General Information of the Compound
| Compound ID |
CP0131605
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| Compound Name |
FOSTAMATINIB
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| Synonyms |
901119-35-5
Fostamatinib
Fostamatinib [USAN:INN]
R 788
R-788
R-788 Free acid
R-935788 Free acid
R788
R7935788
SQ8A3S5101
Tavalisse
UNII-SQ8A3S5101
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| Structure |
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| Formula |
C23H26FN6O9P
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| Molecular Weight |
580.466
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| Canonical SMILES |
COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP(O)(O)=O)c4n3)n2)cc(OC)c1OC
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| InChI |
InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)
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| InChIKey |
GKDRMWXFWHEQQT-UHFFFAOYSA-N
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| CAS |
901119-35-5
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Clinical Information about the Compound