Compound ID |
Compound Name |
Compound Formula |
CP0001250
|
(16E)-14-methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene
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|
C23H24N4O
|
1
|
1 |
IC50 = 33 nM
|
|
|
CP0007430
|
IBRUTINIB
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|
C25H24N6O2
|
2
|
1 |
IC50 = 1350 nM
|
|
|
2 |
IC50 = 6620 nM
|
|
|
CP0024241
|
4-[[[4-[5-chloro-2-[[4-(2-methoxyethylamino)cyclohexyl]amino]pyridin-4-yl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrile
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|
C24H33ClN6O2S
|
1
|
1 |
GI50 = 13 nM
|
|
|
CP0055838
|
3-[2-(4-amino-1-ethylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
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|
C30H31F3N8O
|
1
|
1 |
IC50 = 10000 nM
|
|
|
CP0197842
|
N-[3-[2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]-6,7-dioxo-5-propan-2-ylpteridin-8-yl]phenyl]prop-2-enamide
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|
C30H34N8O3
|
1
|
1 |
IC50 = 9370 nM
|
|
|
CP0322301
|
N-[3-[[4-[4-(piperidine-1-carbonyl)anilino]-1,3,5-triazin-2-yl]amino]phenyl]prop-2-enamide
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|
C24H25N7O2
|
1
|
1 |
IC50 = 6140 nM
|
|
|
CP0383413
|
N-[2-methyl-5-(2-oxo-9-pyrazol-1-ylbenzo[h][1,6]naphthyridin-1-yl)phenyl]prop-2-enamide
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|
C25H19N5O2
|
1
|
1 |
GI50 = 3500 nM
|
|
|
CP0383415
|
N-[2-methyl-5-(2-oxo-9-pyrazol-1-ylbenzo[h][1,6]naphthyridin-1-yl)phenyl]propanamide
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|
C25H21N5O2
|
1
|
1 |
GI50 > 10000 nM
|
|
|
CP0405068
|
N-[3-[[5-fluoro-2-[4-methoxy-3-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C27H31FN6O4
|
1
|
1 |
IC50 = 11320 nM
|
|
|
CP0408300
|
N-[3-[5-chloro-2-[3-methyl-4-[(4-methylphenyl)sulfonylamino]anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
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|
C27H24ClN5O4S
|
1
|
1 |
IC50 = 7230 nM
|
|
|
CP0438691
|
methyl 1-[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]pyrrolidine-2-carboxylate
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|
C27H27ClN6O5
|
1
|
1 |
IC50 = 19700 nM
|
|
|
CP0447341
|
N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide
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|
C36H37N5O5S
|
1
|
1 |
GI50 = 1200 nM
|
|
|
CP0451318
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N,N-dipropylcarbamodithioate
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|
C28H33FN6O2S2
|
1
|
1 |
IC50 > 40000 nM
|
|
|
CP0452681
|
4-[4-(4-methylpiperazin-1-yl)anilino]-2-[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]-1,3-thiazole-5-carboxamide
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|
C29H27F3N6O2S
|
1
|
1 |
IC50 = 1580 nM
|
|
|
CP0452686
|
2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
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|
C32H36N6O2S
|
1
|
1 |
IC50 = 8600 nM
|
|
|
CP0457509
|
N-[3-[[5-chloro-2-[3-chloro-4-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C26H28Cl2N6O3
|
1
|
1 |
IC50 = 2000 nM
|
|
|
CP0478757
|
N-[3-[[5-fluoro-2-[3-methoxy-4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H27FN6O5
|
1
|
1 |
IC50 > 40000 nM
|
|
|
CP0478862
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl pyrrolidine-1-carbodithioate
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|
C26H27FN6O2S2
|
1
|
1 |
IC50 = 2970 nM
|
|
|
CP0481300
|
N-[3-[[2-[4-[[2-[bis(2-methoxyethyl)amino]acetyl]amino]-3-methoxyanilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C28H34ClN7O5
|
1
|
1 |
IC50 = 11000 nM
|
|
|
CP0482298
|
