General Information of the Cell Line
Cell Line ID
CL000266
Cell Line Name
L1210
Synonyms
L 1210
L-1210
Leukemic 1210
Leukemia 1210
Leukemia L1210
Category
Cancer cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0382
Tissue Information
Ascites
Disease
Mouse leukemia (NCIt: C21604)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02055, Dihydrofolate reductase
Compound ID Compound Name Compound Formula
CP0036197
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
   Show/Hide
C20H22N8O5
 3
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 45 nM
   TI
   LI
   LO
   TS
3
Ki = 3900 nM
   TI
   LI
   LO
   TS
CP0053031
4-Aminofolic acid
   Show/Hide
C19H20N8O5
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0514256
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid
   Show/Hide
C26H27N9O6
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0405929
4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid
   Show/Hide
C27H27N9O6
 1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0454354
4-tert-Butylcarbamoyl-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid
   Show/Hide
C23H29N9O4
 1
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
CP0426809
4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid
   Show/Hide
C26H25N9O6
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0056680
2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C21H22N6O5
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0507634
2-(4-{[(2,4-Diamino-quinazolin-6-yl)-methyl-amino]-methyl}-benzoylamino)-pentanedioic acid
   Show/Hide
C22H24N6O5
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0434649
2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H24N6O5
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0514593
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid
   Show/Hide
C25H25N9O6
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0395506
2-{4-[(2,4-Diamino-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C21H22N6O5
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0535593
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-phenylcarbamoyl-butyric acid
   Show/Hide
C25H25N9O4
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0163000
2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H22N6O6
 1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
CP0378548
2-(4-{[(2,4-Diamino-quinazolin-6-yl)-formyl-amino]-methyl}-benzoylamino)-pentanedioic acid
   Show/Hide
C22H22N6O6
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0437651
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-(2,6-dichloro-benzylcarbamoyl)-butyric acid
   Show/Hide
C26H25Cl2N9O4
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0448278
4-Benzylcarbamoyl-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid
   Show/Hide
C26H27N9O4
 1
1
IC50 = 87 nM
   TI
   LI
   LO
   TS
CP0373630
4-(Adamantan-1-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid
   Show/Hide
C29H35N9O4
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0432445
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-(3,4-dichloro-benzylcarbamoyl)-butyric acid
   Show/Hide
C26H25Cl2N9O4
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0268306
2-{4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H24N6O5
 1
1
Ki = 0.0283 nM
   TI
   LI
   LO
   TS
CP0238793
(S)-2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H25N7O5
 1
1
Ki = 990 nM
   TI
   LI
   LO
   TS
CP0088766
(S)-2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C20H21N7O5
 1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS
CP0185067
2-{4-[2-(2,4-Diamino-pteridin-6-yl)-propyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C21H23N7O5
 1
1
Ki = 3000 nM
   TI
   LI
   LO
   TS
CP0057341
(6RS) 2-{4-[2-(2-Amino-5-ethyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C23H29N5O6
 1
1
Ki > 1 nM
   TI
   LI
   LO
   TS
CP0103584
2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H23N5O6
 1
1
Ki > 1 nM
   TI
   LI
   LO
   TS
CP0147087
(5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H27N5O6
 1
1
Ki > 1 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0014938
(5-fluorouracil)5-Fluoro-1H-pyrimidine-2,4-dione
   Show/Hide
C4H3FN2O2  1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0015449
4,7-dihydroxy-11-methylbenzo[a]pyrrolo[3,4-c]carbazole-1,3-(2H,8H)-dione
