Cell Line Information

General Information of the Cell Line

Cell Line ID	CL000254
Cell Line Name	DiFi
Synonyms	DIFI
Category	Cancer cell line
Organism	Homo sapiens (Human)
Cellosaurus ID	CVCL_6895
Tissue Information	Ascites
Disease	Colorectal carcinoma (NCIt: C2955) Gardner syndrome (NCIt: C6728) Gardner syndrome (ORDO: Orphanet_79665)

Map of Molecular Bioactivity Related to the Cell Line

Map of Molecular Bioactivity Related to the Cell Line Cell Line Protein Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Cell Line

Protein ID: PT00922, Epidermal growth factor receptor

Protein Info

Compound ID	Compound Name	Compound Formula
CP0385315 Compound Info	5-[(3-Bromophenyl)amino]-3-[[N-(carboxymethyl)-N-methylamino]methyl]pyrrolo[3,2-g]quinazoline ethyl ester Show/Hide	C21H20BrN5O2	1
1	IC50 = 9.55 nM Bioactivity Info	TI LI LO TS
CP0457105 Compound Info	5-[(3-Bromophenyl)amino]-3-[(4-morpholino)methyl]-pyrrolo[3,2-g]quinazoline Show/Hide	C21H20BrN5O	1
1	IC50 = 9.55 nM Bioactivity Info	TI LI LO TS
CP0214562 Compound Info	5-[(3-Bromophenyl)amino]-3-[(N,N-dimethylamino)-methyl]pyrrolo[3,2-g]quinazoline Show/Hide	C19H18BrN5	1
1	IC50 = 9.772 nM Bioactivity Info	TI LI LO TS
CP0123793 Compound Info	5-[(3-Bromophenyl)amino]-1-methylpyrazolo[4,3-g]-quinazoline Show/Hide	C16H12BrN5	1
1	IC50 = 12.88 nM Bioactivity Info	TI LI LO TS
CP0448952 Compound Info	5-[(3-Bromophenyl)amino]-1-[2-(4-morpholino)ethyl]-pyrrolo[3,2-g]quinazoline Show/Hide	C22H22BrN5O	1
1	IC50 = 15.85 nM Bioactivity Info	TI LI LO TS
CP0064498 Compound Info	5-[(3-Bromophenyl)amino]-1H-pyrazolo[4,3-g]quinazoline Show/Hide	C15H10BrN5	1
1	IC50 = 19.95 nM Bioactivity Info	TI LI LO TS
CP0290381 Compound Info	5-[(3-Bromophenyl)amino]-1H-pyrrolo[3,2-g]quinazoline Show/Hide	C16H11BrN4	1
1	IC50 = 21.88 nM Bioactivity Info	TI LI LO TS
CP0458855 Compound Info	5-[(3-Bromophenyl)amino]-1-methylpyrrolo[3,2-g]-quinazoline Show/Hide	C17H13BrN4	1
1	IC50 = 21.88 nM Bioactivity Info	TI LI LO TS
CP0377769 Compound Info	3-{4-[(3-bromophenyl)amino]-8H-pyrrolo[3,2-g]quinazolin-8-yl}propane-1,2-diol Show/Hide	C19H17BrN4O2	1
1	IC50 = 48.98 nM Bioactivity Info	TI LI LO TS
CP0011998 Compound Info	N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine Show/Hide	C16H14BrN3O2	1
1	IC50 = 70.79 nM Bioactivity Info	TI LI LO TS
CP0428288 Compound Info	5-[(3-Bromophenyl)amino]-1-[3-(4-morpholino)propyl]-pyrrolo[3,2-g]quinazoline Show/Hide	C23H24BrN5O	1
1	IC50 = 77.62 nM Bioactivity Info	TI LI LO TS
CP0039199 Compound Info	(E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide Show/Hide	C24H23ClFN5O2	1
1	IC50 = 79.43 nM Bioactivity Info	TI LI LO TS
CP0353028 Compound Info	5-[(3-Bromophenyl)amino]-3-[(N,N,N-trimethylethylenediamino)methyl]pyrrolo[3,2-g]quinazoline Show/Hide	C22H25BrN6	1
1	IC50 = 81.28 nM Bioactivity Info	TI LI LO TS
CP0238633 Compound Info	4-Dimethylamino-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C23H20BrN5O2	1
1	IC50 = 89.13 nM Bioactivity Info	TI LI LO TS
CP0177915 Compound Info	4-Dipropylamino-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C26H26BrN5O	1
1	IC50 = 128.82 nM Bioactivity Info	TI LI LO TS
CP0137245 Compound Info	2-[({4-[(3-bromophenyl)amino]-8H-pyrrolo[3,2-g]quinazolin-6-yl}methyl)(2-hydroxyethyl)amino]ethan-1-ol Show/Hide	C21H22BrN5O2	1
1	IC50 = 134.9 nM Bioactivity Info	TI LI LO TS
CP0424965 Compound Info	5-[(3-Bromophenyl)amino]-1-[2-(N,N-dimethylamino)-ethyl]pyrrolo[3,2-g]quinazoline Show/Hide	C20H20BrN5	1
1	IC50 = 144.54 nM Bioactivity Info	TI LI LO TS