2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-N-methyl-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxamide
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|
C32H35N5O3S
|
1
|
1 |
IC50 = 34090 nM
|
|
|
CP0482354
|
N-[3-[[2-[4-[3-(4-ethylpiperazin-1-yl)propoxy]-2-methylanilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C29H36FN7O2
|
1
|
1 |
IC50 = 18460 nM
|
|
|
CP0485099
|
CHEMBL4863078
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|
C26H25N5O3
|
1
|
1 |
IC50 = 6638 nM
|
|
|
CP0485775
|
N-[3-[[5-chloro-2-[4-[(4-fluorophenyl)sulfonylamino]-3-methoxyanilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C26H22ClFN6O4S
|
1
|
1 |
IC50 = 6490 nM
|
|
|
CP0489640
|
N-[3-[[2-[4-[[2-[bis(2-methoxyethyl)amino]acetyl]amino]anilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C27H32FN7O4
|
1
|
1 |
IC50 = 35600 nM
|
|
|
CP0489641
|
N-[3-[[5-chloro-2-[4-(oxolan-2-ylmethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C24H24ClN5O3
|
1
|
1 |
IC50 = 10500 nM
|
|
|
CP0518597
|
2-[3-[(4-chlorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylic acid
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|
C28H26ClN5O3S
|
1
|
1 |
IC50 = 23280 nM
|
|
|
CP0518599
|
ethyl 2-[3-[(4-cyanobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylate
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|
C31H30N6O3S
|
1
|
1 |
IC50 = 4280 nM
|
|
|
CP0519597
|
N-[3-[[2-[4-[2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]anilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C27H31ClN6O5
|
1
|
1 |
IC50 = 18100 nM
|
|
|
CP0519598
|
N-[3-[[2-[4-[[2-[bis(2-methoxyethyl)amino]acetyl]amino]anilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
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|
C27H32ClN7O4
|
1
|
1 |
IC50 = 14800 nM
|
|
|
CP0520079
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-propan-2-ylcarbamodithioate
Show/Hide
|
C25H27FN6O2S2
|
1
|
1 |
IC50 = 9310 nM
|
|
|
CP0523262
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-[(4-cyanophenyl)methyl]carbamodithioate
Show/Hide
|
C30H26FN7O2S2
|
1
|
1 |
IC50 = 1030 nM
|
|
|
CP0533230
|
2-[3-[(2-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylic acid
Show/Hide
|
C28H26FN5O3S
|
1
|
1 |
IC50 = 6300 nM
|
|
|
CP0535914
|
oxolan-2-ylmethyl 2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetate
Show/Hide
|
C26H26ClN5O5
|
1
|
1 |
IC50 > 40000 nM
|
|
|
CP0538054
|
N-[3-[5-carbamoyl-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-2-yl]phenyl]thiadiazole-4-carboxamide
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|
C24H24N8O2S2
|
1
|
1 |
IC50 = 4730 nM
|
|
|
CP0538219
|
2-[3-[(4-fluorobenzoyl)amino]phenyl]-4-(4-morpholin-4-ylanilino)-1,3-thiazole-5-carboxylic acid
Show/Hide
|
C27H23FN4O4S
|
1
|
1 |
IC50 = 3510 nM
|
|
|
CP0538964
|
N-[3-[[5-fluoro-2-[4-(oxolan-2-ylmethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C24H24FN5O3
|
1
|
1 |
IC50 = 22300 nM
|
|
|
CP0539337
|
2-[3-[(4-tert-butylbenzoyl)amino]phenyl]-4-[4-(morpholine-4-carbonyl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
|
C32H33N5O4S
|
1
|
1 |
IC50 = 28430 nM
|
|
|
CP0540659
|
N-[3-[[5-chloro-2-[4-methoxy-3-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31ClN6O4
|
1
|
1 |
IC50 = 7310 nM
|
|
|
CP0540865
|
5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyrimidin-2-yl]amino]-3-[(3R)-piperidin-3-yl]oxypyridine-2-carbonitrile
Show/Hide
|
C20H23N9O
|
1
|
1 |
IC50 = 95 nM
|
|
|
CP0547155
|
N-[3-[[2-[4-[[2-[bis(2-methoxyethyl)amino]acetyl]amino]-3-methylanilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C28H34ClN7O4
|
1
|
1 |
IC50 = 19600 nM
|
|
|
CP0548978
|
