General Information of the Protein
Protein ID
PT01120
Protein Name
Trifunctional purine biosynthetic protein adenosine-3
Secondarily
Protein Name
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
AIR synthase
Phosphoribosyl-aminoimidazole synthetase
5'-phosphoribosylglycinamide transformylase
GAR transformylase
Gene Name
GART
Sequence
MAARVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTACAGKISNAAVSVNDHSALAQFCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIPTAQWRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQAEACRAVQEIMQEKSFGAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPAPQVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQVILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEITGFPEAQALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEGAIYRKDIGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTEAVIAGIAAACQQAGCALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLPQLERITEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTRIYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEGELSEEEMARTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKNLIETIQTNGSLVANGFLKSNFPVQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLVISNKAAVAGLDRAERAGIPTRVINHKLYKNRVEFDNAVDHVLEEFSVDIVCLAGFMRILSGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEAVPVRRGDTVATLSERVKVAEHKIFPAALQLVASGAVQLREDGKIHWAKEQ
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Ligase
Function
Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway.
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Uniprot ID
Primary ID:
Q64737

Secondarily ID:
Q3TGI3
Q6NS48
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Ensembl ID
ENSG00000159131
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000346 , L-5178-Y
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0378840
 Compound Info 
2-{4-[Acetyl-(2-amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
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C23H23N5O7
  1
1
Ki = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0040464
 Compound Info 
2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
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C21H21N5O6
  1
1
Ki = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098443
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(2-oxo-2-phenyl-ethyl)-amino]-benzoylamino}-pentanedioic acid
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C29H27N5O7
  1
1
Ki = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0114675
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carboxymethyl-amino]-benzoylamino}-pentanedioic acid
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C23H23N5O8
  1
1
Ki = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0039203
 Compound Info 
US9422297, PDDF
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C24H23N5O6
  1
1
Ki = 6000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0165224
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
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C26H25N7O8
  1
1
Ki = 7000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0279432
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-cyclopropylmethyl-amino]-benzoylamino}-pentanedioic acid
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C25H27N5O6
  1
1
Ki = 8000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0208067
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-cyano-propyl)-amino]-benzoylamino}-pentanedioic acid
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C25H26N6O6
  1
1
Ki = 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0373287
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-ethyl-amino]-benzoylamino}-pentanedioic acid
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C23H25N5O6
  1
1
Ki = 16000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0197158
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-benzyl)-amino]-benzoylamino}-pentanedioic acid
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C28H26FN5O6
  1
1
Ki = 18000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0183272
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid
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C24H27N5O6
  1
1
Ki = 19000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0049103
 Compound Info 
2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(2-carboxy-ethyl)-amino]-benzoylamino}-pentanedioic acid
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C24H25N5O8
  1
1
Ki = 32000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000266 , L1210
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0057341
 Compound Info 
(6RS) 2-{4-[2-(2-Amino-5-ethyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
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C23H29N5O6
  2
1 IC50 = 10 nM
2 IC50 = 500 nM
CP0147087
 Compound Info 
(5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
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C22H27N5O6
  2
1 IC50 = 720 nM
2 IC50 = 14000 nM
CP0046082
 Compound Info 
(2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
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C21H25N5O6
  1
1 IC50 = 780 nM
CP0036197
 Compound Info 
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
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C20H22N8O5
  1
1 IC50 > 20000 nM
CP0103584
 Compound Info 
2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
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C22H23N5O6
  1
1 IC50 > 20000 nM
CP0164699
 Compound Info 
5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,4a,5,6,7,8-octahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid
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C20H27N7O4
  1
1 Ki = 1400 nM