Brief Information of the Cell Line and Protein
Cell Line ID: CL000003 , Ramos
Synonyms
RAMOS
Ramos 1
RA 1
RA.1
Ra #1
Ra No. 1
Ramos(RA1)
Ramos-RA1
Ramos (RA 1)
Ramos (RA)
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0597
Protein ID: PT01441 , Tyrosine-protein kinase SYK
Gene Name SYK
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P43405
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000003  Protein ID: PT01441
 
Compound ID Compound Name Compound Formula
CP0057741
6-(1H-indazol-6-yl)-N-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C23H21N7O
 3
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
2
EC50 = 26 nM
   TI
   LI
   LO
   TS
3
IC50 = 878 nM
   TI
   LI
   LO
   TS
CP0385267
6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-(3-methylanilino)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridine-7-carbonitrile
   Show/Hide
C21H24N6O
 1
1
EC50 < 3 nM
   TI
   LI
   LO
   TS
CP0876093
6-((1R,2S)-2-aminocyclohexylamino)-7-(1H-pyrazol-4-yl)-4-(m-tolylamino)-1H-pyrrolo[3,4-c]pyridin-3(2H)-one
   Show/Hide
C23H27N7O
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0432915
6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-(3-methylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one
   Show/Hide
C20H25N5O
 1
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
CP0237328
6-[[(1R,2S)-2-aminocyclohexyl]amino]-3-oxo-4-pyrazolo[1,5-a]pyridin-3-yl-1,2-dihydropyrrolo[3,4-c]pyridine-7-carbonitrile
   Show/Hide
C21H21N7O
 1
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
CP0240497
6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(3-methylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one
   Show/Hide
C20H24FN5O
 1
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
CP0190764
6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one
   Show/Hide
C17H21FN6O
 1
1
EC50 = 9.8 nM
   TI
   LI
   LO
   TS
CP0368581
N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-6-(5H-pyrrolo[2,3-b]pyrazin-3-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H25N9O
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0547574
N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-6-(1H-pyrazolo[4,3-b]pyridin-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H25N9O
 1
1
EC50 = 13 nM
   TI
   LI
   LO
   TS
CP0131482
1-[4-[[6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-4-methylpiperidin-4-ol
   Show/Hide
C25H25N7O
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0081059
5,5-dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one
   Show/Hide
C19H18F3N5O3
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0238205
8-[[4-(ethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-5,5-dimethyl-1H-4,1-benzoxazepin-2-one
   Show/Hide
C19H21N5O3
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0562819
8-[[4-(cyclopropylamino)furo[3,2-d]pyrimidin-2-yl]amino]-5,5-dimethyl-1H-4,1-benzoxazepin-2-one
   Show/Hide
C20H21N5O3
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0323206
N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-6-(1H-pyrrolo[2,3-b]pyridin-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H26N8O
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0090807
6-(1H-indazol-6-yl)-N-(3-methoxy-4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H23N7O2
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0125698
N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-6-(1H-pyrazolo[3,4-b]pyridin-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H25N9O
 1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
CP0540766
6-(1H-indazol-6-yl)-N-[4-[4-(2-methoxyethyl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H28N8O
 1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
CP0093068
N-(3,4-dimethoxyphenyl)-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C21H18N6O2
 1
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
CP0117509
6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C23H25N9O
 1
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
CP0122058
methyl N-[(3R)-8-[[4-(2,2-difluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-5,5-dimethyl-2-oxo-3,4-dihydro-1H-1-benzazepin-3-yl]carbamate
