General Information of the Compound
Compound ID
CP0464725
Compound Name
(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-m-tolyl-amine
    Show/Hide
Structure
Formula
C20H20N4O3
Molecular Weight
364.405
Canonical SMILES
COc1cc2CNc3c(Nc4cccc(C)c4)ncnc3Oc2cc1OC
    Show/Hide
InChI
InChI=1S/C20H20N4O3/c1-12-5-4-6-14(7-12)24-19-18-20(23-11-22-19)27-15-9-17(26-3)16(25-2)8-13(15)10-21-18/h4-9,11,21H,10H2,1-3H3,(H,22,23,24)
    Show/Hide
InChIKey
KTEORODSZODNSV-UHFFFAOYSA-N
Physicochemical Property
logP
4.26362
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
77.53
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44416429
ChEMBL ID
CHEMBL386365
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000254 DiFi Homo sapiens (Human)  1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS