Duvelisib

5-chloro-2-[(2S,4S)-4-fluoro-1-(7H-purin-6-yl)pyrrolidin-2-yl]-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4-one

1-[(3S)-3-[[9-ethyl-8-(1-ethyl-5-methylpyrazol-4-yl)purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

2-amino-4-[(2S)-2-(5-chloro-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)pyrrolidin-1-yl]pyrimidine-5-carbonitrile

4-[(2S)-2-(4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)pyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

5-chloro-3-(3-fluorophenyl)-2-[(2S)-1-(7H-purin-6-yl)pyrrolidin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-one

2-[(2S)-1-(5-acetyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-2-yl]-5-chloro-3-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-4-one

5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one

1-[(3S)-3-[[8-(2-tert-butyl-1,3-thiazol-5-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

cyclobutyl-[(3S)-3-[[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]methanone

2-[(2S)-1-(5-acetyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-2-yl]-5-fluoro-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4-one

1-[(3S)-3-[[8-(6-methoxy-5-methylpyridin-3-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

cyclopropyl-[(3S)-3-[[9-ethyl-8-[6-(trifluoromethyl)pyridin-3-yl]purin-6-yl]amino]pyrrolidin-1-yl]methanone

cyclopropyl-[(3S)-3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]methanone

(3,3-difluorocyclobutyl)-[(3S)-3-[[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]methanone

cyclobutyl-[(3S)-3-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]oxypyrrolidin-1-yl]methanone

1-[(3S)-3-[[9-(2,2-difluoroethyl)-8-(1-ethyl-5-methylpyrazol-4-yl)purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

[(3S)-3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]-(oxan-4-yl)methanone

2-amino-4-[(2S)-2-(5-chloro-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)azetidin-1-yl]pyrimidine-5-carbonitrile

(2S)-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]butan-1-one

1-[(3S)-3-[[8-(5-fluoro-6-methoxypyridin-3-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

cyclopropyl-[(3S)-3-[[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]methanone

4-[(2S)-2-(5-chloro-4-oxo-3-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)azetidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

2-[(2S)-1-(5-acetyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)azetidin-2-yl]-5-chloro-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4-one

(3S)-3-(cyclopropylmethyl)-5-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]-3-methyl-1H-indol-2-one

1-[(3S)-3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(3S)-3-(cyclopropylmethyl)-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1H-indol-2-one

(3S)-1'-(cyclopropanecarbonyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-1-methylspiro[indole-3,2'-pyrrolidine]-2-one

(3S)-1'-(cyclopropanecarbonyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]spiro[1H-indole-3,2'-pyrrolidine]-2-one

(3,3-difluorocyclobutyl)-[(3S)-3-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]oxypyrrolidin-1-yl]methanone

[(3S)-3-[[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]-(oxan-4-yl)methanone

[(3S)-3-[[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]-(3-methoxycyclobutyl)methanone

1-[(3S)-3-[[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(S)-(3-((9-ethyl-8-(6- (trifluoromethyl)pyridin-3-yl)- 9H-purin-6-yl)oxy)pyrrolidin-1- yl)(3-methoxyazetidin-1- yl)methanone

4-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]-1-(2-methylpropyl)pyrrolidin-2-one

(3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1H-indol-2-one

6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]oxy}-9-ethyl-8-[6- (trifluoromethyl)pyridin-3-yl]- 9H-purine

(3S)-1'-(cyclopropanecarbonyl)-5-[9-methyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]spiro[1H-indole-3,2'-pyrrolidine]-2-one

[(3S)-3-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]oxypyrrolidin-1-yl]-(oxan-4-yl)methanone

1-[1-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]piperidin-4-yl]-3H-imidazo[4,5-b]pyridin-2-one

9-ethyl-6-({(3S)-1-[(3- methoxyazetidin-1- yl)carbonyl]pyrrolidin-3- yl}oxy)-8-(2-methylpyrimidin- 5-yl)-9H-purine

1-[(3S)-3-[[9-methyl-8-[6-(trifluoromethyl)pyridin-3-yl]purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

[(3S)-3-[[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]-(3-methoxyazetidin-1-yl)methanone

CHEMBL4859422

1-[(3S)-3-[[8-(6-methoxypyridin-3-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-3-[[(3S)-oxolan-3-yl]amino]-1H-indol-2-one

(3S)-1'-(cyclopropanecarbonyl)-1-methyl-5-[9-methyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]spiro[indole-3,2'-pyrrolidine]-2-one

1-[(3S)-3-[[9-methyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-[(2-fluoro-2-methylpropyl)amino]-3-methyl-1H-indol-2-one

6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]oxy}-9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purine

[(3S)-3-[[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]amino]pyrrolidin-1-yl]-(1,3-oxazol-4-yl)methanone

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-3-phenyl-1H-indol-2-one

9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(1,3-oxazol-4- ylcarbonyl)pyrrolidin-3-yl]oxy}- 9H-purine

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-(3-methoxy-3-methylazetidin-1-yl)-3-methyl-1H-indol-2-one

(2S)-2-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]-1-morpholin-4-ylbutan-1-one

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-3-(oxetan-2-ylmethyl)-1H-indol-2-one

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-1'-propan-2-ylspiro[1H-indole-3,2'-pyrrolidine]-2-one

[(3S)-3-[9-ethyl-8-[6-(trifluoromethyl)pyridin-3-yl]purin-6-yl]oxypyrrolidin-1-yl]-(oxolan-3-yl)methanone

CHEMBL4870367

(3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-1H-indol-2-one

1-[(3S)-3-[[8-(1-ethyl-2-methylpyrrol-3-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(3S)-3-(cyclobutylamino)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-1H-indol-2-one

[(1R,3S)-3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]cyclopentyl]-morpholin-4-ylmethanone

1-[(3S)-3-[[9-methyl-8-(6-methylpyridin-3-yl)purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-(3-methoxy-3-methylazetidin-1-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridin-2-one

1-[(3R)-3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

6-{[(3S)-1- (cyclopropylcarbonyl)pyrrolidin- 3-yl]oxy}-8-(1-ethyl-5-methyl- 1H-pyrazol-4-yl)-9-methyl-9H- purine

(3S)-3-(2,2-difluoropropylamino)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-1H-indol-2-one

(3S)-3-(cyclopropylmethyl)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-1H-indol-2-one

1-[(3S)-3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-propylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-[(2-fluoro-2-methylpropyl)amino]-3-methyl-1H-pyrrolo[2,3-b]pyridin-2-one

(3S)-3-(cyclopropylmethyl)-3-methyl-5-[9-methyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-1H-indol-2-one

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-3-[[(3S)-oxolan-3-yl]amino]-1H-pyrrolo[2,3-b]pyridin-2-one

(3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-2H-isoindol-1-one

(3S)-3-benzyl-3-methyl-5-(9-methylpurin-6-yl)-1H-indol-2-one

[(3S)-3-[9-ethyl-8-[6-(trifluoromethyl)pyridin-3-yl]purin-6-yl]oxypyrrolidin-1-yl]-(1,3-oxazol-4-yl)methanone

1-[(3S)-3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]piperidin-1-yl]propan-1-one

(3S)-3-methyl-5-[9-methyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-[[(3S)-oxolan-3-yl]amino]-1H-pyrrolo[2,3-b]pyridin-2-one

1-[(3S)-3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-(2,2,2-trifluoroethyl)purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(tetrahydro-2H- pyran-4-ylcarbonyl)pyrrolidin- 3-yl]oxy}-9H-purine

(3S)-3-(cyclobutylamino)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-1H-pyrrolo[2,3-b]pyridin-2-one

(3S)-3-(cyclopropylmethyl)-3-methyl-5-(9-methylpurin-6-yl)-1H-indol-2-one

1-[(3S)-3-[[8-(2-methylpyrimidin-5-yl)-9-propylpurin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(3S)-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)purin-6-yl]-3-methyl-3-(oxetan-3-ylmethyl)-1H-indol-2-one

[(3S)-3-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]sulfanylpyrrolidin-1-yl]-(oxan-4-yl)methanone

(2S)-2-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]-1-morpholin-4-ylpropan-1-one

1-[(3S)-3-[[9-cyclopropyl-8-(1-ethyl-5-methylpyrazol-4-yl)purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(S)-1-(3-(8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9H-purin-6-ylamino)pyrrolidin-1-yl)propan-1-one

[4-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]oxythiophen-2-yl]-morpholin-4-ylmethanone

8-(1-ethyl-5-methylpyrazol-4-yl)-9-methyl-N-[(3S)-1-propylpyrrolidin-3-yl]purin-6-amine

1-[(3S)-3-[[9-(cyclopropylmethyl)-8-(1-ethyl-5-methylpyrazol-4-yl)purin-6-yl]amino]pyrrolidin-1-yl]propan-1-one

(2S)-2-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]-N,N-dimethylbutanamide

1-[3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]azetidin-1-yl]propan-1-one

[3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]azetidin-1-yl]-(oxan-4-yl)methanone

3-[[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]amino]-1-(2-methylpropyl)pyrrolidin-2-one

(3-((8-(1-ethyl-5-methyl-1H- pyrazol-4-yl)-9-methyl-9H-purin-6- yl)methyl)pyrrolidin-1- yl)(tetrahydro-2H-pyran-4- yl)methanone