   Show/Hide
C22H24F2N6O4
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0558177
6-(1H-indol-6-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C27H27N7O
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0834359
(R)-(4-(4-((6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)morpholin-2-yl)methanol
   Show/Hide
C24H23N7O2
 1
1
EC50 = 29 nM
   TI
   LI
   LO
   TS
CP0122057
5,5-dimethyl-8-[[4-(propan-2-ylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one
   Show/Hide
C20H23N5O3
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0238206
5,5-dimethyl-8-[[4-(propylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one
   Show/Hide
C20H23N5O3
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0125451
N-[4-(1,1-dioxo-1,4-thiazinan-4-yl)phenyl]-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C23H21N7O2S
 2
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
2
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0368580
1-[4-[[6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]piperidin-4-ol
   Show/Hide
C24H23N7O
 1
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
CP0834358
N-(4-((1s,5s)-3,7-dioxa-9-azabicyclo[3.3.1]nonan-9-yl)phenyl)-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H23N7O2
 1
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
CP0081062
4-N-cyclopropyl-2-N-(3-methyl-2H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine
   Show/Hide
C17H16N6O
 1
1
EC50 = 34 nM
   TI
   LI
   LO
   TS
CP0067678
2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-(3-methylanilino)-6,7-dihydropyrrolo[3,4-d]pyrimidin-5-one
   Show/Hide
C19H24N6O
 1
1
EC50 = 35 nM
   TI
   LI
   LO
   TS
CP0267292
8-[[4-(cyclopropylamino)furo[3,2-d]pyrimidin-2-yl]amino]-5,5-dimethyl-3,4-dihydro-1H-1-benzazepin-2-one
   Show/Hide
C21H23N5O2
 1
1
EC50 = 35 nM
   TI
   LI
   LO
   TS
CP0574943
N-[4-(4-ethylpiperazin-1-yl)phenyl]-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H26N8
 1
1
EC50 = 36 nM
   TI
   LI
   LO
   TS
CP0323205
N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-6-(1H-pyrazolo[3,4-b]pyrazin-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H24N10O
 1
1
EC50 = 37 nM
   TI
   LI
   LO
   TS
CP0314386
methyl N-[(3R)-8-[[4-(cyclopropylamino)furo[3,2-d]pyrimidin-2-yl]amino]-5,5-dimethyl-2-oxo-3,4-dihydro-1H-1-benzazepin-3-yl]carbamate
   Show/Hide
C23H26N6O4
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0090806
2-[4-[[6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-N-methylanilino]ethanol
   Show/Hide
C22H21N7O
 1
1
EC50 = 42 nM
   TI
   LI
   LO
   TS
CP0562818
5,5-dimethyl-8-[[4-(2-methylpropylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one
   Show/Hide
C21H25N5O3
 1
1
EC50 = 43 nM
   TI
   LI
   LO
   TS
CP0965358
N-(4-((2S,6R)-2,6-dimethylmorpholino)phenyl)-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H25N7O
 1
1
EC50 = 45 nM
   TI
   LI
   LO
   TS
CP0342413
6-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C27H29N7O2
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0570056
N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]-6-(1H-pyrrolo[3,2-b]pyridin-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H26N8O
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0127635
6-(2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H28N8O2
 1
1
EC50 = 46.8 nM
   TI
   LI
   LO
   TS
CP0559741
6-(3H-benzimidazol-5-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H26N8O
 1
1
EC50 = 47 nM
   TI
   LI
   LO
   TS
CP0546652
5,5-dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-3,4-dihydro-1H-1-benzazepin-2-one
   Show/Hide
C20H20F3N5O2
 1
1
EC50 = 49 nM
   TI
   LI
   LO
   TS
CP0041572
BDBM50249542
   Show/Hide
C22H23FN6O5
 2
1
EC50 = 53 nM
   TI
   LI
   LO
   TS
2
IC50 = 457 nM
   TI
   LI
   LO
   TS
CP0329990
6-(1H-indazol-6-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H26N8O
 1
1
EC50 = 53 nM
   TI
   LI
   LO
   TS
CP0397359
6-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-4H-1,4-benzoxazin-3-one
   Show/Hide
C22H19N5O4
 1
1
EC50 = 57 nM
   TI
   LI
   LO
   TS
CP0525500
1-[4-[[6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]azetidin-3-ol
   Show/Hide
C22H19N7O
 1
1
EC50 = 57 nM
   TI
   LI
   LO
   TS
CP0395436
6-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)-N-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C22H21N5O3
 1
1
EC50 = 62 nM
   TI
   LI
   LO
   TS
CP0570055
6-(1H-indazol-6-yl)-N-[4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H21N7O
 1
1
EC50 = 63 nM
   TI
   LI
   LO
   TS
CP0368619
6-(1H-imidazo[4,5-b]pyridin-5-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H25N9O
 1
1
EC50 = 66 nM
   TI
   LI
   LO
   TS
CP0695454
N-(4-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)phenyl)-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H21N7O
 1
1
EC50 = 68 nM
   TI
   LI
   LO
   TS
CP0419327
6-(1H-indazol-6-yl)-N-[4-(1,4-oxazepan-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H23N7O
 1
1
EC50 = 73 nM
   TI
   LI
   LO
   TS
CP0399159
1-[4-[[6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-3-methylazetidin-3-ol
   Show/Hide
C23H21N7O
 1
1
EC50 = 80 nM
   TI
   LI
   LO
   TS
CP0148490
2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-ylamino)nicotinamide hydrochloride
   Show/Hide
C20H18N6O3
 1
1
EC50 = 81 nM
   TI
   LI
   LO
   TS
CP0127634
6-(1H-indazol-6-yl)-N-[4-(7-oxa-2-azaspiro[3.5]nonan-2-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H25N7O
 1
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
CP0057732
N-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C22H19N5O2
 1
1
EC50 = 86 nM
   TI
   LI
   LO
   TS
CP0525503
6-(3,4-dihydro-2H-pyrazino[2,3-b][1,4]oxazin-6-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H27N9O2
 1
1
EC50 = 86 nM
   TI
   LI
   LO
   TS
CP0122055
2-N-(3-methyl-2H-indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine
   Show/Hide
C16H13F3N6O
 1
1
EC50 = 87 nM
   TI
   LI
   LO
   TS
CP0399157
N-(3,4-dimethoxyphenyl)-6-(1H-indol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C22H19N5O2
 1
1
EC50 = 94 nM
   TI
   LI
   LO
   TS
CP0314384
7-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one
   Show/Hide
C17H14F3N5O2
 1
1
EC50 = 101 nM
   TI
   LI
   LO
   TS
CP0090801
N-(4-carbamoylphenyl)-3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]benzamide
   Show/Hide
C28H24N6O4
 1
1
EC50 = 105 nM
   TI
   LI
   LO
   TS
CP0342414
6-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H28N8O2
 1
1
EC50 = 107 nM
   TI
   LI
   LO
   TS
CP0823071
(R)-N-(4-(2-((dimethylamino)methyl)morpholino)phenyl)-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C26H28N8O
 1
1
EC50 = 109 nM
   TI
   LI
   LO
   TS
CP0694111
N-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)phenyl)-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H21N7O
 1
1
EC50 = 113 nM
   TI
   LI
   LO
   TS
CP0081507
2-N-(3-chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine
   Show/Hide
C18H17ClF3N5O2
 1
1
EC50 = 117 nM
   TI
   LI
   LO
   TS
CP0169426
N-(3,4-dimethoxyphenyl)-6-(1H-indazol-5-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C21H18N6O2
 1
1
EC50 = 122 nM
   TI
   LI
   LO
   TS
CP0399156
5-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-2-methylbenzamide
   Show/Hide
C22H21N5O3
 1
1
EC50 = 123 nM
   TI
   LI
   LO
   TS
CP0557399
4-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]benzamide
   Show/Hide
C21H19N5O3
 1
1
EC50 = 127 nM
   TI
   LI
   LO
   TS
CP0169425
4-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-2-fluorobenzamide
   Show/Hide
C21H18FN5O3
 1
1
EC50 = 134 nM
   TI
   LI
   LO
   TS
CP0090805
N-(3,4-dimethoxyphenyl)-6-(1-methylindazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C22H20N6O2
 1
1
EC50 = 136 nM
   TI
   LI
   LO
   TS
CP0415816
6-(3H-benzimidazol-5-yl)-N-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C21H18N6O2
 1
1
EC50 = 139 nM
   TI
   LI
   LO
   TS
CP0131480
6-(2H-benzotriazol-5-yl)-N-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C20H17N7O2
 1
1
EC50 = 151 nM
   TI
   LI
   LO
   TS
CP0059737
6-(1H-indazol-6-yl)-N-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C20H16N6O
 1
1
EC50 = 161 nM
   TI
   LI
   LO
   TS
CP0127636
6-(5-aminopyridin-3-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H26N8O
 1
1
EC50 = 162 nM
   TI
   LI
   LO
   TS
CP0948350
N-(4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)phenyl)-6-(1H-indazol-6-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H23N7O
 1
1
EC50 = 162 nM
   TI
   LI
   LO
   TS
CP0169423
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N-[4-(1H-pyrazol-3-yl)phenyl]benzamide
   Show/Hide
C30H25N7O3
 1
1
EC50 = 166 nM
   TI
   LI
   LO
   TS
CP0558967
7-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-4H-1,4-benzoxazin-3-one
   Show/Hide
C22H19N5O4
 1
1
EC50 = 168 nM
   TI
   LI
   LO
   TS
CP0090813
4-[[3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]benzoyl]amino]benzoic acid
   Show/Hide
C28H23N5O5
 1
1
EC50 = 175 nM
   TI
   LI
   LO
   TS
CP0169427
N-(3,4-dimethoxyphenyl)-6-(1-methylindazol-5-yl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C22H20N6O2
 1
1
EC50 = 183 nM
   TI
   LI
   LO
   TS
CP0940632
6-(1H-indazol-6-yl)-N-(4-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H23N7O
 1
1
EC50 = 187 nM
   TI
   LI
   LO
   TS
CP0329992
6-(3H-imidazo[4,5-b]pyrazin-5-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H24N10O
 1
1
EC50 = 192 nM
   TI
   LI
   LO
   TS
CP0090803
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N-[4-(1H-imidazol-2-yl)phenyl]benzamide
   Show/Hide
C30H25N7O3
 1
1
EC50 = 199 nM
   TI
   LI
   LO
   TS
CP0125452
6-(3-aminophenyl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H27N7O
 1
1
EC50 = 220 nM
   TI
   LI
   LO
   TS
CP0081509
2-N-(1H-indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine
   Show/Hide
C15H11F3N6O
 1
1
EC50 = 235 nM
   TI
   LI
   LO
   TS
CP0558836
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]benzamide
   Show/Hide
C21H19N5O3
 1
1
EC50 = 244 nM
   TI
   LI
   LO
   TS
CP0558837
5-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-2-fluorobenzamide
   Show/Hide
C21H18FN5O3
 1
1
EC50 = 248 nM
   TI
   LI
   LO
   TS
CP0381549
4-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-2-methoxybenzamide
   Show/Hide
C22H21N5O4
 1
1
EC50 = 251 nM
   TI
   LI
   LO
   TS
CP0558993
5-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-2-methoxybenzamide
   Show/Hide
C22H21N5O4
 1
1
EC50 = 268 nM
   TI
   LI
   LO
   TS
CP0125453
6-(6-aminopyridin-2-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H26N8O
 1
1
EC50 = 268 nM
   TI
   LI
   LO
   TS
CP0114932
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N-[4-(1H-pyrazol-4-yl)phenyl]benzamide
   Show/Hide
C30H25N7O3
 1
1
EC50 = 270 nM
   TI
   LI
   LO
   TS
CP0329991
6-(1H-imidazo[4,5-b]pyridin-6-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C25H25N9O
 1
1
EC50 = 286 nM
   TI
   LI
   LO
   TS
CP0131477
methyl 4-[[3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]benzoyl]amino]benzoate
   Show/Hide
C29H25N5O5
 1
1
EC50 = 293 nM
   TI
   LI
   LO
   TS
CP0399155
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N-[4-(1H-tetrazol-5-yl)phenyl]benzamide
   Show/Hide
C28H23N9O3
 1
1
EC50 = 308 nM
   TI
   LI
   LO
   TS
CP0090804
4-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-2-methylbenzamide
   Show/Hide
C22H21N5O3
 1
1
EC50 = 310 nM
   TI
   LI
   LO
   TS
CP0563192
N-propyl-4-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]benzamide
   Show/Hide
C18H18F3N5O2
 1
1
EC50 = 346 nM
   TI
   LI
   LO
   TS
CP0399158
6-(1H-indazol-6-yl)-N-(3-methoxyphenyl)imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C20H16N6O
 1
1
EC50 = 374 nM
   TI
   LI
   LO
   TS
CP0558966
4-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-3-methylbenzamide
   Show/Hide
C22H21N5O3
 1
1
EC50 = 418 nM
   TI
   LI
   LO
   TS
CP0400235
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N,N-dimethylbenzamide
   Show/Hide
C23H23N5O3
 1
1
EC50 = 615 nM
   TI
   LI
   LO
   TS
CP0169424
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N-methylbenzamide
   Show/Hide
C22H21N5O3
 1
1
EC50 = 619 nM
   TI
   LI
   LO
   TS
CP0093067
3-[[3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]benzoyl]amino]benzoic acid
   Show/Hide
C28H23N5O5
 1
1
EC50 = 643 nM
   TI
   LI
   LO
   TS
CP0122056
2,2-dimethyl-6-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-4H-1,4-benzoxazin-3-one
   Show/Hide
C18H16F3N5O3