   Show/Hide
C19H12N2O4  1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0036197
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
   Show/Hide
C20H22N8O5  6
1
IC50 = 2.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 12 nM
   TI
   LI
   LO
   TS
3
IC50 = 24 nM
   TI
   LI
   LO
   TS
4
IC50 = 30 nM
   TI
   LI
   LO
   TS
5
IC50 = 1300 nM
   TI
   LI
   LO
   TS
6
IC50 = 220000 nM
   TI
   LI
   LO
   TS
CP0047751
2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H25N7O5  1
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
CP0048297
3-[(3S)-3-aminopyrrolidine-1-carbonyl]-4,11-dihydroxy-2-methylnaphtho[2,3-f][1]benzofuran-5,10-dione;methanesulfonic acid
   Show/Hide
C23H22N2O9S  1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0053031
4-Aminofolic acid
   Show/Hide
C19H20N8O5  2
1
EC50 = 1.8 nM
   TI
   LI
   LO
   TS
2
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0057341
(6RS) 2-{4-[2-(2-Amino-5-ethyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C23H29N5O6  1
1
IC50 = 57.2 nM
   TI
   LI
   LO
   TS
CP0077456
1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluorouracil
   Show/Hide
C9H11FN2O5  4
1
IC50 = 0.63 nM
   TI
   LI
   LO
   TS
2
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
3
IC50 = 12 nM
   TI
   LI
   LO
   TS
4
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0083030
11H-2,5,11-triaza-benzo[a]trindene-1,3,4,6-tetraone
   Show/Hide
C16H7N3O4  1
1
IC50 = 32700 nM
   TI
   LI
   LO
   TS
CP0088766
(S)-2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C20H21N7O5  1
1
IC50 = 1.5 nM
   TI
   LI
   LO
   TS
CP0111571
4-(2-Benzenesulfonylamino-1-methyl-2-oxo-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid
   Show/Hide
C36H36N6O8S  1
1
IC50 = 8200 nM
   TI
   LI
   LO
   TS
CP0175672
2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C21H25N5O6  1
1
IC50 = 57.2 nM
   TI
   LI
   LO
   TS
CP0185067
2-{4-[2-(2,4-Diamino-pteridin-6-yl)-propyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C21H23N7O5  1
1
IC50 = 0.24 nM
   TI
   LI
   LO
   TS
CP0205751
2-[2-[[11-(3-aminopropylamino)-5,10-dioxonaphtho[2,3-f][1]benzothiol-4-yl]amino]ethyl]guanidine;hydrochloride
   Show/Hide
C22H25ClN6O2S  1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0208036
2-{4-[(2-Methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-prop-2-ynyl-amino]-benzoylamino}-4-[1-(1H-tetrazol-5-yl)-ethylcarbamoyl]-butyric acid
   Show/Hide
C30H31N9O5  2
1
IC50 = 640 nM
   TI
   LI
   LO
   TS
2
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0244326
(R)-2-((S)-4-Carboxy-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-pentanedioic acid; TFA
   Show/Hide
C31H33N5O9  1
1
IC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0246021
2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H25N7O5  1
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS
CP0259513
(S)-2-{4-[(2-Methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-prop-2-ynyl-amino]-benzoylamino}-5-(1H-[1,2,4]triazole-3-sulfonyl)-pentanoic acid
   Show/Hide
C29H29N7O6S  2
1
IC50 = 490 nM
   TI
   LI
   LO
   TS
2
IC50 = 680 nM
   TI
   LI
   LO
   TS
CP0268306
2-{4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H24N6O5  1
1
IC50 = 23.2 nM
   TI
   LI
   LO
   TS
CP0297780
2-{4-[(4-Amino-2-methyl-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C20H21N7O5  1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0299568
2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]-3-fluorobenzoyl]amino]pentanedioic acid
   Show/Hide
C30H30ClFN2O5  1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0308127
4-[3-Carboxy-1-(1H-tetrazol-5-yl)-propylcarbamoyl]-2-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid
   Show/Hide
C32H33N9O7  2
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
2
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0326126
2-[2-[(4-amino-5,10-dioxonaphtho[2,3-f][1]benzothiol-11-yl)amino]ethyl]guanidine;hydrochloride
   Show/Hide
C19H18ClN5O2S  1
1
IC50 = 22000 nM
   TI
   LI
   LO
   TS
CP0358670
2-{4-[(4-Amino-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C19H19N7O5  3
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
2
IC50 = 260 nM
   TI
   LI
   LO
   TS
3
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0359177