N-[3-[[2-[4-[2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]anilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H31FN6O5
|
1
|
1 |
IC50 > 40000 nM
|
|
|
CP0549135
|
N-[3-[[5-chloro-2-[3-methoxy-4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C26H27ClN6O5
|
1
|
1 |
IC50 > 40000 nM
|
|
|
CP0551189
|
2-(4-phenoxyphenyl)-7-(1-prop-2-ynoylpiperidin-4-yl)-5H-imidazo[1,2-b]pyrazole-3-carboxamide
Show/Hide
|
C26H23N5O3
|
1
|
1 |
IC50 = 27.4 nM
|
|
|
CP0554434
|
methyl 2-[[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]amino]propanoate
Show/Hide
|
C25H25ClN6O5
|
1
|
1 |
IC50 = 40800 nM
|
|
|
CP0554866
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-prop-2-enylcarbamodithioate
Show/Hide
|
C25H25FN6O2S2
|
1
|
1 |
IC50 = 4320 nM
|
|
|
CP0554867
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-[(4-methoxyphenyl)methyl]carbamodithioate
Show/Hide
|
C30H29FN6O3S2
|
1
|
1 |
IC50 = 3220 nM
|
|
|
CP0559128
|
methyl 2-[[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]amino]acetate
Show/Hide
|
C24H23ClN6O5
|
1
|
1 |
IC50 = 20900 nM
|
|
|
CP0559757
|
2-[3-[(4-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
Show/Hide
|
C28H27FN6O2S
|
1
|
1 |
IC50 = 1420 nM
|
|
|
CP0561956
|
2-[[5-chloro-2-[4-[(4-methoxyphenyl)sulfonylamino]-3-methylanilino]pyrimidin-4-yl]amino]-N-methylbenzamide
Show/Hide
|
C26H25ClN6O4S
|
1
|
1 |
IC50 = 4610 nM
|
|
|
CP0564443
|
2-[[5-chloro-2-[4-[(4-fluorophenyl)sulfonylamino]-3-methoxyanilino]pyrimidin-4-yl]amino]-N-methylbenzamide
Show/Hide
|
C25H22ClFN6O4S
|
1
|
1 |
IC50 = 24600 nM
|
|
|
CP0564445
|
2-[[5-chloro-2-[3-methyl-4-[(4-methylphenyl)sulfonylamino]anilino]pyrimidin-4-yl]amino]-N-methylbenzamide
Show/Hide
|
C26H25ClN6O3S
|
1
|
1 |
IC50 = 20300 nM
|
|
|
CP0564773
|
2-[[5-chloro-2-[4-[4-(trifluoromethylsulfonylamino)phenoxy]anilino]pyrimidin-4-yl]amino]-N-methylbenzamide
Show/Hide
|
C25H20ClF3N6O4S
|
1
|
1 |
IC50 = 14400 nM
|
|
|
CP0568939
|
2-[[5-chloro-2-[4-[(4-methoxyphenyl)sulfonylamino]anilino]pyrimidin-4-yl]amino]-N-methylbenzamide
Show/Hide
|
C25H23ClN6O4S
|
1
|
1 |
IC50 = 9100 nM
|
|
|
CP0570434
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-methylcarbamodithioate
Show/Hide
|
C23H23FN6O2S2
|
1
|
1 |
IC50 = 5940 nM
|
|
|
CP0570435
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N,N-dibutylcarbamodithioate
Show/Hide
|
C30H37FN6O2S2
|
1
|
1 |
IC50 = 9210 nM
|
|
|
CP0570436
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl N-cyclopropylcarbamodithioate
Show/Hide
|
C25H25FN6O2S2
|
1
|
1 |
IC50 = 5090 nM
|
|
|
CP0570440
|
2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]ethyl 4-(2-hydroxyethyl)piperazine-1-carbodithioate
Show/Hide
|
C28H32FN7O3S2
|
1
|
1 |
IC50 = 3740 nM
|
|
|
CP0570442
|
[2-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]anilino]-2-oxoethyl] N-(pyridin-3-ylmethyl)carbamodithioate
Show/Hide
|
C28H25FN8O2S2
|
1
|
1 |
IC50 = 1130 nM
|
|
|
CP0574425
|
N-[3-[[2-[4-[2-[bis(2-methoxyethyl)amino]-2-oxoethoxy]-3-chloroanilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C27H30Cl2N6O5
|
1
|
1 |
IC50 = 16900 nM
|
|
|
CP0574862
|
N-[3-[[2-[4-[bis(2-methoxyethyl)amino]anilino]-5-chloropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C25H29ClN6O3
|
1
|
1 |
IC50 = 13000 nM
|
|
|
CP0574863
|
N-[3-[[2-[4-[bis(2-methoxyethyl)amino]anilino]-5-fluoropyrimidin-4-yl]amino]phenyl]prop-2-enamide
Show/Hide
|
C25H29FN6O3
|
1
|
1 |
IC50 = 18100 nM
|
|
|
CP0576080
|
2-[3-[(3-fluorobenzoyl)amino]phenyl]-4-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxylic acid
Show/Hide
|
C28H26FN5O3S
|
1
|
1 |
IC50 = 14020 nM
|
|
|
CP0689377
|
SPEBRUTINIB
Show/Hide
|
C22H22FN5O3
|
1
|
1 |
IC50 = 20900 nM
|
|
|