 1
1
EC50 = 723 nM
   TI
   LI
   LO
   TS
CP0090802
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N-[4-(methylsulfonylcarbamoyl)phenyl]benzamide
   Show/Hide
C29H26N6O6S
 1
1
EC50 = 824 nM
   TI
   LI
   LO
   TS
CP0434793
2-[4-[[3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]benzoyl]amino]phenyl]acetic acid
   Show/Hide
C29H25N5O5
 1
1
EC50 = 2165 nM
   TI
   LI
   LO
   TS
CP0093069
6-(1H-indazol-6-yl)-N-[4-(oxan-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C24H22N6O
 1
1
EC50 = 2366 nM
   TI
   LI
   LO
   TS
CP0397360
6-(1H-indazol-6-yl)-N-phenylimidazo[1,2-a]pyrazin-8-amine
   Show/Hide
C19H14N6
 1
1
EC50 > 3300 nM
   TI
   LI
   LO
   TS
CP0722967
5-(1H-indol-4-ylamino)-3-((1R,2S)-2-aminocyclohexylamino)-1,2,4-triazine-6-carboxamide
   Show/Hide
C18H22N8O
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0761533
3-(1H-indol-7-ylamino)-5-((1R,2S)-2-aminocyclohexylamino)pyrazine-2-carboxamide
   Show/Hide
C19H23N7O
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0084714
7-[[(1R,2S)-2-aminocyclohexyl]amino]-5-(1H-indol-4-ylamino)-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C21H23N7O
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0084720
7-[[(3R,4R)-3-aminooxan-4-yl]amino]-5-[(3-methyl-1H-indol-7-yl)amino]-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C21H23N7O2
 1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CP0084716
7-[[(1R,2S)-2-aminocyclohexyl]amino]-5-[(3-methyl-1H-indol-7-yl)amino]-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C22H25N7O
 1
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
CP0183353
6-[[(3R,4R)-3-aminooxan-4-yl]amino]-8-(1H-indol-7-ylamino)-2H-2,7-naphthyridin-1-one
   Show/Hide
C21H22N6O2
 1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
CP0180795
N-tert-butyl-2-[6-fluoro-1-(3-methylsulfonylpropyl)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C22H25FN6O3S
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0084717
7-[[(3R,4R)-3-aminooxan-4-yl]amino]-5-(1H-indol-7-ylamino)-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C20H21N7O2
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0245877
5-[[(1R,2S)-2-aminocyclohexyl]amino]-3-[3-(triazol-2-yl)anilino]pyrazine-2-carboxamide
   Show/Hide
C19H23N9O
 1
1
IC50 = 69 nM
   TI
   LI
   LO
   TS
CP0131332
N-tert-butyl-2-[7-(2-hydroxypropan-2-yl)-2H-indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C21H24N6O2
 1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0138682
2-[6-fluoro-1-(3-methylsulfonylpropyl)indazol-3-yl]-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C22H25FN6O4S
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0222796
6-[[(3R,4R)-3-aminooxan-4-yl]amino]-8-[(2-methylindazol-4-yl)amino]-2H-2,7-naphthyridin-1-one
   Show/Hide
C21H23N7O2
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0188380
N-tert-butyl-2-[5-(difluoromethoxy)-1-(3,4-dihydroxybutyl)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C23H26F2N6O4
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0131333
N-tert-butyl-2-[7-(hydroxymethyl)-2H-indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C19H20N6O2
 1
1
IC50 = 86 nM
   TI
   LI
   LO
   TS
CP0131336
N-tert-butyl-2-[5-(difluoromethoxy)-1H-indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C19H18F2N6O2
 1
1
IC50 = 88 nM
   TI
   LI
   LO
   TS
CP0094511
(4R)-4-[(1R)-1-[[5-(1-methylpyrazol-4-yl)-1,3-benzothiazol-7-yl]oxy]ethyl]pyrrolidin-2-one
   Show/Hide
C17H18N4O2S
 1
1
IC50 = 89 nM
   TI
   LI
   LO
   TS
CP0118574
7-[[(1R,2S)-2-aminocyclohexyl]amino]-5-(1H-indol-7-ylamino)-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C21H23N7O
 1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
CP0183356
6-[[(1R,2S)-2-aminocyclohexyl]amino]-8-[(3-methyl-1H-indol-7-yl)amino]-2H-2,7-naphthyridin-1-one
   Show/Hide
C23H26N6O
 1
1
IC50 = 95 nM
   TI
   LI
   LO
   TS
CP0658097
5-(1H-indol-7-ylamino)-3-((1R,2S)-2-aminocyclohexylamino)-1,2,4-triazine-6-carboxamide
   Show/Hide
C18H22N8O
 1
1
IC50 = 99 nM
   TI
   LI
   LO
   TS
CP0365726
3-[[(1R,2S)-2-aminocyclohexyl]amino]-5-[3-(triazol-2-yl)anilino]-1,2,4-triazine-6-carboxamide
   Show/Hide
C18H22N10O
 1
1
IC50 = 104 nM
