2-(4-methylpiperazin-1-yl)benzoic acid
Show/Hide
|
C24H23ClN6O2
|
1
|
| 1 |
EC50 = 16800 nM
|
|
|
|
CP0075216
|
2-[3-[5-chloro-2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile
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|
C23H22ClFN6
|
1
|
| 1 |
EC50 = 17600 nM
|
|
|
|
CP0258397
|
2-[3-[5-chloro-2-[3-(5-methyl-1,3-oxazol-2-yl)-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile
Show/Hide
|
C27H26ClN7O
|
1
|
| 1 |
EC50 = 21300 nM
|
|
|
|
CP0258398
|
5-[[5-chloro-4-[3-(cyanomethyl)phenyl]pyrimidin-2-yl]amino]-2-(4-methylpiperazin-1-yl)benzonitrile
Show/Hide
|
C24H22ClN7
|
1
|
| 1 |
EC50 = 27700 nM
|
|
|
|
CP0221823
|
3-chloro-5-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]benzonitrile
Show/Hide
|
C23H22Cl2N6O
|
1
|
| 1 |
EC50 = 39500 nM
|
|
|
|
CP0285798
|
2-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)-3-(1,3-oxazol-2-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile
Show/Hide
|
C26H24ClN7O
|
1
|
| 1 |
EC50 = 39600 nM
|
|
|
|
CP0176110
|
5-[[5-chloro-4-[3-(cyanomethyl)phenyl]pyrimidin-2-yl]amino]-N,N-diethyl-2-(4-methylpiperazin-1-yl)benzamide
Show/Hide
|
C28H32ClN7O
|
1
|
| 1 |
EC50 = 50100 nM
|
|
|
|
CP0243914
|
5-[[5-chloro-4-[3-(cyanomethyl)phenyl]pyrimidin-2-yl]amino]-N-methyl-2-(4-methylpiperazin-1-yl)benzamide
Show/Hide
|
C25H26ClN7O
|
1
|
| 1 |
EC50 = 61300 nM
|
|
|
|
CP0308874
|
[3-[[2-[3-ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-methylamino]-4-methylphenyl]methanol
Show/Hide
|
C26H33FN6O3S
|
1
|
| 1 |
IC50 = 540 nM
|
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