General Information of the Compound
Compound ID
CP0525503
Compound Name
6-(3,4-dihydro-2H-pyrazino[2,3-b][1,4]oxazin-6-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
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Structure
Formula
C25H27N9O2
Molecular Weight
485.552
Canonical SMILES
C1OCC1N1CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2cnc3OCCNc3n2)cc1
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InChI
InChI=1S/C25H27N9O2/c1-3-18(32-8-10-33(11-9-32)19-15-35-16-19)4-2-17(1)29-22-24-27-5-7-34(24)14-21(31-22)20-13-28-25-23(30-20)26-6-12-36-25/h1-5,7,13-14,19H,6,8-12,15-16H2,(H,26,30)(H,29,31)
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InChIKey
UMRZARFXLLZDPI-UHFFFAOYSA-N
Physicochemical Property
logP
2.255
Rotatable Bonds
5
Heavy Atom Count
36
Polar Areas
104.97
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
11
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156010651
ChEMBL ID
CHEMBL4633180
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01441, Tyrosine-protein kinase SYK
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos Homo sapiens (Human)  1
1
EC50 = 86 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 7.8 nM