   TI
   LI
   LO
   TS
CP0147657
(5R)-5-[(1R)-1-[[5-[1-(difluoromethyl)pyrazol-4-yl]-1,3-benzothiazol-7-yl]oxy]ethyl]-1,3-oxazolidin-2-one
   Show/Hide
C16H14F2N4O3S
 1
1
IC50 = 107 nM
   TI
   LI
   LO
   TS
CP0131599
N-tert-butyl-2-[5-(hydroxymethyl)-1-methylindazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C20H22N6O2
 1
1
IC50 = 119 nM
   TI
   LI
   LO
   TS
CP0031598
1-[4-[(4-methylpyridin-2-yl)methoxy]-3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)phenyl]ethanone
   Show/Hide
C25H26N2O2
 1
1
IC50 = 125.89 nM
   TI
   LI
   LO
   TS
CP0138683
2-[5-(difluoromethoxy)-1-[3-(dimethylamino)propyl]indazol-3-yl]-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C24H29F2N7O3
 1
1
IC50 = 127 nM
   TI
   LI
   LO
   TS
CP0337854
N-tert-butyl-2-(6-methoxyindazol-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C19H20N6O2
 1
1
IC50 = 129 nM
   TI
   LI
   LO
   TS
CP0131614
2-(6-chloroindazol-1-yl)-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C18H17ClN6O2
 1
1
IC50 = 132 nM
   TI
   LI
   LO
   TS
CP0185405
(4R)-4-[(1R)-1-[[6-(3,4-dimethoxyphenyl)-[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy]ethyl]pyrrolidin-2-one
   Show/Hide
C20H21N3O4S
 1
1
IC50 = 132 nM
   TI
   LI
   LO
   TS
CP0302172
N-tert-butyl-2-[5-(difluoromethoxy)-1-[3-(dimethylamino)propyl]indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C24H29F2N7O2
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0165059
N-tert-butyl-2-(6-fluoro-1-piperidin-4-ylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C23H26FN7O
 1
1
IC50 = 142 nM
   TI
   LI
   LO
   TS
CP0137988
2-(6-fluoro-1-methylindazol-3-yl)-N-(3-hydroxycyclobutyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C19H17FN6O2
 1
1
IC50 = 151 nM
   TI
   LI
   LO
   TS
CP0282163
4-[[3-[7-(3,4-dimethoxyanilino)-[1,3]thiazolo[5,4-d]pyrimidin-5-yl]benzoyl]amino]benzoic acid
   Show/Hide
C27H21N5O5S
 1
1
IC50 = 156 nM
   TI
   LI
   LO
   TS
CP0116125
(4R)-4-[(1R)-1-[[6-(1-methylpyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy]ethyl]pyrrolidin-2-one
   Show/Hide
C17H18N4O2S
 1
1
IC50 = 161 nM
   TI
   LI
   LO
   TS
CP0176762
(5R)-5-[(1R)-1-[[6-(1-methylpyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy]ethyl]-1,3-oxazolidin-2-one
   Show/Hide
C16H16N4O3S
 1
1
IC50 = 166 nM
   TI
   LI
   LO
   TS
CP0189631
N-tert-butyl-2-[5-(difluoromethoxy)-1-(3-methylsulfonylpropyl)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C23H26F2N6O4S
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0776455
4-(1H-indol-7-ylamino)-2-((1R,2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide
   Show/Hide
C19H23N7O
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0093554
BIIB-057
   Show/Hide
C19H23N9O
 2
1
IC50 = 178 nM
   TI
   LI
   LO
   TS
2
IC50 = 223 nM
   TI
   LI
   LO
   TS
CP0165060
N-tert-butyl-2-[5-(difluoromethoxy)-1-methylindazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C20H20F2N6O2
 1
1
IC50 = 179 nM
   TI
   LI
   LO
   TS
CP0165061
N-propan-2-yl-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C19H22N4O4
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0131329
N-tert-butyl-2-[5-(difluoromethoxy)-1-(3-morpholin-4-ylpropyl)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C26H31F2N7O3
 1
1
IC50 = 195 nM
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CP0019810
7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine
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C24H26N2O2
 1
1
IC50 = 199.53 nM
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CP0084719
7-[[(2S)-2-aminopropyl]amino]-5-(1H-indol-7-ylamino)-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C18H19N7O
 1
1
IC50 = 209 nM
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   LO
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CP0189636
N-tert-butyl-2-[1-[3-(3-cyanoazetidin-1-yl)propyl]-5-(difluoromethoxy)indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C26H28F2N8O2
 1
1
IC50 = 211 nM
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CP0244926
2-(6-chloro-1-methylindazol-3-yl)-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C19H19ClN6O2
 1
1
IC50 = 240 nM