2-(4-Carboxy-4-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-4-(1-carboxymethyl-1H-tetrazol-5-yl)-butyric acid
   Show/Hide
C34H35N9O9  1
1
IC50 = 7200 nM
   TI
   LI
   LO
   TS
CP0372614
5-fluoro-1-[(6S)-5-methylidene-2H-pyran-6-yl]pyrimidine-2,4-dione
   Show/Hide
C10H9FN2O3  1
1
IC50 = 18000 nM
   TI
   LI
   LO
   TS
CP0372615
1-[(2S,4S,5R)-4,5-dihydroxy-3-methylideneoxan-2-yl]-5-fluoropyrimidine-2,4-dione
   Show/Hide
C10H11FN2O5  4
1
IC50 = 18000 nM
   TI
   LI
   LO
   TS
2
IC50 = 21000 nM
   TI
   LI
   LO
   TS
3
IC50 = 85000 nM
   TI
   LI
   LO
   TS
4
IC50 > 500000 nM
   TI
   LI
   LO
   TS
CP0372616
(S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyran-2-yl)pyrimidin-2(1H)-one
   Show/Hide
C9H7FN2O4  6
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
2
IC50 = 2500 nM
   TI
   LI
   LO
   TS
3
IC50 = 3500 nM
   TI
   LI
   LO
   TS
4
IC50 = 63000 nM
   TI
   LI
   LO
   TS
5
IC50 = 75000 nM
   TI
   LI
   LO
   TS
6
IC50 = 294000 nM
   TI
   LI
   LO
   TS
CP0373630
4-(Adamantan-1-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid
   Show/Hide
C29H35N9O4  1
1
IC50 = 510 nM
   TI
   LI
   LO
   TS
CP0377175
2-{4-[(2-Amino-4-thioxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C24H23N5O5S  1
1
IC50 = 18000 nM
   TI
   LI
   LO
   TS
CP0378540
7-tert-butylcarbonyloxy-4-hydroxybenzo[a]pyrrolo[3,4-c]carbazole-1,3(2H,8H)-dione
   Show/Hide
C23H18N2O5  1
1
IC50 = 1950 nM
   TI
   LI
   LO
   TS
CP0378548
2-(4-{[(2,4-Diamino-quinazolin-6-yl)-formyl-amino]-methyl}-benzoylamino)-pentanedioic acid
   Show/Hide
C22H22N6O6  1
1
IC50 > 103000 nM
   TI
   LI
   LO
   TS
CP0391320
(2S)-2-[[4-[[4-chloro-2-(fluoromethyl)quinolin-6-yl]methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
   Show/Hide
C26H23ClFN3O5  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0394263
(2S)-5-[[(1R)-1-carboxyethyl]amino]-2-[[4-[(2-methyl-4-oxo-3,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-oxopentanoic acid
   Show/Hide
C30H31N5O7  1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0395506
2-{4-[(2,4-Diamino-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C21H22N6O5  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0405929
4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyric acid
   Show/Hide
C27H27N9O6  2
1
IC50 = 2.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 25000 nM
   TI
   LI
   LO
   TS
CP0409799
2-{4-[(4-Chloro-2-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-pentanedioic acid
   Show/Hide
C26H23ClFN3O5  1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0412551
10-Benzyloxy-1H-pyrido[3'4':4,5]pyrrolo[2,3-a]-pyrrolo[3,4-c]carbazole-5,7-(6H,12H)-dione
   Show/Hide
C26H16N4O3  1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0424055
(2S)-4-[2-(carboxymethyl)tetrazol-5-yl]-2-[[4-[(2-methyl-4-oxo-3,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]butanoic acid
   Show/Hide
C29H28N8O6  2
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
2
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0424299
3-(4-Carboxy-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-benzoic acid
   Show/Hide
C27H27N9O6  1
1
IC50 = 1.6 nM
   TI
   LI
   LO
   TS
CP0426809
4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid
   Show/Hide
C26H25N9O6  2
1
IC50 = 0.39 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
CP0427269
2-{4-[(4-Chloro-2-methyl-quinolin-6-ylmethyl)-ethyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C25H26ClN3O5  1
1
IC50 = 23000 nM
   TI
   LI
   LO
   TS
CP0429035
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-3-phosphono-propionic acid
   Show/Hide
C17H19N8O6P  1
1
IC50 = 390000 nM
   TI
   LI
   LO
   TS
CP0430475
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-phosphono-butyric acid
   Show/Hide
C18H21N8O6P  1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
CP0431009
2-{4-[(2,4-Dichloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C25H20Cl2FN3O5  1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0432445
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-(3,4-dichloro-benzylcarbamoyl)-butyric acid
   Show/Hide
C26H25Cl2N9O4  2
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
2
IC50 = 46 nM
   TI
   LI
   LO
   TS
CP0434007
6-Amino-2-[6-amino-2-(4-carboxy-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-hexanoylamino]-hexanoic acid
