General Information of the Compound
Compound ID
CP0373630
Compound Name
4-(Adamantan-1-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-butyric acid
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Formula
C29H35N9O4
Molecular Weight
573.658
Canonical SMILES
Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)N[C@]34C[C@H]5C[C@H](C[C@H](C5)C3)C4)C(O)=O)cnc2n1
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InChI
InChI=1S/C29H35N9O4/c30-24-23-25(37-28(31)36-24)33-14-20(34-23)13-32-19-3-1-18(2-4-19)26(40)35-21(27(41)42)5-6-22(39)38-29-10-15-7-16(11-29)9-17(8-15)12-29/h1-4,14-17,21,32H,5-13H2,(H,35,40)(H,38,39)(H,41,42)(H4,30,31,33,36,37)/t15-,16+,17-,21?,29-
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InChIKey
IXWQBJKCIWPCJL-GXBINLNZSA-N
Physicochemical Property
logP
2.2445
Rotatable Bonds
10
Heavy Atom Count
42
Polar Areas
211.13
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
10
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL45572
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02055, Dihydrofolate reductase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000266 L1210 Mus musculus (Mouse)  1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000266 L1210 Mus musculus (Mouse)  1
1
IC50 = 510 nM
   TI
   LI
   LO
   TS