CP0059158 Compound Info	(2S)4-(2-Methoxymethyl-pyrrolidin-1-yl)-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C26H24BrN5O2	1
1	IC50 = 151.36 nM Bioactivity Info	TI LI LO TS
CP0436548 Compound Info	4-(4-Fluoro-3-trifluoromethylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Hydrochloride Show/Hide	C19H13F4N3O2	1
1	IC50 = 158.49 nM Bioactivity Info	TI LI LO TS
CP0424966 Compound Info	4-(3-Chlorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14ClN3O2	1
1	IC50 = 181.97 nM Bioactivity Info	TI LI LO TS
CP0289874 Compound Info	4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14BrN3O2	1
1	IC50 = 190.55 nM Bioactivity Info	TI LI LO TS
CP0441551 Compound Info	5-[(3-Bromophenyl)amino]-1-[2-(4-morpholino)ethyl]-pyrazolo[4,3-g]quinazoline Show/Hide	C21H21BrN6O	1
1	IC50 = 190.55 nM Bioactivity Info	TI LI LO TS
CP0424968 Compound Info	4-(4-Isopropylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C21H21N3O2	1
1	IC50 = 229.09 nM Bioactivity Info	TI LI LO TS
CP0460856 Compound Info	5-[(3-Bromophenyl)amino]-1-[3-(N,N-dimethylamino)-propyl]pyrrolo[3,2-g]quinazoline Show/Hide	C21H22BrN5	1
1	IC50 = 229.09 nM Bioactivity Info	TI LI LO TS
CP0528800 Compound Info	N-[4-(3-bromoanilino)-3-cyanoquinolin-6-yl]-4-(dicyclopropylamino)but-2-ynamide Show/Hide	C26H22BrN5O	1
1	IC50 = 251.19 nM Bioactivity Info	TI LI LO TS
CP0039761 Compound Info	5-[(3-Bromophenyl)amino]-1-[2-(N,N-dimethylamino)ethyl]pyrazolo[4,3-g]quinazoline Show/Hide	C19H19BrN6	1
1	IC50 = 263.03 nM Bioactivity Info	TI LI LO TS
CP0087446 Compound Info	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C22H20BrN5O	1
1	IC50 = 309.03 nM Bioactivity Info	TI LI LO TS
CP0123794 Compound Info	3-{5-[(3-bromophenyl)amino]-1H-pyrazolo[4,3-g]quinazolin-1-yl}propane-1,2-diol Show/Hide	C18H16BrN5O2	1
1	IC50 = 316.23 nM Bioactivity Info	TI LI LO TS
CP0335156 Compound Info	3-Methoxymethoxy-propynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C22H17BrN4O3	1
1	IC50 = 331.13 nM Bioactivity Info	TI LI LO TS
CP0489758 Compound Info	4-(3-Bromophenylamino)-6,7-dihydroxyquinoline-3-carbonitrile Show/Hide	C16H10BrN3O2	1
1	IC50 = 346.74 nM Bioactivity Info	TI LI LO TS
CP0397242 Compound Info	4-(2-Isopropylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C21H21N3O2	1
1	IC50 = 363.08 nM Bioactivity Info	TI LI LO TS
CP0504858 Compound Info	4-(3-Bromophenylamino)-6,7-diethoxyquinoline-3-carbonitrile Show/Hide	C20H18BrN3O2	1
1	IC50 = 416.87 nM Bioactivity Info	TI LI LO TS
CP0302936 Compound Info	(3-Bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C19H17BrN4O3	2
1	IC50 = 470 nM Bioactivity Info	TI LI LO TS
2	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0559602 Compound Info	(7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-dibenzo[a,d]cyclohepten-1-yl)-((R)-1-phenyl-ethyl)-amine Show/Hide	C21H23N5O2	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0292135 Compound Info	4-(3-Chloro-4-fluorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H13ClFN3O2	1
1	IC50 = 537.03 nM Bioactivity Info	TI LI LO TS
CP0184555 Compound Info	4-Thiomorpholin-4-yl-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C24H20BrN5OS	1
1	IC50 = 549.54 nM Bioactivity Info	TI LI LO TS
CP0209478 Compound Info	N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-2-[(dimethylamino)methyl]prop-2-enamide Show/Hide	C24H23ClFN5O2	1
1	IC50 = 562.34 nM Bioactivity Info	TI LI LO TS
CP0078046 Compound Info	N-[4-(3-bromoanilino)-3-cyanoquinolin-6-yl]prop-2-enamide Show/Hide	C19H13BrN4O	1
