General Information of the Cell Line
Cell Line ID
CL000346
Cell Line Name
L-5178-Y
Synonyms
L5178Y
LY
Category
Cancer cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_2097
Tissue Information
Thymus
Disease
Mouse thymic lymphoma (NCIt: C134997)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01546, ATP-dependent translocase ABCB1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0378618
 Compound Info 
methyl (1S,12E,14R,15R,18S)-15-ethyl-12-hydroxyimino-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H27N3O3
  1
1
IC50 = 16740 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378614
 Compound Info 
methyl (1S,12E,14R,15S,18S)-15-ethyl-17-methyl-12-(phenylhydrazinylidene)-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C27H32N4O2
  1
1
IC50 = 17040 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0454719
 Compound Info 
methyl (1S,12E,14R,15S,18S)-12-[(5-bromopyridin-2-yl)hydrazinylidene]-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C26H30BrN5O2
  1
1
IC50 = 37640 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398216
 Compound Info 
methyl (1S,14R,15R,18S)-10-benzyl-15-ethyl-17-methyl-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C28H32N2O3
  1
1
IC50 = 38090 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378621
 Compound Info 
methyl (1S,12E,14R,15R,18S)-12-[(5-bromopyridin-2-yl)hydrazinylidene]-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C26H30BrN5O2
  1
1
IC50 = 39930 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398008
 Compound Info 
methyl (1S,12E,14R,15R,18S)-15-ethyl-17-methyl-12-(pyridin-3-ylmethylcarbamothioylhydrazinylidene)-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C28H34N6O2S
  1
1
IC50 = 45210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378619
 Compound Info 
methyl (1S,12E,14R,15S,18S)-15-ethyl-12-hydrazinylidene-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H28N4O2
  1
1
IC50 = 48700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398230
 Compound Info 
methyl (1S,12E,14R,15R,18S)-15-ethyl-12-[(4-methoxyphenyl)methoxycarbonylhydrazinylidene]-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C30H36N4O5
  1
1
IC50 = 52300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398229
 Compound Info 
methyl (1S,12E,14R,15R,18S)-15-ethyl-17-methyl-12-(phenylhydrazinylidene)-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C27H32N4O2
  1
1
IC50 = 52720 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398007
 Compound Info 
methyl (1S,12E,14R,15R,18S)-15-ethyl-12-hydrazinylidene-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H28N4O2
  1
1
IC50 = 73370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378624
 Compound Info 
methyl (1S,14R,15R,18S)-15-ethyl-17-methyl-12-sulfanylidene-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H26N2O2S
  1
1
IC50 = 77920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398214
 Compound Info 
methyl (1S,12S,14R,15S,18S)-15-ethyl-12-hydroxy-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H28N2O3
  1
1
IC50 = 83860 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378620
 Compound Info 
methyl (1S,12E,14R,15R,18S)-15-ethyl-17-methyl-12-(pyrazin-2-ylhydrazinylidene)-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C25H30N6O2
  1
1
IC50 = 84780 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378622
 Compound Info 
methyl (1S,12E,14R,15S,18S)-15-ethyl-12-hydroxyimino-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H27N3O3
  1
1
IC50 = 85360 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451543
 Compound Info 
methyl (1S,14R,15R,18S)-15-ethyl-10,17-dimethyl-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C22H28N2O3
  1
1
IC50 = 89160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378612
 Compound Info 
methyl (1S,12S,14R,15R,18S)-15-ethyl-12-hydroxy-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H28N2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378615
 Compound Info 
methyl (1S,12S,14R,15R,18S)-12-[(E)-but-2-enoyl]oxy-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C25H32N2O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0378623
 Compound Info 