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CP0095463
(4R)-4-[(1R)-1-[[6-(1-methylpyrazol-4-yl)-[1,2]thiazolo[4,3-c]pyridin-4-yl]oxy]ethyl]pyrrolidin-2-one
   Show/Hide
C16H17N5O2S
 1
1
IC50 = 247 nM
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CP0023355
1-[4-[(4-ethylpyridin-2-yl)methoxy]-3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)phenyl]ethanone
   Show/Hide
C26H28N2O2
 1
1
IC50 = 251.19 nM
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CP0316189
N-tert-butyl-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C19H19FN6O
 1
1
IC50 = 252 nM
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CP0131603
2-(3,4-dimethoxyphenyl)-N-(1-hydroxypropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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C18H20N4O4
 1
1
IC50 = 256 nM
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CP0131605
FOSTAMATINIB
   Show/Hide
C23H26FN6O9P
 1
1
IC50 = 267 nM
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CP0118577
6-[[(1R,2S)-2-aminocyclohexyl]amino]-8-[(3-chloro-1H-indol-7-yl)amino]-2H-2,7-naphthyridin-1-one
   Show/Hide
C22H23ClN6O
 1
1
IC50 = 283 nM
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CP0066654
(5R)-5-[(1R)-1-[[6-[1-(difluoromethyl)pyrazol-4-yl]-[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy]ethyl]-1,3-oxazolidin-2-one
   Show/Hide
C15H13F2N5O3S
 1
1
IC50 = 284 nM
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CP0233502
(4R)-4-[(1R)-1-[[6-(1-methylpyrazol-4-yl)-[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy]ethyl]pyrrolidin-2-one
   Show/Hide
C16H17N5O2S
 1
1
IC50 = 284 nM
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CP0337846
2-(6-chloro-1-methylindazol-3-yl)-N-[(2S)-1-hydroxypropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C18H17ClN6O2
 1
1
IC50 = 291 nM
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CP0024034
7-[5-methoxy-2-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine
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C24H26N2O2
 1
1
IC50 = 316.23 nM
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CP0030878
N-methyl-4-[(4-methylpyridin-2-yl)methoxy]-3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide
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C25H27N3O2
 1
1
IC50 = 316.23 nM
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CP0183352
7-[[(1R,2S)-2-aminocyclohexyl]amino]-5-[(3-chloro-1H-indol-7-yl)amino]-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C21H22ClN7O
 1
1
IC50 = 320 nM
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CP0116183
(5R)-5-[(1R)-1-[[6-[1-(difluoromethyl)pyrazol-4-yl]-2,1-benzothiazol-4-yl]oxy]ethyl]-1,3-oxazolidin-2-one
   Show/Hide
C16H14F2N4O3S
 1
1
IC50 = 328 nM
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CP0265842
(4R)-4-[(1R)-1-[[6-[1-(difluoromethyl)pyrazol-4-yl]-2,1-benzothiazol-4-yl]oxy]ethyl]pyrrolidin-2-one
   Show/Hide
C17H16F2N4O2S
 1
1
IC50 = 340 nM
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CP0131328
N-tert-butyl-2-[1-(3,4-dihydroxybutyl)-6-fluoroindazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C22H25FN6O3
 1
1
IC50 = 366 nM
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CP0084715
5-(1H-indol-7-ylamino)-7-[[(3R)-piperidin-3-yl]amino]-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C20H21N7O
 1
1
IC50 = 378 nM
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CP0032712
7-[5-methoxy-2-(pyrazin-2-ylmethoxy)phenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine
   Show/Hide
C22H23N3O2
 1
1
IC50 = 398.11 nM
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CP0796446
2-(1H-indol-7-ylamino)-6-((1R,2S)-2-aminocyclohexylamino)nicotinamide
   Show/Hide
C20H24N6O
 1
1
IC50 = 438 nM
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CP0121931
6-[[(1R,2S)-2-aminocyclohexyl]amino]-2-[3-(triazol-2-yl)anilino]pyridine-3-carboxamide
   Show/Hide
C20H24N8O
 1
1
IC50 = 445 nM
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CP0251299
N-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C18H22N6O
 1
1
IC50 = 450 nM
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CP0032241
7-[6-methyl-3-[(4-methylpyridin-2-yl)methoxy]pyridin-2-yl]-2,3,4,5-tetrahydro-1H-3-benzazepine