1	IC50 = 588.84 nM Bioactivity Info	TI LI LO TS
CP0137246 Compound Info	2-[({4-[(3-bromophenyl)amino]-8H-pyrrolo[3,2-g]quinazolin-6-yl}methyl)(methyl)amino]acetic acid Show/Hide	C20H18BrN5O2	1
1	IC50 = 588.84 nM Bioactivity Info	TI LI LO TS
CP0474005 Compound Info	4-(4-Bromo-3-methylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C19H16BrN3O2	1
1	IC50 = 616.6 nM Bioactivity Info	TI LI LO TS
CP0196856 Compound Info	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C22H19ClFN5O	1
1	IC50 = 645.65 nM Bioactivity Info	TI LI LO TS
CP0302935 Compound Info	(3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C19H16ClFN4O3	2
1	IC50 = 690 nM Bioactivity Info	TI LI LO TS
2	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0378261 Compound Info	4-(3-Fluorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14FN3O2	1
1	IC50 = 741.31 nM Bioactivity Info	TI LI LO TS
CP0504859 Compound Info	6,7-Dimethoxy-4-(3-methylthiophenylamino)quinoline-3-carbonitrile Hydrochloride Show/Hide	C19H17N3O2S	1
1	IC50 = 758.58 nM Bioactivity Info	TI LI LO TS
CP0204500 Compound Info	4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C22H17BrN4O3	1
1	IC50 = 794.33 nM Bioactivity Info	TI LI LO TS
CP0226575 Compound Info	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C23H22BrN5O2	1
1	IC50 = 794.33 nM Bioactivity Info	TI LI LO TS
CP0150186 Compound Info	N-[4-(3-bromoanilino)-3-cyano-7-methoxyquinolin-6-yl]prop-2-enamide Show/Hide	C20H15BrN4O2	1
1	IC50 = 812.83 nM Bioactivity Info	TI LI LO TS
CP0377726 Compound Info	4-(3-Aminophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H16N4O2	1
1	IC50 = 812.83 nM Bioactivity Info	TI LI LO TS
CP0465279 Compound Info	4-(3-Bromo-2-methylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C19H16BrN3O2	1
1	IC50 = 831.76 nM Bioactivity Info	TI LI LO TS
CP0478356 Compound Info	4-(3-Dimethylaminophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C20H20N4O2	1
1	IC50 = 851.14 nM Bioactivity Info	TI LI LO TS
CP0378262 Compound Info	4-(3-Nitrophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14N4O4	1
1	IC50 = 870.96 nM Bioactivity Info	TI LI LO TS
CP0529108 Compound Info	(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-(3-ethynyl-phenyl)-amine Show/Hide	C21H18N4O3	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0551230 Compound Info	N-benzyl-8,9-dimethoxy-6,11-dihydro-5H-pyrimido[4,5-b][1,4]benzodiazepin-4-amine Show/Hide	C20H21N5O2	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0039860 Compound Info	But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C21H15BrN4O2	1
1	IC50 = 912.01 nM Bioactivity Info	TI LI LO TS
CP0193403 Compound Info	But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C20H13BrN4O	1
1	IC50 = 933.25 nM Bioactivity Info	TI LI LO TS
CP0201089 Compound Info	3-(2-Methoxy-ethoxy)-propynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C23H19BrN4O3	1
1	IC50 = 933.25 nM Bioactivity Info	TI LI LO TS
CP0177916 Compound Info	4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C21H15BrN4O2	1
1	IC50 = 954.99 nM Bioactivity Info	TI LI LO TS
CP0480482 Compound Info	4-(3-Chloro-4-fluorophenylamino)-6,7-diethoxyquinoline-3-carbonitrile Show/Hide	C20H17ClFN3O2	1
1	IC50 = 977.24 nM Bioactivity Info	TI LI LO TS
CP0337228 Compound Info	(3-Bromo-phenyl)-(8-methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C18H15BrN4O2	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0503127 Compound Info	4-(3-Bromophenylamino)-6,7-bis(2-methoxyethoxy)-quinoline-3-carbonitrile Show/Hide	C22H22BrN3O4	1