   Show/Hide
C32H46N12O7  1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0434649
2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H24N6O5  1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0435748
10-Hydroxy-1H-pyrido[3'4':4,5]pyrrolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H,12H)-dione
   Show/Hide
C19H10N4O3  1
1
IC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0436458
1H-pyrido[3'4':4,5]pyrrolo[2,3-a]pyrrolo[3,4-c]-carbazole-5,7-(6H,12H)-dione
   Show/Hide
C19H10N4O2  1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0437651
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-(2,6-dichloro-benzylcarbamoyl)-butyric acid
   Show/Hide
C26H25Cl2N9O4  3
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.7 nM
   TI
   LI
   LO
   TS
3
IC50 = 61000 nM
   TI
   LI
   LO
   TS
CP0437855
2-{4-[(4-Chloro-2-trifluoromethyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C26H21ClF3N3O5  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0440214
2-{4-[(2-Carbamoyl-4-chloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C26H23ClN4O6  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0440223
2-{4-[(4-Cyano-2-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C27H24N4O5  1
1
IC50 = 75000 nM
   TI
   LI
   LO
   TS
CP0441711
2-{4-[(4-Chloro-2-methyl-quinolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C23H22ClN3O5  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0444084
2-{4-[(2-Amino-4-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C26H26N4O5  1
1
IC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0448244
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C22H22N8O5  1
1
IC50 = 1.4 nM
   TI
   LI
   LO
   TS
CP0448989
(S)-4-((S)-1-Carboxy-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid
   Show/Hide
C28H29N5O7  2
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
2
IC50 = 790 nM
   TI
   LI
   LO
   TS
CP0453077
2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C23H26N6O5  1
1
IC50 = 12.1 nM
   TI
   LI
   LO
   TS
CP0453649
2-{4-[(2,4-Dimethyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C27H27N3O5  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0454354
4-tert-Butylcarbamoyl-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid
   Show/Hide
C23H29N9O4  2
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
2
IC50 = 22000 nM
   TI
   LI
   LO
   TS
CP0454692
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-3-ureido-propionic acid
   Show/Hide
C19H22N10O4  1
1
IC50 = 9.4 nM
   TI
   LI
   LO
   TS
CP0457476
9-Benzyloxy-1H-pyrido[3'4':4,5]pyrrolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione
   Show/Hide
C26H16N4O3  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0458868
5-(2-Chloro-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid
   Show/Hide
C22H26ClN9O4  1
1
IC50 = 105 nM
   TI
   LI
   LO
   TS
CP0460781
2-{4-[(4-Chloro-2-methyl-quinolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C24H24ClN3O5  1
1
IC50 = 24000 nM
   TI
   LI
   LO
   TS
CP0462832
2-{4-[(2-Chloro-4-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C26H24ClN3O5  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0463413
2-{4-[1-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid
   Show/Hide
C23H29N5O6  1
1
IC50 = 34.6 nM
   TI
   LI
   LO
   TS
CP0475992
6-(2-Bromo-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-hexanoic acid
   Show/Hide
C23H28BrN9O4  1
1
IC50 = 0.096 nM
   TI
   LI
   LO
   TS
CP0480410
2-({4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-5,6,7,8-tetrahydro-naphthalene-1-carbonyl}-amino)-pentanedioic acid
   Show/Hide
C24H27N7O5  1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0483239
2-{4-[Ethyl-(4-thioxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C23H24N4O5S  1
1
IC50 = 31000 nM
   TI
   LI
   LO
   TS
CP0493425
2-[4-(1,3-Diamino-7,8,9,10-tetrahydro-pyrimido[4,5-c]isoquinolin-8-yl)-benzoylamino]-pentanedioic acid
   Show/Hide
C23H24N6O5  1
1
IC50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0493566
2-{4-[(2,4-Dichloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C25H21Cl2N3O5  1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0497674
2-{4-[(2-Methyl-4-thioxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid
   Show/Hide