   Show/Hide
C23H25N3O
 1
1
IC50 = 501.19 nM
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CP0159500
2-(6-chloro-1-methylindazol-3-yl)-N-propan-2-yl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C18H17ClN6O
 1
1
IC50 = 512 nM
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CP0021278
1-[4-[(4-ethoxypyridin-2-yl)methoxy]-3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)phenyl]ethanone
   Show/Hide
C26H28N2O3
 1
1
IC50 = 630.96 nM
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CP0024035
7-[4-methoxy-2-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine
   Show/Hide
C24H26N2O2
 1
1
IC50 = 630.96 nM
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CP0283985
N-propan-2-yl-2-(1,5,5-trimethyl-6,7-dihydro-4H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C20H26N6O
 1
1
IC50 = 738 nM
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CP0183360
7-[[(1R,2S)-2-aminocyclohexyl]amino]-5-[3-(triazol-2-yl)anilino]-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C21H23N9O
 1
1
IC50 = 778 nM
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CP0131600
N-(3-amino-1-methylcyclobutyl)-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C20H20FN7O
 1
1
IC50 = 848 nM
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CP0095465
N'-[7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl]propane-1,3-diamine
   Show/Hide
C19H23N5
 1
1
IC50 = 951 nM
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CP0016722
4-[(4-methylpyridin-2-yl)methoxy]-3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzonitrile
   Show/Hide
C24H23N3O
 1
1
IC50 = 1000 nM
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CP0213833
N'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine
   Show/Hide
C18H21N5
 1
1
IC50 = 1258.93 nM
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CP0131597
2-(1,6-dimethylindazol-3-yl)-N-(3-methylpyrrolidin-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C21H23N7O
 1
1
IC50 = 1310 nM
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CP0419284
N-[(3R,5S)-5-aminooxan-3-yl]-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C20H20FN7O2
 1
1
IC50 = 1371 nM
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CP0697634
N-(5-aminotetrahydro-2H-pyran-3-yl)-2-(6-fluoro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C20H20FN7O2
 1
1
IC50 = 1477 nM
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CP0137166
N-[(3R,5R)-5-aminooxan-3-yl]-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C20H20FN7O2
 1
1
IC50 = 1841 nM
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CP0131595
N-tert-butyl-2-[5-(difluoromethoxy)-1-[(1-methylazetidin-3-yl)methyl]indazol-3-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C24H27F2N7O2
 1
1
IC50 = 2790 nM
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CP0246641
N-(3-amino-1-methylcyclobutyl)-2-(6-fluoro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C20H20FN7O
 1
1
IC50 = 3690 nM
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CP0137168
2-(6-fluoro-1-methylindazol-3-yl)-N-(4-methylpiperidin-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C21H22FN7O
 1
1
IC50 = 3700 nM
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CP0131615
2-[1-[3-(dimethylamino)propyl]-6-methylindazol-3-yl]-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C24H31N7O2
 1
1
IC50 = 6920 nM
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CP0244626
7-[[(1R,2S)-2-aminocyclohexyl]amino]-5-[(1-methylindol-7-yl)amino]-3H-pyrido[4,3-d]pyrimidin-4-one
   Show/Hide
C22H25N7O
 1
1
IC50 = 9274 nM
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CP0032490
2-(4-methoxyphenyl)-6-methyl-3-[(4-methylpyridin-2-yl)methoxy]pyridine
   Show/Hide
C20H20N2O2
 1
1
IC50 = 10000 nM
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CP0131338
N-tert-butyl-2-(6-chloro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
   Show/Hide
C19H19ClN6O
 1
1
IC50 > 31000 nM
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CP0030178
1-[3-(4-methoxyphenyl)-4-(pyridin-2-ylmethoxy)phenyl]ethanone
   Show/Hide
C21H19NO3
 1
1
IC50 > 50118.72 nM
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