1	IC50 = 1096.48 nM Bioactivity Info	TI LI LO TS
CP0551233 Compound Info	1-(3-bromo-phenylsulfanyl)-7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene Show/Hide	C19H16BrN3O3S	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0339915 Compound Info	2-{5-[(3-bromophenyl)amino]-1H-pyrazolo[4,3-g]quinazolin-1-yl}acetic acid Show/Hide	C17H12BrN5O2	1
1	IC50 = 1202.26 nM Bioactivity Info	TI LI LO TS
CP0524731 Compound Info	6,7-Dimethoxy-4-(3-trifluoromethylphenylamino)-quinoline-3-carbonitrile Show/Hide	C19H14F3N3O2	1
1	IC50 = 1445.44 nM Bioactivity Info	TI LI LO TS
CP0505183 Compound Info	4-(3-Chloro-4-methylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Hydrochloride Show/Hide	C19H16ClN3O2	1
1	IC50 = 1479.11 nM Bioactivity Info	TI LI LO TS
CP0289906 Compound Info	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Show/Hide	C24H24BrN5O2	1
1	IC50 = 1584.89 nM Bioactivity Info	TI LI LO TS
CP0551231 Compound Info	(3-chloro-4-fluoro-benzyl)-(7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C20H19ClFN5O2	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0206023 Compound Info	(E)-But-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C20H15BrN4O	1
1	IC50 = 1621.81 nM Bioactivity Info	TI LI LO TS
CP0385341 Compound Info	2-{4-[(3-bromophenyl)amino]-8H-pyrrolo[3,2-g]quinazolin-8-yl}acetic acid Show/Hide	C18H13BrN4O2	1
1	IC50 = 1778.28 nM Bioactivity Info	TI LI LO TS
CP0530943 Compound Info	4-(3-Bromo-4-methylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C19H16BrN3O2	1
1	IC50 = 1778.28 nM Bioactivity Info	TI LI LO TS
CP0381838 Compound Info	1-(3-bromo-phenoxy)-7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene Show/Hide	C19H16BrN3O4	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0337229 Compound Info	(3-Bromo-phenyl)-(7-methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C18H15BrN4O2	1
1	IC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0245701 Compound Info	(E)-4-Diethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C25H25ClFN5O2	1
1	IC50 = 1905.46 nM Bioactivity Info	TI LI LO TS
CP0385320 Compound Info	4-(3-Azidophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14N6O2	1
1	IC50 = 2187.76 nM Bioactivity Info	TI LI LO TS
CP0059160 Compound Info	(E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-quinolin-6-yl]-amide Show/Hide	C24H21ClFN5O2	1
1	IC50 = 2290.87 nM Bioactivity Info	TI LI LO TS
CP0485259 Compound Info	(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-naphthalen-2-yl-amine Show/Hide	C23H20N4O3	1
1	IC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0061045 Compound Info	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C23H21ClFN5O2	1
1	IC50 = 2344.23 nM Bioactivity Info	TI LI LO TS
CP0337225 Compound Info	(3-Chloro-4-fluoro-phenyl)-(8-methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C18H14ClFN4O2	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0562390 Compound Info	1-(3-chloro-phenylsulfanyl)-7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene Show/Hide	C19H16ClN3O3S	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0207234 Compound Info	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-trifluoromethoxy-quinolin-6-yl]-amide Show/Hide	C23H18ClF4N5O2	1
1	IC50 = 2630.27 nM Bioactivity Info	TI LI LO TS
CP0087447 Compound Info	N-[4-(3-chloro-4-fluoroanilino)-3-cyanoquinolin-6-yl]-2-(morpholin-4-ylmethyl)prop-2-enamide Show/Hide	C24H21ClFN5O2	1
1	IC50 = 2691.53 nM Bioactivity Info	TI LI LO TS