C25H24N4O5S  1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0502292
2-{4-[(4-Methoxy-2-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C27H27N3O6  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0502698
2-{4-[(4-Chloro-2-methoxy-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C26H24ClN3O6  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0505526
2-{4-[(4-Bromo-2-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C26H24BrN3O5  1
1
IC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0505693
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-5-phosphono-pentanoic acid
   Show/Hide
C19H23N8O6P  1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0511400
(S)-4-((S)-1-Carboxy-2-phenyl-ethylcarbamoyl)-2-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid
   Show/Hide
C34H33N5O7  1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0514256
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid
   Show/Hide
C26H27N9O6  1
1
IC50 = 38000 nM
   TI
   LI
   LO
   TS
CP0515183
2-[2-[[11-[2-(methylamino)ethylamino]-5,10-dioxonaphtho[2,3-f][1]benzothiol-4-yl]amino]ethyl]guanidine;hydrochloride
   Show/Hide
C22H25ClN6O2S  1
1
IC50 = 23000 nM
   TI
   LI
   LO
   TS
CP0518169
5-(2-Bromo-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid
   Show/Hide
C22H26BrN9O4  1
1
IC50 = 0.126 nM
   TI
   LI
   LO
   TS
CP0523970
(2S)-4-[1-(3-carboxypropyl)tetrazol-5-yl]-2-[[4-[(2-methyl-4-oxo-3,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]butanoic acid
   Show/Hide
C31H32N8O6  1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0525400
3-(4-Carboxy-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-benzene m-boronalide(methotrexate gama-(m-boronalide))
   Show/Hide
C26H28BN9O6  1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0527642
2-{4-[(4-Chloro-2-hydroxymethyl-quinolin-6-ylmethyl)-ethyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C25H26ClN3O6  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0528439
9-Hydroxy-1H-pyrido[3'4':4,5]pyrrolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H,12H)-dione
   Show/Hide
C19H10N4O3  1
1
IC50 = 80700 nM
   TI
   LI
   LO
   TS
CP0529728
4-hydroxy-11-methyl-7-hydroxysulfonyloxybenzo[a]pyrrolo-[3,4-c]carbazole-1,3(2H,8H)-dione
   Show/Hide
C19H12N2O7S  1
1
IC50 = 25600 nM
   TI
   LI
   LO
   TS
CP0529872
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-6-phosphono-hexanoic acid
   Show/Hide
C20H25N8O6P  1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0532708
2--[3-(2-Carboxy-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-ethylchloro) -n-nitraso]-ethyl ester
   Show/Hide
C23H28ClN11O5  1
1
IC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0535593
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-phenylcarbamoyl-butyric acid
   Show/Hide
C25H25N9O4  3
1
IC50 = 3.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
3
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0535758
2-{4-[(4-Hydroxy-2-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C26H25N3O6  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0543962
; hydrate2-{4-[(2-Methyl-4-methylsulfanyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ; hydrate
   Show/Hide
C27H27N3O5S  1
1
IC50 = 100000 nM
   TI
   LI
   LO
   TS
CP0545267
(2R)-2-[[(4S)-4-carboxy-4-[[4-[(2-methyl-4-oxo-3,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]butanoyl]-methylamino]pentanedioic acid
   Show/Hide
C33H35N5O9  1
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0553495
N'-[2-[[11-[2-(1-aminoethylideneamino)ethylamino]-5,10-dioxonaphtho[2,3-f][1]benzothiol-4-yl]amino]ethyl]ethanimidamide;hydrochloride
   Show/Hide
C24H27ClN6O2S  1
1
IC50 = 36000 nM
   TI
   LI
   LO
   TS
CP0565389
(2S)-4-[1-(carboxymethyl)tetrazol-5-yl]-2-[[4-[(2-methyl-4-oxo-3,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]butanoic acid
   Show/Hide
C29H28N8O6  1
1
IC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0573415
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-3-(3-methyl-ureido)-propionic acid
   Show/Hide
C20H24N10O4  1
1
IC50 = 34.3 nM
   TI
   LI
   LO
   TS
CP0719695
(R)-2-((S)-4-Carboxy-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-butyrylamino)-hexanedioic acid TFA
   Show/Hide
C34H35F4N5O11  1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0786904
