General Information of the Compound
Compound ID
CP0302937
Compound Name
4-N-(3-chloro-4-fluorophenyl)-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepine-4,8-diamine
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Structure
Formula
C17H13ClFN5O
Molecular Weight
357.776
Canonical SMILES
Nc1ccc2Oc3ncnc(Nc4ccc(F)c(Cl)c4)c3NCc2c1
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InChI
InChI=1S/C17H13ClFN5O/c18-12-6-11(2-3-13(12)19)24-16-15-17(23-8-22-16)25-14-4-1-10(20)5-9(14)7-21-15/h1-6,8,21H,7,20H2,(H,22,23,24)
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InChIKey
BTNALJYZXFMSPP-UHFFFAOYSA-N
Physicochemical Property
logP
4.3127
Rotatable Bonds
2
Heavy Atom Count
25
Polar Areas
85.09
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44409043
ChEMBL ID
CHEMBL206197
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000254 DiFi Homo sapiens (Human)  1
1
IC50 = 9100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3700 nM