CP0263305 Compound Info	(3-Chloro-4-fluoro-phenyl)-(10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C17H12ClFN4O	1
1	IC50 = 2700 nM Bioactivity Info	TI LI LO TS
CP0397241 Compound Info	4-(4-Methylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C19H17N3O2	1
1	IC50 = 2754.23 nM Bioactivity Info	TI LI LO TS
CP0239125 Compound Info	(E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-8-methoxy-quinolin-6-yl]-amide Show/Hide	C23H22BrN5O2	1
1	IC50 = 2884.03 nM Bioactivity Info	TI LI LO TS
CP0378263 Compound Info	4-(3,5-Dichloro-4-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H13Cl2N3O3	1
1	IC50 = 3162.28 nM Bioactivity Info	TI LI LO TS
CP0524733 Compound Info	4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-carbaldehyde Show/Hide	C18H15BrN2O3	1
1	IC50 = 3388.44 nM Bioactivity Info	TI LI LO TS
CP0163010 Compound Info	(E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C25H24BrN5O3	1
1	IC50 = 3801.89 nM Bioactivity Info	TI LI LO TS
CP0529107 Compound Info	(5-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C19H16ClFN4O3	1
1	IC50 = 3900 nM Bioactivity Info	TI LI LO TS
CP0524732 Compound Info	4-(2-Bromophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14BrN3O2	1
1	IC50 = 4168.69 nM Bioactivity Info	TI LI LO TS
CP0337226 Compound Info	(8-Chloro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-(3-chloro-4-fluoro-phenyl)-amine Show/Hide	C17H11Cl2FN4O	1
1	IC50 = 4300 nM Bioactivity Info	TI LI LO TS
CP0464725 Compound Info	(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-m-tolyl-amine Show/Hide	C20H20N4O3	1
1	IC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0562391 Compound Info	(3-chloro-2-fluoro-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C19H16ClFN4O3	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0238503 Compound Info	(E)-4-Diethylamino-pent-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C26H27ClFN5O2	1
1	IC50 = 4786.3 nM Bioactivity Info	TI LI LO TS
CP0532092 Compound Info	10-[(3-bromophenyl)amino]-2H,3H,4H-[1,4]dioxepino[2,3-g]quinoline-9-carbonitrile Show/Hide	C19H14BrN3O2	1
1	IC50 = 5128.61 nM Bioactivity Info	TI LI LO TS
CP0207235 Compound Info	(E)-4-Dimethylamino-pent-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C24H23ClFN5O2	1
1	IC50 = 5248.07 nM Bioactivity Info	TI LI LO TS
CP0209467 Compound Info	(E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-8-methoxy-quinolin-6-yl]-amide Show/Hide	C25H24BrN5O3	1
1	IC50 = 5370.32 nM Bioactivity Info	TI LI LO TS
CP0320274 Compound Info	N-[4-(3-bromoanilino)-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepin-8-yl]prop-2-enamide Show/Hide	C20H16BrN5O2	1
1	IC50 = 5400 nM Bioactivity Info	TI LI LO TS
CP0485257 Compound Info	7-(3-bromophenoxy)-13,14-dimethoxy-9-methyl-2-oxa-4,6,9-triazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaene Show/Hide	C20H18BrN3O4	1
1	IC50 = 6100 nM Bioactivity Info	TI LI LO TS
CP0385317 Compound Info	4-(3-Hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H15N3O3	1
1	IC50 = 6309.57 nM Bioactivity Info	TI LI LO TS
CP0390200 Compound Info	4-(4-Bromophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14BrN3O2	1
1	IC50 = 6606.93 nM Bioactivity Info	TI LI LO TS
CP0506660 Compound Info	6,7-dialkoxyquinoline-3-carbonitrile deriv. 58 Show/Hide	C17H10BrN3O2	1
1	IC50 = 6760.83 nM Bioactivity Info	TI LI LO TS
CP0512455 Compound Info	4-(3-Bromophenylamino)-6,7-bis(methoxymethoxy)-quinoline-3-carbonitrile Show/Hide	C20H18BrN3O4	1