methyl (1S,12E,14R,15R,18S)-12-(carbamoylhydrazinylidene)-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C22H29N5O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398009
 Compound Info 
methyl (1S,12E,14R,15S,18S)-12-(carbamoylhydrazinylidene)-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C22H29N5O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398215
 Compound Info 
methyl (1S,14R,15S,18S)-15-ethyl-17-methyl-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H26N2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398231
 Compound Info 
methyl (1S,14R,15R,18S)-15-ethyl-17-methyl-10-(3-methylbenzoyl)-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C29H32N2O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398232
 Compound Info 
methyl (1S,12E,14R,15S,18S)-15-ethyl-17-methyl-12-(pyrazin-2-ylhydrazinylidene)-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C25H30N6O2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0441824
 Compound Info 
methyl (1S,14R,15R,18S)-10-[2-(diethylamino)ethyl]-15-ethyl-17-methyl-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C27H39N3O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0447584
 Compound Info 
methyl (1S,12S,14R,15S,18S)-12-(adamantane-1-carbonyloxy)-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C32H42N2O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451544
 Compound Info 
methyl (1S,14R,15R,18S)-15-ethyl-17-methyl-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
C21H26N2O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT05760, Beta-2 adrenergic receptor
 Protein Info 
Protein ID: PT01120, Glycinamide ribonucleotide synthetase
 Protein Info 
Protein ID: PT03003, Histone-lysine N-methyltransferase EZH2
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0026997
 Compound Info 
Alternariol
   Show/Hide
 C14H10O5  1
1
EC50 = 6583.278473 nM
   TI
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   TS
CP0378612
 Compound Info 
methyl (1S,12S,14R,15R,18S)-15-ethyl-12-hydroxy-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C21H28N2O3  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0378622
 Compound Info 
methyl (1S,12E,14R,15S,18S)-15-ethyl-12-hydroxyimino-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C21H27N3O3  1
1
IC50 = 60100 nM
   TI
   LI
   LO
   TS
CP0378624
 Compound Info 
methyl (1S,14R,15R,18S)-15-ethyl-17-methyl-12-sulfanylidene-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C21H26N2O2S  1
1
IC50 = 54490 nM
   TI
   LI
   LO
   TS
CP0398007
 Compound Info 
methyl (1S,12E,14R,15R,18S)-15-ethyl-12-hydrazinylidene-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C21H28N4O2  1
1
IC50 = 69840 nM
   TI
   LI
   LO
   TS
CP0398009
 Compound Info 
methyl (1S,12E,14R,15S,18S)-12-(carbamoylhydrazinylidene)-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C22H29N5O3  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0398214
 Compound Info 
methyl (1S,12S,14R,15S,18S)-15-ethyl-12-hydroxy-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C21H28N2O3  1
1
IC50 = 55650 nM
   TI
   LI
   LO
   TS
CP0398230
 Compound Info 
methyl (1S,12E,14R,15R,18S)-15-ethyl-12-[(4-methoxyphenyl)methoxycarbonylhydrazinylidene]-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C30H36N4O5  1
1
IC50 = 34280 nM
   TI
   LI
   LO
   TS
CP0447584
 Compound Info 
methyl (1S,12S,14R,15S,18S)-12-(adamantane-1-carbonyloxy)-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C32H42N2O4  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0451543
 Compound Info 
methyl (1S,14R,15R,18S)-15-ethyl-10,17-dimethyl-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C22H28N2O3  1
1
IC50 = 40430 nM
   TI
   LI
   LO
   TS
CP0451544
 Compound Info 
methyl (1S,14R,15R,18S)-15-ethyl-17-methyl-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C21H26N2O3  1
1
IC50 = 82370 nM
   TI
   LI
   LO
   TS
CP0454719
 Compound Info 
methyl (1S,12E,14R,15S,18S)-12-[(5-bromopyridin-2-yl)hydrazinylidene]-15-ethyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
   Show/Hide
 C26H30BrN5O2  1
1
IC50 = 29210 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Thymus)
Cell Line Name Organism Disease
Cf2Th-CCR5
 Cell Line Info 
Canis lupus familiaris (Dog) -
CF2.Th
 Cell Line Info 
Canis lupus familiaris (Dog) -