2-{2-Fluoro-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid hydrate
   Show/Hide
C25H23FN4O6  1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0847326
2-{2,3-Difluoro-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid ;hydrate (2H2O)
   Show/Hide
C25H22F2N4O6  1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0869934
6-[(3,4,5-Trimethoxy-phenylamino)-methyl]-3H-quinazolin-4-one
   Show/Hide
C18H19N3O4  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0897235
(R)-2-((S)-4-Carboxy-4-{4-[methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-butyrylamino)-pentanedioic acid TFA
   Show/Hide
C30H32F3N5O11  1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0899706
2-{2,5-Difluoro-4-[methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid ;hydrate (H2O)
   Show/Hide
C23H22F2N4O6  1
1
IC50 = 75 nM
   TI
   LI
   LO
   TS
CP0902152
SID536072
   Show/Hide
C25H28ClFN3O9P  2
1
IC50 = 0.63 nM
   TI
   LI
   LO
   TS
2
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0903163
2-{4-[(2-Acetylamino-4-chloro-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid TFA with hydrate
   Show/Hide
C29H26ClF3N4O8  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0916072
2-{2,6-Difluoro-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid hydrate (H2O)
   Show/Hide
C25H22F2N4O6  1
1
IC50 = 62 nM
   TI
   LI
   LO
   TS
CP0920687
(R)-2-((S)-4-Carboxy-4-{2-fluoro-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-pentanedioic acid TFA
   Show/Hide
C32H31F4N5O11  1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0945051
(R)-2-((S)-4-Carboxy-4-{2-fluoro-4-[methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-butyrylamino)-pentanedioic acid TFA
   Show/Hide
C30H31F4N5O11  1
1
IC50 = 650 nM
   TI
   LI
   LO
   TS
CP0947325
2-{2,6-Difluoro-4-[methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid ;hydrate (1.25H2O)
   Show/Hide
C23H22F2N4O6  1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Ascites)
Cell Line Name Organism Disease
PEO1 Homo sapiens (Human) BRCA2-associated hereditary breast and ovarian cancer syndrome
MAST Homo sapiens (Human) Breast carcinoma
Ramos Homo sapiens (Human) Burkitt lymphoma
CA46 Homo sapiens (Human) Burkitt lymphoma
CellSensor STAT6-bla RA-1 Homo sapiens (Human) Burkitt lymphoma
NCI-H716 Homo sapiens (Human) Cecum adenocarcinoma
COLO 205 Homo sapiens (Human) Colon adenocarcinoma
COLO 201 Homo sapiens (Human) Colon adenocarcinoma
DiFi Homo sapiens (Human) Colorectal carcinoma
U-2932 Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
DB Homo sapiens (Human) Diffuse large B-cell lymphoma germinal center B-cell type
HEC-50B Homo sapiens (Human) Endometrial adenocarcinoma
SNU-5 Homo sapiens (Human) Gastric adenocarcinoma
SNU-16 Homo sapiens (Human) Gastric adenocarcinoma
SNU-620 Homo sapiens (Human) Gastric adenocarcinoma
SNU-638 Homo sapiens (Human) Gastric adenocarcinoma
SNU-668 Homo sapiens (Human) Gastric signet ring cell adenocarcinoma
OVCAR-3 Homo sapiens (Human) High grade ovarian serous adenocarcinoma
OVCAR-5 Homo sapiens (Human) High grade ovarian serous adenocarcinoma
COV318 Homo sapiens (Human) High grade ovarian serous adenocarcinoma
ZR-75-1 Homo sapiens (Human) Invasive breast carcinoma of no special type
SK-HEP-1 Homo sapiens (Human) Liver and intrahepatic bile duct epithelial neoplasm
OV-90 Homo sapiens (Human) Ovarian adenocarcinoma
LK2 Homo sapiens (Human) Ovarian carcinoma
RMG-I Homo sapiens (Human) Ovarian clear cell adenocarcinoma
PA-1 Homo sapiens (Human) Ovarian mixed germ cell tumor
SK-OV-3 Homo sapiens (Human) Ovarian serous cystadenocarcinoma
SKOV3/TR Homo sapiens (Human) Ovarian serous cystadenocarcinoma
AsPC-1 Homo sapiens (Human) Pancreatic ductal adenocarcinoma
HEC Homo sapiens (Human) Peritoneal malignant mesothelioma
Ehrlich-Lettre ascites strain E Mus musculus (Mouse) Malignant neoplasms of the mouse mammary gland
RAW 264.7 Mus musculus (Mouse) Mouse leukemia
L1210/R81 Mus musculus (Mouse) Mouse leukemia
RAW-Lucia ISG Mus musculus (Mouse) Mouse leukemia
RAW-Lucia ISG-KO-STING Mus musculus (Mouse) Mouse leukemia
RAW 264 Mus musculus (Mouse) Mouse leukemia
J774 Mus musculus (Mouse) Mouse reticulum cell sarcoma
J774A1 Mus musculus (Mouse) Mouse reticulum cell sarcoma
HTC Rattus norvegicus (Rat) Rat hepatocellular carcinoma