1	IC50 = 6760.83 nM Bioactivity Info	TI LI LO TS
CP0167044 Compound Info	(3-Bromo-phenyl)-(8-fluoro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C17H12BrFN4O	1
1	IC50 = 6900 nM Bioactivity Info	TI LI LO TS
CP0215296 Compound Info	N-[4-(3-bromoanilino)-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepin-8-yl]methanesulfonamide Show/Hide	C18H16BrN5O3S	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0154778 Compound Info	(3-Chloro-4-fluoro-phenyl)-(8-fluoro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C17H11ClF2N4O	1
1	IC50 = 7200 nM Bioactivity Info	TI LI LO TS
CP0302979 Compound Info	(8-Bromo-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-(3-bromo-phenyl)-amine Show/Hide	C17H12Br2N4O	1
1	IC50 = 7200 nM Bioactivity Info	TI LI LO TS
CP0480483 Compound Info	4-(3-Acetylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C20H17N3O3	1
1	IC50 = 7413.1 nM Bioactivity Info	TI LI LO TS
CP0212726 Compound Info	(E)-But-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Show/Hide	C22H18ClFN4O2	1
1	IC50 = 7585.78 nM Bioactivity Info	TI LI LO TS
CP0543772 Compound Info	(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-(4-fluoro-phenyl)-amine Show/Hide	C19H17FN4O3	1
1	IC50 = 7600 nM Bioactivity Info	TI LI LO TS
CP0385318 Compound Info	3-(3-Cyano-6,7-dimethoxyquinolin-4-ylamino)benzamide Show/Hide	C19H16N4O3	1
1	IC50 = 7762.47 nM Bioactivity Info	TI LI LO TS
CP0263306 Compound Info	(3-Bromo-phenyl)-(10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C17H13BrN4O	1
1	IC50 = 8100 nM Bioactivity Info	TI LI LO TS
CP0192718 Compound Info	(8-Bromo-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-(3-chloro-4-fluoro-phenyl)-amine Show/Hide	C17H11BrClFN4O	1
1	IC50 = 8400 nM Bioactivity Info	TI LI LO TS
CP0339824 Compound Info	Benzyl-(8-methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C19H18N4O2	1
1	IC50 = 8500 nM Bioactivity Info	TI LI LO TS
CP0167043 Compound Info	(3-Chloro-4-fluoro-phenyl)-(7-methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C18H14ClFN4O2	1
1	IC50 = 8900 nM Bioactivity Info	TI LI LO TS
CP0320272 Compound Info	N-[4-(3-chloro-4-fluoroanilino)-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepin-8-yl]prop-2-enamide Show/Hide	C20H15ClFN5O2	1
1	IC50 = 8900 nM Bioactivity Info	TI LI LO TS
CP0302937 Compound Info	4-N-(3-chloro-4-fluorophenyl)-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepine-4,8-diamine Show/Hide	C17H13ClFN5O	1
1	IC50 = 9100 nM Bioactivity Info	TI LI LO TS
CP0424967 Compound Info	4-(3-Chloro-4-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14ClN3O3	1
1	IC50 = 9120.11 nM Bioactivity Info	TI LI LO TS
CP0250972 Compound Info	Biphenyl-3-yl-(8-methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C24H20N4O2	1
1	IC50 = 9800 nM Bioactivity Info	TI LI LO TS
CP0339823 Compound Info	Biphenyl-3-yl-(8-fluoro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C23H17FN4O	1
1	IC50 = 9900 nM Bioactivity Info	TI LI LO TS
CP0271201 Compound Info	(E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide Show/Hide	C26H26BrN5O3	1
1	IC50 = 10232.93 nM Bioactivity Info	TI LI LO TS
CP0076540 Compound Info	(E)-4-Morpholin-4-yl-pent-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C26H25ClFN5O3	1
1	IC50 = 10471.29 nM Bioactivity Info	TI LI LO TS
CP0529127 Compound Info	(7,8-dimethoxy-10,11-dihydro-5H-2,4,5,11-tetraaza-dibenzo[a,d]cyclohepten-1-yl)-(3-methoxy-benzyl)-amine Show/Hide	C21H23N5O3	1
1	IC50 = 11700 nM Bioactivity Info	TI LI LO TS
CP0204083 Compound Info	(E)-4-Morpholin-4-yl-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide Show/Hide	C25H23ClFN5O3	1
1	IC50 = 13489.63 nM Bioactivity Info	TI LI LO TS
CP0359193 Compound Info	4-(4-Chloro-2-fluorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H13ClFN3O2	1
1	IC50 = 13803.84 nM Bioactivity Info	TI LI LO TS
CP0385316 Compound Info	4-(3-Cyanophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C19H14N4O2	1
1	IC50 = 14125.38 nM Bioactivity Info	TI LI LO TS
CP0385321 Compound Info	4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-carboxylic Acid Amide Show/Hide	C18H16BrN3O3	1
1	IC50 = 15135.61 nM Bioactivity Info	TI LI LO TS
CP0378264 Compound Info	4-(5-Chloro-2-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Hydrochloride Show/Hide	C18H14ClN3O3	1
1	IC50 = 16982.44 nM Bioactivity Info	TI LI LO TS
CP0511404 Compound Info	4-(3-Bromophenylamino)-7-ethoxy-6-methoxyquinoline-3-carbonitrile Show/Hide	C19H16BrN3O2	1
1	IC50 = 21379.62 nM Bioactivity Info	TI LI LO TS
CP0154779 Compound Info	(3-Bromo-phenyl)-(8-chloro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C17H12BrClN4O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0263304 Compound Info	(3-Bromo-phenyl)-(7,9-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C19H17BrN4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0320275 Compound Info	1-(3-Chloro-4-fluoro-phenylamino)-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene-8-carboxylic acid Show/Hide	C18H12ClFN4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0328916 Compound Info	Benzyl-(8-fluoro-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C18H15FN4O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0337223 Compound Info	Benzyl-(8-bromo-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C18H15BrN4O	1
1	IC50 = 30000 nM Bioactivity Info	TI LI LO TS
CP0337224 Compound Info	4-N-(3-bromophenyl)-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepine-4,8-diamine Show/Hide	C17H14BrN5O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0339820 Compound Info	1-(3-Bromo-phenylamino)-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cycloheptene-8-carboxylic acid Show/Hide	C18H13BrN4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0511405 Compound Info	4-(3-Bromophenylamino)-6-ethoxy-7-methoxyquinoline-3-carbonitrile Show/Hide	C19H16BrN3O2	1
1	IC50 = 33113.11 nM Bioactivity Info	TI LI LO TS
CP0078684 Compound Info	4-(3-Bromophenylamino)-6,7-dimethoxyquinoline-3-carboxylic Acid Show/Hide	C18H15BrN2O4	1
1	IC50 = 33884.42 nM Bioactivity Info	TI LI LO TS
CP0499007 Compound Info	4-(4-Fluorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C18H14FN3O2	1
1	IC50 = 47863.01 nM Bioactivity Info	TI LI LO TS
CP0193983 Compound Info	4-(3,4-Dimethoxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C20H19N3O4	1
1	IC50 = 50118.72 nM Bioactivity Info	TI LI LO TS
CP0504860 Compound Info	4-(3-Isopropylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile Show/Hide	C21H21N3O2	1
1	IC50 = 61659.5 nM Bioactivity Info	TI LI LO TS
CP0532091 Compound Info	6,7-dialkoxyquinoline-3-carbonitrile deriv. 40 Show/Hide	C20H18N4O3	1
1	IC50 = 69183.1 nM Bioactivity Info	TI LI LO TS
CP0505184 Compound Info	1-(3-Bromophenylamino)-6,7-dimethoxyisoquinoline-4-carbonitrile Show/Hide	C18H14BrN3O2	1
1	IC50 = 70794.58 nM Bioactivity Info	TI LI LO TS
CP0480529 Compound Info	1-(3-Chlorophenylamino)-6,7-dimethoxyisoquinoline-4-carbonitrile Show/Hide	C18H14ClN3O2	1
1	IC50 = 89125.09 nM Bioactivity Info	TI LI LO TS
CP0543771 Compound Info	(2-chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C19H16ClFN4O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0559605 Compound Info	(4-bromo-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine Show/Hide	C19H17BrN4O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

Protein family and CMB statistics Related to the Cell Line

Cell Lines Derived from the same Tissue Source (Ascites)

Cell Line Name		Organism	Disease
PEO1	Cell Line Info	Homo sapiens (Human)	BRCA2-associated hereditary breast and ovarian cancer syndrome
MAST	Cell Line Info	Homo sapiens (Human)	Breast carcinoma
Ramos	Cell Line Info	Homo sapiens (Human)	Burkitt lymphoma
CA46	Cell Line Info	Homo sapiens (Human)	Burkitt lymphoma
CellSensor STAT6-bla RA-1	Cell Line Info	Homo sapiens (Human)	Burkitt lymphoma
NCI-H716	Cell Line Info	Homo sapiens (Human)	Cecum adenocarcinoma
COLO 205	Cell Line Info	Homo sapiens (Human)	Colon adenocarcinoma
COLO 201	Cell Line Info	Homo sapiens (Human)	Colon adenocarcinoma
U-2932	Cell Line Info	Homo sapiens (Human)	Diffuse large B-cell lymphoma activated B-cell type
DB	Cell Line Info	Homo sapiens (Human)	Diffuse large B-cell lymphoma germinal center B-cell type
HEC-50B	Cell Line Info	Homo sapiens (Human)	Endometrial adenocarcinoma
SNU-5	Cell Line Info	Homo sapiens (Human)	Gastric adenocarcinoma
SNU-16	Cell Line Info	Homo sapiens (Human)	Gastric adenocarcinoma
SNU-620	Cell Line Info	Homo sapiens (Human)	Gastric adenocarcinoma
SNU-638	Cell Line Info	Homo sapiens (Human)	Gastric adenocarcinoma
SNU-668	Cell Line Info	Homo sapiens (Human)	Gastric signet ring cell adenocarcinoma
OVCAR-3	Cell Line Info	Homo sapiens (Human)	High grade ovarian serous adenocarcinoma
OVCAR-5	Cell Line Info	Homo sapiens (Human)	High grade ovarian serous adenocarcinoma
COV318	Cell Line Info	Homo sapiens (Human)	High grade ovarian serous adenocarcinoma
ZR-75-1	Cell Line Info	Homo sapiens (Human)	Invasive breast carcinoma of no special type
SK-HEP-1	Cell Line Info	Homo sapiens (Human)	Liver and intrahepatic bile duct epithelial neoplasm
OV-90	Cell Line Info	Homo sapiens (Human)	Ovarian adenocarcinoma
LK2	Cell Line Info	Homo sapiens (Human)	Ovarian carcinoma
RMG-I	Cell Line Info	Homo sapiens (Human)	Ovarian clear cell adenocarcinoma
PA-1	Cell Line Info	Homo sapiens (Human)	Ovarian mixed germ cell tumor
SK-OV-3	Cell Line Info	Homo sapiens (Human)	Ovarian serous cystadenocarcinoma
SKOV3/TR	Cell Line Info	Homo sapiens (Human)	Ovarian serous cystadenocarcinoma
AsPC-1	Cell Line Info	Homo sapiens (Human)	Pancreatic ductal adenocarcinoma
HEC	Cell Line Info	Homo sapiens (Human)	Peritoneal malignant mesothelioma
Ehrlich-Lettre ascites strain E	Cell Line Info	Mus musculus (Mouse)	Malignant neoplasms of the mouse mammary gland
RAW 264.7	Cell Line Info	Mus musculus (Mouse)	Mouse leukemia
L1210	Cell Line Info	Mus musculus (Mouse)	Mouse leukemia
L1210/R81	Cell Line Info	Mus musculus (Mouse)	Mouse leukemia
RAW-Lucia ISG	Cell Line Info	Mus musculus (Mouse)	Mouse leukemia
RAW-Lucia ISG-KO-STING	Cell Line Info	Mus musculus (Mouse)	Mouse leukemia
RAW 264	Cell Line Info	Mus musculus (Mouse)	Mouse leukemia
J774	Cell Line Info	Mus musculus (Mouse)	Mouse reticulum cell sarcoma
J774A1	Cell Line Info	Mus musculus (Mouse)	Mouse reticulum cell sarcoma
HTC	Cell Line Info	Rattus norvegicus (Rat)	Rat hepatocellular carcinoma

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About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han